Abstract:
:It is hypothesized on the basis of experimental intervertebral disc degeneration that herniated disc is actually newly synthesized proliferative metaplastic fibrocartilage and not herniation of pre-existing disc tissue, particularly that of the nucleus pulposus. Human material in selected surgical tissues was examined to test this concept. Histology revealed evidence for proliferative fronts of fibroblastic cells in herniated discs with hypocellular interiors. Hydroxypyridinium cross-link assay was used to determine the maturity of the collagen. Results indicated, with statistical significance, that herniated disc is a younger tissue than in situ annulus fibrosis, and that herniated disc is not from the nucleus pulposus, thus supporting the hypothesis.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Lipson SJdoi
10.1097/00007632-198809000-00014subject
Has Abstractpub_date
1988-09-01 00:00:00pages
1055-60issue
9eissn
0362-2436issn
1528-1159journal_volume
13pub_type
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