Abstract:
STUDY DESIGN:Retrospective review of prospectively collected data. OBJECTIVE:To evaluate (1) if the segmental resection of the content of the spinal canal could provide an Enneking appropriate tumor-free margin for local control of primary bone tumors surrounding and invading the canal and (2) the safety profile of the segmental resection of the neurostructures. SUMMARY OF BACKGROUND DATA:Treatment outcomes of primary malignant and benign aggressive bone tumors of the spine have been dramatically changed by the application of the musculoskeletal oncologic principles described by Enneking. However, the efficacy of spinal oncology surgery might be limited by unique features of spinal anatomy. METHODS:Database search was conducted with the following inclusion criteria: en bloc resection, segmental inclusion of the spinal canal content in the surgical specimen, histologically proven diagnosis, minimum follow-up of 2 years. Exclusion criteria were piecemeal excision of the tumor (debulking) and diagnosis other than primary bone tumors (metastasis, or local extension of extraosseous tumors). RESULTS:A consecutive cohort of eight patients (three men, five women) was available for review. Two patients died within 3 months from the surgery for systemic disease progression or sequelae of the surgery. En bloc resection with segmental spinal canal content inclusion was able to achieve local control of the disease in four out of remaining six cases (66.7%) at an average follow-up of 68.7 months (range 12-174 mo). Three patients in whom local control was achieved are free from disease at an average follow-up of 98.7 months (range 38-174), and one died for systemic disease progression (after 38 mo). Seven out of 8 patients (87.5%) experienced overall 16 complications. CONCLUSION:En bloc resection including the spinal canal content (spinal amputation) to achieve a tumor-free margin might be considered to perform an Enneking appropriate treatment for motivated patients. LEVEL OF EVIDENCE:4.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Girolami M,Boriani S,Ghermandi R,Bandiera S,Barbanti-Brodano G,Terzi S,Tedesco G,Evangelisti G,Pipola V,Ricci A,Cecchinato R,Gasbarrini Adoi
10.1097/BRS.0000000000003356subject
Has Abstractpub_date
2020-05-15 00:00:00pages
657-665issue
10eissn
0362-2436issn
1528-1159pii
00007632-202005150-00008journal_volume
45pub_type
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