Metaplastic proliferative fibrocartilage as an alternative concept to herniated intervertebral disc.

Abstract:

:It is hypothesized on the basis of experimental intervertebral disc degeneration that herniated disc is actually newly synthesized proliferative metaplastic fibrocartilage and not herniation of pre-existing disc tissue, particularly that of the nucleus pulposus. Human material in selected surgical tissues was examined to test this concept. Histology revealed evidence for proliferative fronts of fibroblastic cells in herniated discs with hypocellular interiors. Hydroxypyridinium cross-link assay was used to determine the maturity of the collagen. Results indicated, with statistical significance, that herniated disc is a younger tissue than in situ annulus fibrosis, and that herniated disc is not from the nucleus pulposus, thus supporting the hypothesis.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Lipson SJ

doi

10.1097/00007632-198809000-00014

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

1055-60

issue

9

eissn

0362-2436

issn

1528-1159

journal_volume

13

pub_type

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