Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis.

abstract：:Langerhans cell histocytosis (LCH) and Erdheim-Chester disease are two rare histiocytic disorders. Their occurrence in the same patient is more infrequent, but has been described. We report a case of a 38-year-old woman who presented with a diagnosis of single system cutaneous LCH. Subsequently, she developed multiple...

journal_title：Journal of cutaneous pathology

authors： Johnson WT,Patel P,Hernandez A,Grandinetti LM,Huen AC,Marks S,Ho J,Monaco SE,Jaffe R,Picarsic J

更新日期：2016-03-01 00:00:00

abstract：:An electron microscopic study was made of a patient with erythema elevatum diutinum, a rare variant of cutaneous leukocytoclastic vasculitis. Biopsies were obtained from early evolving and late fibroproliferative lesions. Early lesions showed vasculitis and a massive dermal infiltrate composed mainly of neutrophils, h...

journal_title：Journal of cutaneous pathology

authors： Lee AY,Nakagawa H,Nogita T,Ishibashi Y

更新日期：1989-08-01 00:00:00

abstract：:Verrucous hemangioma represents a rare congenital vascular proliferation that may be mistaken for angiokeratoma. Histopathological examination of a deep biopsy is necessary to confirm the diagnosis of verrucous hemangioma based on its involvement of the deep dermis and subcutaneous tissue. We present two cases of verr...

journal_title：Journal of cutaneous pathology

authors： Clairwood MQ,Bruckner AL,Dadras SS

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The Wnt-signaling pathway, involving beta-catenin, apc, and axin, plays a critical role in numerous developmental events. Alterations in the Wnt-signaling pathway have been detected in a wide variety of neoplasms. However, similar aberrations have not been described in Merkel cell carcinoma (MCC). The aim of...

journal_title：Journal of cutaneous pathology

authors： Liu S,Daa T,Kashima K,Kondoh Y,Yokoyama S

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Recent genetic investigations support the idea that basal cell carcinoma (BCC) is trichoblastic carcinoma. However, it is generally thought that clear cell basal cell carcinoma is a result of degeneration rather than tricholemmal differentiation. METHODS:We report a case of BCC, with clear cell components, ...

journal_title：Journal of cutaneous pathology

authors： Misago N,Satoh T,Narisawa Y

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Becker nevus (BN) is a unilateral, hairy, pigmented cutaneous hamartoma that frequently appears in adolescence. Several features of BN suggest that increased androgen sensitivity plays a role in its pathogenesis. There have been only a few studies of histopathologic and immunohistochemical characteristics of...

journal_title：Journal of cutaneous pathology

authors： Kim YJ,Han JH,Kang HY,Lee ES,Kim YC

更新日期：2008-12-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL/SLL) is the most common leukemia in the western world and its cutaneous dissemination a very uncommon phenomenon. Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder characterized by chronic, recurrent and self healing skin lesions. Up to 20% of patients with LyP have...

journal_title：Journal of cutaneous pathology

authors： Hibler J,Salavaggione AL,Martin A,Gru AA

更新日期：2015-04-01 00:00:00

abstract：:A malignant pilomatricoma is described in a dog. The primary tumor apparently developed in the metatarsal area where there were multiple intradermal skin nodules. Lymphatic invasion by tumor cells resulted in metastasis to the mammary glands, lymph nodes and lungs. The tumor is compared to the pilomatricoma in man whe...

journal_title：Journal of cutaneous pathology

authors： Goldschmidt MH,Thrall DE,Jeglum KA,Everett JI,Wood MG

更新日期：1981-10-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) is a well-established marker for sweat gland differentiation in adnexal neoplasms. In contrast to previous assumptions, CEA does not represent a single oncofetal antigen but comprises a family of homologous glycoproteins, i.e. the classical CEA-180, biliary glycoprotein (BGP), and non-sp...

journal_title：Journal of cutaneous pathology

authors： Metze D,Grunert F,Neumaier M,Bhardwaj R,Amann U,Wagener C,Luger TA

更新日期：1996-02-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by small vessel involvement that leads to tissue ischemia and fibroblast stimulation resulting in accumulation of collagen (fibrosis) in the skin and internal organs. Lipomembranous panniculitis is a peculiar type of fat necrosis and has been rep...

journal_title：Journal of cutaneous pathology

authors： Almeida MS,Lima SC,Carvalho LL,Almeida JV,Santos LG,Rolim JR,Rocha TE

更新日期：2010-11-01 00:00:00

abstract：:Epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) are important keratinocyte mitogens. Their effects are mediated by a cell membrane receptor (EGFR), quantitative and qualitative abnormalities of which may be responsible for deranged keratinocyte proliferation and differentiation. We have ...

