Abstract:
:The outcome of spinal cord injury depends on the extent of secondary damage produced by a series of cellular and molecular events initiated by the primary trauma. This article reviews the evidence that secondary spinal cord injury involves the apoptotic as well as necrotic death of neurons and glial cells. Also discussed are the major factors that can contribute to cell death, such as glutamatergic excitotoxicity, free radical damage, cytokines, and inflammation. The development of innovative therapeutic strategies to reduce secondary spinal cord injury depends on an increased understanding of secondary injury mechanisms at the molecular and biochemical level. Such therapeutic interventions may include the use of antiapoptotic drugs, free radical scavengers, and anti-inflammatory agents. These could be targeted to block key reactions on cellular and molecular injury cascades, thus reducing secondary tissue damage, minimizing side effects, and improving functional recovery.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Lu J,Ashwell KW,Waite Pdoi
10.1097/00007632-200007150-00022keywords:
subject
Has Abstractpub_date
2000-07-15 00:00:00pages
1859-66issue
14eissn
0362-2436issn
1528-1159journal_volume
25pub_type
杂志文章,评审相关文献
SPINE文献大全abstract:STUDY DESIGN:Randomized prevention trial. OBJECTIVE:To compare the long-term effect of strengthening versus flexibility exercises and to evaluate the additional effect of abdominal bracing in recurrent low back pain (LBP). SUMMARY OF BACKGROUND DATA:No conclusions could be made regarding appropriate exercise types or...
journal_title:Spine
pub_type: 杂志文章,随机对照试验
doi:10.1097/BRS.0000000000000338
更新日期:2014-06-01 00:00:00
abstract::The results of a long-term study of 28 patients operated on for adhesive lumbar arachnoiditis are presented. The technique involved was microscopic lysis of adhesions. The first case of surgery was performed in 1966 and the last, in 1970, with followup through 1976. Numerous observations are made regarding the clinica...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-197803000-00008
更新日期:1978-03-01 00:00:00
abstract:STUDY DESIGN:Analysis of the clinical results of 20 patients with thoracic scoliosis treated by anterior procedure with Kaneda anterior spinal system. OBJECTIVES:To evaluate the efficacy of the anterior surgical correction procedure with a new anterior instrumentation in thoracic scoliosis. SUMMARY OF BACKGROUND DATA...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199706150-00015
更新日期:1997-06-15 00:00:00
abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To report results at a minimum 5 years after pedicle subtraction osteotomy for fixed sagittal imbalance. SUMMARY OF BACKGROUND DATA:No one has reported results of pedicle subtraction osteotomies with a 5- to 8-year follow-up. METHOD:Thirty-five consecutive patients with sa...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31814b8371
更新日期:2007-09-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of anterior and posterior fusions for treatment of adolescent idiopathic thoracic scoliosis. OBJECTIVES:To delineate the best factors determining final lumbar curve magnitude in patients with adolescent idiopathic scoliosis undergoing a selective thoracic anterior or posterior spinal ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000106488.51299.75
更新日期:2004-02-01 00:00:00
abstract:STUDY DESIGN:This study demonstrated the therapeutic value of chemonucleolysis with chondroitinase ABC to canine intervertebral disc displacement. OBJECTIVES:To determine the efficacy of Chondroitinase ABC in the management of canine intervertebral disc displacement. SUMMARY OF BACKGROUND DATA:No previous study has a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199707010-00002
更新日期:1997-07-01 00:00:00
abstract:STUDY DESIGN:Randomized controlled trial. OBJECTIVE.: To determine the effect of low-dose ketamine on the voltage needed to elicit maximal amplitude of the motor-evoked response to transcranial electrical stimulation during propofol/remifentanil anesthesia in children undergoing scoliosis surgery. SUMMARY OF BACKGROUN...
