Real-time direct measurement of spinal cord blood flow at the site of compression: relationship between blood flow recovery and motor deficiency in spinal cord injury.

Abstract:

STUDY DESIGN:An in vivo study to measure rat spinal cord blood flow in real-time at the site of compression using a newly developed device. OBJECTIVES:To evaluate the change in thoracic spinal cord blood flow by compression force and to clarify the association between blood flow recovery and motor deficiency after a spinal cord compression injury. SUMMARY OF BACKGROUND DATA:Until now, no real-time measurement of spinal cord blood flow at the site of compression has been conducted. In addition, it has not been clearly determined whether blood flow recovery is related to motor function after a spinal cord injury. METHODS:Our blood flow measurement system was a combination of a noncontact type laser Doppler system and a spinal cord compression device. The rat thoracic spinal cord was exposed at the 11th vertebra and spinal cord blood flow at the site of compression was continuously measured before, during, and after the compression. The functioning of the animal's hind-limbs was evaluated by the Basso, Beattie and Bresnahan scoring scale and the frequency of voluntary standing. Histologic changes such as permeability of blood-spinal cord barrier, microglia proliferation, and apoptotic cell death were examined in compressed spinal cord tissue. RESULTS:The spinal blood flow decreased on each increase in the compression force. After applying a 5-g weight, the blood flow decreased to <40% of the precompression level. Complete ischemia was reached using a 20-g weight. After decompression, the blood flow level in the 20-minute complete ischemia group was significantly higher than that in the 40-minute complete ischemia group. The hind-limb motor function in the 40-minute complete ischemia group was significantly less than that in the sham group (without compression), while no significant difference was observed between the 20-minute ischemia group and the sham group. In the 20-minute ischemia group, the rats whose spinal cord blood flow recovery was incomplete showed significant motor function loss compared with rats that completely recovered blood flow. Extensive breakdown of blood-spinal cord barrier integrity and the following microglia proliferation and apoptotic cell death were detected in the 40-minute complete ischemia group. CONCLUSION:Duration of ischemia/compression and blood flow recovery of the spinal cord are important factors in the recovery of motor function after a spinal cord injury.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Hamamoto Y,Ogata T,Morino T,Hino M,Yamamoto H

doi

10.1097/BRS.0b013e3181316310

subject

Has Abstract

pub_date

2007-08-15 00:00:00

pages

1955-62

issue

18

eissn

0362-2436

issn

1528-1159

pii

00007632-200708150-00005

journal_volume

32

pub_type

杂志文章

相关文献

SPINE文献大全
  • Accuracy of fluoroscopy versus computer-assisted navigation for the placement of anterior cervical pedicle screws.

    abstract:STUDY DESIGN:Randomized laboratory cadaver study. OBJECTIVE:The objective of this study was to determine the accuracy of anterior transpedicular screw placement in the cervical spine using conventional fluoroscopy versus computer-assisted navigation. SUMMARY OF BACKGROUND DATA:Traditionally, global cervical instabili...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000786

    authors: Patton AG,Morris RP,Kuo YF,Lindsey RW

    更新日期:2015-04-01 00:00:00

  • Analysis of risk factors associated with fusion failure after anterior odontoid screw fixation.

    abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To evaluate the incidence of fusion failure after anterior screw fixation of type II and rostral shallow type III fractures and to identify related risk factors. SUMMARY OF BACKGROUND DATA:Although several studies have reported fusion rates after anterior odontoid screw fix...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31820e6418

    authors: Cho DC,Sung JK

    更新日期:2012-01-01 00:00:00

  • The Impact of COVID-19 pandemic on Spine Surgeons: An Asia Pacific Spine Society (APSS) Survey.

    abstract:STUDY DESIGN:Cross-sectional survey. OBJECTIVE:The aim of this study was to investigate the impact of COVID-19 pandemic on the clinical practices of spine surgeons within the Asia Pacific region. SUMMARY OF BACKGROUND DATA:COVID-19 pandemic had changed spine surgeons' clinical practices and their concerns toward pers...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003622

    authors: Chan CYW,Chiu CK,Cheung JPY,Cheung PWH,Gani SMA,Kwan MK

    更新日期:2020-09-15 00:00:00

  • Direct vertebral body derotation, thoracoplasty, or both: which is better with respect to inclinometer and scoliosis research society-22 scores?

