Abstract:
:Synthesis and degradation of glycerophospholipids in HL-60 cells and retinoic acid (RA)-treated HL-60 cells were examined. The synthesis of each subclass of ethanolamine-containing glycerophospholipids was extremely suppressed in RA-treated HL-60 cells, while that of other glycerophospholipids was not seriously affected. A pulse-chase experiment revealed that about 88% of 1,2-diacyl and 28% of 1-alkenyl-2-acyl glycerophosphoethanolamine were degraded during 4 days in RA-treated HL-60 cells. These characteristics of metabolism observed in RA-treated HL-60 cells might be responsible for the change of subclass composition of ethanolamine-containing glycerophospholipids in HL-60 cells during differentiation to granulocytes.
journal_name
J Biochemjournal_title
Journal of biochemistryauthors
Naito M,Kudo I,Nakagawa Y,Waku K,Nojiri H,Saito M,Inoue Kdoi
10.1093/oxfordjournals.jbchem.a123604subject
Has Abstractpub_date
1991-10-01 00:00:00pages
469-71issue
4eissn
0021-924Xissn
1756-2651journal_volume
110pub_type
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