Metaplastic proliferative fibrocartilage as an alternative concept to herniated intervertebral disc.


:It is hypothesized on the basis of experimental intervertebral disc degeneration that herniated disc is actually newly synthesized proliferative metaplastic fibrocartilage and not herniation of pre-existing disc tissue, particularly that of the nucleus pulposus. Human material in selected surgical tissues was examined to test this concept. Histology revealed evidence for proliferative fronts of fibroblastic cells in herniated discs with hypocellular interiors. Hydroxypyridinium cross-link assay was used to determine the maturity of the collagen. Results indicated, with statistical significance, that herniated disc is a younger tissue than in situ annulus fibrosis, and that herniated disc is not from the nucleus pulposus, thus supporting the hypothesis.


Spine (Phila Pa 1976)




Lipson SJ




Has Abstract


1988-09-01 00:00:00














  • Morphometric evaluation of the cervico-thoracic junction. Practical considerations for posterior fixation of the spine.

    abstract:STUDY DESIGN:Linear and angular measurements were performed on 128 vertebrae (16 spines) from C5 to T5. OBJECTIVES:Vertebrae were studied to characterize vertebral shape and size changes in the cervico-thoracic region. SUMMARY OF BACKGROUND DATA:Analysis of vertebral anatomy has been extensive and well characterized....


    pub_type: 杂志文章


    authors: Stanescu S,Ebraheim NA,Yeasting R,Bailey AS,Jackson WT

    更新日期:1994-09-15 00:00:00

  • Advances in secondary spinal cord injury: role of apoptosis.

    abstract::The outcome of spinal cord injury depends on the extent of secondary damage produced by a series of cellular and molecular events initiated by the primary trauma. This article reviews the evidence that secondary spinal cord injury involves the apoptotic as well as necrotic death of neurons and glial cells. Also discus...


    pub_type: 杂志文章,评审


    authors: Lu J,Ashwell KW,Waite P

    更新日期:2000-07-15 00:00:00

  • Incision of the anulus fibrosus induces nerve root morphologic, vascular, and functional changes. An experimental study.

    abstract:STUDY DESIGN:The effects on nerve root structure, vasculature, and function after incision of the adjacent disc was studied in a dog model. OBJECTIVES:To see if only incision of the disc per se is sufficient for inducing similar changes. SUMMARY OF BACKGROUND DATA:It is well known that nucleus pulposus will induce ne...


    pub_type: 杂志文章


    authors: Kayama S,Konno S,Olmarker K,Yabuki S,Kikuchi S

    更新日期:1996-11-15 00:00:00

  • Cervical and thoracic juxtafacet cysts causing neurologic deficits.

    abstract:STUDY DESIGN:Case reports and review of the literature. OBJECTIVES:To review the clinical features, treatment, and outcome of juxtafacet cysts. SUMMARY OF BACKGROUND DATA:There have previously been 4 reported cases of thoracic juxtafacet cysts and 19 cases of cervical juxtafacet cysts. Cervical cysts have usually ori...


    pub_type: 杂志文章,评审


    authors: Stoodley MA,Jones NR,Scott G

    更新日期:2000-04-15 00:00:00

  • Predictors of Extended Length of Hospital Stay in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Segmental Instrumented Fusion: An Analysis of 407 Surgeries Performed at a Large Academic Center.

    abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:The aims of this study were to (1) compare patient and procedure-specific characteristics among those who had short versus long hospital stays and (2) identify independent risk factors that may correlate with extended length of hospital stay (LOS) in patients with ado...


    pub_type: 杂志文章


    authors: Sultan AA,Berger RJ,Cantrell WA,Samuel LT,Ramanathan D,Churchill J,Minkara AA,Golubovsky J,Bachour S,Pasadyn S,Karnuta JM,Tamer P,Kuivila TE,Gurd DP,Goodwin RC

    更新日期:2019-05-15 00:00:00

  • American Society of Anesthesiologists' Status Association With Cost and Length of Stay in Lumbar Laminectomy and Fusion: Results From an Institutional Database.

    abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:The objective of this study was to characterize the costs associated with American Society of Anesthesiologists (ASA) class, and to determine the extent to which ASA status is a predictor of increased cost and LOS following lumbar laminectomy and fusion (LLF). SUMMAR...


    pub_type: 杂志文章


    authors: Bronheim RS,Caridi JM,Steinberger J,Hunter S,Neifert SN,Deutsch BC,DeMaria S Jr,Hermann L,Gal JS

    更新日期:2020-03-01 00:00:00

  • Preoperative MRI analysis of patients with idiopathic scoliosis: a prospective study.