    abstract:STUDY DESIGN:Prospective, longitudinal cohort (nonrandomized). OBJECTIVE:To compare thoracoplasty (Th), direct vertebral body derotation (DVBD), and Th and DVBD with respect to correction of the rib prominence and Scoliosis Research Society (SRS) self-image scores in patients undergoing surgery for adolescent idiopath...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31824a4911

    authors: Samdani AF,Hwang SW,Miyanji F,Lonner B,Marks MC,Sponseller PD,Newton PO,Cahill PJ,Shufflebarger HL,Betz RR

    更新日期:2012-06-15 00:00:00

  • A controlled study of caudal epidural injections of triamcinolone plus procaine for the management of intractable sciatica.

    abstract::The management of sciatica due to lumbar nerve root compromise remains controversial, probably because few well-controlled studies of conservative management have been performed. This preliminary study assesses the efficacy of epidural injections of 80 mg triamcinolone acetonide plus 0.5% procaine hydrochloride in sal...

    journal_title:Spine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007632-199105000-00015

    authors: Bush K,Hillier S

    更新日期:1991-05-01 00:00:00

  • Acute effects of nucleus pulposus on blood flow and endoneurial fluid pressure in rat dorsal root ganglia.

    abstract:STUDY DESIGN:An experimental study to elucidate the initial factors in the pathogenesis of lumbar pain caused by disc herniation. OBJECTIVE:To evaluate the effects of autologous nucleus pulposus on blood flow and endoneurial fluid pressure in dorsal root ganglia. SUMMARY OF BACKGROUND DATA:Human sciatica is known to ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199812010-00006

    authors: Yabuki S,Kikuchi S,Olmarker K,Myers RR

    更新日期:1998-12-01 00:00:00

  • Adolescents undergoing surgery for idiopathic scoliosis: how physical and psychological characteristics relate to patient satisfaction with the cosmetic result.

    abstract:STUDY DESIGN:Patient satisfaction with the cosmetic result of spinal fusion surgery was studied in 42 cases of adolescent idiopathic scoliosis. Neutral or dissatisfied patients were compared with satisfied patients on several physical and psychological characteristics. OBJECTIVES:To determine whether adolescents gener...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200110010-00015

    authors: Koch KD,Buchanan R,Birch JG,Morton AA,Gatchel RJ,Browne RH

    更新日期:2001-10-01 00:00:00

  • Intramedullary injection of contrast into the cervical spinal cord during cervical myelography: a case report.

    abstract:STUDY DESIGN:A case of iatrogenic intramedullary contrast injection during a C1-C2 cervical myelography is reported. OBJECTIVE:To investigate the occurrence of iatrogenic intramedullary contrast injection during a current C1-C2 cervical myelography. SUMMARY OF BACKGROUND DATA:Intramedullary injection of contrast is a...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200205150-00026

    authors: Simon SL,Abrahams JM,Sean Grady M,LeRoux PD,Rushton SA

    更新日期:2002-05-15 00:00:00

  • Beneficial influence of titanium mesh cage on infection healing and spinal reconstruction in hematogenous septic spondylitis: a retrospective analysis of surgical outcome of twenty-five consecutive cases and review of literature.

    abstract:STUDY DESIGN:Single institution, single surgeon retrospective review. OBJECTIVE:To investigate if the use of titanium mesh cage on the site of infection could be beneficial for successful outcome of the operative treatment for pyogenic spondylitis. SUMMARY OF BACKGROUND DATA:There is a controversy concerning the opti...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e318187875e

    authors: Korovessis P,Repantis T,Iliopoulos P,Hadjipavlou A

    更新日期:2008-10-01 00:00:00

  • Molecular interactions between human cartilaginous endplates and nucleus pulposus cells: a preliminary investigation.

    abstract:STUDY DESIGN:Conditioned media (CM) of cartilaginous endplates (CEPs) of intervertebral discs were analyzed in a bioassay with regard to their influence on matrix turnover and inflammatory factors on nucleus pulposus (NP) cells of the same patient. CEP tissue underwent further histological and ultrastructural analysis....

