Metaplastic proliferative fibrocartilage as an alternative concept to herniated intervertebral disc.


:It is hypothesized on the basis of experimental intervertebral disc degeneration that herniated disc is actually newly synthesized proliferative metaplastic fibrocartilage and not herniation of pre-existing disc tissue, particularly that of the nucleus pulposus. Human material in selected surgical tissues was examined to test this concept. Histology revealed evidence for proliferative fronts of fibroblastic cells in herniated discs with hypocellular interiors. Hydroxypyridinium cross-link assay was used to determine the maturity of the collagen. Results indicated, with statistical significance, that herniated disc is a younger tissue than in situ annulus fibrosis, and that herniated disc is not from the nucleus pulposus, thus supporting the hypothesis.


Spine (Phila Pa 1976)




Lipson SJ




Has Abstract


1988-09-01 00:00:00














  • Efficacy of traction for nonspecific low back pain. 12-week and 6-month results of a randomized clinical trial.

    abstract:STUDY DESIGN:A randomized clinical trial. OBJECTIVES:To assess the efficacy of motorized continuous traction for low back pain. SUMMARY OF BACKGROUND DATA:The available studies on the efficacy of lumbar traction do not allow clear conclusions because of severe methodologic flaws. The current trial aimed to overcome t...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Beurskens AJ,de Vet HC,Köke AJ,Regtop W,van der Heijden GJ,Lindeman E,Knipschild PG

    更新日期:1997-12-01 00:00:00

  • Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report.

    abstract:STUDY DESIGN:Case report. OBJECTIVE:To describe a rare case of tenosynovial giant cell tumor, diffuse type/pigmented villonodular synovitis (PVNS) in a pars defect in a patient with lumbar spondylolysis. SUMMARY OF BACKGROUND DATE:PVNS rarely occurred in lumbar spine, and no studies in the English literature have rep...


    pub_type: 杂志文章


    authors: Kimura T,Nishisho T,Sakai T,Miyagi R,Takao S,Iwamoto S,Higashino K,Takata Y,Goda Y,Toki S,Sairyo K

    更新日期:2015-06-15 00:00:00

  • Safety and Efficacy of Revision Minimally Invasive Lumbar Decompression in the Ambulatory Setting.

    abstract:STUDY DESIGN:A retrospective analysis. OBJECTIVE:The aim of this study was to investigate differences in perioperative outcomes between patients undergoing revision minimally invasive lumbar spine decompression (MIS LD) in the ambulatory and hospital-based surgical settings. SUMMARY OF BACKGROUND DATA:Revision LD has...


    pub_type: 杂志文章


    authors: Hirsch BP,Khechen B,Patel DV,Cardinal KL,Guntin JA,Singh K

    更新日期:2019-04-15 00:00:00

  • Finite element analysis of the effects of pedicle screw fixation nut loosening on lumbar interbody fusion based on the elasto-plateau plasticity of bone characteristics.

    abstract:STUDY DESIGN:Cylindrical cages and pedicle screw fixation (PSF) have been used for the setting of a lumbar interbody fusion. OBJECTIVE:To investigate the effects of PSF-nut loosening on lumbar interbody fusion based on the elasto-plateau plasticity of bone characteristics. SUMMARY OF BACKGROUND DATA:The stress-strain...


    pub_type: 杂志文章


    authors: Kim Y,Kim TW

    更新日期:2010-03-15 00:00:00

  • Preoperative fibrinogen plasma concentration is associated with perioperative bleeding and transfusion requirements in scoliosis surgery.

    abstract:STUDY DESIGN:Prospective observational study. OBJECTIVE:To investigate the potential association between fibrinogen, bleeding, and transfusion requirements after scoliosis surgery. SUMMARY OF BACKGROUND DATA:Bleeding complications during and after orthopedic surgery are associated with increased morbidity and mortali...


    pub_type: 杂志文章


    authors: Carling MS,Jeppsson A,Wessberg P,Henriksson A,Baghaei F,Brisby H

    更新日期:2011-04-01 00:00:00

  • The osteogenic potential of rib autografts can be preserved in culture.

    abstract:STUDY DESIGN:This was an experimental study to compare various methods of storing rib autograft between stages of spinal surgery. OBJECTIVE:The authors' goal was to determine the optimum conditions for storing bone graft, while preserving its osteogenic potential. SUMMARY OF BACKGROUND DATA:It never has been demonstr...


    pub_type: 杂志文章


    authors: Evans CE,Williamson JB

    更新日期:1994-04-01 00:00:00

  • Electromagnetic topographical technique of curve evaluation for adolescent idiopathic scoliosis.

