Abstract：
BACKGROUND AND OBJECTIVE:To analyze the serum levels of immunoglobulin G (IgG) subclasses in a broad range of elderly patients with bronchiectasis. PATIENTS AND METHOD:Data were collected from all patients who had a high-resolution chest computerized axial tomography diagnosis of bronchiectasis in our center. We gathered data related to case history, respiratory symptoms, forced spirometry, general laboratory tests, immunoglobulin concentration (including IgG subclasses), Mantoux test, sputum culture and staining, paranasal sinus X-rays/computerized axial tomography, and a specific etiologic evaluation based on the available clinical evidence. RESULTS:A total of 128 patients were included -mean age (standard deviation): 71.6 (5.1) years; range: 65-88; 44.5% males- and 20.3% of them had chronic sputum colonization with Pseudomonas aeruginosa. 28.1% cases had a post-infectious nature and in 40.6% the etiology was unknown. Sixteen patients (12.5%) had decreased levels of at least one of the sIgG compared to normal values. The most frequent deficiency corresponded to IgG2 levels. These subjects showed a characteristic profile of bronchiectasis with an increased lung extension of the disease (p = 0.02); greater presence of cylindrical and diffuse bronchiectasis (p = 0.02 and 0.01, respectively), greater percentage of an unknown etiology (p = 0.004); greater presence of paranasal sinus X-ray abnormalities (p = 0.004) and increased number of past repeated upper airway infections (p = 0.03). CONCLUSIONS:Decreased serum levels of IgG subclasses might be associated with a characteristic profile of bronchiectasis in elderly patients in whom other etiologies have been ruled out.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Martínez-García MA,Román-Sánchez P,Perpiñá-Tordera M,Soler-Cataluña JJ,Saura-Vinuesa A,Yago M,Pastor MJdoi
10.1157/13111419subject
Has Abstractpub_date
2007-10-20 00:00:00pages
525-9issue
14eissn
0025-7753issn
1578-8989pii
S0025-7753(07)72906-8journal_volume
129pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND:Vertebral bone metastases represent the most frequently affected region within the skeleton. They are of important relevance because of the risk of medullar compression. The diagnosis of medullar canal invasion is of particular interest in order to prevent neurological dysfunction. A prospective study was ca...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-09-26 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Obesity is characterized by a generalized increase of adipose tissue, high production of adipocytokines and presence of oxidative systemic stress. The objective of this study was to evaluate the changes generated in the oxidative stress and anthropometric parameters in obese subjects by the pre...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.12.015
更新日期：2015-07-06 00:00:00
abstract：BACKGROUND:The prognosis of sarcoidosis is difficult to predict. In general, sarcoidosis is considered as chronic when it remains active for over 2 years. The aim of this study was to analyze predictive factors in the persistence of sarcoidosis activity 2 years after diagnosis. METHODS:One hundred fifty-five patients ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1991-12-07 00:00:00
abstract：:In the last years stem cells (SC) have generated huge expectations and have become a new hope for the development of novel cell therapies in the context of regenerative medicine. So far, the hypothetic therapeutic effects of SC, both of embryonic and adult origin, have been demonstrated only in a very few cases. Embry...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1157/13073565
更新日期：2005-04-09 00:00:00
abstract：INTRODUCTION:Recently diagnosis of latent tuberculosis infection (LTBI) can be made using the tuberculin skin test (TST) or by techniques known as interferon-γ release assays (IGRAS), being QuantiFERON(®)-TB Gold In-Tube (QF-G-IT) the most used. The IGRAS avoid some drawbacks of the TST, especially cross-reaction with ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2014.11.027
更新日期：2015-11-20 00:00:00
abstract：BACKGROUND:To evaluate differences in the temporal profile of acute phase response (APR) between ischemic stroke (IS) and intracerebral hemorrhage (ICH). PATIENTS AND METHOD:We studied APR parameters (< 24 h and 3-5 day) in 88 consecutive patients (43 ICH and 45 IS). The increase/decrease of the parameters between bot...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(01)71717-4
更新日期：2001-01-20 00:00:00
abstract：BACKGROUND:The aim of the present study was to determine the prevalence and diagnostic usefulness of antineutrophil cytoplasmic antibodies (ANCA) in a Spanish population of patients with inflammatory bowel disease from the province of Tarragona. PATIENTS AND METHODS:One hundred and fifty-six sera obtained from 116 pat...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1998-01-17 00:00:00
abstract：:The aim of a case-control design is to make a measurement of the highest possible accuracy, reducing to a minimum the possible selection, information and confusion biases. The design, methods and procedures of a multicentric study carried out in 14 hospitals from 4 autonomous communities in Spain are discussed. Overal...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1989-05-06 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To analyze the effects of an aquatic biodance based therapy on sleep quality, anxiety, depression, pain and quality of life in fibromyalgia patients. PATIENTS AND METHOD:Randomized controlled trial with 2 groups. Fifty-nine patients were assigned to 2 groups: experimental group (aquatic biodan...
