Modulation of SIRT1 expression in different neurodegenerative models and human pathologies.

abstract：:Midbrain dopamine neurons are critical in mediating the rewarding effects of opiates in dependent rats, as well as modulating some manifestations of opiate withdrawal. Morphine is known to excite dopamine neurons and thereby facilitate forebrain dopamine transmission through inhibition of GABA neurons. Cholinergic neu...

journal_title：Neuroscience

authors： Miller AD,Forster GL,Yeomans JS,Blaha CD

更新日期：2005-01-01 00:00:00

abstract：:Extracellular recordings were made from serotonergic neurons of the rat dorsal raphe nucleus in a slice preparation. In the presence of phenylephrine (3 microM) to restore the pacemaker activity of otherwise silent serotonergic neurons, superfusion with the 5-hydroxytryptamine1A agonist ipsapirone depressed the firing...

journal_title：Neuroscience

authors： Haj-Dahmane S,Hamon M,Lanfumey L

更新日期：1991-01-01 00:00:00

abstract：:Extinction of drug-seeking is an integral part of addiction treatment, and can profoundly reverse or ameliorate the harmful consequences of drug use. These consequences may be the most deleterious during adolescence. The studies presented here build from recent evidence that adolescent rats are more resistant to extin...

journal_title：Neuroscience

authors： Brenhouse HC,Dumais K,Andersen SL

更新日期：2010-08-25 00:00:00

abstract：:Activation of neurokinin-1 (NK-1) receptors in the rostral ventromedial medulla (RVM) can facilitate pain transmission in conditions such as inflammation, and thereby contribute to hyperalgesia. Since blockade of NK-1 receptors in the RVM can attenuate hyperalgesia produced by prolonged inflammation, we examined the r...

journal_title：Neuroscience

authors： Khasabov SG,Brink TS,Schupp M,Noack J,Simone DA

更新日期：2012-11-08 00:00:00

abstract：:Glomeruli are functional units of the olfactory bulb responsible for early processing of odor information encoded by single olfactory receptor genes. Glomerular neural circuitry includes numerous external tufted (ET) cells whose rhythmic burst firing may mediate synchronization of bulbar activity with the inhalation c...

journal_title：Neuroscience

authors： Ma J,Lowe G

更新日期：2007-02-09 00:00:00

abstract：:Increased brain deposition of amyloid beta protein (Abeta) and cognitive deficits are classical signs of Alzheimer's disease (AD) that have been widely associated to inflammatory response. We have recently shown that a single i.c.v. injection of aggregated beta-amyloid peptide-(1-40) (Abeta(1-40)) (400 pmol/mouse) res...

journal_title：Neuroscience

authors： Prediger RD,Medeiros R,Pandolfo P,Duarte FS,Passos GF,Pesquero JB,Campos MM,Calixto JB,Takahashi RN

更新日期：2008-02-06 00:00:00

abstract：:A role has been suggested for hypothalamic alpha1 adrenoceptors in the acute stress-induced activation of the hypothalamic-pituitary-adrenal axis. Using a polyclonal antiserum against the rat alpha1B adrenergic receptor protein, we have demonstrated alpha1B receptor immunoreactivity in neurons and especially in puncta...

journal_title：Neuroscience

authors： Williams AM,Morilak DA

更新日期：1997-02-01 00:00:00

abstract：:We have recently shown that the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate enhances the depolarization induced, calcium dependent release of [3H]dopamine from cultured brain neurons in the rat. In the present study the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the kinetic parameters of depolarizatio...

journal_title：Neuroscience

authors： Zurgil N,Yarom M,Zisapel N

更新日期：1986-12-01 00:00:00

abstract：:Executive control requires behavioral adaptation to environmental contingencies. In the stop signal task (SST), participants exhibit slower go trial reaction time (RT) following a stop trial, whether or not they successfully interrupt the motor response. In previous fMRI studies, we demonstrated activation of the righ...

journal_title：Neuroscience

authors： Zhang Y,Ide JS,Zhang S,Hu S,Valchev NS,Tang X,Li CR

更新日期：2017-08-15 00:00:00

abstract：:Functional imaging studies have implicated the hippocampus and parahippocampal gyrus in cue-guided spatial navigation, but also many other regions. Furthermore, little is known about de-activations that take place during performance of navigation tasks, something that is of interest given that the hippocampus is a com...

