当前位置： SCI文献检索 > HEMOGLOBIN期刊下所有文献 > Can iron chelators influence the progression of atherosclerosis?

Can iron chelators influence the progression of atherosclerosis?

Abstract：

:Epidemiological studies and experimental data suggest iron involvement in atherosclerosis. The relation between iron and atherosclerosis is complex and remains contradictory. In thalassemia patients, non transferrin bound iron (NTBI) and free hemoglobin (Hb) are present in plasma and may accelerate atherogenesis, but its progression may be inhibited by iron chelators. The mechanism whereby iron may stimulate atherogenesis has been intensively investigated. Non transferrin bound iron and sera from subjects with hemochromatosis induced endothelial activation with expression of vascular adhesion molecules and endothelial inflammatory chemokines. Such events could be inhibited by iron chelators and oxygen radical scavengers with intracellular activity. Iron chelators may be effective in preventing vascular damage in patients with high concentrations of NTBI as found in thalassemia.

journal_name

Hemoglobin

journal_title

Hemoglobin

authors

Marx JJ,Kartikasari AE,Georgiou NA

doi

10.1080/03630260701726871

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

123-34

issue

1-2

eissn

0363-0269

issn

1532-432X

pii

790612462

journal_volume

32

pub_type

杂志文章,评审

相关文献

HEMOGLOBIN文献大全
  • Genotype-phenotype correlation in Iranian patients with Hb H disease.

    abstract：:Thalassemia is the most common genetic disorder in Iran. Some α-globin genotypes leading to Hb H disease may cause severe anemia and dependence on regular blood transfusions. In this study, 40 patients were analyzed for the molecular basis and the genotype-phenotype correlation of Hb H disease in Iran. α-Globin molecu...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269.2010.546314

    authors： Ebrahimkhani S,Azarkeivan A,Bayat N,Houry-Parvin M,Jalil-Nejad S,Zand S,Golkar Z,Hadavi V,Imanian H,Oberkanins C,Najmabadi H

    更新日期：2011-01-01 00:00:00

  • A Kindred with a β-Globin Base Substitution [β89(F5)Ser→Arg (AGT>AGG); HBB: c.270T>G] Resulting in Hemoglobin Vanderbilt.

    abstract：:High oxygen affinity hemoglobins (Hbs), characterized by a decreased ability to release oxygen to the tissues and a left-shifted oxygen dissociation curve, are a rare cause of secondary erythrocytosis. Here, we report a base substitution in the β-globin gene at codon 89 (AGT>AGG) in a kindred with familial erythrocyto...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630269.2019.1680382

    authors： Shomali W,Brar R,Arekapudi SR,Gotlib JR

    更新日期：2019-01-01 00:00:00

  • Molecular heterogeneity of beta-thalassemia in Algeria: how to face up to a major health problem.

    abstract：:This study concerns the molecular characterization of beta-thalassemia (beta-thal) alleles in 210 chromosomes. In the studied population, mutations were detected in 98% of the beta-thalassemic chromosomes. Twenty-one molecular defects have been found, where the five dominant mutations, IVS-I-110 (G>A), nonsense mutati...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630260802626061

    authors： Boudrahem-Addour N,Zidani N,Carion N,Labie D,Belhani M,Beldjord C

    更新日期：2009-01-01 00:00:00

  • Hb Olivet (HBA1: C.40G > A; p.Ala14Thr), a Novel Silent Hemoglobin Variant in Two Families of Distinct Origin.

    abstract：:We report two families, members of which are carriers of a novel hemoglobin (Hb) variant that was named Hb Olivet [α13(A11)Ala→Thr (α1) (GCC > ACC); HBA1: c.40G > A; p.Ala14Thr]. The analysis of these cases allowed a clear description of this anomaly that behaves as a silent Hb. In the first family, of Portuguese ethn...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630269.2016.1210160

    authors： Harteveld CL,Pissard S,Korver AM,Riou J,Legac E,Lansbergen G,Pardijs IL,Giordano PC,Versteegh FG