    abstract:STUDY DESIGN:A prospective trial of preoperative MRI study in patients with "idiopathic" scoliosis. OBJECTIVES:To investigate the prevalence of neural axis malformations and the clinical relevance of MRI in the evaluation of patients with idiopathic scoliosis undergoing surgical intervention. SUMMARY OF BACKGROUND DA...


    pub_type: 杂志文章


    authors: Inoue M,Minami S,Nakata Y,Otsuka Y,Takaso M,Kitahara H,Tokunaga M,Isobe K,Moriya H

    更新日期:2005-01-01 00:00:00

  • Delirium after spinal surgery in Korean population.

    abstract:STUDY DESIGN:The incidence and risk factors of postoperative delirium were retrospectively examined in patients who had spine surgery for degenerative lumbar disease. OBJECTIVE:The aim of this study is to examine the incidence, pre- and postoperative risk factors and clinical results of postoperative delirium after sp...


    pub_type: 杂志文章


    authors: Lee JK,Park YS

    更新日期:2010-08-15 00:00:00

  • Changes in life satisfaction and self-esteem in patients with adolescent idiopathic scoliosis with and without surgical intervention.

    abstract:STUDY DESIGN:Pre-/poststudy comparing surgical and nonsurgical treatment. OBJECTIVE:To identify whether orthopedic spinal surgery can effectively improve life satisfaction and self-esteem in patients with adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA:There have been many studies about the effect of spin...


    pub_type: 杂志文章


    authors: Zhang J,He D,Gao J,Yu X,Sun H,Chen Z,Li M

    更新日期:2011-04-20 00:00:00

  • Decrease in postural sway and trunk stiffness during cognitive dual-task in nonspecific chronic low back pain patients, performance compared to healthy control subjects.

    abstract:STUDY DESIGN:A 2-group experimental design. OBJECTIVE:To investigate the effect of a cognitive dual-task on postural sway of pelvis and trunk during unstable sitting in nonspecific chronic patients with low back pain (CLBP) compared to healthy control subjects. SUMMARY OF BACKGROUND DATA:Higher cognitive systems as w...


    pub_type: 杂志文章


    authors: Van Daele U,Hagman F,Truijen S,Vorlat P,Van Gheluwe B,Vaes P

    更新日期:2010-03-01 00:00:00

  • Acute axis fractures. Analysis of management and outcome in 340 consecutive cases.

    abstract:STUDY DESIGN:Retrospective review of acute axis fractures treated at a tertiary referral center. OBJECTIVE:To determine the optimal treatment of axis fractures based on 340 cases from a single institution. SUMMARY OF BACKGROUND DATA:Axis fractures account for almost 20% of acute cervical spine fractures. However, the...


    pub_type: 杂志文章


    authors: Greene KA,Dickman CA,Marciano FF,Drabier JB,Hadley MN,Sonntag VK

    更新日期:1997-08-15 00:00:00

  • Patients with neck pain demonstrate reduced electromyographic activity of the deep cervical flexor muscles during performance of the craniocervical flexion test.

    abstract:STUDY DESIGN:Cross-sectional study. OBJECTIVE:The present study compared activity of deep and superficial cervical flexor muscles and craniocervical flexion range of motion during a test of craniocervical flexion between 10 patients with chronic neck pain and 10 controls. SUMMARY OF BACKGROUND DATA:Individuals with c...


    pub_type: 杂志文章


    authors: Falla DL,Jull GA,Hodges PW

    更新日期:2004-10-01 00:00:00

  • Validity of clinical tests in the diagnosis of root compression in cervical disc disease.

    abstract::The purpose of this study was to test the validity of three clinical tests (the neck compression, the axial manual traction, and the shoulder abduction test) in the diagnosis of root compression in 43 patients with cervical disc disease. The validity was investigated regarding radicular pain, neurologic signs, and roo...


    pub_type: 杂志文章


    authors: Viikari-Juntura E,Porras M,Laasonen EM

    更新日期:1989-03-01 00:00:00

  • Physiologic changes of nerve root during posterior lumbar discectomy.

    abstract:STUDY DESIGN AND OBJECTIVES:The effects of nerve root retraction in posterior discectomy on pressure, blood flow, and electrophysiologic changes of the nerve root were investigated. OBJECTIVES:This study was performed to assess the effects of nerve root retraction in posterior discectomy on pressure, blood flow, and e...


    pub_type: 杂志文章


    authors: Matsui H,Kitagawa H,Kawaguchi Y,Tsuji H

    更新日期:1995-03-15 00:00:00

  • Higher electrical stimulus intensities are required to activate chronically compressed nerve roots. Implications for intraoperative electromyographic pedicle screw testing.

