Arterial concentration of 99mTc-sestamibi at rest, during peak exercise and after dipyridamole infusion.

Abstract:

:Tracers for myocardial perfusion imaging during stress should not only have high cardiac uptake but they should also have a fast blood clearance to prevent myocardial tracer uptake after the ischaemic stimulus. The present study characterize the early phase of the arterial (99m)Tc-sestamibi (MIBI) time-activity curve after venous bolus injection at rest, during peak exercise and after dipyridamole infusion. We included 11 patients undergoing angioplasty for one-vessel disease (rest study) and 20 patients evaluated for the detection of haemodynamic significant coronary stenoses by (99m)Tc-sestamibi single photon emission computed tomography (SPECT) using either bicycle exercise testing (10 patients) or standard dipyridamole testing (10 patients). Arterial blood samples of 1 ml were taken from the left femoral artery (rest study) or the right radial artery (exercise and dipyridamole studies) every 5 s during the first 5 min postinjection. In the exercise and the dipyridamole studies blood sampling were extended to include blood samples every 5 min 5-30 min postinjection. Peak MIBI concentration was lower and decrease in concentration slower after tracer injection during exercise than during dipyridamole stress testing. This may cause an underestimation of perfusion defects during exercise because of MIBI uptake after the ischaemic stimulus. The implications of the study not only refer to the choice of stress modality when using MIBI. This study also underlines the importance of considering early blood clearance in addition to regional myocardial tracerkinetic aspects such as myocardial extraction fraction when new tracers are introduced.

authors

Sand NP,Juelsgaard P,Rasmussen K,Flø C,Thuesen L,Bagger JP,Nielsen TT,Rehling M

doi

10.1111/j.1475-097X.2004.00570.x

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

394-7

issue

6

eissn

1475-0961

issn

1475-097X

pii

CPF570

journal_volume

24

pub_type

临床试验,杂志文章
  • Circulating norepinephrine and cerebrovascular control in conscious humans.

    abstract:BACKGROUND:Cerebral vasoconstriction without concurrent changes in systemic arterial blood pressure has been observed in both normal individuals and those with idiopathic orthostatic intolerance following several minutes of postural stress when circulating catecholamines are elevated. Therefore, we tested the hypothesi...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1475-0961.2003.00507.x

    authors: Kimmerly DS,Tutungi E,Wilson TD,Serrador JM,Gelb AW,Hughson RL,Shoemaker JK

    更新日期:2003-11-01 00:00:00

  • Effects of a Ginkgo biloba extract on forearm haemodynamics in healthy volunteers.

    abstract::The aim was to validate possible vasodilating effects of a Ginkgo biloba extract with a secondary aim of finding a pharmacodynamic signal relating to the active component of these extracts. We studied the effect of G. biloba extract on forearm haemodynamics in 16 healthy subjects (nine females, seven males) with a med...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1475-097x.2002.00445.x

    authors: Mehlsen J,Drabaek H,Wiinberg N,Winther K

    更新日期:2002-11-01 00:00:00

  • Cardiovascular effects of ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel.

    abstract::The objective of this randomized, double-masked, cross-over study was to compare the cardiovascular effects of two glaucoma formulations, ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel. Twenty-four young healthy subjects received for 2 weeks either twice daily 0.5% timolol solution or once daily 0....

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1475-097x.2002.00430.x

    authors: Niño J,Tahvanainen K,Uusitalo H,Turjanmaa V,Hutri-Kähönen N,Kaila T,Ropo A,Kuusela T,Kähönen M

    更新日期:2002-07-01 00:00:00

  • Neurovascular responses to sequential deep inspirations assessed via laser-Doppler perfusion changes in dorsal finger skin.

    abstract::A vasomotor reflex triggered by a rapid and deep inspiration causes arteriolar vasoconstriction and a transient decrease in skin blood flow in most people. This is the inspiratory gasp vascular response (IGVR). The most common site of its measurement has been on the palmar or plantar aspect of the digits and little is...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1046/j.1475-097x.2002.00404.x

    authors: Mayrovitz HN,Groseclose EE

    更新日期:2002-01-01 00:00:00

  • Texture analysis of ultrasound images is a sensitive method to follow-up muscle damage induced by eccentric exercise.

    abstract::The grey level of co-occurrence matrix (GLCM) is a texture analysis approach accounting for spatial distribution of the pixels from an image and can be a promising method for exercise-induced muscle damage (EIMD) studies. We followed up the time changes of two GLCM texture parameters and echo intensity (EI) on ultraso...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12441

    authors: Matta TTD,Pereira WCA,Radaelli R,Pinto RS,Oliveira LF

    更新日期:2018-05-01 00:00:00

  • Acute effects of resistance training on cytokines and osteoprotegerin in women with metabolic syndrome.

    abstract::Chronic inflammation has been identified as an important component of metabolic syndrome (MetS). Inhibition of the inflammatory mediator signals is a promising strategy against insulin resistance, atherosclerosis and other problems associated with MetS. Regular exercise decreases the components associated with MetS, i...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12004

    authors: Pereira GB,Tibana RA,Navalta J,Sousa NM,Córdova C,Souza VC,Nóbrega OT,Prestes J,Perez SE