journal_title：Neuroscience

authors： Salgado-Pineda P,Landin-Romero R,Pomes A,Spanlang B,Sarró S,Salvador R,Slater M,McKenna PJ,Pomarol-Clotet E

更新日期：2017-09-01 00:00:00

abstract：:Immunosuppression remains a key issue in neural transplantation. Systemic administration of cyclosporin-A is currently widely used but has many severe adverse side effects. Newer immunosuppressive agents, such as tacrolimus (TAC) and rapamycin (RAPA), have been investigated for their neuroprotective properties on dopa...

journal_title：Neuroscience

authors： Alemdar AY,Sadi D,McAlister V,Mendez I

更新日期：2007-04-25 00:00:00

abstract：:Cholecystokinin binding sites were labeled with [3H]cholecystokinin-8, [125I]cholecystokinin-33, and [125I]cholecystokinin-8 in major structures of macaque basal ganglia by in vitro receptor autoradiography. Analysis of autoradiograms revealed areas of heavy cholecystokinin binding in the neostriatum and substantia ni...

journal_title：Neuroscience

authors： Kritzer MF,Innis RB,Goldman-Rakic PS

更新日期：1990-01-01 00:00:00

abstract：:Oscillatory activity is a prominent characteristic of electrophysiological recordings in the olfactory system and has been proposed to play a key role in encoding olfactory representations. Studies in several systems have shown that some aspects of information coding involve characteristics that intertwine spikes and ...

journal_title：Neuroscience

authors： Litaudon P,Garcia S,Buonviso N

更新日期：2008-10-15 00:00:00

abstract：:It has been reported that N-methyl-D-aspartate receptor (NMDAR)-triggered neurotoxicity is related to excessive Ca(2+) loading and an increase in nitric oxide (NO) concentration. However, the molecular mechanisms that underlie these events are not completely understood. NMDARs and neuronal NO synthase each binds to th...

journal_title：Neuroscience

authors： Zhang M,Xu JT,Zhu X,Wang Z,Zhao X,Hua Z,Tao YX,Xu Y

更新日期：2010-04-14 00:00:00

abstract：:Cerebral ischemia is the most common cause of stroke with high morbidity, disability and mortality. Sirtuin-2 (Sirt2), a vitally important NAD+-dependent deacetylase which has been widely researched in central nervous system diseases, has also been identified as a promising treatment target using its specific inhibito...

journal_title：Neuroscience

authors： Wu D,Lu W,Wei Z,Xu M,Liu X

更新日期：2018-03-15 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens. Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of ho...

journal_title：Neuroscience

authors： Song C,Merali Z,Anisman H

更新日期：1999-01-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) and nesfatin-1/nucleobindin 2 (NUCB2) are assumed to play a role in feeding and adaptation to stress. Both peptides are highly expressed in the midbrain non-preganglionic Edinger-Westphal nucleus (npEW), a center implicated in the regulation of stress adaptation and...

journal_title：Neuroscience

authors： Xu L,Bloem B,Gaszner B,Roubos EW,Kozicz T

更新日期：2010-10-13 00:00:00

abstract：:Neurosteroids such as dehydroepiandrosterone (DHEA), pregnenolone and 17beta-estradiol are synthesized by cytochrome P450s from endogenous cholesterol. We previously reported a new cytochrome P450 enzyme, CYP7B, highly expressed in rat and mouse brain that metabolizes DHEA and related steroids by hydroxylation at the ...

journal_title：Neuroscience

authors： Yau JL,Rasmuson S,Andrew R,Graham M,Noble J,Olsson T,Fuchs E,Lathe R,Seckl JR

更新日期：2003-01-01 00:00:00

abstract：:The 5-HT6 receptor (5-HT6R) is almost exclusively expressed in the brain and has emerged as a promising target for cognitive disorders, including Alzheimer's disease. In the present study, we have determined the cell types on which the 5-HT6R is expressed by colocalizing 5-HT6R mRNA with that of a range of neuronal an...

journal_title：Neuroscience

authors： Helboe L,Egebjerg J,de Jong IE

更新日期：2015-12-03 00:00:00

abstract：:Even simple behaviors of vertebrates are typically generated by the concerted action of large numbers of brain cells. However, the mechanisms by which groups of neurons work together as functional populations to guide behavior remain largely unknown. One of the major model systems for exploring these mechanisms has be...

