Abstract：
:Over 20 yr have elapsed since the end of the First Gulf War, yet approximately one-third of the veterans exhibit Gulf War Illness (GWI) symptoms, particularly depression and memory impairments. Exposure to organophosphate (OP) compounds is implicated for GWI development. The role of calcium (Ca2+) signaling in learning, memory, and mood is well established and disruptions in Ca2+ homeostasis are observed in many neurological disorders. However, the status of Ca2+ homeostasis in the development of GWI behavioral impairments is not known. Male Sprague-Dawley rats were exposed to OP agent diisopropyl fluorophosphate (DFP; 0.5 mg/kg, s.c. 5 days), and at 6 mo post-DFP exposure, rats were subjected to behavioral assays for the determination of GWI neurological morbidities. Fura-2AM loaded acutely isolated hippocampal neurons were used for [Ca2+]i estimations. We observed chronic depressive symptoms and cognitive deficits in rats exposed to repeated low-dose DFP. The GWI rats also manifested elevations in hippocampal [Ca2+]i along with a significant increase in the number of neurons displaying these elevations. As Ca2+ is a major second-messenger molecule, such sustained increases in its levels could activate multiple signaling cascades and alter gene expression of proteins involved in synaptic plasticity and possibly underlie the neuronal injury and chronic morbidities in GWI.
journal_name
Mil Medjournal_title
Military medicineauthors
Phillips KF,Deshpande LSdoi
10.1093/milmed/usx148subject
Has Abstractpub_date
2018-03-01 00:00:00pages
552-555issue
suppl_1eissn
0026-4075issn
1930-613Xpii
4959934journal_volume
183pub_type
杂志文章abstract：:From May 21 to June 4, 1993, a collaborative training project involving U.S. Army veterinary personnel, the Lao-American Integrated Rural Development Project, and the Lao Department of Livestock and Veterinary Services occurred in the Houa Muang District of Houa Phan Province in northeastern Laos. The project focus wa...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:This article describes the circumstances surrounding an intense, constant pain in the temporal region (visual analog scale 9-10) experienced by a 22-year-old combat officer in the Israel Defense Forces following a mild facial injury. The officer's wound included penetration of shrapnel particles into the facial skin, ...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.172.12.1284
更新日期：2007-12-01 00:00:00
abstract：:Non-cardiogenic pulmonary edema (NCPE) is a rare entity manifested by pulmonary edema with normal pulmonary arterial pressures. NCPE has been described in children and recently reported in adults. Onset is rapid and late recognition or inappropriate treatment may lead to a fatal outcome. Most adult cases have been att...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:Confederate Lieutenant General Thomas J. "Stonewall" Jackson was wounded by his own men at the Battle of Chancellorsville during the American Civil War. While being removed from the field, Jackson fell from the litter and struck the right side of his chest on a large stone or stump. Four days following the amputation ...
journal_title：Military medicine
pub_type： 传,历史文章,杂志文章
doi：10.7205/milmed-d-11-00272
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Having a mentor is associated with higher job satisfaction among U.S. physicians. The objective of this study was to assess satisfaction among military medical officers and to assess if mentorship and job satisfaction are associated with intention to continue military service. MATERIALS AND METHODS:This i...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usz327
更新日期：2020-03-02 00:00:00
abstract：INTRODUCTION:Military personnel with a diagnosis of asthma report increased respiratory symptoms in the deployment and post-deployment periods. The long-term effect of deployment on pulmonary function in this population is unknown. This study sought to determine the effect of deployment on post-deployment pulmonary fun...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usaa558
更新日期：2020-12-21 00:00:00
abstract：:Hymenoptera venom allergy accounts for approximately 17% of all cases of anaphylaxis. Insect stings are a common occurrence across the world, with significant impact on active duty personnel. Venom immunotherapy (VIT) provides an effective treatment for those with systemic reactions to insect stings and other similar ...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-15-00536
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:To evaluate a managed care demonstration project in CHAMPUS (Civilian Health and Medical Program of the Uniformed Services), the insurance program covering physical and mental health care services for the dependents of active duty military personnel, military retirees, and the retirees' dependents. The demon...
journal_title：Military medicine
pub_type： 临床试验,杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:This study was designed to provide information to assist in planning health promotion and wellness programs for military trainees. During their first semester at West Point, 179 cadets completed measures of holistic wellness, perceived stress, and mattering. The highest wellness scores were in areas of social support,...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.169.6.475
更新日期：2004-06-01 00:00:00
abstract：Objective:To quantitatively measure tissue composition and hemodynamics during resuscitative endovascular balloon occlusion of the aorta (REBOA) in two tissue compartments using non-invasive two-channel broadband diffuse optical spectroscopy (DOS). Methods:Tissue concentrations of oxy- and deoxyhemoglobin (HbO2 and Hb...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usx163
更新日期：2018-03-01 00:00:00
abstract：:Operation Desert Shield/Storm provided an opportunity to evaluate current medical assets and doctrine in support of Army air-land battle operations. The missions assigned to a medical company (clearing) during Operation Desert Shield/Storm demonstrated the value of the area support medical battalion as authorized unde...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVE:To increase accessibility and availability of secondary medical care, 10 secondary unit specialist clinics were established side-by-side with five existing regional specialist centers, thus achieving decentralization. The purpose was to analyze the impact of this reorganization on overall consumption of secon...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.171.12.1229
更新日期：2006-12-01 00:00:00
abstract：INTRODUCTION:Soldiers are exposed to extreme training regimens in order to optimally prepare for real battle. High attrition rates are a known issue during training courses, especially for elite troops. An underlying factor might be the disbalance between stress/strain and recovery. The aim of this review is to give in...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usy274
更新日期：2019-05-01 00:00:00
abstract：:We report on two patients with head and neck injuries, who remained asymptomatic after the earthquake for 1 and 2 years, respectively. They developed late transient ischemic neurological signs and eventually presented with complete occlusion of the internal carotid artery. They made a good recovery with medical treatm...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.169.7.556
更新日期：2004-07-01 00:00:00
abstract：:Community-acquired, methicillin-resistant Staphylococcus aureus (cMRSA), soft tissue infections are becoming increasingly prevalent in the outpatient setting. Few studies have been specifically designed to examine the efficacy of oral antibiotic therapy for these infections. We performed an observational study to dete...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.171.6.504
更新日期：2006-06-01 00:00:00
abstract：:This cross-sectional telephone survey study assessed prevalence rates of current chemical sensitivity, frequency of chemical odor intolerance, and self-reported Persian Gulf chemical exposures among 41 randomly sampled Department of Veterans Affairs outpatients who were Persian Gulf War (PGW) and PGW-era veterans. The...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:A random clinical trial was performed to determine the immediate effects of early ankle mobilization on active duty military members with moderate and severe lateral ankle sprains. Sixty-four subjects were randomly allocated to one of three treatments: a plaster cast, an air-stirrup (Aircast Inc., Summit, New Jersey),...