    更新日期：2016-09-01 00:00:00

  • Structure in relation to behavior of mutant hemoglobins in citrate agar electrophoresis.

    abstract：:The comparative mobilities, in citrate agar electrophoresis, of 91 mutant hemoglobins are presented in relation to their molecular structure and in some cases, to their mobilities in other types of electrophoresis. More than a third of the alpha chain mutants (11 of the 27 examined) and half of the beta chain mutants ...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630267709027861

    authors： Schneider RG,Hightower B

    更新日期：1977-01-01 00:00:00

  • Identification of the first mutation in a BRE motif of the β-globin gene and its inheritance with two other α-globin gene mutations in a Lebanese family.

    abstract：:A 7-year old boy presented with a history of recurrent respiratory infections and hypochromic microcytic anemia. Iron profiles were normal thereby prompting genetic analysis of α- and β-globin mutations. The first mutation in a BRE motif of the β-globin gene in the proband, sibling and the mother was identified. The p...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269.2013.772523

    authors： Inati A,Abbas HA,Al-Danaf J,Souaid M,Kahale M,Koussa S,Abou Nasr T,Davis L,Luo HY,Chui DH

    更新日期：2013-01-01 00:00:00

  • Hb Chile [beta28(B10)Leu-->Met]: an unstable hemoglobin associated with chronic methemoglobinemia and sulfonamide or methylene blue-induced hemolytic anemia.

    abstract：:Among the causes of life-long cyanosis are congenital methemoglobinemia due to M hemoglobins, congenital methemoglobinemia due to methemoglobin reductase deficiency, a small number of low oxygen affinity hemoglobins, and a small number of unstable hemoglobins that spontaneously form methemoglobin in vivo at an acceler...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269908996157

    authors： Hojas-Bernal R,McNab-Martin P,Fairbanks VF,Holmes MW,Hoyer JD,McCormick DJ,Kubik KS

    更新日期：1999-05-01 00:00:00

  • Molecular and cellular analysis of a novel HBA2 mutation (HBA2: c.94A > G) shows activation of a cryptic splice site and generation of a premature termination codon.

    abstract：:In this study, we describe the clinical features and provide experimental analyses of a novel point mutation affecting the penultimate nucleotide of the first exon of the HBA2 (HBA2: c.94A > G) gene identified in a 26-year-old female who also carries a heterozygous Hb E (HBB: c.79G > A) variant. The aim of the study w...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269.2013.858639

    authors： Qadah T,Finlayson J,Joly P,Ghassemifar R

    更新日期：2014-01-01 00:00:00

  • Relationship between impaired glycation and the N-terminal structure of the Hb Görwihl [beta5(A2)Pro-->Ala] variant.

    abstract：:We studied the structural environment surrounding the beta-N-terminal glycation site of a hemoglobin (Hb) molecule in which the proline residue at beta5(A2) was substituted by alanine in silico. By computer analysis that used Protein Data Bank data (PDB ID: 1BZ0), we tried to clarify the reason for impaired glycation ...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630261003676785

    authors： Ito S,Nakahari T,Yamamoto D

    更新日期：2010-01-01 00:00:00

  • The thalassemia syndromes: molecular characterization in the Spanish population.

    abstract：:This work compiles the results of our research on alpha- and beta-thalassemias, and includes a literature review of the molecular genetics of alpha- and beta-thalassemias in Spain. We studied 1,564 subjects with thalassemia (294 with beta-thalassemia and 1,264 with alpha-thalassemia) by molecular biology techniques. I...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1081/hem-100105220

    authors： Villegas A,Ropero P,González FA,Anguita E,Espinós D

    更新日期：2001-08-01 00:00:00

  • Hb Graz or alpha 2 beta 2(2)(NA2)His-->Leu; a new beta chain variant observed in four families from southern Austria.

