Neuropeptide changes in compressed spinal nerve roots.

Abstract:

STUDY DESIGN:Compression-induced changes in the concentration of substance P and VIP (vasoactive intestinal polypeptide), in spinal nerve roots and dorsal root ganglia were studied in an experimental nerve root compression model in pigs. OBJECTIVES:To analyze by radioimmunoassay the concentration of the neuropeptides substance P and VIP in a model for experimental chronic nerve root compression. SUMMARY OF BACKGROUND DATA:Neuropeptides such as substance P and VIP seem to be involved in the transmission of pain and changes in the levels of these neuropeptides have been described in models where peripheral or spinal nerve injury was induced. METHODS:An ameroid constrictor was applied on a spinal nerve root just cranial to the dorsal root ganglion. The inner diameter of this constrictor is gradually reduced. After 1 or 4 weeks, tissue samples were taken from the nerve root cranial to the constrictor and from the dorsal root ganglion for measurement of substance P and VIP concentrations. RESULTS:There was a statistically significant increase in substance P concentrations in the compressed dorsal root ganglia when compared to the noncompressed dorsal root ganglia at both 1 and 4 weeks. Substance P concentration was also significantly increased in the nerve root after 1 but not after 4 weeks. The VIP levels were not significantly changed in either tissue. CONCLUSIONS:The results of the study indicates an increase in substance P levels in the dorsal root ganglion (after 1 and 4 weeks) and in the nerve root (after 1 week) in a model for chronic nerve root compression in pigs. There were no significant differences in the VIP concentrations. The study thus indicates that changes in substance P are related to experimental chronic nerve root compression.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Cornefjord M,Olmarker K,Farley DB,Weinstein JN,Rydevik B

doi

10.1097/00007632-199503150-00007

subject

Has Abstract

pub_date

1995-03-15 00:00:00

pages

670-3

issue

6

eissn

0362-2436

issn

1528-1159

journal_volume

20

pub_type

杂志文章

相关文献

SPINE文献大全
  • Fusion risk score: evaluating baseline risk in thoracic and lumbar fusion surgery.

    abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:The fusion risk score (FRS) is introduced to assess baseline risk of spine fusion surgery preoperatively. An objective method of stratifying risk allows the surgeon to control risk through tailoring intervention and explain differences in complication profile in high-...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3182a8c3b7

    authors: Hartin NL,Mehbod AA,Joglekar SB,Transfeldt EE

    更新日期:2013-12-01 00:00:00

  • Anterior decompression and stabilization of thoracolumbar burst fractures by the use of the Slot-Zielke device.

    abstract::Between July 1983 and November 1986, 29 patients with thoracolumbar burst fractures underwent a one-stage operation consisting of anterior decompression by subtotal vertebrectomy, reduction, and stabilization with the Slot-Zielke device. The mean follow-up was 3.1 years. Most patients with incomplete neurologic lesion...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199101000-00013

    authors: Been HD

    更新日期:1991-01-01 00:00:00

  • Intra-arterial indocyanine green angiography in the management of spinal arteriovenous fistulae: technical case reports.

    abstract:STUDY DESIGN:We first present 2 cases of spinal arteriovenous fistulae (AVFs) successfully treated with the help of intra-arterial indocyanine green (ICG) angiography. OBJECTIVE:To demonstrate the efficacy of intra-arterial ICG angiography in spinal AVFs compared with the role of intravenous ICG injection and intraope...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31822ba834

    authors: Horie N,So G,Debata A,Hayashi K,Morikawa M,Suyama K,Nagata I

    更新日期:2012-02-15 00:00:00

  • Detection of Mycobacterium tuberculosis in formaldehyde solution-fixed, paraffin-embedded tissue by polymerase chain reaction in Pott's disease.

    abstract:STUDY DESIGN:Twenty-five formaldehyde solution-fixed, paraffin-embedded tissue blocks from vertebral biopsy specimen materials with presumptive diagnosis of tuberculous spondylitis and nonspecific vertebral osteomyelitis were studied. OBJECTIVES:To evaluate the sensitivity and specificity of polymerase chain reaction ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199609010-00011

    authors: Berk RH,Yazici M,Atabey N,Ozdamar OS,Pabuccuoglu U,Alici E

    更新日期:1996-09-01 00:00:00

  • Osteochondroma of the C5 lamina with cord compression: case report and review of the literature.

    abstract:STUDY DESIGN:Case report of a solitary osteochondroma of the cervical spine causing myelopathy in a 66-year-old woman. OBJECTIVES:To review the relevant literature and describe a highly unusual clinical manifestation of solitary osteochondroma. SUMMARY OF BACKGROUND DATA:Osteochondromas are common benign bony lesions...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/00007632-200005150-00017

    authors: Ratliff J,Voorhies R

    更新日期:2000-05-15 00:00:00

  • The evidence for intraoperative neurophysiological monitoring in spine surgery: does it make a difference?