journal_title：Journal of cutaneous pathology

authors： Groves RW,Allen MH,MacDonald DM

更新日期：1992-02-01 00:00:00

abstract：:The lymphocytic subtypes effecting allogeneic graft-versus-host disease (GVHD) are unknown. We studied 35 skin biopsy specimens from 19 women transplanted with bone marrow from men for patterns and time course of infiltration of the skin by Y chromosome-bearing lymphocytes using in situ hybridization. Immunophenotypic...

journal_title：Journal of cutaneous pathology

authors： Horn TD,Haskell J

更新日期：1998-04-01 00:00:00

abstract：:A case of eosinophilic ulcer of the tongue is presented. Although the entity is rarely described, the distinctive histopathologic pattern featuring the remarkable presence of eosinophils in the superficial corium and in between muscle bundles, together with the benign clinical course, make a diagnosis possible. ...

journal_title：Journal of cutaneous pathology

authors： Borroni G,Pericoli R,Gabba P,Rosso R,Rabbiosi G

更新日期：1984-08-01 00:00:00

abstract：:Early cutaneous Lyme disease, erythema migrans, may show different histopathologic patterns. The intent of this case series is to raise awareness of these findings to prevent misdiagnosis and keep this entity in the differential. Erythema migrans develops after a tick bite and subsequent infection with the spirochete,...

journal_title：Journal of cutaneous pathology

authors： Miraflor AP,Seidel GD,Perry AE,Castanedo-Tardan MP,Guill MA,Yan S

更新日期：2016-01-01 00:00:00

abstract：:Discrete junctional cellular aggregates ("nests"), partially staining with melanocytic markers, are described in lichenoid tissue reaction, mainly from chronically sun-exposed skin. The concomitant epidermal flattening and papillary dermal fibrosis with melanophages, may raise the differential diagnosis to that of a r...

journal_title：Journal of cutaneous pathology

authors： Ferrara G,Bradamante M,Broglia I,Petrillo G,Stefanato CM

更新日期：2020-07-01 00:00:00

abstract：:Free-living amebae are ubiquitous in our environment, but rarely cause cutaneous infection. Balamuthia mandrillaris has a predilection for infecting skin of the central face. Infection may be restricted to the skin or associated with life-threatening central nervous system (CNS) involvement. We report a case of a 91-y...

journal_title：Journal of cutaneous pathology

authors： Chang OH,Liu F,Knopp E,Muehlenbachs A,Cope JR,Ali I,Thompson R,George E

更新日期：2016-10-01 00:00:00

abstract：:We report a 2-year-old girl with developmental delay who, from the age of 1 year, developed perniotic lesions of the hands and feet initially diagnosed as chilblain lupus. Histological examination showed features of epidermal necrosis with intraepidermal bulla formation, interface dermatitis, lymphocytic vasculitis wi...

journal_title：Journal of cutaneous pathology

authors： Kolivras A,Aeby A,Crow YJ,Rice GI,Sass U,André J

更新日期：2008-08-01 00:00:00

abstract：:Granulomatous reactions at sites of previous cutaneous herpes zoster lesions occur, but their etiology is not known. Three tissue specimens from 5 cases identified clinically and histologically as post-zosteric granulomatous reactions were studied for the presence of varicella-zoster virus (VZV) deoxyribonucleic acid ...

journal_title：Journal of cutaneous pathology

authors： Serfling U,Penneys NS,Zhu WY,Sisto M,Leonardi C

更新日期：1993-02-01 00:00:00

abstract：:Antibodies reactive with S100 protein are useful markers in a diagnostic immunohistochemistry laboratory dealing with cutaneous tumors. However, S100 protein is not a single protein but instead a group of S100 proteins with diverse functions. S100 proteins constitute a family of acidic calcium-binding proteins that ar...

journal_title：Journal of cutaneous pathology

authors： McNutt NS

更新日期：1998-11-01 00:00:00

abstract：:Extraskeletal Ewing's sarcoma has been recognized as being histologically indistinguishable from Ewing's sarcoma of bone. Although the occurrence of extraosseous Ewing's sarcoma in deep soft tissues has been well described, such cutaneous lesions are rare. We report the clinical history, histopathologic findings, and ...

