CO2 elimination at varying inspiratory pause in acute lung injury.

Abstract:

:Previous studies have indicated that, during mechanical ventilation, an inspiratory pause enhances gas exchange. This has been attributed to prolonged time during which fresh gas of the tidal volume is present in the respiratory zone and is available for distribution in the lung periphery. The mean distribution time of inspired gas (MDT) is the mean time during which fractions of fresh gas are present in the respiratory zone. All ventilators allow setting of pause time, T(P), which is a determinant of MDT. The objective of the present study was to test in patients the hypothesis that the volume of CO(2) eliminated per breath, V(T)CO(2), is correlated to the logarithm of MDT as previously found in animal models. Eleven patients with acute lung injury were studied. When T(P) increased from 0% to 30%, MDT increased fourfold. A change of T(P) from 10% to 0% reduced V(T)CO(2) by 14%, while a change to 30% increased V(T)CO(2) by 19%. The relationship between V(T)CO(2) and MDT was in accordance with the logarithmic hypothesis. The change in V(T)CO(2) reflected to equal extent changes in airway dead space and alveolar PCO(2) read from the alveolar plateau of the single breath test for CO(2). By varying T(P), effects are observed on V(T)CO(2), airway dead space and alveolar PCO(2). These effects depend on perfusion, gas distribution and diffusion in the lung periphery, which need to be further elucidated.

authors

Aboab J,Niklason L,Uttman L,Kouatchet A,Brochard L,Jonson B

doi

10.1111/j.1475-097X.2007.00699.x

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

2-6

issue

1

eissn

1475-0961

issn

1475-097X

pii

CPF699

journal_volume

27

pub_type

临床试验,杂志文章
  • Assessment of body composition by dual-energy X-ray absorptiometry, bioimpedance analysis and anthropometrics in children: the Physical Activity and Nutrition in Children study.

    abstract:OBJECTIVE AND METHODS:We compared InBody720 segmental multifrequency bioimpedance analysis (SMF-BIA) with Lunar Prodigy Advance dual-energy X-ray absorptiometry (DXA) in assessment of body composition among 178 predominantly prepubertal children. Segmental agreement analysis of body compartments was carried out, and in...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12118

    authors: Tompuri TT,Lakka TA,Hakulinen M,Lindi V,Laaksonen DE,Kilpeläinen TO,Jääskeläinen J,Lakka HM,Laitinen T

    更新日期:2015-01-01 00:00:00

  • A new non-invasive ultrasonic method for simultaneous measurements of longitudinal and radial arterial wall movements: first in vivo trial.

    abstract::During recent years, the radial movement of the arterial wall has been extensively studied, and measurements of the radial movement are now an important tool in cardiovascular research for characterizing the mechanical properties of the arterial wall. In contrast, the longitudinal movement of vessels has gained little...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1046/j.1475-097x.2003.00504.x

    authors: Persson M,Ahlgren AR,Jansson T,Eriksson A,Persson HW,Lindström K

    更新日期:2003-09-01 00:00:00

  • A single 60-min bout of peristaltic pulse external pneumatic compression transiently upregulates phosphorylated ribosomal protein s6.

    abstract::We investigated whether a single 60-min bout of whole leg, peristaltic pulse external pneumatic compression (EPC) altered select growth factor-related mRNAs and/or various phospho(p)-proteins related to cell growth, proliferation, inflammation and apoptosis signalling (e.g. Akt-mTOR, Jak-Stat). Ten participants (8 mal...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12343

    authors: Martin JS,Kephart WC,Mobley CB,Wilson TJ,Goodlett MD,Roberts MD

    更新日期:2017-11-01 00:00:00

  • Diagnostic performance of cardiac magnetic resonance imaging in coronary artery disease.

    abstract:BACKGROUND:Cardiac magnetic resonance imaging (CMR) is a promising method for detecting coronary artery disease (CAD). The first reports of new diagnostic techniques indicated generally unrealistic diagnostic performance relying on retrospectively observed cut-off values of quantitative parameters. Although visual anal...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1475-097X.2009.00908.x

    authors: Pärkkä JP,Koskenvuo JW,Kervinen H,Poutanen VP,Lohela P,Järvinen V

    更新日期:2010-03-01 00:00:00

  • Fixed ratio or lower limit of normal for the FEV1 /VC ratio: relation to symptoms and extended lung function tests.

    abstract::There is no general agreement on the spirometric definition of chronic obstructive pulmonary disease (COPD). The global initiative for obstructive lung disease recommends a fixed ratio between forced expiratory volume in one-second (FEV1 ) and forced vital capacity (FVC) of <0·7 (FR) for the diagnosis of COPD. Europea...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12294

    authors: Wollmer P,Frantz S,Engström G,Dencker M,Löfdahl CG,Nihlén U

    更新日期:2017-05-01 00:00:00

  • Poincaré plot indexes of heart rate variability capture dynamic adaptations after haemodialysis in chronic renal failure patients.

