Functional MRI and other non-invasive imaging technologies: providing visual biomarkers for spinal cord structure and function after injury.

abstract：:Diffuse noxious inhibitory controls (DNIC) are very powerful long-lasting descending inhibitory controls which are pivotal in modulating the activity of spinal and trigeminal nociceptive neurons. DNIC are subserved by a loop involving supraspinal structures such as the lateral parabrachial nucleus and the subnucleus r...

journal_title：Experimental neurology

authors： Chebbi R,Boyer N,Monconduit L,Artola A,Luccarini P,Dallel R

更新日期：2014-06-01 00:00:00

abstract：:We have previously shown that lesions of the sensorimotor cortex induced by either thermocoagulation or aspiration produce different effects on axonal plasticity. We have now investigated whether these methods of lesion also influence the behavioral outcome. The behavioral effects of unilateral and bilateral lesions o...

journal_title：Experimental neurology

authors： Napieralski JA,Banks RJ,Chesselet MF

更新日期：1998-11-01 00:00:00

abstract：:Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...

journal_title：Experimental neurology

authors： Han PJ,Shukla S,Subramanian PS,Hoffman PN

更新日期：2004-10-01 00:00:00

abstract：:In recent years, it has become evident that Parkinson's disease is associated with a self-sustaining cycle of neuroinflammation and neurodegeneration, with dying neurons activating microglia, which, once activated, can release several factors that kill further neurons. One emerging pharmacological target that has the ...

journal_title：Experimental neurology

authors： Concannon RM,Okine BN,Finn DP,Dowd E

更新日期：2016-09-01 00:00:00

abstract：:When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containi...

journal_title：Experimental neurology

authors： Wang XT,Unnerstall JR,Ibuki T,Wang H,Pappas GD

更新日期：2000-01-01 00:00:00

abstract：:The axonal trajectories of inspiratory bulbospinal neurons were examined after deposition of the anterograde neuronal tracer phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventral respiratory group in rats. At the level of the phrenic nucleus, PHA-L-labeled bulbospinal axons crossed the midline of the spi...

journal_title：Experimental neurology

authors： Goshgarian HG,Ellenberger HH,Feldman JL

更新日期：1991-01-01 00:00:00

abstract：:Polymerized collagen rolls enclosing Schwann cells (SCs) raised in culture were grafted into cystic cavities formed after lesioning the thoracic spinal cord of adult rats. Axons were already present within the graft by 14 days after implantation and both ensheathed and myelinated axons were numerous by 28 days. This a...

journal_title：Experimental neurology

authors： Paino CL,Bunge MB

更新日期：1991-11-01 00:00:00

abstract：:Parkinson's disease (PD) is associated with complex compensatory changes in the functional and neurochemical anatomy of the basal ganglia resulting from striatal dopamine deficiency. Available evidence suggests that glutamatergic corticostriatal pathway becomes overactive following nigrostriatal dopaminergic denervati...

journal_title：Experimental neurology

authors： Betarbet R,Poisik O,Sherer TB,Greenamyre JT

更新日期：2004-05-01 00:00:00

abstract：:Neurotrophic factors as candidates for ALS therapeutics have previously been studied in the context of attempts to slow disease progression. For a variety of reasons, clinical trials of neurotrophic factors have failed to show efficacy in ALS patients. Previous studies in Parkinson's Disease (PD) models have shown pro...

journal_title：Experimental neurology

authors： Gross SK,Shim BS,Bartus RT,Deaver D,McEachin Z,Bétourné A,Boulis NM,Maragakis NJ

更新日期：2020-01-01 00:00:00

abstract：:The beta-Amyloid peptide (A beta) is hypothesized to mediate the neurodegeneration seen in Alzheimer's disease. Recently, we proposed a new hypothesis to explain the toxicity of A beta based on the free-radical generating capacity of A beta. We have recently demonstrated using electron paramagnetic resonance (EPR) spe...