    更新日期:2013-03-01 00:00:00

  • Detection of chronic rejection by quantitative ventilation scintigrams in lung-transplanted patients: a pilot study.

    abstract::The suspicion of chronic rejection [bronchiolithis obliterans syndrome (BOS)] is usually based on deteriorating forced expired volume in 1 s. It is however, desirable to develop more sensitive methods as increased anti-inflammatory therapy is thought to stop progression of the rejection. The aim of the present study w...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2005.00609.x

    authors: Johansson A,Moonen M,Enocson A,Mårtensson G,Bake B

    更新日期:2005-05-01 00:00:00

  • Clinical applications of diffusion-weighted magnetic resonance imaging in diagnosis of renal lesions - a systematic review.

    abstract::Diffusion-weighted magnetic resonance imaging (DW-MRI) is an established technique to detect the changes of the diffusion of water in biological tissues and reflect the pathophysiological process on the molecular level. It is a promising non-invasive imaging modality in detection of microstructural and functional chan...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1111/cpf.12313

    authors: Ye J,Kumar BS,Li XB,Li HM,Zhou YW,Liu LQ

    更新日期:2017-09-01 00:00:00

  • The influence of athletic status on maximal and rapid isometric torque characteristics and postural balance performance in Division I female soccer athletes and non-athlete controls.

    abstract::The purpose of this study was to examine the effectiveness of maximal and rapid isometric torque characteristics of the hip extensor muscles and postural balance performance to discriminate between female collegiate soccer athletes and non-athlete controls. Ten athletes (mean ± SE: age = 19·20 ± 0·36 year; mass = 62·2...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12167

    authors: Palmer TB,Hawkey MJ,Thiele RM,Conchola EC,Adams BM,Akehi K,Smith DB,Thompson BJ

    更新日期:2015-07-01 00:00:00

  • Diagnostic evaluation of planar and tomographic ventilation/perfusion lung images in patients with suspected pulmonary emboli.

    abstract::Planar lung ventilation/perfusion scintigraphy (V/P(PLANAR)) is a standard method for diagnosis of pulmonary embolism (PE). The goals of this study were to test whether the diagnostic information of ventilation/perfusion tomography (V/P(SPET)) applied in clinical routine might enhance information compared with V/P(PLA...

    journal_title:Clinical physiology and functional imaging

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1475-097X.2004.00546.x

    authors: Bajc M,Olsson CG,Olsson B,Palmer J,Jonson B

    更新日期:2004-09-01 00:00:00

  • Impact of abnormal cerebrovascular reactivity on BOLD fMRI: a preliminary investigation of moyamoya disease.

    abstract::Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies of patients with cerebrovascular disease have largely ignored the confounds associated with abnormal cerebral blood flow, vascular reactivity and neurovascular coupling. We studied BOLD fMRI activation and cerebrovascular reactivi...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12387

    authors: Mazerolle EL,Ma Y,Sinclair D,Pike GB

    更新日期:2018-01-01 00:00:00

  • Subendocardial versus transmural ischaemia in myocardial perfusion SPECT--a Monte Carlo study.

    abstract:UNLABELLED:Myocardial perfusion imaging with single-photon emission computed tomography (SPECT) is useful for the evaluation of patients with known or suspected coronary artery disease. Parameters of interest are the reduction in the blood perfusion (severity) and the lesion volume (extent). The aim of this study was t...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2006.00705.x

    authors: Bartosik J,El-Ali HH,Nilsson U,Dahlström J,Edenbrandt L,Ljungberg M

    更新日期:2006-11-01 00:00:00

  • An assessment of pulmonary function testing and ventilatory kinematics by optoelectronic plethysmography.

    abstract::New advances in computer processing and imaging have allowed the development of innovative techniques to assess lung function. A promising methodology is optoelectronic plethysmography (OEP). OEP evaluates ventilatory kinematics through the use of infrared imaging. Markers are placed, and images read on the chest, bac...

    journal_title:Clinical physiology and functional imaging

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1475-097X.2011.01028.x

    authors: Layton AM,Garber CE,Basner RC,Bartels MN

    更新日期:2011-09-01 00:00:00

  • Gender aspects on exercise-induced ECG changes in relation to scintigraphic evidence of myocardial ischaemia.

    abstract:BACKGROUND:This retrospective study aimed to determine the diagnostic performance of exercise-induced ST response in relation to findings by myocardial perfusion single photon emission computed tomography (MPS), with focus on gender differences, in patients with suspected or established stable ischemic heart disease. ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12483

    authors: Akil S,Hedén B,Pahlm O,Carlsson M,Arheden H,Engblom H

    更新日期:2018-09-01 00:00:00

  • Brain glucose and lactate levels during ventilator-induced hypo- and hypercapnia.

