Abstract:
BACKGROUND:Glaucoma is mainly characterized by the loss of retinal ganglion cells. Ciliary neurotrophic factor (CNTF) is believed to stimulate the regeneration of axons of retinal ganglion cells. The objective of our study was to detect the expression of CNTF in the retina of a rat glaucoma model with increased intraocular pressure (IOP). METHODS:The rat glaucoma model was set up by electrocoagulating at least three episcleral and limbal veins. The location and the expression level of CNTF were detected at 1, 3, 7, 14, and 28 days post-surgery by immunohistochemistry, semiquantitative reverse-transcription polymerase chain reaction (RT-PCR), and Western blot analysis. RESULTS:The rat glaucoma model with chronic, moderately elevated IOP was successfully produced. A minimum expression of CNTF was found in the ganglion cell layer of the retinas of the control group, and temporally increased expression and intensity of CNTF were found in the experimental retinas. CONCLUSION:The expression of endogenous CNTF in the rat retina was found altered after the induction of ocular hypertension.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Wu Q,Zhang M,Song BW,Lu B,Hu Psubject
Has Abstractpub_date
2007-10-20 00:00:00pages
1825-9issue
20eissn
0366-6999issn
2542-5641journal_volume
120pub_type
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