journal_title：Neuroscience

authors： Crish SD,Dengler-Crish CM,Comer CM

更新日期：2006-01-01 00:00:00

abstract：:The neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamus were demonstrated by electrolytic lesion studies and fluorescent retrograde tracing combined with immunocytochemistry. Three-to-five-day-old rats were used, because the immunoreactivity of neurotensin fibers in anteri...

journal_title：Neuroscience

authors： Fukami K,Kiyama H,Shiotani Y,Tohyama M

更新日期：1988-09-01 00:00:00

abstract：:Sleep mechanisms and synaptic plasticity are thought to interact to regulate homeostasis and memory formation. However, the influences of molecules that mediate synaptic plasticity on sleep are not well understood. In this study we demonstrate that mice lacking Rab3 interacting molecule 1 alpha (RIM1 alpha) (Rim1 alph...

journal_title：Neuroscience

authors： Lonart G,Tang X,Simsek-Duran F,Machida M,Sanford LD

更新日期：2008-06-23 00:00:00

abstract：:Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated dep...

journal_title：Neuroscience

authors： Russo RE,Hounsgaard J

更新日期：1994-07-01 00:00:00

abstract：:A recent study has described synchronous burst discharges of dentate hilar neurons and area CA3 pyramidal cells in the presence of the convulsants 4-aminopyridine and picrotoxin in guinea-pig hippocampal slices [Müller W. and Misgeld U. (1991) J. Neurophysiol. 65, 141-147]. To examine the synchronous activity of denta...

journal_title：Neuroscience

authors： Scharfman HE

更新日期：1994-03-01 00:00:00

abstract：:Six-day-old neuronal cultures derived from 14-day-old embryonic rat cerebral hemispheres were highly enriched in GABAergic neurons, as was demonstrated by immunocytochemistry using an anti-glutamate decarboxylase antiserum. They contained about 64% glutamate decarboxylase-positive neurons. About 8% of these neurons pr...

journal_title：Neuroscience

authors： Deloulme JC,Gensburger C,Sarhan S,Seiler N,Sensenbrenner M

更新日期：1991-01-01 00:00:00

abstract：:Lesioning of the mammalian striatum with the excitotoxin quinolinic acid results in a pattern of neuropathology that resembles that of post mortem Huntington's disease brain. Certain neurotrophic factors can rescue degenerating cells in a variety of lesion types, including those produced by neurotoxins. Several neurot...

journal_title：Neuroscience

authors： Alexi T,Venero JL,Hefti F

更新日期：1997-05-01 00:00:00

abstract：:Botulinum toxin is an agent that is typically encountered in two settings: as an agent that can cause disease (e.g. botulism), and as an agent that can be used to treat disease (i.e., a variety of neurologic disorders). In both cases it would be advantageous to develop a sound understanding of the mechanisms by which ...

journal_title：Neuroscience

authors： Joshi SG,Elias M,Singh A,Al-Saleem FH,Ancharski D,Nasser Z,Takahashi T,Simpson LL

更新日期：2011-04-14 00:00:00

abstract：:In cultured bovine adrenal medullary cells, neosurugatoxin and histrionicotoxin inhibited carbachol-induced influx of 22Na, 45Ca and secretion of catecholamines with IC50 of 27 nM and 3 microM, respectively. The inhibitory effects of neosurugatoxin were reversed by the increased concentrations of carbachol, whereas th...

journal_title：Neuroscience

authors： Wada A,Uezono Y,Arita M,Tsuji K,Yanagihara N,Kobayashi H,Izumi F

更新日期：1989-01-01 00:00:00

abstract：:To clarify the mechanism of yokukansan (TJ-54), a traditional Japanese medicine, against glutamate-mediated excitotoxicity, the effects of TJ-54 on glutamate uptake function were first examined using cultured rat cortical astrocytes. Under thiamine-deficient conditions, the uptake of glutamate into astrocytes, and the...

journal_title：Neuroscience

authors： Kawakami Z,Kanno H,Ueki T,Terawaki K,Tabuchi M,Ikarashi Y,Kase Y

更新日期：2009-04-10 00:00:00

abstract：:Membrane potential or ionic conductance of neurones of the mammalian central or peripheral nervous system maintained in vitro can be measured over periods of several hours. Drugs or transmitters which change potential or conductance can be applied repeatedly under equilibrium conditions, and pharmacological null metho...

journal_title：Neuroscience

authors： North RA

更新日期：1986-04-01 00:00:00