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000372

    authors: Neidlinger-Wilke C,Boldt A,Brochhausen C,Galbusera F,Carstens C,Copf F,Schultheiss M,Lazary A,Brayda-Bruno M,Ignatius A,Wilke HJ

    更新日期:2014-08-01 00:00:00

  • Does early management of whiplash-associated disorders assist or impede recovery?

    abstract:STUDY DESIGN:Narrative review of the literature and commentary. OBJECTIVE:To discuss from an epidemiological and sociological perspective whether the early clinical management of whiplash-associated disorders can lead to iatrogenic disability. SUMMARY OF BACKGROUND DATA:There is a lack of evidence supporting the effe...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3182388d32

    authors: Côté P,Soklaridis S

    更新日期:2011-12-01 00:00:00

  • Thoracolumbar kyphosis in treated mucopolysaccharidosis 1 (Hurler syndrome).

    abstract:STUDY DESIGN:A retrospective radiographical follow-up study of thoracolumbar deformity in 33 children with mucopolysaccharidosis 1 (Hurler syndrome). OBJECTIVE:To report the severity, natural history, risk factors for progression, and results of intervention for thoracolumbar kyphosis in children with Hurler syndrome....

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000157

    authors: Yasin MN,Sacho R,Oxborrow NJ,Wraith JE,Williamson JB,Siddique I

    更新日期:2014-03-01 00:00:00

  • Effect of spinal construct stiffness on short segment fusion mass incorporation.

    abstract:STUDY DESIGN:Three segment (L3-L5) pedicle screw constructs were implanted in caprine spines, and the resulting ankylosis evaluated mechanically and compared 12 weeks after surgery. OBJECTIVES:To determine if a construct of maximal stiffness could impair the biologic process of spinal arthrodesis by "stress-shielding....

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199511001-00006

    authors: Johnston CE 2nd,Welch RD,Baker KJ,Ashman RB

    更新日期:1995-11-15 00:00:00

  • Intraoperative electrophysiological monitoring in spine surgery.

    abstract:STUDY DESIGN:Review of the literature with analysis of pooled data. OBJECTIVE:To assess common intraoperative neuromonitoring (IOM) changes that occur during the course of spinal surgery, potential causes of change, and determine appropriate responses. Further, there will be discussion of appropriate application of IO...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3181f6f0d0

    authors: Malhotra NR,Shaffrey CI

    更新日期:2010-12-01 00:00:00

  • Pain response to sagittal end-range spinal motion. A prospective, randomized, multicentered trial.

    abstract::This article reports a prospective, randomized, multicentered study documenting changes in the intensity and location of low-back and referred pain to repeated end-range lumbar flexion and extension movements performed first while standing and then while recumbent during a single clinical patient evaluation. Significa...

    journal_title:Spine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00007632-199106001-00006

    authors: Donelson R,Grant W,Kamps C,Medcalf R

    更新日期:1991-06-01 00:00:00

  • Use of epidural steroids after discectomy may predispose to infection.

    abstract:STUDY DESIGN:This is a report of three cases of epidural abscess occurring after use of intraoperative epidural methylprednisolone in 31 patients who had undergone lumbar microdiscectomy. The possible role of epidural steroids in the cause of these abscesses is discussed, and a review the literature concerning its valu...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200002150-00020

    authors: Lowell TD,Errico TJ,Eskenazi MS

    更新日期:2000-02-15 00:00:00

  • Function Preservation or Oncological Appropriateness in Spinal Bone Tumors?: A Case Series of Segmental Resection of the Spinal Canal Content (Spinal Amputation).

    abstract:STUDY DESIGN:Retrospective review of prospectively collected data. OBJECTIVE:To evaluate (1) if the segmental resection of the content of the spinal canal could provide an Enneking appropriate tumor-free margin for local control of primary bone tumors surrounding and invading the canal and (2) the safety profile of th...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003356

    authors: Girolami M,Boriani S,Ghermandi R,Bandiera S,Barbanti-Brodano G,Terzi S,Tedesco G,Evangelisti G,Pipola V,Ricci A,Cecchinato R,Gasbarrini A