    abstract:OBJECTIVE:The objective of this article was to undertake a systematic review of the literature to determine whether IOM is able to sensitively and specifically detect intraoperative neurologic injury during spine surgery and to assess whether IOM results in improved outcomes for patients during these procedures. SUMMA...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3181d8338e

    authors: Fehlings MG,Brodke DS,Norvell DC,Dettori JR

    更新日期:2010-04-20 00:00:00

  • A Profile of Low Back Pain: Treatment and Costs Associated With Patients Referred to Orthopedic Specialists in Sweden.

    abstract:STUDY DESIGN:Analysis of Swedish national and regional register data. OBJECTIVES:The aim of this study was to characterize healthcare resource utilization, productivity loss, and costs of patients with low back pain (LBP) with or without leg pain, who have been referred from primary care settings to orthopedic special...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002089

    authors: Jonsson E,Olafsson G,Fritzell P,Hägg O,Borgström F

    更新日期:2017-09-01 00:00:00

  • Vertebroplasty with high-viscosity polymethylmethacrylate cement facilitates vertebral body restoration in vitro.

    abstract:STUDY DESIGN:In vitro biomechanical study on 6 fresh frozen human thoracolumbar spine specimens. OBJECTIVE:Using a novel high viscosity polymethylmethacrylate (PMMA) cement and vertebroplasty kit to correct the kyphosis angle of wedge compression fractures (AO/ASIF 1.2). SUMMARY OF BACKGROUND DATA:Vertebroplasty is t...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181b61d10

    authors: Rüger M,Schmoelz W

    更新日期:2009-11-15 00:00:00

  • Lumbar Degenerative Spondylolisthesis: Changes in Surgical Indications and Comparison of Instrumented Fusion With Two Surgical Decompression Procedures.

    abstract:STUDY DESIGN:Single-center retrospective case series. OBJECTIVE:To compare outcomes of instrumented fusion and two methods of decompression for degenerative spondylolisthesis. SUMMARY OF BACKGROUND DATA:There is no consensus on the surgical indications or optimum techniques for lumbar degenerative spondylolisthesis. ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001688

    authors: Inui T,Murakami M,Nagao N,Miyazaki K,Matsuda K,Tominaga Y,Kitano M,Hasegawa H,Tominaga S

    更新日期:2017-01-01 00:00:00

  • Amaurosis secondary to massive blood loss after lumbar spine surgery.

    abstract::Reported herein is the unusual complication of blindness resulting from massive blood loss during a lumbar spine surgery. Amaurosis resulting from distant hemorrhage is rare and, to the authors' knowledge, has not been reported in the orthopedic literature. Although there have been several case reports in the ophthalm...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199402001-00018

    authors: Katzman SS,Moschonas CG,Dzioba RB

    更新日期:1994-02-15 00:00:00

  • Ventral discectomy with pmma interbody fusion for cervical disc disease: long-term results in 249 patients.

    abstract:STUDY DESIGN:Retrospective study of patients who underwent ventral discectomy and polymethyl-methacrylate (PMMA) interbody fusion for cervical radiculopathy. OBJECTIVES:To evaluate the long-term outcome after ventral discectomy and PMMA interbody fusion and to compare it with previous data from other surgical techniqu...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200102010-00009

    authors: Hamburger C,Festenberg FV,Uhl E

    更新日期:2001-02-01 00:00:00

  • Spinal cord injury. Review of basic and applied research.

    abstract::This review examines, in a condensed manner, many of the major achievements related to spinal cord injury research during the last quarter century. Most of the advances have been made within the past 10 years. They include such basic and clinical tools as evoked potentials, regional and local spinal blood flows, neuro...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:

    authors: de la Torre JC

    更新日期:1981-07-01 00:00:00

  • Concurrent measurement of isokinetic muscle strength of the trunk, knees, and ankles in patients with lumbar disc herniation with sciatica.

    abstract:STUDY DESIGN:A cross-sectional study comparing normal subjects and patients with lumbar disc herniation (LDH) with sciatica. OBJECTIVE:To simultaneously measure the isokinetic muscle strength of the trunk, knees, and ankles in both groups. SUMMARY OF BACKGROUND DATA:Coordination between the trunk and lower extremity ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181d12642

    authors: Chen LC,Kuo CW,Hsu HH,Chang ST,Ni SM,Ho CW

    更新日期:2010-12-15 00:00:00

  • 30-Day Recurrence, Readmission Rate, and Clinical Outcome After Emergency Lumbar Discectomy.