    abstract::The hypothesis that the Poincaré plot indexes of heart rate variability (HRV) detect dynamic changes after haemodialysis (HD) over the HRV in haemodynamically stable chronic renal failure (CRF) patients was examined. Minor axis (SD1), major axis (SD2) and the SD1/SD2 ratio were compared against standard HRV indexes in...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1046/j.1475-097x.2003.00466.x

    authors: Lerma C,Infante O,Pérez-Grovas H,José MV

    更新日期:2003-03-01 00:00:00

  • Separating the left cardiac ventricle from the atrium in short axis MR images using the equation of the atrioventricular plane.

    abstract::Short axis (SA) images obtained from cardiac magnetic resonance imaging are used to advantage in the calculation of important clinical parameters such as the ejection fraction and stroke volume (SV). A prerequisite for these calculations is the separation of the left ventricle and the left atrium. When only using the ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2008.00799.x

    authors: Thunberg P,Emilsson K,Rask P,Kähäri A

    更新日期:2008-07-01 00:00:00

  • Effect of exercise intensity on oxygen consumption kinetics in non-exercising muscle during exercise.

    abstract::This study examined the effect of exercise intensity on the kinetics of muscle oxygen consumption in non-exercising forearm flexor muscles (VO(2mf)) during exercise. Seven healthy male subjects performed cycling exercise for 60 min at 30% of maximal oxygen consumption (%VO(2max)) and 30 min at 50% VO(2max) on separate...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1475-097X.2011.01073.x

    authors: Nagasawa T

    更新日期:2012-05-01 00:00:00

  • Increased arterial stiffness in males with abdominal aortic aneurysm.

    abstract:BACKGROUND:Abdominal aortic aneurysm (AAA), a localized dilatation of the abdominal aorta, has a prevalence of about 1.5%-3% among 65- to 70-year-old males in Europe. AAA confers an increased risk of developing major cardiovascular events in addition to the risk of aneurysm rupture. The aim of this study was to evaluat...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12667

    authors: Åström Malm I,De Basso R,Blomstrand P,Bjarnegård N

    更新日期:2021-01-01 00:00:00

  • Echocardiography in Fabry disease: diagnostic value of endocardial border binary appearance.

    abstract:BACKGROUND AND AIM:It has been reported that the endocardium in Fabry disease has a binary appearance on transthoracic echocardiography. It has been suggested that this sign could be used with good accuracy to differentiate Fabry disease from hypertrophic cardiomyopathy and even as a first filter to screen for suspecte...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2008.00851.x

    authors: Koskenvuo JW,Engblom E,Kantola IM,Hartiala JJ,Saraste A,Kiviniemi TO,Mononen I,Saraste M

    更新日期:2009-05-01 00:00:00

  • Comparison of stroke volume estimation for non-steady-state and steady-state graded exercise testing.

    abstract::The stroke volume (SV) during exercise is an important index of the heart's functional capacity. A new method has been developed for the non-invasive estimation of exercise SV (SVex). It requires the determination of the slope for the oxygen uptake versus heart rate relationship in the steady state of graded exercise ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2004.00585.x

    authors: Davis JA,Sorrentino KM,Soriano AC,Pham PH

    更新日期:2005-01-01 00:00:00

  • Angiotensin converting enzyme 2 polymorphisms and postexercise hypotension in hypertensive medicated individuals.

    abstract::The renin-angiotensin aldosterone system (RAAS) is associated with diverse physiological responses and adaptations to exercise. The angiotensin converting enzyme (ACE) 2 has vasodilatory effects, which might be associated with the blood pressure (BP) responses to acute exercise. The aim of this study was to investigat...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12400

    authors: Goessler KF,Polito MD,Mota GF,de Oliveira EM,Cornelissen VA

    更新日期:2018-03-01 00:00:00

  • Cardiac imaging in patients with chronic liver disease.

    abstract::Cirrhotic cardiomyopathy (CCM) is characterized by an impaired contractile response to stress, diastolic dysfunction and the presence of electrophysiological abnormalities, and it may be diagnosed at rest in some patients or demasked by physiological or pharmacological stress. CCM seems to be involved in the developme...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1111/cpf.12311

    authors: Wiese S,Hove JD,Møller S

    更新日期:2017-07-01 00:00:00

  • Vascular ultrasound for monitoring of inflammatory activity in Takayasu arteritis.

