Abstract:
:The renin-angiotensin system (RAS) is developmentally up-regulated and it is essential for kidney development in several species. Given the fact that the rat lung undergoes postnatal development, the mammalian lung possesses the highest angiotensin-converting enzyme (ACE) levels and ACE activity increases during the first weeks postpartum, we tested the hypothesis that ACE inhibition influences postnatal lung development. Rats were given the ACE inhibitor enalapril (10 mg kg(-1)) from 0 to 9 days of age and their lungs were examined at day 4 and 9. Lung structure was evaluated by means of light microscopy, and surface tension of bronchoalveolar lavage fluid was measured by means of a Wilhelmy balance. Neonatal ACE inhibition lowered the surface tension of bronchoalveolar lavage fluid and caused widening of respiratory airspaces and thinning of alveolar septa. Our results suggest that early postnatal ACE inhibition in rats interferes with lung development.
journal_name
Clin Physiol Funct Imagingjournal_title
Clinical physiology and functional imagingauthors
Lasaitiene D,Chen Y,Nannmark U,Wollmer P,Friberg Pdoi
10.1046/j.1475-0961.2003.00530.xkeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
65-8issue
1eissn
1475-0961issn
1475-097Xpii
530journal_volume
24pub_type
杂志文章abstract:BACKGROUND:In MRI studies of carotid plaques, ultrasound is used to find plaques, which are later imaged using MRI. The performance in plaque detection has not been compared between the modalities. The aim of the current study was to compare the performance of MRI and ultrasound in detecting carotid artery plaques and ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12415
更新日期:2018-03-01 00:00:00
abstract::The aim of this study was to investigate the effect of repeated cycling sprints on power profiles while assessing upper body muscle contraction. Eighteen physically active participants performed 8 × 10 s repeated sprints while muscle activity was recorded via surface electromyography (sEMG) from the brachioradialis (B...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12159
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Levels of glucose and lactate were measured in the brain by means of microdialysis in order to evaluate the effects of ventilator-induced hypocapnia and hypercapnia on brain metabolism in healthy non-brain-traumatized animals. DESIGN AND SETTING:Prospective animal study in a university laboratory. SUBJECTS:...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2004.00557.x
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by inflammation of the lung in association with airflow obstruction. There is increasing evidence of upper airway involvement in COPD and we have reported that this nasal inflammation is proportional to that in the lung. Given recognized relations...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2006.00683.x
更新日期:2006-07-01 00:00:00
abstract::Diffusion-weighted magnetic resonance imaging (DW-MRI) is an established technique to detect the changes of the diffusion of water in biological tissues and reflect the pathophysiological process on the molecular level. It is a promising non-invasive imaging modality in detection of microstructural and functional chan...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章,评审
doi:10.1111/cpf.12313
更新日期:2017-09-01 00:00:00
abstract::The aim was to investigate and compare the effects of proprioceptive neuromuscular facilitation (PNF) and static stretching (SS) on maximal voluntary contraction (MVC) and muscle activation in indoor soccer players. Thirty-three young adult men were divided into two groups: (i) sedentary and (ii) trained. Each group c...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12047
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Historically, Q-wave myocardial infarction (MI) has been equated with transmural MI. This association have, however, recently been rejected. The endocardial extent of MI is another potential determinant of pathological Q waves, since the first part of the QRS complex where the Q wave appears reflects depolar...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2007.00723.x
更新日期:2007-03-01 00:00:00
abstract::Literature does not agree with the usefulness of exercise blood pressure (BP) in predicting hypertension or target organ damage. In this prospective 10 years of follow-up, we evaluated if exaggerated BP responses to tests may improve the prediction of left ventricular mass index (LVMI). At baseline, BP was recorded by...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1046/j.1475-097x.2002.00412.x
更新日期:2002-05-01 00:00:00
abstract::The relationships between electromyographic (EMG) activity and force as well as muscle blood flow and work have been well established. However, the association between muscle blood flow and EMG activity remains unsolved. Thus, to test the hypothesis that muscle EMG activity relates to muscle perfusion in different com...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2006.00656.x
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Many patients with pulmonary hypertension (PH) have symptoms of angina without evidence of occlusive coronary artery disease. For the first time, this study addresses the influence of progressively increasing pulmonary artery pressure (PAP) on left anterior descending artery flow in a rat model of PH. The ro...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2011.01049.x
更新日期:2011-11-01 00:00:00
abstract:SUMMARY:Increasing evidence suggests that local blood flow should be monitored during microdialysis (MD) as the recovery of analytes is affected by local blood flow. At present ethanol clearance is the standard technique for this purpose, but it is not functional at very low perfusion velocities. Here, we introduce a t...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2009.00904.x
更新日期:2010-01-01 00:00:00
abstract::This cross-sectional study provides values for lumbar spine bone mineral content (BMC) and density (BMD) in 41 healthy full-term born Finnish infants, 19 boys and 22 girls, during the first year of life measured by dual energy X-ray absorptiometry (DXA) using the Lunar DPX densitometer. Lumbar BMC correlated with the ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1046/j.1475-097x.2002.00422.x
更新日期:2002-05-01 00:00:00
abstract::In this study, we examined possible differences in brain activation between smooth pursuit and optokinetic reflexive (OKR) eye movements using functional magnetic resonance imaging (fMRI). Eighteen healthy subjects performed two different eye movement paradigms. In the first paradigm, smooth pursuit eye movements were...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2009.00858.x
更新日期:2009-07-01 00:00:00