    abstract:STUDY DESIGN:Diagnostic testing. OBJECTIVE:The goal of this study is to measure the accuracy and reliability of the Orthoscan (Orthoscan Technologies, Inc.) and to determine whether it can be substituted for radiographs in the surveillance of adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA:AIS is us...


    pub_type: 杂志文章


    authors: Knott P,Mardjetko S,Nance D,Dunn M

    更新日期:2006-11-15 00:00:00

  • Prevalence and risk factors associated with low back pain among health care providers in a Kuwait hospital.

    abstract:STUDY DESIGN:A cross-sectional survey among health professionals working in a Kuwait hospital. OBJECTIVE:To investigate the prevalence and factors associated with low back pain (LBP). SUMMARY OF BACKGROUND DATA:The literature suggests that health professionals are exposed to occupational risk factors that predispose ...


    pub_type: 杂志文章


    authors: Landry MD,Raman SR,Sulway C,Golightly YM,Hamdan E

    更新日期:2008-03-01 00:00:00

  • The Impact of Body Mass Index (BMI) on 30-day Outcomes Following Posterior Spinal Fusion in Neuromuscular Scoliosis.

    abstract:STUDY DESIGN:Retrospective. OBJECTIVE:Assess the impact of varying severity of BMI on 30-day outcomes following posterior spinal fusions in neuromuscular scoliosis. SUMMARY OF BACKGROUND DATA:Obesity in the pediatric population is shown to be associated with adverse outcomes across varying specialties. The weight-out...


    pub_type: 杂志文章


    authors: Malik AT,Tamer R,Yu E,Kim J,Khan SN

    更新日期:2019-10-01 00:00:00

  • Magnetic Resonance Imaging Safety of Magnetically Controlled Growing Rods in an In Vivo Animal Model.

    abstract:STUDY DESIGN:Experimental animal study. OBJECTIVE:To investigate the interaction between magnetically controlled growing rods (MCGRs) and magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND DATA:Growing rod treatment through serial operations results in adverse effects on the patient and high treatment costs. MCG...


    pub_type: 杂志文章


    authors: Eroglu M,Demirkiran G,Kocyigit IA,Bilgili H,Kaynar MB,Bumin A,Ozcan S,Yazici M

    更新日期:2017-05-01 00:00:00

  • Estimating the effective radiation dose imparted to patients by intraoperative cone-beam computed tomography in thoracolumbar spinal surgery.

    abstract:STUDY DESIGN:Observational. OBJECTIVE:To estimate the radiation dose imparted to patients during typical thoracolumbar spinal surgical scenarios. SUMMARY OF BACKGROUND DATA:Minimally invasive techniques continue to become more common in spine surgery. Computer-assisted navigation systems coupled with intraoperative c...


    pub_type: 杂志文章


    authors: Lange J,Karellas A,Street J,Eck JC,Lapinsky A,Connolly PJ,Dipaola CP

    更新日期:2013-03-01 00:00:00

  • Intraabdominal pressure response to loads applied to the torso in normal subjects.

    abstract::The study is an investigation into the form of the abdominal pressure reflex in normal individuals under isometric loading of the torso. Various directions of load are imposed, and both flexed and upright postures are adopted. The sensitivity of the pressurization to the applied moment is calculated, the form of the r...


    pub_type: 杂志文章


    authors: Grew ND

    更新日期:1980-03-01 00:00:00

  • Cervical stability after sequential capsule resection.

    abstract::A portion of the cervical facet joint must be resected to expose and decompress cervical nerve roots from a posterior approach. When posterior fusion is performed, it is common to remove the facet capsule only for the joints being fused. This study was performed to examine the effect of resection of the facet capsule ...


    pub_type: 杂志文章


    authors: Zdeblick TA,Abitbol JJ,Kunz DN,McCabe RP,Garfin S

    更新日期:1993-10-15 00:00:00

  • Pre-injury emotional trauma and chronic back pain. An unexpected finding.

    abstract:STUDY DESIGN:A retrospective study investigated pre-injury emotional trauma in out-of-work, blue collar patients with chronic back pain (N = 27) who participated in a 30-hour workshop in which a wide range of cognitive skills was taught to help patients with rehabilitation and return them to work. OBJECTIVES:This stud...


    pub_type: 杂志文章


    authors: Blair JA,Blair RS,Rueckert P

    更新日期:1994-05-15 00:00:00

  • Anatomical and pathological considerations in percutaneous vertebroplasty and kyphoplasty: a reappraisal of the vertebral venous system.

    abstract:OBJECTIVES:To focus attention of the clinician on the anatomy and (patho)physiology of the vertebral venous system, so as to offer a tool to better understand and anticipate (potential) complications that are related to the application of percutaneous vertebroplasty and kyphoplasty. BACKGROUND:Percutaneous vertebropla...