    abstract:BACKGROUND:Takayasu arteritis (TA) is a rare large-vessel arteritis that primarily affects the aorta and its major branches. The aim of this study was to describe the value of high frequency ultrasound for monitoring of inflammatory activity. METHODS:Twenty-five patients, range 11-71 years, diagnosed with TA were inve...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12601

    authors: Svensson C,Eriksson P,Zachrisson H

    更新日期:2020-01-01 00:00:00

  • The effects of exercise training on arterial stiffness in coronary artery disease patients: a state-of-the-art review.

    abstract::The purpose of this state-of-the-art review was to examine the effects of exercise training on arterial stiffness (AS) in patients with coronary artery disease (CAD). A PubMed and SCOPUS literature search was conducted up to March of 2013. Two authors performed the selection of the studies and the subsequent data extr...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1111/cpf.12093

    authors: Oliveira NL,Ribeiro F,Alves AJ,Campos L,Oliveira J

    更新日期:2014-07-01 00:00:00

  • Sequence effects of combined resistance exercises with step choreography in the same session in women's oxygen uptake during and postexercise.

    abstract::The combination of step choreography (SC) with resistance training exercises (RE) in the same session is common in class fitness rooms populated mainly by women to increase energy expenditure. The aim of this study was to evaluate the differences in the exercise oxygen uptake and postexercise between two different com...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12382

    authors: Vilaça-Alves J,Regado A,Marinho D,Neves EB,Rosa C,Saavedra F,Reis VM

    更新日期:2018-01-01 00:00:00

  • Haemodynamic limitations and exercise performance in peripheral arterial disease.

    abstract::It has been frequently argued that haemodynamic limitations are poor predictors of exercise performance in people with peripheral arterial disease (PAD) and intermittent claudication. This review has tried to address this argument through a review of published data that appears to support or counterbalance it, brief c...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2281.2002.00400.x

    authors: Green S

    更新日期:2002-03-01 00:00:00

  • Arterial concentration of 99mTc-sestamibi at rest, during peak exercise and after dipyridamole infusion.

    abstract::Tracers for myocardial perfusion imaging during stress should not only have high cardiac uptake but they should also have a fast blood clearance to prevent myocardial tracer uptake after the ischaemic stimulus. The present study characterize the early phase of the arterial (99m)Tc-sestamibi (MIBI) time-activity curve ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1475-097X.2004.00570.x

    authors: Sand NP,Juelsgaard P,Rasmussen K,Flø C,Thuesen L,Bagger JP,Nielsen TT,Rehling M

    更新日期:2004-11-01 00:00:00

  • Brain glucose and lactate levels during ventilator-induced hypo- and hypercapnia.

    abstract:OBJECTIVE:Levels of glucose and lactate were measured in the brain by means of microdialysis in order to evaluate the effects of ventilator-induced hypocapnia and hypercapnia on brain metabolism in healthy non-brain-traumatized animals. DESIGN AND SETTING:Prospective animal study in a university laboratory. SUBJECTS:...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2004.00557.x

    authors: van Hulst RA,Lameris TW,Haitsma JJ,Klein J,Lachmann B

    更新日期:2004-07-01 00:00:00

  • Neonatal ACE inhibition in rats interferes with lung development.

    abstract::The renin-angiotensin system (RAS) is developmentally up-regulated and it is essential for kidney development in several species. Given the fact that the rat lung undergoes postnatal development, the mammalian lung possesses the highest angiotensin-converting enzyme (ACE) levels and ACE activity increases during the f...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1046/j.1475-0961.2003.00530.x

    authors: Lasaitiene D,Chen Y,Nannmark U,Wollmer P,Friberg P

    更新日期:2004-01-01 00:00:00

  • Gender aspects on exercise-induced ECG changes in relation to scintigraphic evidence of myocardial ischaemia.

    abstract:BACKGROUND:This retrospective study aimed to determine the diagnostic performance of exercise-induced ST response in relation to findings by myocardial perfusion single photon emission computed tomography (MPS), with focus on gender differences, in patients with suspected or established stable ischemic heart disease. ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12483

    authors: Akil S,Hedén B,Pahlm O,Carlsson M,Arheden H,Engblom H

    更新日期:2018-09-01 00:00:00

  • Intramuscular water movement during and after isometric muscle contraction: evaluation at different exercise intensities.

    abstract::We aimed at evaluating the effect of isometric muscle contraction on intramuscular water movement at different exercise intensities. Seven men performed 1-min isometric ankle dorsiflexion (20% and 50% maximal voluntary contractions [MVCs]) with a non-magnetic custom-made dynamometer, inside a magnetic resonance (MR) d...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12239

    authors: Yanagisawa O,Kurihara T

    更新日期:2016-09-01 00:00:00

  • High-intensity interval training using whole-body exercises: training recommendations and methodological overview.