    abstract：:Two abnormal hemoglobins were accidentally detected by cation exchange high performance liquid chromatography with the Diamat system of Bio-Rad Laboratories; the variants eluted together with the fast-moving Hb A1c. Structural analysis of isolated beta chains and sequence analysis of amplified DNA identified a new var...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269208993117

    authors： Liu JS,Molchanova TP,Gu LH,Wilson JB,Hopmeier P,Schnedl W,Balaun E,Krejs GJ,Huisman TH

    更新日期：1992-01-01 00:00:00

  • Usefulness of HPLC methodology for the characterization of combinations of the common beta chain variants Hbs S, C, and O-Arab, and the alpha chain variant Hb G-Philadelphia.

    abstract：:We have analyzed the blood samples from seven members of two families that contained mixtures of different hemoglobin types due to the simultaneous presence of different beta chain variants and the alpha chain variant Hb G-Philadelphia. The methods used were isoelectrofocusing and cation exchange high performance liqu...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269308998885

    authors： Kutlar F,Kutlar A,Nuguid E,Prchal J,Huisman TH

    更新日期：1993-02-01 00:00:00

  • Novel therapies targeting the endothelium in sickle cell disease.

    abstract：:The recognition of sickle cell disease as a chronic vasculopathy characterized by endothelial injury has led to new insights into complex biological processes and offers the potential for novel pharmacological treatments. Endothelial injury has been related to impaired nitric oxide (NO) homeostasis, inflammation, oxid...

    journal_title：Hemoglobin

    pub_type： 杂志文章,评审

    doi：10.3109/03630269.2011.606482

    authors： Hoppe CC

    更新日期：2011-01-01 00:00:00

  • DNAase I hypersensitive site 3' to the beta-globin gene cluster containing two TAA insertions and a G-->A polymorphism is predominantly associated with the beta+-thalassemia IVS-I-6 (T-->C) mutation.

    abstract：:Analysis of DNA polymorphic sites is an important tool for the detection of gene flow in human evolutionary studies and to study the genetic background for gene mutations. The beta-globin locus contains several single-base restriction fragment length polymorphism (RFLP) sites throughout chromosome 11. In addition to t...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：

    authors： Martins JT,Bordin S,de Albuquerque DM,Saad ST,Costa FF

    更新日期：2005-01-01 00:00:00

  • Analysis of Deletional Hb H Diseases in Samples with Hb A2-Hb H and Hb A2-Hb Bart's on Capillary Electrophoresis.

    abstract：:The capillary electrophoresis (CE) system allows the quantification of Hb Bart's (γ4) and Hb H (β4) that is used for screening of Hb H disease. However, Hb Bart's hydrops fetalis and Hb H are not always codetected in patients with Hb H disease. In this study, 35 samples were analyzed for the α0-thalassemia (α0-thal) [...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630269.2019.1683573

    authors： Khongthai K,Ruengdit C,Panyasai S,Pornprasert S

    更新日期：2019-01-01 00:00:00

  • A double heterozygote for (deltabeta)0-thalassemia and codons 41/42 (-TTCT) behaves as a homozygote for the frameshift mutation in a Chinese family.

    abstract：:We present the case of a child in whom beta-thalassemia (thal) major was apparently caused by homozygosity for a 4-base deletion mutation [codons 41/42 (-TTCT)] of the beta-globin gene. However, the mutation was not identified in the father. The presence of a deletional beta-thal was detected by long-range polymerase ...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630260701459432

    authors： Liao C,Feng Q,Li J,Huang Y,Li D

    更新日期：2007-01-01 00:00:00

  • Minor components of Hb Bart's.

    abstract：:The minor components of Hb Bart's were separated by CM-cellulose chromatography, reverse-phase HPLC, and DEAE-cellulose chromatography. These were characterized by amino acid analysis, tryptic peptide analysis by HPLC, electrophoresis, and carbohydrate and phosphate analysis. Acetylated and glycated components of Hb B...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630268709042852

    authors： Abraham EC,Abraham A,Kasten-Jolly J

    更新日期：1987-01-01 00:00:00

  • Further identification of Hb G-Coushatta [beta22(B4)Glu-->Ala (GAA-->GCA)] in Thailand by the polymerase chain reaction-single-strand conformation polymorphism technique and by amplification refractory mutation system-polymerase chain reaction.