journal_title：Medicina clinica
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.medcli.2012.09.036
更新日期：2013-12-07 00:00:00
abstract：BACKGROUND:The values of the squamous cell carcinoma (SCC) antigen in benign diseases were studied with the aim of determining false positive values in the study of epidermoid carcinomas. METHODS:Serum determinations of the SCC antigen were performed by radioimmunoanalysis with the Abbott SCC-RIA kit. The control grou...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1996-02-17 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.02.025
更新日期：2017-10-11 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Information about the prevalence of chronic kidney disease (CKD) in the population treated in primary care is scarce. The aim of this study was to assess the prevalence of CKD in Spanish hypertensive women aged 64 years or older, and to determine possible associated factors. PATIENTS AND METH...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medcli.2011.03.038
更新日期：2012-05-05 00:00:00
abstract：:We discuss different interpretations of the term poison as well as the need of bringing up to date the changes in this matter according to the science progress. A clear and exact definition is proposed after analysing the factors that affect the relativity of the concept and its boundaries. The proposal for a definiti...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2011.02.002
更新日期：2012-02-18 00:00:00
abstract：:The serum levels of cholesterol bound to high density lipoproteins (HDL-C) were determined by the heparin-manganese chloride precipitation method in 306 subjects, 182 male with ages ranging from 11 to 81 years, and 124 female with ages ranging from 7 to 78 years. Twenty six subjects belonged to a lacto-vegetarian comm...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-03-25 00:00:00
abstract：:The main objective is to detail the main biases in the study of prognostic factors. Confounding bias is illustrated with social class, a prognostic factor still discussed. Within selection bias several cases are commented: response bias, specially frequent when the patients of a clinical trial are used; the shortcomin...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Sense of Coherence (SOC) is a construct relating to coping strategies in the face of traumatic events. SOC is defined as a personal disposition towards perceiving life experiences as understandable, manageable and meaningful. The construct has shown itself to be a predictor of self-reported and...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13100935
更新日期：2007-04-07 00:00:00
abstract：BACKGROUND:It is estimated that 5-10% of breast cancers have an hereditary origin, germline mutations of BRCA1 and BRCA2 genes causing a predisposition. In the present study we analyzed BRCA1 and BRCA2 mutations in moderate to high risk breast cancer patients in order to find out the types and frequency of these mutati...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)73450-7
更新日期：2002-10-12 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of this prospective randomized trial was to compare the effectiveness and morbidity of surgical vs chemical sphincterotomy in the treatment of chronic anal fissure after a 3-year follow-up period. PATIENTS AND METHOD:Eighty patients with chronic anal fissure were treated either with cl...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1157/13074137
更新日期：2005-04-23 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Many countries have developed screening programs for CH that bring about a normal somatic and psychological development. The aim of this study is to evaluate the evolution of cases detected by the screening program of congenital hypothyroidism in Catalonia. PATIENTS AND METHODS:The was a descr...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2009.07.048
更新日期：2010-03-13 00:00:00
abstract：BACKGROUND AND OBJECTIVE:White coat effect (WCE) (i.e., the difference between office blood pressure [OBP] and awake ambulatory blood pressure monitoring [ABPM]) may be present in hypertensive individuals. The relationship between occurrence of WCE and target organ damage (TOD) has not yet been assessed in true resista...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.04.031
