E-cadherin adhesion activates c-Src signaling at cell-cell contacts.

abstract：:Colony-stimulating factor-1 (CSF-1) induces expression of immediate early gene, such as c-myc and c-fos and delayed early genes such as D-type cyclins (D1 and D2), whose products play essential roles in the G1 to S phase transition of the cell cycle. Little is known, however, about the cytoplasmic signal transduction ...

journal_title：Molecular biology of the cell

authors： Dey A,She H,Kim L,Boruch A,Guris DL,Carlberg K,Sebti SM,Woodley DT,Imamoto A,Li W

更新日期：2000-11-01 00:00:00

abstract：:Trafficking through the Golgi apparatus requires members of the Arf family of GTPases, whose activation is regulated by guanine nucleotide exchange factors (GEFs). Once activated, Arf-GTP recruits effectors such as coat complexes and lipid-modifying enzymes to specific membrane sites, creating a domain competent for c...

journal_title：Molecular biology of the cell

authors： Niu TK,Pfeifer AC,Lippincott-Schwartz J,Jackson CL

更新日期：2005-03-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is an incurable disease of the lung that is characterized by excessive deposition of extracellular matrix (ECM), resulting in disruption of normal lung function. The signals regulating fibrosis include both transforming growth factor beta (TGF-β) and tissue rigidity and a major sign...

journal_title：Molecular biology of the cell

authors： Monaghan-Benson E,Wittchen ES,Doerschuk CM,Burridge K

更新日期：2018-09-01 00:00:00

abstract：:The gamma-tubulin small complex (gamma-TuSC) is an evolutionarily conserved heterotetramer essential for microtubule nucleation. We have determined the structure of the Saccharomyces cerevisiae gamma-TuSC at 25-A resolution by electron microscopy. gamma-TuSC is Y-shaped, with an elongated body connected to two arms. G...

journal_title：Molecular biology of the cell

authors： Kollman JM,Zelter A,Muller EG,Fox B,Rice LM,Davis TN,Agard DA

更新日期：2008-01-01 00:00:00

abstract：:This essay records a voyage of discovery from the "cradle of cell biology" to the present, focused on the biology of the oldest known cell organelle, the cilium. In the "romper room" of cilia and microtubule (MT) biology, the sliding MT hypothesis of ciliary motility was born. From the "summer of love," students and c...

journal_title：Molecular biology of the cell

authors： Satir P

更新日期：2014-11-01 00:00:00

abstract：:Insulin maintains whole body blood glucose homeostasis, in part, by regulating the amount of the GLUT4 glucose transporter on the cell surface of fat and muscle cells. Insulin induces the redistribution of GLUT4 from intracellular compartments to the plasma membrane, by stimulating a large increase in exocytosis and a...

journal_title：Molecular biology of the cell

authors： Zeigerer A,McBrayer MK,McGraw TE

更新日期：2004-10-01 00:00:00

abstract：:In biogenesis of membrane proteins on the endoplasmic reticulum, a protein-conducting channel called the translocon functions in both the membrane translocation of lumenal domains and the integration of transmembrane segments. Here we analyzed the environments of polypeptide chains during the processes by water-depend...

journal_title：Molecular biology of the cell

authors： Kida Y,Kume C,Hirano M,Sakaguchi M

更新日期：2010-02-01 00:00:00

abstract：:Polypeptides targeted to the yeast endoplasmic reticulum (ER) posttranslationally are thought to be kept in the cytoplasm in an unfolded state by Hsp70 chaperones before translocation. We show here that Escherichia coli beta-lactamase associated with Hsp70, but adopted a native-like conformation before translocation i...

journal_title：Molecular biology of the cell

authors： Paunola E,Suntio T,Jämsä E,Makarow M

更新日期：1998-04-01 00:00:00

abstract：:Platelet secretion is critical to hemostasis. Release of granular cargo is mediated by soluble NSF attachment protein receptors (SNAREs), but despite consensus on t-SNAREs usage, it is unclear which Vesicle Associated Membrane Protein (VAMPs: synaptobrevin/VAMP-2, cellubrevin/VAMP-3, TI-VAMP/VAMP-7, and endobrevin/VAM...

journal_title：Molecular biology of the cell

authors： Ren Q,Barber HK,Crawford GL,Karim ZA,Zhao C,Choi W,Wang CC,Hong W,Whiteheart SW

更新日期：2007-01-01 00:00:00

abstract：:How recycling receptors are segregated from down-regulated receptors in the endosome is unknown. In previous studies, we demonstrated that substitutions in the transferrin receptor (TR) transmembrane domain (TM) convert the protein from an efficiently recycling receptor to one that is rapidly down regulated. In this s...