    更新日期:2020-05-15 00:00:00

  • The Optimal Timing of Hydrogel Injection for Treatment of Intervertebral Disc Degeneration: Quantitative Analysis Based on T1ρ MR Imaging.

    abstract:STUDY DESIGN:Animal experimental study. OBJECTIVE:The aim of this study was to investigate the optimal time of hydrogel injection for regenerating intervertebral disc degeneration (IDD) based on T1ρ magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND DATA:Currently, different approaches are being pursued to regen...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003667

    authors: Liu Z,Li J,Hu M,Wang X,Chen N,Cui S,Li S,Liu H,Chen G,Pan X,Sun H,Liu S,Wei F

    更新日期:2020-11-15 00:00:00

  • Pedicle and spinal canal parameters of the lower thoracic and lumbar vertebrae in the achondroplast population.

    abstract:STUDY DESIGN:Retrospective morphometric population study. OBJECTIVE:To characterize pedicle and spinal canal morphology of the achondroplastic lower thoracic and lumbar vertebrae and to suggest dimensions for improving pedicle screw selection and placement. SUMMARY OF BACKGROUND DATA:Although morphometric population ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181574286

    authors: Srikumaran U,Woodard EJ,Leet AI,Rigamonti D,Sponseller PD,Ain MC

    更新日期:2007-10-15 00:00:00

  • The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model.

    abstract:STUDY DESIGN:A study on the efficacy of recombinant human bone morphogenetic protein 2 (rhBMP-2) in a nonhuman primate anterior interbody fusion model. OBJECTIVES:To investigate the efficacy of rhBMP-2 with an absorbable collagen sponge carrier to promote spinal fusion in a nonhuman primate anterior interbody fusion m...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199904010-00004

    authors: Hecht BP,Fischgrund JS,Herkowitz HN,Penman L,Toth JM,Shirkhoda A

    更新日期:1999-04-01 00:00:00

  • Migration of a Lumbar Spinal Fusion Rod Into the Posterolateral Knee: A Case Report.

    abstract:STUDY DESIGN:Case report (level V evidence). OBJECTIVE:We report a case of a 33-year-old man with Marfan syndrome that visited our clinic for left knee pain and stiffness. Radiographs of the left knee and lumbar spine demonstrated a spinal rod in the posterolateral left knee and its origin being a broken rod from his ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003804

    authors: Long MK,Enders T,Leven D,Cappellino A

    更新日期:2021-02-01 00:00:00

  • Isokinetic muscle strength of the trunk and bilateral knees in young subjects with lumbar disc herniation.

    abstract:STUDY DESIGN:Cross-sectional study comparing normal subjects and patients with lumbar disc herniation. OBJECTIVE:To evaluate trunk and knee muscle strength in patients with L4-L5 and/or L5-S1 disc herniation. SUMMARY OF BACKGROUND DATA:Numerous studies have shown that patients with low back pain have weaker trunk mus...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000179307.34310.7d

    authors: Ho CW,Chen LC,Hsu HH,Chiang SL,Li MH,Jiang SH,Tsai KC

    更新日期:2005-09-15 00:00:00

  • Implication of Biomarker Mutations for Predicting Survival in Patients With Metastatic Lung Cancer to the Spine.

    abstract:STUDY DESIGN:A retrospective cohort study. OBJECTIVE:We performed a retrospective study of patients treated at our institution over the last 7 years to ascertain whether gene expression signatures in patients with advanced metastatic disease are associated with survival, when the disease has progressed to the spine. ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002683

    authors: Choi BD,Shankar GM,Sivaganesan A,Van Beaver LA,Oh K,Shin JH

    更新日期:2018-11-01 00:00:00

  • Effects of continuous quantitative vibration on rheologic and biological behaviors of the intervertebral disc.

    abstract::The authors attempted to investigate the effect of vibration on the physiologic behavior of the intervertebral disc from rheologic and biological responses. Using fresh disc-cartilaginous end plate complexes of porcine coccygeal vertebrae, the frequency characteristics of dynamic compressive elastic modulus and dissip...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199203001-00002

    authors: Ishihara H,Tsuji H,Hirano N,Ohshima H,Terahata N

    更新日期:1992-03-01 00:00:00

  • Changes in lumbar disc angles of Chinese subjects from upright to flexion.

