Abstract:
:We have analyzed the blood samples from seven members of two families that contained mixtures of different hemoglobin types due to the simultaneous presence of different beta chain variants and the alpha chain variant Hb G-Philadelphia. The methods used were isoelectrofocusing and cation exchange high performance liquid chromatography for the separation of the hemoglobin components, and reversed phase high performance liquid chromatography for that of the various alpha and beta chains; the chromatographic procedures also provided quantitative data. Application of these fast and simple high performance liquid chromatographic methods greatly aided in defining the different hemoglobinopathies that were present in these persons, including an additional alpha-thalassemia-2 heterozygosity or homozygosity.
journal_name
Hemoglobinjournal_title
Hemoglobinauthors
Kutlar F,Kutlar A,Nuguid E,Prchal J,Huisman THdoi
10.3109/03630269308998885subject
Has Abstractpub_date
1993-02-01 00:00:00pages
55-66issue
1eissn
0363-0269issn
1532-432Xjournal_volume
17pub_type
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