journal_title:Spine
pub_type: 杂志文章,随机对照试验
doi:10.1097/BRS.0b013e3181573eb4
更新日期:2007-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective clinical study. OBJECTIVE:The aim of this study was to examine whether the Tokuhashi score correlates with the neurologic outcome in early surgical treatment in metastatic spinal cord compression (MSCC). A retrospective analysis of 35 consecutive incomplete tetraplegic and paraplegic patient...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318188b98f
更新日期:2008-11-15 00:00:00
abstract:STUDY DESIGN:Self-assembling peptide gel (SPG-178) provides new evidence for the role of a scaffold for treatment of the spinal cord through induction of neuroprotective factors. OBJECTIVE:To verify the reproducibility of SPG-178 as scaffold after spinal cord injury, we examine the characteristics of SPG-178 and prote...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001611
更新日期:2016-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of magnetic resonance imaging and discography in patients investigated for low back pain before spinal fusion. OBJECTIVE:To determine the sensitivity of magnetic resonance imaging in the detection of painful anular tears manifested by the high-intensity zone. SUMMARY OF BACKGROUND DA...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199802150-00009
更新日期:1998-02-15 00:00:00
abstract:STUDY DESIGN:Case report of a solitary osteochondroma of the cervical spine causing myelopathy in a 66-year-old woman. OBJECTIVES:To review the relevant literature and describe a highly unusual clinical manifestation of solitary osteochondroma. SUMMARY OF BACKGROUND DATA:Osteochondromas are common benign bony lesions...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/00007632-200005150-00017
更新日期:2000-05-15 00:00:00
abstract::Pain is an extremely complex process that involves the interaction of an array of neurotransmitters and neuromodulators at all levels of the neuraxis. Identification of the receptors and processes that are involved in the transmission of pain at a spinal level has led to the use of new agents and new techniques in pai...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/00007632-199701010-00016
更新日期:1997-01-01 00:00:00
abstract::The influences of age, sex, disc level, and degree of degenration on the mechanical behavior of 42 fresh cadaver lumbar motion segments are reported. The motions and intradiscal pressure changes that result from the application of flexion, extension, lateral bending, and torsional moments; compression; and anterior, p...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-197901000-00001
更新日期:1979-01-01 00:00:00
abstract:STUDY DESIGN:Prospective observational study. OBJECTIVE:This study aims to quantify the incidence of intraoperative waste in spine surgery and to examine the efficacy of an educational program directed at surgeons to induce a reduction in the intraoperative waste. SUMMARY OF BACKGROUND DATA:Spine procedures are assoc...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31822a58c1
更新日期:2011-09-01 00:00:00
abstract:STUDY DESIGN:A radiographic, histologic, biochemical, and gene expression study was conducted in vivo in a rabbit model to determine the effect of injection of the N-terminal 30 kDa fibronectin fragment (Fn-f) into the intervertebral disc along with various control substances. OBJECTIVE:To determine if the Fn-f is abl...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000096943.27853.BC
更新日期:2003-10-15 00:00:00
abstract:STUDY DESIGN:A prospective, nonblinded, multicenter study of outcomes in patients undergoing single-level anterior lumbar discectomy and interbody fusion with InFUSE Bone Graft. OBJECTIVE:To determine the safety and effectiveness of InFUSE Bone Graft applied to an absorbable collagen sponge in anterior lumbar interbod...
