Abstract:
Objective:To quantitatively measure tissue composition and hemodynamics during resuscitative endovascular balloon occlusion of the aorta (REBOA) in two tissue compartments using non-invasive two-channel broadband diffuse optical spectroscopy (DOS). Methods:Tissue concentrations of oxy- and deoxyhemoglobin (HbO2 and HbR), water, and lipid were measured in a porcine model (n = 10) of massive hemorrhage (65% total blood volume over 1 h) and 30-min REBOA superior and inferior to the aortic balloon. Results:After hemorrhage, hemoglobin oxygen saturation (StO2 = HbO2/[HbO2 + HbR]) at both sites decreased significantly (-29.9% and -42.3%, respectively). The DOS measurements correlated with mean arterial pressure (MAP) (R2 = 0.79, R2 = 0.88), stroke volume (SV) (R2 = 0.68, R2 = 0.88), and heart rate (HR) (R2 = 0.72, R2 = 0.88). During REBOA, inferior StO2 continued to decline while superior StO2 peaked 12 min after REBOA before decreasing again. Inferior DOS parameters did not associate with MAP, SV, or HR during REBOA. Conclusions:Dual-channel regional tissue DOS measurements can be used to non-invasively track the formation of hemodynamically distinct tissue compartments during hemorrhage and REBOA. Conventional systemic measures MAP, HR, and SV are uncorrelated with tissue status in inferior (downstream) sites. Multi-compartment DOS may provide a more complete picture of the efficacy of REBOA and similar resuscitation procedures.
journal_name
Mil Medjournal_title
Military medicineauthors
Lam JH,O'Sullivan TD,Park TS,Choi JH,Warren RV,Chen WP,McLaren CE,Cancio LC,Batchinsky AI,Tromberg BJdoi
10.1093/milmed/usx163subject
Has Abstractpub_date
2018-03-01 00:00:00pages
150-156issue
suppl_1eissn
0026-4075issn
1930-613Xpii
4959944journal_volume
183pub_type
杂志文章abstract:INTRODUCTION:Tinnitus is an auditory problem frequently reported by military personnel and is currently responsible for 1 billion dollars annually in disability compensation. Recent military conflicts in Iraq and Afghanistan saw high levels of combat exposure coupled with a surge in blast weaponry, both of which can ad...
journal_title:Military medicine
pub_type: 杂志文章
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更新日期:2020-09-18 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
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journal_title:Military medicine
pub_type: 杂志文章
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
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journal_title:Military medicine
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journal_title:Military medicine
pub_type: 杂志文章
doi:
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journal_title:Military medicine
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
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journal_title:Military medicine
pub_type: 历史文章,杂志文章,评审
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更新日期:2005-04-01 00:00:00
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journal_title:Military medicine
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journal_title:Military medicine
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journal_title:Military medicine
pub_type: 杂志文章
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journal_title:Military medicine
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2012-06-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-17-00068
更新日期:2017-09-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
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journal_title:Military medicine
pub_type: 社论
doi:10.7205/milmed-d-11-00356
更新日期:2012-03-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
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journal_title:Military medicine
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,评审
doi:
更新日期:2000-07-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2003-02-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,评审
doi:
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