    abstract:STUDY DESIGN:A comparison of the electrical thresholds required to evoke myogenic responses from direct stimulation of normal and chronically compressed nerve roots. OBJECTIVE:To determine whether intraoperative electromyographic testing to confirm the integrity of instrumented pedicles should be performed at higher s...


    pub_type: 杂志文章


    authors: Holland NR,Lukaczyk TA,Riley LH 3rd,Kostuik JP

    更新日期:1998-01-15 00:00:00

  • Unusual back pain caused by intervertebral disc degeneration associated with schmorl node at Th11/12 in a young athlete, successfully treated by anterior interbody fusion: a case report.

    abstract:STUDY DESIGN:A case report describing thoracic intervertebral disc degeneration and spondylolisthesis associated with a Schmorl node in a young athlete, which was successfully treated by anterior interbody fusion (AIF). OBJECTIVE:To describe a rare pathologic condition with a clinical outcome of a surgical interventio...


    pub_type: 杂志文章


    authors: Fukuta S,Miyamoto K,Iwata A,Hosoe H,Iwata H,Shirahashi K,Shimizu K

    更新日期:2009-03-01 00:00:00

  • Factors associated with recurrent back pain and cyst recurrence after surgical resection of one hundred ninety-five spinal synovial cysts: analysis of one hundred sixty-seven consecutive cases.

    abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:Compare outcomes of different treatment methods for intraspinal synovial cysts. SUMMARY OF BACKGROUND DATA:Intraspinal synovial cysts are cited as an increasing cause of back pain and radiculopathy. To date, few studies have compared outcomes of differing treatment methods ...


    pub_type: 杂志文章


    authors: Xu R,McGirt MJ,Parker SL,Bydon M,Olivi A,Wolinsky JP,Witham TF,Gokaslan ZL,Bydon A

    更新日期:2010-05-01 00:00:00

  • Two Doses of Tranexamic Acid Reduce Blood Transfusion in Complex Spine Surgery: A Prospective Randomized Study.

    abstract:STUDY DESIGN:Prospective, double-blinded, randomized controlled study. OBJECTIVE:To determine whether the use of 2 doses of tranexamic acid (TXA) can reduce perioperative blood loss and blood transfusions in low-risk adult patients undergoing complex laminectomy. SUMMARY OF BACKGROUND DATA:Complex laminectomy (multil...


    pub_type: 杂志文章,随机对照试验


    authors: Raksakietisak M,Sathitkarnmanee B,Srisaen P,Duangrat T,Chinachoti T,Rushatamukayanunt P,Sakulpacharoen N

    更新日期:2015-12-01 00:00:00

  • The Ninth International Forum for Primary Care Research on Low Back Pain.

    abstract:STUDY DESIGN:Review of oral and poster presentations and of workshop summaries from the Ninth International Forum for Primary Care Research on Low Back Pain held in Majorca, Spain, October 4-6, 2007. OBJECTIVE:Summarize highlights of the conference. SUMMARY OF BACKGROUND DATA:The International Forum for Primary Care ...


    pub_type: 杂志文章


    authors: Cherkin D,Kovacs FM,Croft P,Borkan J,Foster NE,Oberg B,Urrútia G,Zamora J,International Organizing Committee of the Ninth International Forum for Primary Care Research on Low Back Pain and All the Participants.

    更新日期:2009-02-01 00:00:00

  • Distribution of the basic fibroblast growth factor and its receptor gene expression in normal and degenerated rat intervertebral discs.

    abstract:STUDY DESIGN:Using a rat spondylosis model, the distributions of cells expressing the basic fibroblast growth factor and its receptor were investigated in normal and degenerated intervertebral discs. Cell-proliferating activity in degenerated discs was also assessed. OBJECTIVES:This study was conducted to determine wh...


    pub_type: 杂志文章


    authors: Nagano T,Yonenobu K,Miyamoto S,Tohyama M,Ono K

    更新日期:1995-09-15 00:00:00

  • The Impact of Metastatic Spinal Tumor Location on 30-Day Perioperative Mortality and Morbidity After Surgical Decompression.

    abstract:STUDY DESIGN:A retrospective cohort study from 2011 to 2014 was performed using the American College of Surgeons National Surgical Quality Improvement Program database. OBJECTIVE:The purpose of this study was to assess the impact of tumor location in the cervical, thoracic, or lumbosacral spine on 30-day perioperative...


    pub_type: 杂志文章


    authors: Hussain AK,Vig KS,Cheung ZB,Phan K,Lima MC,Kim JS,Kaji DA,Arvind V,Cho SK

    更新日期:2018-06-01 00:00:00

  • Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion.

    abstract:STUDY DESIGN:An established rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine. OBJECTIVE:To determine whether osteogenic protein-1 should be considered as a bone graft alternative for the patient who smokes. SUMMARY OF BACK...