journal_title：Military medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-01-01 00:00:00
abstract：INTRODUCTION:Veterans with mental illness tend to have shorter life spans and suboptimal physical health because of a variety of factors. These factors include poor nutrition, being overweight, and smoking cigarettes. Nonphysical contributors that may affect quality of life are the stigma associated with mental illness...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-16-00405
更新日期：2017-09-01 00:00:00
abstract：:U.S. military researchers have made major contributions to the discovery, diagnosis, treatment, and prevention of a number of parasitic diseases. We review the paramount U.S. military contributions to the understanding of leishmaniasis, filariasis, schistosomiasis, trypanosomiasis, gastrointestinal parasites, intestin...
journal_title：Military medicine
pub_type： 历史文章,杂志文章,评审
doi：10.7205/milmed.170.4s.17
更新日期：2005-04-01 00:00:00
abstract：INTRODUCTION:Interventions that encourage good nutrition-related behaviors in the dining environment can potentially influence the health of large numbers of military personnel. Thus, the Army has studied the effectiveness of implementing nutrition education and dining facility (DFAC) changes that included healthier re...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usaa522
更新日期：2020-11-30 00:00:00
abstract：:Leading a medical treatment facility (MTF) through the construction phases of a major upgrade, repair, or any sizable facility project is a challenging and complex endeavor. The Executive Staff can make the process easier on everyone and ensure the final product is in tune with the MTFs needs by taking positive leader...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVES:Soldiers failing to meet Army Regulation 600-9 (AR 600-9) for weight-to-height standards are required to undergo body fat taping assessment. This article describes a clinical performance improvement project in which battalion medical staff identified a simpler way to improve on meeting AR 600-9 standards wit...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-16-00049
更新日期：2017-03-01 00:00:00
abstract：INTRODUCTION:The purpose of this study is to characterize self-reported protective factors against suicide or self-harm within free-response comments from a harm-risk screening. MATERIALS AND METHODS:Veterans enrolled in Department of Veterans Affairs mental health care were administered a self-harm and suicide screen...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usz111
更新日期：2019-12-01 00:00:00
abstract：:A series of 51 active duty patients who elected to undergo ambulatory surgery in a Navy Fleet Hospital Training Set (a modified field hospital) over a 2-year period were followed prospectively for perioperative complications. All patients were active duty personnel, ranging in grade from E1 to O5, who voluntarily gave...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：:The objective of the present study was to assess the physical fitness of patients after apical resection and partial apical pleurectomy for the treatment of primary spontaneous pneumothorax (PSP). Between 1982 and 1999, 58 patients received surgical treatment for PSP in our department. Twelve patients needed bilateral...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.170.9.760
更新日期：2005-09-01 00:00:00
abstract：:Headaches are a typical presentation to a military medical department or emergency room. Having a broad differential diagnosis and utilizing a thorough physical exam can assist providers in honing down the list of pathology and in identifying potentially life-threatening causes of cephalgia such as intracranial tumors...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usy401
更新日期：2019-07-01 00:00:00
abstract：:For nasopharyngeal carcinoma (NPC), radiotherapy is the primary treatment. However, complications occur after radiation to the nasopharynx, which could potentially affect the flying safety. Four fighter pilots with NPC were reported. With early to locally advanced NPC, they received radiotherapy with or without concur...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usz276
更新日期：2020-03-02 00:00:00
abstract：:In an attempt to overcome some of the difficulties encountered with transabdominal ultrasonography we report on 55 patients who underwent 88 transvaginally directed sonograms. In 24 patients in whom a diagnosis of an early intrauterine pregnancy was made, the mean crow-rump length (CRL) was 10.7 mm (range, 3 to 27). I...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The purpose of this study was to examine changes in select anaerobic and aerobic dependent physical performance tasks in U.S. Marines exposured to field operations at moderate altitude. The subjects (N = 16) completed Wingate anaerobic power, submaximal aerobic cycle ergometry, hand grip strength, and push-up tests on...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Over the past few years, the indications for resuscitative thoracotomy in civilian trauma have been refined. The use of this procedure for military casualities has received only brief mention. We have described our experience with 93 consecutive thoracotomies performed in a level I trauma center and have attempted to ...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