abstract::Monitoring alterations in fingertip temperature during ischaemia and the subsequent hyperaemia provides a novel way of studying microvascular reactivity. The relations between parameters characterizing blood perfusion and the thermal response of fingertips were studied using experimental and theoretical approaches. Du...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2010.00981.x
更新日期:2011-01-01 00:00:00
abstract::There is no general agreement on the spirometric definition of chronic obstructive pulmonary disease (COPD). The global initiative for obstructive lung disease recommends a fixed ratio between forced expiratory volume in one-second (FEV1 ) and forced vital capacity (FVC) of <0·7 (FR) for the diagnosis of COPD. Europea...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12294
更新日期:2017-05-01 00:00:00
abstract::The aim of this investigation was to evaluate the inter- and intra-session reliability of spatio-temporal gait variables collected during walking and stair climbing with the Intelligent Device for Energy Expenditure and physical Activity (IDEEA) accelerometer-based system. Eighteen healthy subjects (10 men, 8 women) c...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2009.00864.x
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Delayed enhancement magnetic resonance imaging depicts scar in the left ventricle which can be quantitatively measured. Manual segmentation and scar determination is time consuming. The purpose of this study was to evaluate a software for infarct quantification, to compare with manual scar determination, and...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2007.00765.x
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to analyse gender differences in neuromuscular behaviour of the gastrocnemius and vastus lateralis during the take-off phase of a countermovement jump (CMJ), using direct measures (ground reaction forces, muscle activity and dynamic ultrasound). METHODS:Sixty-four young adults (ag...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12369
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Abdominal aortic aneurysm (AAA), a localized dilatation of the abdominal aorta, has a prevalence of about 1.5%-3% among 65- to 70-year-old males in Europe. AAA confers an increased risk of developing major cardiovascular events in addition to the risk of aneurysm rupture. The aim of this study was to evaluat...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12667
更新日期:2021-01-01 00:00:00
abstract::Magnetic resonance imaging (MRI) of the abdomen is a widely established imaging modality in the diagnostic workup of patients suffering from abdominal disorders. Small-bowel motility analyses using MRI have recently been introduced to provide functional information about the intestine not provided by morphological ana...
journal_title:Clinical physiology and functional imaging
pub_type: 临床试验,杂志文章
doi:10.1111/cpf.12124
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Differences in circulating bubble production have been described after exposures in altitude chambers between men and women. The present study was designed to examine gender differences in circulating bubble production after a dive. METHODS:Fifty-two men and 52 women performed the same dive profile (25 min t...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2009.00884.x
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:The assessment of temporal changes in systolic and diastolic regional left ventricle function by two-dimensional speckle tracking echocardiography (STE) after successful reperfusion therapy of acute myocardial infarction (AMI). METHODS:A total of 97 consecutive patients admitted with AMI and treated with succe...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12553
更新日期:2019-03-01 00:00:00
abstract::Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a rel...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2010.00947.x
更新日期:2010-09-01 00:00:00
abstract:AIMS:To investigate the association between glucose abnormalities and left ventricular (LV) function assessed by tissue Doppler imaging (TDI) in patients with previous history of myocardial infarction and without known diabetes mellitus. PATIENTS AND METHODS:In a cross-sectional study, 123 patients, aged 31-80 years, ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2007.00717.x
更新日期:2007-01-01 00:00:00
abstract::A brief Valsalva manoeuvre, lasting 2-3 s, performed by young healthy men during strength exercise reduces transmural pressure acting on intrathoracic arteries. In this study, we sought to verify this finding in older men. Twenty normotensive, prehypertensive and moderately hypertensive otherwise healthy men 46-69 yea...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12080
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:Notwithstanding recent progress on molecular mechanisms underlying heart failure with preserved ejection fraction (HFpEF), multiple pathophysiological aspects of this condition including the basis of anaemia and other haematological disorders remain unresolved. In this study, we sought to determine the rel...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12614
更新日期:2020-03-01 00:00:00
abstract::The objective of this randomized, double-masked, cross-over study was to compare the cardiovascular effects of two glaucoma formulations, ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel. Twenty-four young healthy subjects received for 2 weeks either twice daily 0.5% timolol solution or once daily 0....
journal_title:Clinical physiology and functional imaging
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1475-097x.2002.00430.x
更新日期:2002-07-01 00:00:00
abstract::Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies of patients with cerebrovascular disease have largely ignored the confounds associated with abnormal cerebral blood flow, vascular reactivity and neurovascular coupling. We studied BOLD fMRI activation and cerebrovascular reactivi...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12387
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:We investigated if image- and diagnostic quality in SPECT MPI could be maintained despite a reduced acquisition time adding Depth Dependent Resolution Recovery (DDRR) for image reconstruction. Images were compared with filtered back projection (FBP) and iterative reconstruction using Ordered Subsets Expect...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12354
更新日期:2017-11-01 00:00:00
abstract::The hypothesis that the Poincaré plot indexes of heart rate variability (HRV) detect dynamic changes after haemodialysis (HD) over the HRV in haemodynamically stable chronic renal failure (CRF) patients was examined. Minor axis (SD1), major axis (SD2) and the SD1/SD2 ratio were compared against standard HRV indexes in...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1046/j.1475-097x.2003.00466.x
更新日期:2003-03-01 00:00:00