Abstract:
:Two kinds of 3-hydroxypyridine-2(1H)-thiones were synthesized. The visible (VIS) spectroscopic analysis indicated that 3-hydroxy-1-methylpyridine-2(1H)-thione (4a) and 3-hydroxy-1-(2-hydroxyethyl)pyridine-2(1H)-thione (4b) formed stable 3:1 Fe(III) complexes. The stability constant of the 4b-Fe(III) complex was estimated from the competitive reaction with EDTA and was found to be 36.7 in logbeta3. Treatment of compound 4b with Ga(acac)3 in D2O:CD3OD (9:1) solution afforded 3:1 Ga(Ill) complex, which was assigned by means of 1H nuclear magnetic resonance (1H NMR) spectroscopy. Treatment of compound 4b with Pb(NO3)2 gave 4b-Pb(II) complex. The Pb(II) selectivity over biologically relevant Mg(ll) and Ca(ll) was remarkably improved by adopting N-hydroxyethyl functionality instead of N-methyl group.
journal_name
Hemoglobinjournal_title
Hemoglobinauthors
Katoh A,Harada K,Saito Rdoi
10.1080/03630260500455342keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
81-92issue
1eissn
0363-0269issn
1532-432Xpii
N18X266722006HLGjournal_volume
30pub_type
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