更新日期：2013-01-05 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Twin and family studies support large genetic influences on variability in body mass index (BMI), with heritability estimates ranging from 47% to over 90%. Our objective was to study the relative contributions of genetics and environment to BMI, evaluating sex differences, in an adolescent twin...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2014.05.039
更新日期：2015-08-21 00:00:00
abstract：:The use of physical and pharmacological restraint is controversial but is currently accepted as inevitable. It is indicated for controlling behavioral disorders and psychomotor agitation that put patients and third parties at risk. Its indication should be medical, and we should opt for the least restrictive measure. ...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(14)70068-5
更新日期：2014-03-01 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) consists of an excessive depositing of fat in the liver, which can end up by causing inflammation, fibrosis and also cirrhosis with the corresponding complications including liver cancer. NAFLD has become the most common liver disease worldwide. The incidence has increased in ...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/j.medcli.2017.06.026
更新日期：2017-12-20 00:00:00
abstract：:Gaucher's disease (GD) is an inherited metabolic disease due to lack of activity of the enzyme betaglucocerebrosidase. The diagnosis of GD is usually performed by fluorimetric analysis of the enzyme betaglucocerebrosidase. It can also be done by measuring the activity of tandem mass spectrometry. This enzyme can be an...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/S0025-7753(11)70011-2
更新日期：2011-09-01 00:00:00
abstract：:Nesidioblastosis is an anatomopathological situation defined as the transformation or the exocrine ductal epithelium into endocrine tissue which can be hormonally active or inactive. In this study we present two cases which to our knowledge fulfil criteria for nesidioblastosis. Both patients were male (73 and 45 years...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1990-09-22 00:00:00
abstract：BACKGROUND:Anal intraepithelial neoplasia is considered a precursor lesion of anal squamous carcinoma. The population with increased risk of this conditions are immunocompromised individuals, especially HIV-infected, with anal sex practices. The aim of this study was to describe the sexual habits of patients who were s...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.05.047
更新日期：2014-02-20 00:00:00
abstract：BACKGROUND:To determine the nonfulfillment of antiinfectious therapy in clinical practice. MATERIAL AND METHODS:Fulfillment was quantified by tablet counting (TC) in the homes of 366 patients undergoing antibiotic treatment and the motives and predictive factors were identified. RESULTS:Nonfulfillment was of 61% (95%...
journal_title：Medicina clinica
pub_type： 杂志文章,多中心研究
doi：
更新日期：1999-05-29 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In the last years, a study is being conducted about exposure to asbestos among shipyards workers in order to know the diagnosis of the diseases associated with the exposure. Our goal was to know the asbestos pulmonary contents in this population. MATERIAL AND METHODS:We obtained autopsy pulmon...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2012.01.023
更新日期：2013-02-16 00:00:00
abstract：:GLP-1 receptors agonists have been a substantial change in treatment of type 2 diabetes mellitus, and its weekly administration has broken pre-established schemes. Daily exenatide is administered every 12 hours (BID) subcutaneously, while weekly exenatide is administered once a week. Both molecules share a common mech...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：10.1016/S0025-7753(14)70105-8
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Autoimmune diseases/autoantibodies tend sometimes to cumulate in the same individual, probably as a consequence of defects in immune regulation with breakdown of self-tolerance. Autoimmune hepatitis and microscopic polyangiitis have been occasionally reported with other autoimmune diseases, but...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2010.10.015
更新日期：2011-03-26 00:00:00
