Abstract:
:We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene. By deletion analysis we have characterized a region upstream of the TATA box which is the promoter region of the gene. Several consensus sequences have been identified, including an SRE and AP-1 binding site whose relative positions are identical to those in the 5' upstream region of the c-fos gene. We have also shown that FosB and c-Fos can downregulate the activity of the fosB promoter to a similar extent. The fosB gene is located in the [A1-B1] region of mouse chromosome 7.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Lazo PS,Dorfman K,Noguchi T,Mattéi MG,Bravo Rdoi
10.1093/nar/20.2.343subject
Has Abstractpub_date
1992-01-25 00:00:00pages
343-50issue
2eissn
0305-1048issn
1362-4962journal_volume
20pub_type
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journal_title:Nucleic acids research
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