journal_title：Molecular biology of the cell

authors： Zaliauskiene L,Kang S,Brouillette CG,Lebowitz J,Arani RB,Collawn JF

更新日期：2000-08-01 00:00:00

abstract：:The eukaryotic flagellum is a large structure into which specific constituent proteins must be targeted, transported and assembled after their synthesis in the cytoplasm. Using Trypanosoma brucei and a proteomic approach, we have identified and characterized a novel set of adenylate kinase proteins that are localized ...

journal_title：Molecular biology of the cell

authors： Pullen TJ,Ginger ML,Gaskell SJ,Gull K

更新日期：2004-07-01 00:00:00

abstract：:The architecture of the cytoskeleton and its remodeling are tightly regulated by dynamic reorganization of keratin-rich intermediate filaments. Plakin family proteins associate with the network of intermediate filaments (IFs) and affect its reorganization during migration, differentiation, and response to stress. The ...

journal_title：Molecular biology of the cell

authors： Gujrati M,Mittal R,Ekal L,Mishra RK

更新日期：2019-02-01 00:00:00

abstract：:Eukaryotic cells actively block entry into mitosis in the presence of DNA damage or incompletely replicated DNA. This response is mediated by signal transduction cascades called cell cycle checkpoints. We show here that the human checkpoint control protein hRAD9 physically associates with two other checkpoint control ...

journal_title：Molecular biology of the cell

authors： St Onge RP,Udell CM,Casselman R,Davey S

更新日期：1999-06-01 00:00:00

abstract：:The mitochondrial cytochrome c oxidase assembles in the inner membrane from subunits of dual genetic origin. The assembly process of the enzyme is initiated by membrane insertion of the mitochondria-encoded Cox1 subunit. During complex maturation, transient assembly intermediates, consisting of structural subunits and...

journal_title：Molecular biology of the cell

authors： Bareth B,Nikolov M,Lorenzi I,Hildenbeutel M,Mick DU,Helbig C,Urlaub H,Ott M,Rehling P,Dennerlein S

更新日期：2016-05-15 00:00:00

abstract：:Starvation induces Dictyostelium amoebae to secrete cAMP, toward which other amoebae stream, forming multicellular mounds that differentiate and develop into fruiting bodies containing spores. We find that the double deletion of cortexillin (ctx) I and II alters the actin cytoskeleton and substantially inhibits all mo...

journal_title：Molecular biology of the cell

authors： Shu S,Liu X,Kriebel PW,Daniels MP,Korn ED

更新日期：2012-01-01 00:00:00

abstract：:During oogenesis, two successive meiotic cell divisions occur without functional centrosomes because of the inactivation and subsequent elimination of maternal centrosomes during the diplotene stage of meiosis I. Despite being a conserved phenomenon in most metazoans, the means by which this centrosome behavior is con...

journal_title：Molecular biology of the cell

authors： Matsuura R,Ashikawa T,Nozaki Y,Kitagawa D

更新日期：2016-03-01 00:00:00

abstract：:RAM (regulation of Ace2p transcription factor and polarized morphogenesis) is a conserved signaling network that regulates polarized morphogenesis in yeast, worms, flies, and humans. To investigate the role of the RAM network in cell polarity and hyphal morphogenesis of Candida albicans, each of the C. albicans RAM ge...

journal_title：Molecular biology of the cell

authors： Song Y,Cheon SA,Lee KE,Lee SY,Lee BK,Oh DB,Kang HA,Kim JY

更新日期：2008-12-01 00:00:00

abstract：:The Rho GTPases RhoA and Rac1 function as master regulators of cytokinesis by controlling the actomyosin cytoskeleton. RhoA and Rac1 have to be respectively activated and inactivated at the division plane for cytokinesis to occur properly. The inactivation of Rac1 at the cleavage furrow is controlled by MgcRacGAP. How...

journal_title：Molecular biology of the cell

authors： Cannet A,Schmidt S,Delaval B,Debant A

更新日期：2014-12-15 00:00:00

abstract：:Clathrin-mediated endocytosis (CME) is the major mechanism for internalization in mammalian cells. CME initiates by recruitment of adaptors and clathrin to form clathrin-coated pits (CCPs). Nearly half of nascent CCPs abort, whereas others are stabilized by unknown mechanisms and undergo further maturation before pinc...

journal_title：Molecular biology of the cell

authors： Antonescu CN,Aguet F,Danuser G,Schmid SL

更新日期：2011-07-15 00:00:00

abstract：:The last steps of multivesicular body (MVB) formation, human immunodeficiency virus (HIV)-1 budding and cytokinesis require a functional endosomal sorting complex required for transport (ESCRT) machinery to facilitate topologically equivalent membrane fission events. Increased sodium tolerance (IST) 1, a new positive ...

journal_title：Molecular biology of the cell

authors： Agromayor M,Carlton JG,Phelan JP,Matthews DR,Carlin LM,Ameer-Beg S,Bowers K,Martin-Serrano J