    abstract：:Thalassemias and hemoglobinopathies are very common among Southeast Asian populations, particularly in Thailand, where it is estimated that nearly 30% of the population carries at least one such disorder. Moreover, the heterogeneity of different mutant alpha- and beta-globin alleles contributes to the complexity in di...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630260601059225

    authors： Chinchang W,Viprakasit V

    更新日期：2007-01-01 00:00:00

  • Hb Rancho Mirage [beta 143(H21)His----Asp]; a variant in the 2,3-DPG binding site showing normal oxygen affinity at physiological pH.

    abstract：:Hb Rancho Mirage was detected in a 17-year-old male in association with a mild anemia. Hemoglobin electrophoresis revealed the variant had a mobility between Hbs A and J on cellulose acetate (pH 8.6) and a mobility like Hb F on citrate agar (pH 6.4). A substitution of His----Asp was found at position 143 in the beta c...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269209005674

    authors： Moo-Penn WF,Hine TK,Johnson MH,Jue DL,Holland S,George S,Pierce AM,Michalski LA,McDonald MJ

    更新日期：1992-01-01 00:00:00

  • A local equation for differential diagnosis of β-thalassemia trait and iron deficiency anemia by logistic regression analysis in Southeast Iran.

    abstract：:The most common differential diagnosis of β-thalassemia (β-thal) trait is iron deficiency anemia. Several red blood cell equations were introduced during different studies for differential diagnosis between β-thal trait and iron deficiency anemia. Due to genetic variations in different regions, these equations cannot ...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269.2014.948187

    authors： Sargolzaie N,Miri-Moghaddam E

    更新日期：2014-01-01 00:00:00

  • The beta+-IVS-I-6 (T-->C) mutation accounts for half of the thalassemia chromosomes in the Palestinian populations of the mountain regions.

    abstract：:A study of the spectrum of beta-thalassemia mutations in the southern part of the West Bank of the Palestinian Authority revealed the presence of 10 different beta-globin mutations. The study included 41 patients and 54 carriers of beta-thalassemia and sickle cell anemia. The spectrum of mutations observed was typical...

    journal_title：Hemoglobin

    pub_type： 历史文章,杂志文章

    doi：10.1081/hem-120002938

    authors： El-Latif MA,Filon D,Rund D,Oppenheim A,Kanaan M

    更新日期：2002-02-01 00:00:00

  • A new β-thalassemia deletion mutation [codon 36 (-C)] observed in a Chinese woman.

    abstract：:In this study we present the first report of the detection of a new β-thalassemia (β-thal) mutation at codon 36 (-C) in the Chinese population. This frameshift mutation generates a TGA stop codon at position 60, resulting in a thalassemia phenotype. This is the first example of a premature stop codon at position 60 be...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630269.2010.526841

    authors： Huang H,Xu L,Lin N,Xu J,He D,Li Y,Zheng L,Liu H,Lin Y

    更新日期：2010-01-01 00:00:00

  • A Rare Hb H Hydrops Fetalis Syndrome Caused by the - -SEA Deletion in Combination with the Rare Hb Hirosaki Mutation in a Chinese Patient.

    abstract：:Despite the milder clinical severity of Hb H patients compared with those of Hb Bart's hydrops fetalis or patients with β-thalassemia major (β-TM), a few cases of Hb H hydrops fetalis syndrome have been reported so far. Here, we describe, for the first time in the Chinese population, one case of a neonate with Hb H hy...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630269.2018.1536665

    authors： Li Q,Li Y,Zhong M,Zhang VW,Jin W,Li S,Li L

    更新日期：2018-07-01 00:00:00

  • δ-Globin Chain Variants Associated with Decreased Hb A2 Levels: A National Reference Laboratory Experience.