journal_title：Experimental neurology

authors： Harris ME,Hensley K,Butterfield DA,Leedle RA,Carney JM

更新日期：1995-02-01 00:00:00

abstract：:Given the profound negative public health effects of major depressive disorder (MDD), and data suggesting only modest effectiveness of existing psychological and pharmacological treatments for this condition, there has been increasing interest in exploring the antidepressant potential of non-pharmacological, brain-bas...

journal_title：Experimental neurology

authors： Giacobbe P,Mayberg HS,Lozano AM

更新日期：2009-09-01 00:00:00

abstract：:Anterograde transneuronal degeneration is caused by the loss of afferent input to the nerve cells and may occur in a number of neuronal systems. Transection of the adult spinal cord, causing anterograde transneuronal degeneration in ventral horn neurons, distal to the lesion, has been reported by some authors, while o...

journal_title：Experimental neurology

authors： Bjugn R,Nyengaard JR,Rosland JH

更新日期：1997-11-01 00:00:00

abstract：:Ascending and descending spinal cord potentials were recorded during conduction block produced by compression and ischemia to the spinal cord of cats. Dorsally and ventrally applied compression produced proportional changes in both ascending and descending potentials. Results for induced ischemia were much more variab...

journal_title：Experimental neurology

authors： Bennett MH

更新日期：1983-06-01 00:00:00

abstract：:The aim of this study was to characterize the microglial and astroglial reactions to degeneration of (a) hippocampal CA1 pyramidal cells and dentate hilar neurons induced by cerebral ischemia and (b) CA3 pyramidal cells and dentate hilar neurons induced by intraventricular injections of kainic acid (KA). The microglia...

journal_title：Experimental neurology

authors： Jørgensen MB,Finsen BR,Jensen MB,Castellano B,Diemer NH,Zimmer J

更新日期：1993-03-01 00:00:00

abstract：:Among endogenous adaptive systems to hypoxia, neuroglobin, a recently discovered heme protein, was suggested as a novel oxygen-dependent neuroprotectant. We aimed to characterize i) maturational age-related regulation of neuroglobin in the developing mouse brain under normoxic and hypoxic conditions, and ii) the role ...

journal_title：Experimental neurology

authors： Hümmler N,Schneider C,Giessl A,Bauer R,Walkinshaw G,Gassmann M,Rascher W,Trollmann R

更新日期：2012-07-01 00:00:00

abstract：:Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate wh...

journal_title：Experimental neurology

authors： Chen CC,Litvak V,Gilbertson T,Kühn A,Lu CS,Lee ST,Tsai CH,Tisch S,Limousin P,Hariz M,Brown P

更新日期：2007-05-01 00:00:00

abstract：:The development of the corpus callosum (CC) was examined in BALB/cCF mice in relation to the effects of a 32-h period of maternal fasting. The treatment was imposed on days 15 and 16 during gestation, which immediately precedes the time when the initial callosal axons cross the midline. The BALB/c strain was used beca...

journal_title：Experimental neurology

authors： Wainwright P,Gagnon M

更新日期：1984-07-01 00:00:00

abstract：:While acute spinal cord injury has been the object of intensive research, chronic spinal cord injury has received less attention although most clinical cases of spinal cord injury become chronic. We attempted to surgically "repair" chronic and acute spinal cord injury in a complete transection rat model using a multip...

journal_title：Experimental neurology

authors： Fraidakis MJ,Spenger C,Olson L

更新日期：2004-07-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...

journal_title：Experimental neurology

authors： Kato AC,Lindsay RM

更新日期：1994-12-01 00:00:00

abstract：:Spinal motor neurons of Sprague-Dawley rats were examined to determine which of the neuronal isoforms of actin (beta or gamma) upregulate following axon injury. In situ hybridization studies showed greater beta-actin mRNA levels but no change in gamma-actin mRNA levels-suggesting that axon regrowth utilizes beta-actin...