    abstract:STUDY DESIGN:A retrospective cohort study. OBJECTIVE:To investigate the 30-day recurrence rate after emergency lumbar discectomy. Secondary aims were to investigate the factors affecting the 30-day recurrence and readmission rates and clinical outcome. SUMMARY OF BACKGROUND DATA:Excluding cauda equine syndrome (CES) ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003519

    authors: Reito A,Kyrölä K,Pekkanen L,Paloneva J

    更新日期:2020-09-15 00:00:00

  • Advances in secondary spinal cord injury: role of apoptosis.

    abstract::The outcome of spinal cord injury depends on the extent of secondary damage produced by a series of cellular and molecular events initiated by the primary trauma. This article reviews the evidence that secondary spinal cord injury involves the apoptotic as well as necrotic death of neurons and glial cells. Also discus...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/00007632-200007150-00022

    authors: Lu J,Ashwell KW,Waite P

    更新日期:2000-07-15 00:00:00

  • Whiplash and the compensation hypothesis.

    abstract:STUDY DESIGN:Review article. OBJECTIVE:To explain why the evidence that compensation-related factors lead to worse health outcomes is not compelling, either in general, or in the specific case of whiplash. SUMMARY OF BACKGROUND DATA:There is a common view that compensation-related factors lead to worse health outcome...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3182388411

    authors: Spearing NM,Connelly LB

    更新日期:2011-12-01 00:00:00

  • Dual growing rod technique followed for three to eleven years until final fusion: the effect of frequency of lengthening.

    abstract:STUDY DESIGN:Retrospective case review of children completing dual growing rod treatment at our institutions. Patients had a minimum of 2 years follow-up. OBJECTIVE:To identify the factors influencing dual growing rod treatment outcome followed to final fusion. SUMMARY OF BACKGROUND DATA:Published reports on dual gro...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31816c8b4e

    authors: Akbarnia BA,Breakwell LM,Marks DS,McCarthy RE,Thompson AG,Canale SK,Kostial PN,Tambe A,Asher MA,Growing Spine Study Group.

    更新日期:2008-04-20 00:00:00

  • Long-term follow-up of lower lumbar fusion patients.

    abstract::To determine the long-term effects of lower lumbar fusion, 94 subjects were catalogued from medical records. They had a lumbar arthrodesis at the third lumbar level or below and their operations were performed before 1964. Twenty-four were not located and 8 were deceased. Sixty-two subjects (72% of available sample) c...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198703000-00004

    authors: Lehmann TR,Spratt KF,Tozzi JE,Weinstein JN,Reinarz SJ,el-Khoury GY,Colby H

    更新日期:1987-03-01 00:00:00

  • mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs.

    abstract:STUDY DESIGN:The mRNA expressions of cytokines and chemokines were assessed in herniated lumbar disc specimens. OBJECTIVES:To investigate whether the mRNAs of interleukin (IL)-1alpha, tumor necrosis factor (TNF)-alpha, RANTES, IL-8, IL-10, and transforming growth factor (TGF)-beta are expressed in surgically obtained ...

    journal_title:Spine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007632-200205010-00005

    authors: Ahn SH,Cho YW,Ahn MW,Jang SH,Sohn YK,Kim HS

    更新日期:2002-05-01 00:00:00

  • New uses and refinements of the paraspinal approach to the lumbar spine.

    abstract::The paraspinal approach was described by our group in 1968. It differs from the approach described by Melvin Watkins in 1953 in that it is a longitudinal separation of the sacrospinalis group between the multifidus and longissimus, and not between the lateral border of the entire sacrospinalis group and quadratus lumb...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Wiltse LL,Spencer CW

    更新日期:1988-06-01 00:00:00

  • 1995 Volvo Award in basic sciences. The use of an osteoinductive growth factor for lumbar spinal fusion. Part I: Biology of spinal fusion.

    abstract:STUDY DESIGN:The histology of lumbar intertransverse process spinal fusion was studied in an experimental model in rabbits. OBJECTIVES:To qualitatively and quantitatively analyze the sequential histology of spinal fusion using a previously validated animal model. SUMMARY OF BACKGROUND DATA:Few previous studies have d...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199512150-00003

    authors: Boden SD,Schimandle JH,Hutton WC,Chen MI

    更新日期:1995-12-15 00:00:00

  • The efficacy of a treatment program focusing on specific stabilizing exercises for pelvic girdle pain after pregnancy: a randomized controlled trial.

    abstract:STUDY DESIGN:A randomized controlled trial with stratified block design. OBJECTIVES:To evaluate a treatment program focusing on whether specific stabilizing exercises for patients with pelvic girdle pain after pregnancy reduce pain, improve functional status, and improve quality of life. SUMMARY OF BACKGROUND DATA. : ...

    journal_title:Spine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.brs.0000090827.16926.1d

    authors: Stuge B,Laerum E,Kirkesola G,Vøllestad N

    更新日期:2004-02-15 00:00:00

  • Comparison of Freshly Isolated Adipose Tissue-derived Stromal Vascular Fraction and Bone Marrow Cells in a Posterolateral Lumbar Spinal Fusion Model.