    abstract:STUDY DESIGN:This study analyzed the sizes and angles of vertebrae and discs in Chinese subjects. Lateral lumbar spine radiograph films were taken of subjects in upright and 60 degrees flexion positions to evaluate disc height and angle changes. OBJECTIVES:This study sought to gather data regarding the contribution of...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199407000-00013

    authors: Chen MW,Yang SW,Lee MC

    更新日期:1994-07-01 00:00:00

  • Upper thoracic versus lower thoracic upper instrumented vertebrae endpoints have similar outcomes and complications in adult scoliosis.

    abstract:STUDY DESIGN:Retrospective review-multicenter database. OBJECTIVE:The purpose of this study was to compare the upper thoracic (UT) and lower thoracic (LT) upper instrumented vertebrae (UIV) in long fusions to the sacrum for adult scoliosis. SUMMARY OF BACKGROUND DATA:The optimal UIV for stopping long fusions to the s...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0000000000000339

    authors: Kim HJ,Boachie-Adjei O,Shaffrey CI,Schwab F,Lafage V,Bess S,Gupta MC,Smith JS,Deviren V,Akbarnia B,Mundis GM,OʼBrien M,Hostin R,Ames C,International Spine Study Group.

    更新日期:2014-06-01 00:00:00

  • The comparative study of magnetic resonance angiography diagnosis and pathology of blunt vertebral artery injury.

    abstract:STUDY DESIGN:Observational and comparative study of the vertebral artery injury detected by 2-dimensional (2-D) time-of-flight magnetic resonance angiography (MRA) for admitting patients. Construct a strike-induced flexion injury model of cervical spine with blunt vertebral artery injury in dogs. OBJECTIVES:To evaluat...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000231722.86887.93

    authors: Ren X,Wang W,Zhang X,Pu Y,Wang M,Jiang T

    更新日期:2006-08-15 00:00:00

  • The Minimum Clinically Important Difference for Patient Health Questionnaire-9 in Minimally Invasive Transforaminal Interbody Fusion.

    abstract:STUDY DESIGN:Retrospective Cohort OBJECTIVE.: Investigate and establish minimum clinically important differences (MCID) for PHQ-9 among patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND:Spine surgery is linked to postoperative improvements in anxiety, depre...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003853

    authors: Lynch CP,Cha EDK,Jenkins NW,Parrish JM,Mohan S,Jadczak CN,Geoghegan CE,Singh K

    更新日期:2020-12-07 00:00:00

  • Neuropeptide changes in compressed spinal nerve roots.

    abstract:STUDY DESIGN:Compression-induced changes in the concentration of substance P and VIP (vasoactive intestinal polypeptide), in spinal nerve roots and dorsal root ganglia were studied in an experimental nerve root compression model in pigs. OBJECTIVES:To analyze by radioimmunoassay the concentration of the neuropeptides ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199503150-00007

    authors: Cornefjord M,Olmarker K,Farley DB,Weinstein JN,Rydevik B

    更新日期:1995-03-15 00:00:00

  • Efficacy of Intraoperative Intervention Following Transcranial Motor-evoked Potentials Alert During Posterior Decompression and Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study of the Monitor

    abstract:STUDY DESIGN:Prospective, multicenter, observational study. OBJECTIVE:The aim of this study was to investigate the efficacy of intervention after an alert in intraoperative neurophysiological monitoring (IONM) using transcranial motor-evoked potentials (Tc-MEPs) during surgery for thoracic ossification of the posterio...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003774

    authors: Kobayashi K,Imagama S,Yoshida G,Ando M,Kawabata S,Yamada K,Kanchiku T,Fujiwara Y,Taniguchi S,Iwasaki H,Tadokoro N,Takahashi M,Wada K,Yamamoto N,Shigematsu H,Funaba M,Yasuda A,Ushirozako H,Tani T,Matsuyama Y

    更新日期:2021-02-15 00:00:00