    abstract：:High prevalence of hemoglobin (Hb) disorders mandates national programs for screening and genetic counseling in many countries. Increased Hb A2 levels are commonly associated with β-thalassemias, however, various disorders including alteration of δ chains may result in decreased production of Hb A2, thus hindering the...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630269.2020.1831531

    authors： Rets AV,Reading NS,Agarwal AM

    更新日期：2020-11-01 00:00:00

  • Databases of human hemoglobin variants and other resources at the globin gene server.

    abstract：:Building on the pioneering efforts of Professor Huisman, several different databases of hemoglobin variants have been developed, each with progressively increased capacity for sophisticated queries and prompt updating. These resources are reviewed in the context of a larger plan for providing related resources on hemo...

    journal_title：Hemoglobin

    pub_type： 杂志文章,评审

    doi：10.1081/hem-100104027

    authors： Hardison RC,Chui DH,Riemer C,Giardine B,Lehväslaiho H,Wajcman H,Miller W

    更新日期：2001-05-01 00:00:00

  • Mutant hemoglobins having elongated chains.

    abstract：:Globin subunits may be elongated because of a base substitution in the termination codon, a crossover out of phase (frame shift) or a crossover in phase. This review presents structural, genetic, biosynthetic and clinical information on the eight variants having elongated chains which have been described to date. ...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630267808999185

    authors： Bunn HF

    更新日期：1978-01-01 00:00:00

  • The phenotype of sheep hemoglobins containing distinct alpha chains is influenced by beta chain genotype.

    abstract：:In sheep carrying simultaneously extra alpha-globin genes (triplications and quadruplications) and two alpha-chain allelic variants, a gradient of decreasing expression of the downstream genes was previously reported. We show here that in these sheep the proportions of the normal and variant Hbs reflect not only the p...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1081/hem-120035916

    authors： Vestri R,Massa A

    更新日期：2004-05-01 00:00:00

  • A Novel 31.1 kb α-Thalassemia Deletion (- -MEX3) Found in a Mexican Family.

    abstract：:α-Thalassemia (α-thal), a genetic disease characterized by microcytosis, hypochromia and anemia, is predominantly caused by deletions of the α-globin genes, HBA2 and HBA1. In this study, we describe a novel 31.1 kb α-thal deletion, - -MEX3 (NC_000016.10: g.151479_182582del), observed in a Mexican family, probably orig...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630269.2017.1356330

    authors： Rentería-López VM,Perea-Díaz FJ,Rizo-delaTorre LC,Sánchez-López JY,Ibarra-Cortés B

    更新日期：2017-05-01 00:00:00

  • Drepa-Opia: A Pilot Study to Determine the Predictive Factors of Morphine Use and Consumption in Hospitalized Adult Patients with Sickle Cell Disease.

    abstract：:The aim of this study was to evaluate the clinical, biological and genetic factors that could be associated with the use and dose of morphine during hospitalization for vaso-occlussive crisis (VOC) in adults with sickle cell disease. Ninety-nine hospitalizations for acute VOC (58 sickle cell disease patients aged 18 t...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.1080/03630269.2018.1529602

    authors： Sabrie M,Cannas G,Tazarourte K,Poutrel S,Connes P,Hot A,Renoux C,Fattoum J,Joly P

    更新日期：2018-07-01 00:00:00

  • The identification of five rare beta-chain abnormal hemoglobins by high performance liquid chromatographic procedures.

    abstract：:The detection, quantitation, and characterization of five relatively rare beta chain abnormal hemoglobins mainly by high performance liquid chromatographic procedures are described. The variants involved are Hb City of Hope (beta 69 Gly----Ser), Hb Austin (beta 40 Arg----Ser), Hb Leiden (beta 6 or 7 Glu----0), Hb Loui...

    journal_title：Hemoglobin

    pub_type： 杂志文章

    doi：10.3109/03630268609072470

    authors： Wilson JB,Chen SS,Webber BB,Kutlar A,Kutlar F,Villegas A,Huisman TH

    更新日期：1986-01-01 00:00:00