    abstract:STUDY DESIGN:Rat posterolateral lumbar fusion model. OBJECTIVE:To compare the efficacy of freshly isolated adipose tissue-derived stromal vascular fraction (A-SVF) and bone marrow cells (BMC) cells in achieving spinal fusion in a rat model. SUMMARY OF BACKGROUND DATA:Adipose tissue-derived stromal cells (ASCs) offer ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003709

    authors: Perdomo-Pantoja A,Holmes C,Cottrill E,Rindone AN,Ishida W,Taylor M,Tomberlin C,Lo SL,Grayson WL,Witham TF

    更新日期:2020-09-24 00:00:00

  • A prospective and consecutive study of surgically treated lumbar spinal stenosis. Part II: Five-year follow-up by an independent observer.

    abstract:STUDY DESIGN:A prospective and consecutive study of surgical results obtained during serial follow-up investigations in patients who underwent surgery for central lumbar spinal stenosis. OBJECTIVES:To evaluate the result after surgical decompression for lumbar spinal stenosis, at regular intervals after surgery, and t...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199712150-00017

    authors: Jönsson B,Annertz M,Sjöberg C,Strömqvist B

    更新日期:1997-12-15 00:00:00

  • Neurologic improvement after thoracic, thoracolumbar, and lumbar spinal cord (conus medullaris) injuries.

    abstract:STUDY DESIGN:Retrospective. OBJECTIVE:With approximately 10,000 new spinal cord injury (SCI) patients in the United States each year, predicting public health outcomes is an important public health concern. Combining all regions of the spine in SCI trials may be misleading if the lumbar and sacral regions (conus) have...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181fd6b36

    authors: Harrop JS,Naroji S,Maltenfort MG,Ratliff JK,Tjoumakaris SI,Frank B,Anderson DG,Albert T,Vaccaro AR

    更新日期:2011-01-01 00:00:00

  • Vertebrodiatasis experimental lengthening of the juvenile goat spine.

    abstract::The purpose of this study is to describe the biology of spinal lengthening (vertebrodiatasis) in a juvenile goat model. A small Orthofix dynamic fixator was affixed to 5.5 mm pedicular halfpins placed bilaterally at T12, L1, L5 and L6 in six juvenile goats. Distraction was performed across vertebral endplates between ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199309000-00008

    authors: Stefko RM,Cain JE Jr,Lauerman WC 2nd,Brann C,Platenburg RC,Pyka R

    更新日期:1993-09-15 00:00:00

  • Correction of thoracic adolescent idiopathic scoliosis with segmental hooks, rods, and Wisconsin wires posteriorly: it's bad and obsolete, correct?

    abstract:STUDY DESIGN:Forty-four consecutive thoracic idiopathic adolescent curves surgically treated between 1995 and 1999 at one institution were analyzed. All were thoracic curves; there were no lumbar curves, double major curves, or triple major curves. OBJECTIVES:To study the clinical and radiographic results for these 44...

    journal_title:Spine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007632-200209150-00018

    authors: Bridwell KH,Hanson DS,Rhee JM,Lenke LG,Baldus C,Blanke K

    更新日期:2002-09-15 00:00:00

  • Ultrastructure of the human interspinous ligament and ligamentum flavum. A preliminary study.

    abstract::The ultrastructure of ligamenta flava (LF) and interspinous ligaments (ISL) obtained from four patients who underwent surgery for vertebral fracture (control group) and five patients operated for disc herniation was studied. The fine structure of LF was composed of elastic and elaunin fibers. Small diameter collagen f...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199004000-00002

    authors: Yahia LH,Garzon S,Strykowski H,Rivard CH

    更新日期:1990-04-01 00:00:00

  • Percutaneous dorsal column stimulator for chronic pain control.

    abstract::This is a retrospective review of 26 patients with chronic intractable pain in which dorsal column stimulation was used as a salvage procedure. On follow-up of 12 to 42.7 months, 21 of the patients had diminished narcotic usage. Seventeen patients subjectively rated their pain relief as good to excellent. Another five...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198901000-00001

    authors: Racz GB,McCarron RF,Talboys P

    更新日期:1989-01-01 00:00:00

  • Solitary Plasmacytoma of Bone of the Spine: Results From Surveillance, Epidemiology, and End Results (SEER) Registry.

    abstract:STUDY DESIGN:Retrospective analysis. OBJECTIVE:To determine the prognostic indicators in patients with solitary plasmacytoma of bone (SPB) of the spine. SUMMARY OF BACKGROUND DATA:Population-level estimates for prognosis among patients with SPB of the spine are still lacking. Sociodemographic and clinical predictors ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002777

    authors: Wang Y,Li H,Liu C,Chen C,Yan J

    更新日期:2019-01-15 00:00:00