    pub_type: 杂志文章,评审


    authors: Groen RJ,du Toit DF,Phillips FM,Hoogland PV,Kuizenga K,Coppes MH,Muller CJ,Grobbelaar M,Mattyssen J

    更新日期:2004-07-01 00:00:00

  • A Whole Exome Study Identifies Novel Candidate Genes for Vertebral Bone Marrow Signal Changes (Modic Changes).

    abstract:STUDY DESIGN:A family-based study. OBJECTIVE:The aim of this study was to identify rare genetic factors predisposing to Modic changes (MCs). SUMMARY OF BACKGROUND DATA:Lumbar disc degeneration (LDD) is one of the contributing factors behind low back pain (LBP). Lumbar MC visualized as bone marrow signal intensity cha...


    pub_type: 杂志文章


    authors: Kraatari M,Skarp S,Niinimäki J,Karppinen J,Männikkö M

    更新日期:2017-08-15 00:00:00

  • The clinical usefulness of intraoperative spinal stiffness measurements.

    abstract:STUDY DESIGN:Determination of clinical results at least 2 years after lumbar spine surgery during which spinal stiffness measurements were made. OBJECTIVES:To determine whether spine stiffness is predictive of clinical results after lumbar spine surgery for spinal stenosis, disc herniation, or degenerative spondylolis...


    pub_type: 临床试验,杂志文章


    authors: Brown MD,Wehman KF,Heiner AD

    更新日期:2002-05-01 00:00:00

  • Experimental posterolateral lumbar spinal fusion with a demineralized bone matrix gel.

    abstract:STUDY DESIGN:A controlled rabbit model of lumbar posterolateral intertransverse process arthrodesis was used to evaluate a bone graft substitute. OBJECTIVE:To determine the efficacy of demineralized bone matrix gel as an autograft extender, using different ratios of demineralized bone matrix to autograft and to determ...


    pub_type: 杂志文章,评审


    authors: Morone MA,Boden SD

    更新日期:1998-01-15 00:00:00

  • Effect of Preoperative Sagittal Balance on Cervical Laminoplasty Outcomes.

    abstract:STUDY DESIGN:Retrospective case series. OBJECTIVE:To clarify how preoperative global sagittal imbalance influences outcomes in patients with cervical compression myelopathy undergoing cervical laminoplasty. SUMMARY OF BACKGROUND DATA:The influence of sagittal balance on outcomes of cervical laminoplasty remains uncer...


    pub_type: 杂志文章


    authors: Oshima Y,Takeshita K,Taniguchi Y,Matsubayashi Y,Doi T,Ohya J,Soma K,Kato S,Oka H,Chikuda H,Tanaka S

    更新日期:2016-11-01 00:00:00

  • Tumor necrosis factor-α-dependent infiltration of macrophages into the dorsal root ganglion in a rat disc herniation model.

    abstract:STUDY DESIGN:A prospective molecular mechanism of macrophages infiltration in experimental disc herniation. OBJECTIVE:To investigate the mechanisms of macrophages infiltration into the dorsal root ganglion (DRG) in a rat model of disc herniation. SUMMARY OF BACKGROUND DATA:Macrophages infiltrate the DRG after applica...


    pub_type: 杂志文章


    authors: You C,Zhu K,Liu X,Xi C,Zhang Z,Xu G,Yan J

    更新日期:2013-11-01 00:00:00

  • Dynamic response of human cervical spine ligaments.

    abstract::This study was undertaken to investigate the dynamic response of human cervical spine ligaments. Uniaxial tensile failure tests were conducted on anterior longitudinal ligament (AL) and ligamentum flavum (LF) structures. These ligaments were tested under in situ conditions by transecting all the elements except the on...


    pub_type: 杂志文章


    authors: Yoganandan N,Pintar F,Butler J,Reinartz J,Sances A Jr,Larson SJ

    更新日期:1989-10-01 00:00:00

  • Electrochemotherapy to Metastatic Spinal Melanoma: A Novel Treatment of Spinal Metastasis?

    abstract:STUDY DESIGN:Preliminary report of new antitumor treatment. OBJECTIVE:To evaluate the effectiveness of electrochemotherapy as a novel treatment of spinal metastasis. SUMMARY OF BACKGROUND DATA:Electrochemotherapy is a new antitumor treatment that combines systemic bleomycin with electric pulses delivered locally at t...


    pub_type: 杂志文章


    authors: Gasbarrini A,Campos WK,Campanacci L,Boriani S

    更新日期:2015-12-01 00:00:00

  • Kinematics of cervical total disc replacement adjacent to a two-level, straight versus lordotic fusion.