    abstract::HIIT whole body (HWB)-based exercise is a new calisthenics exercise programme approach that can be considered an effective and safe method to improve physical fitness and body composition. HWB is a method that can be applied to different populations and ages. The purpose of this study was to describe possible methodol...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1111/cpf.12433

    authors: Machado AF,Baker JS,Figueira Junior AJ,Bocalini DS

    更新日期:2019-11-01 00:00:00

  • The acute hemodynamic effects of blood flow restriction in the absence of exercise.

    abstract::The purpose was to investigate the acute effects of blood flow restriction (BFR) on arterial and venous hemodynamic parameters. Nine participants completed a 10-min time control (resting condition) and then a lower body BFR protocol. The protocol was five, 5-min bouts of restrictive cuff inflation with 3-min of deflat...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2012.01157.x

    authors: Loenneke JP,Fahs CA,Thiebaud RS,Rossow LM,Abe T,Ye X,Kim D,Bemben MG

    更新日期:2013-01-01 00:00:00

  • EMG signs of neuromuscular fatigue related to the ventilatory threshold during cycling exercise.

    abstract::We questioned whether electromyographic (EMG) signs of neuromuscular fatigue accompany the changes in respiratory variables measured at the ventilatory threshold (VTh) during exercise on a cycloergometer. This was based on the assumption that the activation of muscle afferents sensitive to accumulation of lactate and ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1046/j.1475-097x.2003.00497.x

    authors: Hug F,Faucher M,Kipson N,Jammes Y

    更新日期:2003-07-01 00:00:00

  • Diagnostic evaluation of planar and tomographic ventilation/perfusion lung images in patients with suspected pulmonary emboli.

    abstract::Planar lung ventilation/perfusion scintigraphy (V/P(PLANAR)) is a standard method for diagnosis of pulmonary embolism (PE). The goals of this study were to test whether the diagnostic information of ventilation/perfusion tomography (V/P(SPET)) applied in clinical routine might enhance information compared with V/P(PLA...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1475-097X.2004.00546.x

    authors: Bajc M,Olsson CG,Olsson B,Palmer J,Jonson B

    更新日期:2004-09-01 00:00:00

  • Impact of gender on echocardiographic characteristics in heart transplant recipients.

    abstract:AIMS:Assessment following heart transplantation (HTx) is routinely performed using transthoracic echocardiography. Differences in long-term mortality following HTx related to donor-recipient matching have been reported, but effects of gender on cardiac size and function are not well studied. The aims of this study were...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12565

    authors: Ingvarsson A,Werther-Evaldsson A,Smith GJ,Waktare J,Nilsson J,Stagmo M,Roijer A,Rådegran G,Meurling C

    更新日期:2019-07-01 00:00:00

  • Effects of different periods of hypoxic training on glucose metabolism and insulin sensitivity.

    abstract::This study examined the effects of different periods of hypoxic training on glucose metabolism. Sedentary subjects underwent hypoxic training (FiO2 = 15.0%) for either 2 weeks (2-week group; n = 11) or 4 weeks (4-week group; n = 10). The 2-week group conducted training sessions on 6 days week(-1) for 2 weeks, whereas ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/cpf.12133

    authors: Morishima T,Hasegawa Y,Sasaki H,Kurihara T,Hamaoka T,Goto K

    更新日期:2015-03-01 00:00:00

  • Long-term changes in dynamic cerebral autoregulation: a 10 years follow up study.

    abstract::This study takes a novel approach to describing time-related changes in dynamic cerebral autoregulation (dCA). It is well-recognized that dCA exhibits both intra- and inter- subject variability, and this study seeks to characterize the extent to which intra-subject variability occurs after a significant period of time...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2009.00880.x

    authors: Brodie FG,Panerai RB,Foster S,Evans DH,Robinson TG

    更新日期:2009-09-01 00:00:00

  • Comparison of air-displacement plethysmography results using predicted and measured lung volumes over a protracted period of time.

    abstract:BACKGROUND:Air-displacement plethysmography (ADP) systems can either measure or predict lung volume (LV) in their test trials. The repeatability of the predicted and the measured value is an important factor in the accuracy of the final test result. OBJECTIVE:Compare the variability and accuracy of ADP tests using pre...

    journal_title:Clinical physiology and functional imaging

    pub_type: 历史文章,杂志文章

    doi:10.1111/cpf.12129

    authors: Otterstetter R,Johnson KE,Kiger DL,Agnor SE,Kappler RM,Reinking M,Tessmer K

    更新日期:2015-09-01 00:00:00