Comparative safety and efficacy of subcutaneous and intradermal administration of inactivated Japanese encephalitis vaccine during predeployment preparations in the Australian Defence Force.

Abstract:

:Japanese encephalitis is a viral disease emerging in areas of influence for the Australian Defence Force immediately north of the continent, including the Torres Strait border of Australia and Papua, New Guinea. Only the mouse brain-derived, inactivated, Nakayama strain vaccine is commercially available to the Australian Defence Force. This vaccine has a high cost and significant adverse event profile, requiring restricted duties after administration. To address these issues, intradermal vaccination (either single intradermal administration or two intradermal injections at two separate sites) was assessed, compared with the conventional subcutaneous vaccination method, in a randomized controlled trial among soldiers preparing for deployment. Dual intradermal vaccination (0.1 mL at two sites) was found to have a slightly more favorable adverse event profile while maintaining comparable serological efficacy and reduced cost. An expansion of the concept and a test of logistics were conducted by vaccinating a battalion formation during predeployment medical preparations. The method of vaccination was well accepted and retained comparable immunogenicity.

journal_name

Mil Med

journal_title

Military medicine

authors

Kitchener S,Nasveld P,Brennan L,Ward D

doi

10.7205/milmed.171.12.1190

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1190-5

issue

12

eissn

0026-4075

issn

1930-613X

journal_volume

171

pub_type

临床试验,杂志文章,随机对照试验
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    journal_title:Military medicine

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