    abstract:STUDY DESIGN:In vitro biomechanical study. OBJECTIVE:To characterize cervical total disc replacement (TDR) kinematics above two-level fusion, and to determine the effect of fusion alignment on TDR response. SUMMARY OF BACKGROUND DATA:Cervical TDR may be a promising alternative for a symptomatic adjacent level after p...


    pub_type: 杂志文章


    authors: Martin S,Ghanayem AJ,Tzermiadianos MN,Voronov LI,Havey RM,Renner SM,Carandang G,Abjornson C,Patwardhan AG

    更新日期:2011-08-01 00:00:00

  • Predictors of outcome in neck and shoulder symptoms: a cohort study in general practice.

    abstract:STUDY DESIGN:An observational prospective cohort study in general practice. OBJECTIVES:To describe the clinical course and to identify predictors of recovery, changes in pain intensity, and changes in functional disability in patients with neck or shoulder symptoms at 3- and 12-month follow-up. SUMMARY OF BACKGROUND ...


    pub_type: 杂志文章


    authors: Bot SD,van der Waal JM,Terwee CB,van der Windt DA,Scholten RJ,Bouter LM,Dekker J

    更新日期:2005-08-15 00:00:00

  • The evidence for intraoperative neurophysiological monitoring in spine surgery: does it make a difference?

    abstract:OBJECTIVE:The objective of this article was to undertake a systematic review of the literature to determine whether IOM is able to sensitively and specifically detect intraoperative neurologic injury during spine surgery and to assess whether IOM results in improved outcomes for patients during these procedures. SUMMA...


    pub_type: 杂志文章,评审


    authors: Fehlings MG,Brodke DS,Norvell DC,Dettori JR

    更新日期:2010-04-20 00:00:00

  • Importance of pelvic compensation in posture and motion after posterior spinal fusion using CD instrumentation for idiopathic scoliosis.

    abstract:STUDY DESIGN:Posture and motion analysis after a Cotrel-Dubousset instrumentation. OBJECTIVES:To investigate the compensation role of pelvis. SUMMARY OF BACKGROUND DATA:Few existing studies found no compensation at the lower unfused level but did not investigate the pelvis. METHODS:Thirty patients were analyzed befo...


    pub_type: 杂志文章


    authors: Skalli W,Zeller RD,Miladi L,Bourcereau G,Savidan M,Lavaste F,Dubousset J

    更新日期:2006-05-20 00:00:00

  • Cervical Alignment Variations in Different Postures and Predictors of Normal Cervical Kyphosis: A New Understanding.

    abstract:STUDY DESIGN:Comparative study of prospectively collected radiographic data. OBJECTIVE:To predict physiological alignment of the cervical spine and study its morphology in different postures. SUMMARY OF BACKGROUND DATA:There is increasing evidence that normal cervical spinal alignment may vary from lordosis to neutra...


    pub_type: 杂志文章


    authors: Hey HWD,Lau ET,Wong GC,Tan KA,Liu GK,Wong HK

    更新日期:2017-11-01 00:00:00

  • Pedicle diameter determined by computed tomography. Its relevance to pedicle screw fixation in the lumbar spine.

    abstract::Intraoperative technical complications of pedicle screw fixation include screw cutout or maldirection and pedicle fracture. The aims of this study were 1) to use computed tomography to determine the average pedicle diameter; and 2) to compare these measurements with the outer diameter measurements of commonly used ped...


    pub_type: 杂志文章


    authors: Bernard TN Jr,Seibert CE

    更新日期:1992-06-01 00:00:00

  • Spinal metastasis of glioblastoma multiforme: an uncommon suspect?

    abstract:STUDY DESIGN:Case report. OBJECTIVE:To report a case and review the literature on glioblastoma multiforme (GBM) with drop-like metastasis to the spine. SUMMARY OF BACKGROUND DATA:GBM constitutes the most common adult malignant brain tumor with poor prognosis. Spinal metastases of this malignancy are quite rare and di...


    pub_type: 杂志文章


    authors: Birbilis TA,Matis GK,Eleftheriadis SG,Theodoropoulou EN,Sivridis E

    更新日期:2010-04-01 00:00:00

  • Repositioning error in low back pain. Comparing trunk repositioning error in subjects with chronic low back pain and control subjects.

    abstract:STUDY DESIGN:Repositioning error of the trunk was tested in 20 subjects with chronic low back pain and in 20 control subjects. The 3Space Tracker (Polhemus, Colchester, VT), a device that measures three-dimensional position in space, was used to determine the subject's trunk position. OBJECTIVES:To determine whether r...


    pub_type: 杂志文章


    authors: Newcomer K,Laskowski ER,Yu B,Larson DR,An KN

    更新日期:2000-01-15 00:00:00