Abstract:
:High level of exposure to manganese (Mn) can cause a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of [123I]-fluoropropyl (FP)-CIT SPECT of a liver cirrhotic with atypical parkinsonism. The patient developed atypical parkinsonian features associated with elevated blood Mn from hepatic dysfunction. [123I]-FP-CIT brain SPECT images of dopamine transporter (DAT) demonstrated overall normal range of DAT uptake in the striatum although there were scattered small hypodense regions. The globus pallidum had increased signal on T1-weighted magnetic resonance imaging (MRI). All these findings are compatible with those of manganism, and are remarkably different from that in PD.
journal_name
Ind Healthjournal_title
Industrial healthauthors
Kim J,Kim JM,Kim YK,Shin JW,Choi SH,Kim SE,Kim Ydoi
10.2486/indhealth.45.497subject
Has Abstractpub_date
2007-06-01 00:00:00pages
497-500issue
3eissn
0019-8366issn
1880-8026pii
JST.JSTAGE/indhealth/45.497journal_volume
45pub_type
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