journal_title：Journal of cutaneous pathology

authors： Peters MS,Reiman HM,Muller SA

更新日期：1985-12-01 00:00:00

abstract：:We first report a case of granular cell histiocytosis occurring as a solitary polypoid lesion of the nipple in a 15-year-old girl. Histologically, the lesion was composed of a dermal population of medium- to large-sized, short spindle- to round- to epithelioid-shaped cells with eosinophilic cytoplasm containing numero...

journal_title：Journal of cutaneous pathology

authors： Caltabiano R,Magro G,Vecchio GM,Lanzafame S

更新日期：2010-02-01 00:00:00

abstract：:Biologic therapies targeting tumor necrosis factor (TNF)-alpha have become a mainstay in the management of a number of autoimmune diseases. We report a series of adverse skin eruptions in six patients (four females, two males, age: 21-58 years, mean: 39) receiving 4 months to 10 years (mean 3.1 years) of anti-TNF-alph...

journal_title：Journal of cutaneous pathology

authors： Hawryluk EB,Linskey KR,Duncan LM,Nazarian RM

更新日期：2012-05-01 00:00:00

abstract：:Misonidazole, a hypoxic cell radiation-sensitizer, has been used in vivo to analyze its effect on normal and x-irradiated epidermis. The drug action was evaluated 3 days after being implanted subcutaneously. The response of the epidermis and especially of the basal cells to the drug alone and in combination with x-rad...

journal_title：Journal of cutaneous pathology

authors： de Rey BM,Lanfranchi HE,Klein-Szanto AJ,Itoiz ME

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:Cicatricial forms of alopecia, including lichen planopilaris (LPP) and discoid lupus erythematosus (DLE), may present with overlapping clinical features. In such cases, histopathological examination may provide key information for resolving the differential diagnosis. Optimally, microscopical analysis for al...

journal_title：Journal of cutaneous pathology

authors： Nguyen JV,Hudacek K,Whitten JA,Rubin AI,Seykora JT

更新日期：2011-05-01 00:00:00

abstract：:CD44 is a widely distributed cell surface protein thought to be involved in multiple steps of normal immune cell function, including T-cell activation, and in cellular adhesion where it mediates cell attachment to hyaluronate. In normal skin, CD44 is found by immunohistochemical means to be primarily in eccrine coil c...

journal_title：Journal of cutaneous pathology

authors： Sawaya ME,Bakshandeh H,Hordinsky MK,Penneys NS

更新日期：1994-06-01 00:00:00

abstract：:Malignant transformation occurred in pre-existing sweat gland tumors in 7 patients. Three lesions showed an histologic pattern of eccrine spiradenoma, 2 eccrine poroma, one cylindroma and one papillary eccrine adenoma. Malignant transformation was histologically characterized by the presence of solid tumor areas popul...

journal_title：Journal of cutaneous pathology

authors： Galadari E,Mehregan AH,Lee KC

更新日期：1987-02-01 00:00:00

abstract：:We report an unusual case occurring in a 25-year-old male of a balloon cell nevus which also showed clinical and pathological features of a halo nevus. ...

journal_title：Journal of cutaneous pathology

authors： Côté J,Watters AK,O'Brien EA

更新日期：1986-04-01 00:00:00

abstract：:Adult-onset Still disease (AOSD) is a rare autoinflammatory syndrome characterized by recurring fevers, arthralgia, and consistent laboratory abnormalities that include leukocytosis and hyperferritinemia. Skin findings accompany the disease in nearly 90% of the cases. Early reports described evanescent, pruritic, salm...

journal_title：Journal of cutaneous pathology

authors： Santa E,McFalls JM,Sahu J,Lee JB

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Cutaneous tumor metastasis may be the first manifestation of cancer, but more often is a harbinger of advanced disease that portends an ominous prognosis. All skin accessions over the past 10 years from a large Veterans Administration (VA) hospital were reviewed. METHODS:Archived histories, glass slides, an...

journal_title：Journal of cutaneous pathology

authors： Saeed S,Keehn CA,Morgan MB

更新日期：2004-07-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is a CD30+ T-cell non-Hodgkin lymphoma with 2 main clinical presentations: primary cutaneous ALCL (pcALCL) and systemic ALCL (sALCL). While rare cases of myxoid sALCL have been reported, there are no previous cases of myxoid pcALCL reported. We present 2 unusual cases of pcALCL sh...

journal_title：Journal of cutaneous pathology

authors： Fernandez-Flores A,Eginli A,Cassarino DS

更新日期：2017-09-01 00:00:00