更新日期：2009-03-01 00:00:00

abstract：:The RNA-binding protein HuD binds to a regulatory element in the 3' untranslated region (3' UTR) of the GAP-43 mRNA. To investigate the functional significance of this interaction, we generated PC12 cell lines in which HuD levels were controlled by transfection with either antisense (pDuH) or sense (pcHuD) constructs....

journal_title：Molecular biology of the cell

authors： Mobarak CD,Anderson KD,Morin M,Beckel-Mitchener A,Rogers SL,Furneaux H,King P,Perrone-Bizzozero NI

更新日期：2000-09-01 00:00:00

abstract：:The potential to migrate is one of the most fundamental functions for various epithelial, mesenchymal, and immune cells. Image analysis of motile cell populations, both primary and cultured, typically reveals an intercellular variability in migration speeds. However, cell migration chromatography, the sorting of large...

journal_title：Molecular biology of the cell

authors： Arora A,Niño JLG,Myaing MZ,Chia S,Arasi B,Ravasio A,Huang RY,Dasgupta R,Biro M,Viasnoff V

更新日期：2020-12-01 00:00:00

abstract：:Jak tyrosine kinases have a unique domain structure containing a kinase domain (JH1) adjacent to a catalytically inactive pseudokinase domain (JH2). JH2 is crucial for inhibition of basal Jak activity, but the mechanism of this regulation has remained elusive. We show that JH2 negatively regulated Jak2 in bacterial ce...

journal_title：Molecular biology of the cell

authors： Saharinen P,Vihinen M,Silvennoinen O

更新日期：2003-04-01 00:00:00

abstract：:The cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase type I (cGKI) pathway regulates many cellular functions. The current study shows that 8-Br-cGMP stimulates the number of attached primary but not that of subcultured murine vascular smooth muscle cells (VSMCs). These effects of 8-Br-cGMP require t...

journal_title：Molecular biology of the cell

authors： Weinmeister P,Lukowski R,Linder S,Traidl-Hoffmann C,Hengst L,Hofmann F,Feil R

更新日期：2008-10-01 00:00:00

abstract：:Protein kinase D2 (PKD2) belongs to the PKD family of serine/threonine kinases that is activated by phorbol esters and G protein-coupled receptors (GPCRs). Its C-terminal regulatory domain comprises two cysteine-rich domains (C1a/C1b) followed by a pleckstrin homology (PH) domain. Here, we examined the role of the reg...

journal_title：Molecular biology of the cell

authors： Auer A,von Blume J,Sturany S,von Wichert G,Van Lint J,Vandenheede J,Adler G,Seufferlein T

更新日期：2005-09-01 00:00:00

abstract：:Severe heat stress causes protein denaturation in various cellular compartments. If Saccharomyces cerevisiae cells grown at 24 degrees C are preconditioned at 37 degrees C, proteins denatured by subsequent exposure to 48-50 degrees C can be renatured when the cells are allowed to recover at 24 degrees C. Conformationa...

journal_title：Molecular biology of the cell

authors： Hänninen AL,Simola M,Saris N,Makarow M

更新日期：1999-11-01 00:00:00

abstract：:NSF and p97 are related AAA proteins implicated in membrane trafficking and organelle biogenesis. p97 is also involved in pathways that lead to ubiquitin-dependent proteolysis, including ER-associated degradation (ERAD). In this study, we have used dominant interfering ATP-hydrolysis deficient mutants (NSF(E329Q) and ...

journal_title：Molecular biology of the cell

authors： Dalal S,Rosser MF,Cyr DM,Hanson PI

更新日期：2004-02-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein expressed on microglia within the brain. Several rare mutations in TREM2 cause an early-onset form of neurodegeneration when inherited homozygously. Here we investigate how these mutations affect the intracellular transport of TREM2. W...

journal_title：Molecular biology of the cell

authors： Sirkis DW,Aparicio RE,Schekman R

更新日期：2017-10-01 00:00:00

abstract：:The organization of the endoplasmic reticulum (ER) in the cortex of Xenopus oocytes was investigated during maturation and activation using a green fluorescent protein chimera, immunofluorescence, and electron microscopy. Dense clusters of ER developed on the vegetal side (the side opposite the meiotic spindle) during...

journal_title：Molecular biology of the cell

authors： Terasaki M,Runft LL,Hand AR

更新日期：2001-04-01 00:00:00

abstract：:end4-1 was isolated as a temperature-sensitive endocytosis mutant. We cloned and sequenced END4 and found that it is identical to SLA2/MOP2. This gene is required for growth at high temperature, viability in the absence of Abp1p, polarization of the cortical actin cytoskeleton, and endocytosis. We used a mutational an...

journal_title：Molecular biology of the cell

authors： Wesp A,Hicke L,Palecek J,Lombardi R,Aust T,Munn AL,Riezman H

更新日期：1997-11-01 00:00:00