journal_title:Spine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007632-200211010-00015
更新日期:2002-11-01 00:00:00
abstract::Records of 41 patients were reviewed for early complications resulting from reduction of high-grade spondylolisthesis. Blood loss averaged 1,427 ml. There were no cases of infection, dural tears, or bladder or bowel dysfunction. Two cases of transient foot drop and one case of permanent foot drop developed. A lumbar p...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199106001-00025
更新日期:1991-06-01 00:00:00
abstract:STUDY DESIGN:Antimicrobial effect of a novel silver-impregnated pedicle screw in rabbits. OBJECTIVE:A novel spine implant model was designed to study the antimicrobial effect of a modified Titanium (Ti) pedicle screws with methicillin-resistant Staphylococcus aureus (MRSA) in multiple surgical sites in the lumbar spin...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001223
更新日期:2016-03-01 00:00:00
abstract:STUDY DESIGN:Retrospective analysis. OBJECTIVE:To determine, in pediatric patients with neuromuscular deformity undergoing vertebral column resection (VCR), the (1) characteristics of the surgery performed; (2) amount of pelvic obliquity restoration, and coronal and sagittal correction achieved; (3) associated blood l...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318244460d
更新日期:2012-05-15 00:00:00
abstract:STUDY DESIGN:Case study. OBJECTIVE:To present three complicated cases of giant cell tumor of the spine treated with sodium ibandronate. SUMMARY OF BACKGROUND DATA:Spinal giant cell tumors are a rare clinical entity with a high recurrence rate after operation. Furthermore, complete resection of such lesions remains a ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3182127f91
更新日期:2011-08-01 00:00:00
abstract:STUDY DESIGN:A case report of 3 patients with posterior migration of bullet-shaped fusion cages after transforaminal lumbar interbody fusion (TLIF). One patient required emergency revision surgery; the other 2 patients are being observed during conservative treatment. OBJECTIVE:To review cases of posterior migration o...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181918aae
更新日期:2009-01-01 00:00:00
abstract::Improving spinal fusion by optimizing scaffold and surface engineering is a topic of interest for both surgeons and researchers. Concerns regarding patient safety with off-label use of bone morphogenetic protein (BMP) have increased, and patients are choosing minimally invasive spine surgery to lessen morbidity by avo...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001426
更新日期:2016-04-01 00:00:00
abstract:STUDY DESIGN:Analysis of Swedish national and regional register data. OBJECTIVES:The aim of this study was to characterize healthcare resource utilization, productivity loss, and costs of patients with low back pain (LBP) with or without leg pain, who have been referred from primary care settings to orthopedic special...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002089
更新日期:2017-09-01 00:00:00
abstract:STUDY DESIGN:Retrospective analysis using kinetic magnetic resonance images (MRIs). OBJECTIVE:To investigate the relationship of changes in the sagittal alignment of the cervical spine on the kinematics of the functional motion unit and disc degeneration. SUMMARY OF BACKGROUND DATA:Normal lordotic alignment is one of...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181839733
更新日期:2008-11-01 00:00:00
abstract:STUDY DESIGN:Evaluation of the psychometric properties of the Neck Pain and Disability Scale (NPDS). OBJECTIVE:Translating, culturally adapting, and validating the Italian version of the NPDS-I. SUMMARY OF BACKGROUND DATA:Great importance is devoted to validated and comprehensive outcome measures to improve intervent...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318175c2b0
更新日期:2008-06-01 00:00:00
abstract:STUDY DESIGN:The pretension of the Dynesys cord was varied to evaluate its effects on both tissue responses and screw-spacer behaviors by the finite-element method. OBJECTIVE:This study aimed to provide detailed information about the motion-preserving and load-shielding mechanisms of the Dynesys screw-spacer joint. S...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318290fb2e
更新日期:2013-06-01 00:00:00
abstract:STUDY DESIGN:A randomized, placebo-controlled trial in which patients received either usual care by a general practitioner (information and analgesics), or placebo physiotherapy given by a physiotherapist, or exercise therapy given by a physiotherapist. OBJECTIVE:To assess the efficacy of exercise therapy on sickness ...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-199504150-00012
更新日期:1995-04-15 00:00:00
abstract:STUDY DESIGN:Case-control study. OBJECTIVE:We designed a case-control study to analyze the risk factors associated with the development of heterotopic ossification (HO) in patients with traumatic spinal cord injury. SUMMARY OF BACKGROUND DATA:Patients with spinal cord injury have a high risk of developing HO, althoug...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31825ee81b
更新日期:2012-11-01 00:00:00
abstract:STUDY DESIGN:Porcine lumbar spine specimens were cyclically loaded in flexion and extension with a pure moment. The resistance to flexion and extension of the individual spinal elements was quantified using a sequential resection procedure. OBJECTIVE:To determine the biomechanical contribution of the individual poster...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200406010-00010
更新日期:2004-06-01 00:00:00
abstract::The mechanics of the muscle-ligament system for a weight lift in man is described. The adaptations of the human spine and the hip to this mechanism are indicated. The efficiency of this mechanism in the human is compared with other primates showing the vast superiority of man in this aspect over his nearest relatives....
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-197812000-00006
更新日期:1978-12-01 00:00:00