Abstract:
:Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Ferri C,Antonelli A,Mascia MT,Sebastiani M,Fallahi P,Ferrari D,Giunti M,Pileri SA,Zignego ALdoi
10.1016/j.autrev.2007.02.019subject
Has Abstractpub_date
2007-12-01 00:00:00pages
114-20issue
2eissn
1568-9972issn
1873-0183pii
S1568-9972(07)00060-2journal_volume
7pub_type
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journal_title:Autoimmunity reviews
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2009.10.004
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/s1568-9972(02)00121-0
更新日期:2003-01-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2010.02.014
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2007.08.003
更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2020.102495
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pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2010.07.009
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pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2013.04.003
更新日期:2013-08-01 00:00:00