journal_title：Experimental neurology

authors： Lund LM,Machado VM,McQuarrie IG

更新日期：2002-12-01 00:00:00

abstract：:Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that exposure of mice to low ...

journal_title：Experimental neurology

authors： Hatcher JM,Richardson JR,Guillot TS,McCormack AL,Di Monte DA,Jones DP,Pennell KD,Miller GW

更新日期：2007-04-01 00:00:00

abstract：:Peripheral nerve regeneration proceeds through a series of phases which include axonal sprouting, elongation, and maturation. Each phase requires interaction between intrinsic properties of the injured neuron and nonneural elements in the environment into which the nerve grows. It has been difficult, however, to separ...

journal_title：Experimental neurology

authors： Carlsen RC

更新日期：1983-10-01 00:00:00

abstract：:We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and long-term adhesion assays using monoclonal antibodies directed against topographically distinct epitopes on the molecules. Whereas antibodies to mouse liver memb...

journal_title：Experimental neurology

authors： Morganti MC,Taylor J,Pesheva P,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:To determine whether or not brain damage is likely to occur in the repeated apneic episodes experienced by some alcoholics during intoxicated sleep, rats were anesthetized with alcohol and subjected to repeated episodes to asphyxia. Each episode lasted 90 s, arterial PO2 was less than 50 mm Hg for 60 s, and 30 episode...

journal_title：Experimental neurology

authors： Cragg B,Phillips S

更新日期：1984-04-01 00:00:00

abstract：:Mitochondrial dysfunction and pathology that contribute to a host of neurodegenerative diseases are deduced from changes in ultrastructure, routinely examined by a host of optical techniques. We adapted the technique of photon correlation spectroscopy (PCS) to evaluate calcium-induced structural alterations in isolate...

journal_title：Experimental neurology

authors： Lifshitz J,Janmey PA,McIntosh TK

更新日期：2006-02-01 00:00:00

abstract：:Male white mice were exposed to electroshock and then injected intravenously with 5-[3H]uridine immediately after the shock. After 5, 30, or 60 min or 6, 12, or 24 h, the mice were killed, microautoradiographs were prepared, and grains were counted in the cortex, hippocampus, and basal ganglia. The results of the grai...

journal_title：Experimental neurology

authors： Pakkenberg H,Pakkenberg B,Fog R

更新日期：1985-07-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) have been shown to generate neural cells under experimental conditions in vitro and following transplantation into animal models of stroke and traumatic CNS injury. Hastened recovery from the neurological deficit has not correlated with structural repair of the lesion in the stroke mod...

journal_title：Experimental neurology

authors： Song S,Kamath S,Mosquera D,Zigova T,Sanberg P,Vesely DL,Sanchez-Ramos J

更新日期：2004-01-01 00:00:00

abstract：:Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is decreased while administration of alternative substrates has been shown to be neuroprotective. Changes in energy metabolism following TBI ...

journal_title：Experimental neurology

authors： Greco T,Vespa PM,Prins ML

更新日期：2020-07-01 00:00:00

abstract：:We have used retrograde labeling with horseradish peroxidase (HRP) and a wheat germ agglutinin conjugate of HRP (WGA:HRP) to investigate the projections of the nucleus postglomerulosus (nPg) both in normal goldfish and in animals which had undergone retinal removal. In normal animals, our evidence indicates that nPg p...

journal_title：Experimental neurology

authors： Levine RL,Dethier S

更新日期：1988-11-01 00:00:00

abstract：:Lead induces peripheral nerve segmental demyelination in rats. Arsenic and thallium produce a peripheral neuropathy characterized by axonal degeneration in humans. Mercury and thallium appear to damage both the peripheral and the central nervous system. It is not known whether this difference in effect is due to diffe...

journal_title：Experimental neurology

authors： Windebank AJ

更新日期：1986-10-01 00:00:00