Abstract：
BACKGROUND:Zenker's diverticulum (ZD) is an uncommon disease, which is typically treated surgically. The alternative to surgery is a diverticulotomy, performed endoscopically. Given the rarity of this condition, it is not possible to obtain training. There has been no animal model identified that resembles the disease in human beings. OBJECTIVE:To present an animal model of ZD that resembles the disease in human beings. DESIGN:We prospectively characterized the endoscopy, the radiography, and the histologic anatomy of the pharyngeal diverticulum in the pig. SETTINGS:Domestic pigs scheduled for euthanasia underwent radiography and endoscopy and, after euthanasia, neck dissection of the pharyngeal diverticulum. INTERVENTIONS AND METHODS:Thirteen consecutive animals were studied. Pictures were taken for the endoscopic view, as well as radiographies during barium swallow in 1 pig. The neck region was dissected, and the pharynx and the upper esophagus were extracted. The size of the diverticulum was measured, and the block was fixed in formalin. Fixed specimens were cut in the transverse and coronal axis, and pictures were taken. The septum between the diverticulum and the esophagus was reviewed microscopically. RESULTS:The pharyngeal diverticulum measured an average of 2.7 cm (1.3-5 cm), depending on the size of the pig. From an endoscopic and radiologic perspective, the pig pharyngeal diverticulum is identical to a ZD. The septum contains muscle as well as fibrous tissue and fat. These anatomical characteristics closely resemble the anatomy in human beings. CONCLUSIONS:We believe that we established an animal training model for the endoscopic treatment of ZD.
journal_name
Gastrointest Endoscjournal_title
Gastrointestinal endoscopyauthors
Seaman DL,de la Mora Levy J,Gostout CJ,Rajan E,Herman L,Knipschield Mdoi
10.1016/j.gie.2006.10.052subject
Has Abstractpub_date
2007-06-01 00:00:00pages
1050-3issue
7eissn
0016-5107issn
1097-6779pii
S0016-5107(06)03170-1journal_volume
65pub_type
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