    pub_type: 杂志文章


    authors: Patel TC,Erulkar JS,Grauer JN,Troiano NW,Panjabi MM,Friedlaender GE

    更新日期:2001-08-01 00:00:00

  • "Conservative" cranio-cervical decompression in the treatment of syringomyelia-Chiari I complex. A prospective study of 20 adult cases.

    abstract:STUDY DESIGN:This study was designed to investigate prospectively a series of patients with syringomyelia-Chiari I complex operated on by a minimally invasive procedure. OBJECTIVE:The objective was to determine whether a relatively simple and low-risk osteo-dural decompression would obtain as good clinico-radiological...


    pub_type: 杂志文章


    authors: Di Lorenzo N,Palma L,Palatinsky E,Fortuna A

    更新日期:1995-12-01 00:00:00

  • Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation?

    abstract:STUDY DESIGN:Experimental animal study. OBJECTIVE:To determine whether corticosteroids produce additional benefit to nerve root infiltration (NRI) for experimental lumbar disc herniation. SUMMARY OF BACKGROUND DATA:NRI is used for nonsurgical treatment of radicular symptoms caused by lumbar disc herniation or lumbar ...


    pub_type: 杂志文章


    authors: Tachihara H,Sekiguchi M,Kikuchi S,Konno S

    更新日期:2008-04-01 00:00:00

  • Predicting long-term disability in low back injured workers presenting to a spine consultant.

    abstract::Low back pain (LBP) is the most common, costly, and disabling musculoskeletal condition. Although most LBP patients recover within two months, 2-3% eventually develop disabling chronic low back pain (DCLBP). Due to the prevalence of DCLBP problems, models have been developed to predict which acute low back pain patien...


    pub_type: 杂志文章


    authors: Lehmann TR,Spratt KF,Lehmann KK

    更新日期:1993-06-15 00:00:00

  • Acute respiratory compromise associated with flexed cervical traction after C2 fractures.

    abstract:STUDY DESIGN:Acute respiratory compromise is occasionally observed in a subgroup of patients with upper spinal injuries involving the C2 vertebrae. A retrospective review was performed to identify fracture types and risk factors for early respiratory deterioration following injury to the upper cervical spine. OBJECTIV...


    pub_type: 杂志文章


    authors: Harrop JS,Vaccaro A,Przybylski GJ

    更新日期:2001-02-15 00:00:00

  • A ligament in the lumbar foramina: inverted Y ligament: an anatomic report.

    abstract:OBJECTIVES:The objective of this study was to investigate the ligaments in the exit zone of lumbar foramen and describe their anatomic relationships with adjacent structures. Few studies have been reported on the ligaments of foramen and the anatomic relationships on the lumbar level. The ligament described in this stu...


    pub_type: 杂志文章


    authors: Caglar Y YS,Dolgun H,Ugur HC,Kahilogullari G,Tekdemir I,Elhan A

    更新日期:2004-07-15 00:00:00

  • The biomechanical advantage of lordosis and hip extension for upright activity. Man as compared with other anthropoids.

    abstract::The mechanics of the muscle-ligament system for a weight lift in man is described. The adaptations of the human spine and the hip to this mechanism are indicated. The efficiency of this mechanism in the human is compared with other primates showing the vast superiority of man in this aspect over his nearest relatives....


    pub_type: 杂志文章


    authors: Farfan HF

    更新日期:1978-12-01 00:00:00

  • Vestibular-evoked myogenic potential (VEMP) to evaluate cervical myelopathy in human T-cell lymphotropic virus type I infection.

    abstract:STUDY DESIGN:Cross-seccional analysis. OBJECTIVE:To define the clinical usefulness of vestibular-evoked myogenic potential (VEMP) in detecting cervical medullar involvement related to human T-cell lymphotropic virus type 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP). SUMMARY OF BACKGROUND DA...


    pub_type: 杂志文章


    authors: Felipe L,Gonçalves DU,Santos MA,Proietti FA,Ribas JG,Carneiro-Proietti AB,Lambertucci JR

    更新日期:2008-05-15 00:00:00

  • Effectiveness and cost-effectiveness analysis of neuroreflexotherapy for subacute and chronic low back pain in routine general practice: a cluster randomized, controlled trial.

    abstract:STUDY DESIGN:A cluster randomized, controlled trial was performed. OBJECTIVES:To assess the clinical effectiveness and cost-effectiveness of adding patients' referral to neuroreflexotherapy intervention to the usual management of subacute and chronic low back pain in routine general practice. SUMMARY OF BACKGROUND DA...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kovacs FM,Llobera J,Abraira V,Lázaro P,Pozo F,Kleinbaum D,KAP Group.

    更新日期:2002-06-01 00:00:00