Abstract:
BACKGROUND:The risk of endoscopic interventions in thrombocytopenia has received little attention in the medical literature. OBJECTIVE:The aim of this study was to assess the safety of endoscopic interventions including evaluation of GI bleeding (GIB) in patients with thrombocytopenia. DESIGN AND SETTING:Retrospective study, tertiary oncology center. PATIENTS AND INTERVENTION:Review of consecutive endoscopies with preprocedure platelet counts (PCs) of 75 × 10(3)/μL or lower. MAIN OUTCOME MEASUREMENTS:Risk of bleeding with routine endoscopic interventions and transfusion requirement after evaluation of GIB. RESULTS:A total of 617 (351 upper, 266 lower [90 colonoscopies]) endoscopies were performed in 395 patients. Forceps-biopsy specimens were obtained in 398 endoscopies (mean ± standard deviation [SD] PC: 38.21 ± 11.7 × 10(3)/μL) and 45 polypectomies were performed in 17 endoscopies (mean ± SD PC: 39.65 ± 8.53 × 10(3)/μL). The risk of bleeding was 1.5% (6 of 398 endoscopies) at the biopsy site and 4% (2 of 45 polypectomies) at the polypectomy site. Active GIB (mean ± SD PC: 32.85 ± 4.0 × 10(3)/μL) was observed in 68 (11% of 617) endoscopies and intervention (mean ± SD PC: 33.68 ± 4.6 × 10(3)/μL) was performed in 41 procedures. Together, angiodysplasias and ulcers were the most common etiology (51.2% of 41). Hemostasis was achieved in 39 (95.1% of 41) procedures. Comparison of blood transfusions ± 3 days of successful therapy showed a 52% reduction (P < .001). By multivariate analysis, a higher aggregate blood transfusion 3 days preceding endoscopy (odds ratio 1.32; 95% confidence interval, 1.16-1.50; P < .001) predicted endoscopic findings of active GIB. LIMITATIONS:Retrospective design, single center. CONCLUSIONS:In the largest endoscopic experience reported in thrombocytopenic patients (Common Terminology Criteria for Adverse Events grade 3 or lower), bleeding caused by standard forceps biopsy and polypectomy (≤10 mm) was minor and easily controlled. Endoscopic therapy for GIB is safe and significantly reduces the packed red blood cell requirement and should be considered in patients with thrombocytopenia in the setting of an appropriate transfusion strategy.
journal_name
Gastrointest Endoscjournal_title
Gastrointestinal endoscopyauthors
Krishna SG,Rao BB,Thirumurthi S,Lee JH,Ramireddy S,Guindani M,Ross WAdoi
10.1016/j.gie.2014.02.023subject
Has Abstractpub_date
2014-09-01 00:00:00pages
425-34issue
3eissn
0016-5107issn
1097-6779pii
S0016-5107(14)00193-Xjournal_volume
80pub_type
杂志文章abstract:BACKGROUND:New therapies are needed for pancreatic cancer. OBJECTIVE:To determine the feasibility and safety of a new endoscopic treatment. Secondary endpoints were to determine effects on tumor growth measured with CT scan and to find the overall survival. DESIGN:A cohort study of patients with local progression of ...
journal_title:Gastrointestinal endoscopy
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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