Abstract：
:New findings obtained during the past years, especially the discovery of mutations in the genes associated with brain iron metabolism, have provided key insights into the homeostatic mechanisms of brain iron metabolism and the pathological mechanisms responsible for neurodegenerative diseases. The accumulated evidence demonstrates that misregulation in brain iron metabolism is one of the initial causes for neuronal death in some neurodegenerative disorders. The errors in brain iron metabolism found in these disorders have a multifactorial pathogenesis, including genetic and nongenetic factors. The disturbances of iron metabolism might occur at multiple levels, including iron uptake and release, storage, intracellular metabolism and regulation. It is the increased brain iron that triggers a cascade of deleterious events, leading to neuronal death in these diseases. In the article, the recent advances in studies on neurochemistry and neuropathophysiology of brain iron metabolism were reviewed.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Ke Y,Qian ZMdoi
10.1016/j.pneurobio.2007.07.009subject
Has Abstractpub_date
2007-10-01 00:00:00pages
149-73issue
3eissn
0301-0082issn
1873-5118pii
S0301-0082(07)00143-8journal_volume
83pub_type
杂志文章,评审abstract：:Reorganization of the somatotopic map in the spinal dorsal horn may be elicited by a variety of deafferenting lesions, including transection of peripheral nerves or dorsal roots, or the application of neurotoxins. While such lesions give rise to a variety of neurochemical and morphological changes in the dorsal horn, ...
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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更新日期：2017-06-01 00:00:00
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journal_title：Progress in neurobiology
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更新日期：2010-07-01 00:00:00
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0301-0082(98)00094-x
更新日期：1999-09-01 00:00:00
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doi：10.1016/j.pneurobio.2012.01.009
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doi：10.1016/j.pneurobio.2013.04.002
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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abstract：:Chronic restraint stress leads to increases in brain derived neurotrophic factor (BDNF) mRNA and protein in some regions of the brain, e.g. the basal lateral amygdala (BLA) but decreases in other regions such as the CA3 region of the hippocampus and dendritic spine density increases or decreases in line with these cha...
journal_title：Progress in neurobiology
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doi：10.1016/j.pneurobio.2013.10.005
更新日期：2014-01-01 00:00:00