    abstract:OBJECTIVE:Levels of glucose and lactate were measured in the brain by means of microdialysis in order to evaluate the effects of ventilator-induced hypocapnia and hypercapnia on brain metabolism in healthy non-brain-traumatized animals. DESIGN AND SETTING:Prospective animal study in a university laboratory. SUBJECTS:...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2004.00557.x

    authors: van Hulst RA,Lameris TW,Haitsma JJ,Klein J,Lachmann B

    更新日期:2004-07-01 00:00:00

  • Nicotine effects on exercise performance and physiological responses in nicotine-naïve individuals: a systematic review.

    abstract::The purpose of this systematic review was to evaluate the effects of smokeless forms of nicotine on physiological responses and exercise performance. Methodology and reporting were based on the PRISMA statement. The intervention was defined as any product containing nicotine that did not require smoking. Searches were...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1111/cpf.12443

    authors: Johnston R,Doma K,Crowe M

    更新日期:2018-07-01 00:00:00

  • Vascular ultrasound for monitoring of inflammatory activity in Takayasu arteritis.

    abstract:BACKGROUND:Takayasu arteritis (TA) is a rare large-vessel arteritis that primarily affects the aorta and its major branches. The aim of this study was to describe the value of high frequency ultrasound for monitoring of inflammatory activity. METHODS:Twenty-five patients, range 11-71 years, diagnosed with TA were inve...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12601

    authors: Svensson C,Eriksson P,Zachrisson H

    更新日期:2020-01-01 00:00:00

  • Haemostatic and inflammatory responses to blood flow-restricted exercise in patients with ischaemic heart disease: a pilot study.

    abstract::Low-intensity resistance exercise can effectively induce muscle hypertrophy and increases in strength when combined with moderate blood flow restriction (BFR). As this type of exercise does not require lifting heavy weights, it might be a feasible method of cardiac rehabilitation, in which resistance exercise has been...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1475-097X.2012.01158.x

    authors: Madarame H,Kurano M,Fukumura K,Fukuda T,Nakajima T

    更新日期:2013-01-01 00:00:00

  • Telemetry-derived heart rate variability responses to a physical stressor.

    abstract::Analysis of heart rate variability (HRV) responses to an orthostatic challenge can be used to investigate autonomic control of heart rate, an index of cardiovascular function. HRV is typically assessed using the electrocardiogram (ECG), which can be impractical for use with large population-based studies. PURPOSE:To ...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12320

    authors: Montaño A,Brown F,Credeur DP,Williams MA,Stoner L

    更新日期:2017-07-01 00:00:00

  • Exercise intensity and muscle hypertrophy in blood flow-restricted limbs and non-restricted muscles: a brief review.

    abstract::Although evidence for high-intensity resistance training-induced muscle hypertrophy has accumulated over the last several decades, the basic concept of the training can be traced back to ancient Greece: Milo of Croton lifted a bull-calf daily until it was fully grown, which would be known today as progressive overload...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章,评审

    doi:10.1111/j.1475-097X.2012.01126.x

    authors: Abe T,Loenneke JP,Fahs CA,Rossow LM,Thiebaud RS,Bemben MG

    更新日期:2012-07-01 00:00:00

  • Nasal symptoms, airway obstruction and disease severity in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by inflammation of the lung in association with airflow obstruction. There is increasing evidence of upper airway involvement in COPD and we have reported that this nasal inflammation is proportional to that in the lung. Given recognized relations...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2006.00683.x

    authors: Hurst JR,Kuchai R,Michael P,Perera WR,Wilkinson TM,Wedzicha JA

    更新日期:2006-07-01 00:00:00

  • Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary microvascular function: An iPOWER substudy.

    abstract:BACKGROUND:A significant number of women with angina and no obstructive coronary artery disease (CAD; <50% stenosis) have coronary microvascular dysfunction (CMD) which carries an adverse cardiovascular prognosis. Coronary microvascular function can be evaluated by transthoracic Doppler echocardiography (TTDE) as a cor...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12669

    authors: Bechsgaard DF,Hove JD,Michelsen MM,Mygind ND,Pena A,Hansen PR,Hansen HS,Kastrup J,Høst N,Gustafsson I,Prescott E

    更新日期:2021-01-01 00:00:00

  • Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

    abstract::Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a rel...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2010.00947.x

    authors: Wirestam R,Lindgren E,van Westen D,Bloch KM,Ståhlberg F,Knutsson L

    更新日期:2010-09-01 00:00:00

  • Signal-morphology impedance cardiography during incremental cardiopulmonary exercise testing in pulmonary arterial hypertension.

    abstract:BACKGROUND:Haemodynamic responses to exercise are related to physical impairment and worse prognosis in patients with pulmonary arterial hypertension (PAH). It is clinically relevant, therefore, to investigate the practical usefulness of non-invasive methods of monitoring exercise haemodynamics in this patient populati...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2012.01135.x

    authors: Ferreira EM,Ota-Arakaki JS,Barbosa PB,Siqueira AC,Bravo DM,Kapins CE,Silva CM,Nery LE,Neder JA

    更新日期:2012-09-01 00:00:00

  • Acute effects of proprioceptive neuromuscular facilitation and static stretching on maximal voluntary contraction and muscle electromyographical activity in indoor soccer players.

    abstract::The aim was to investigate and compare the effects of proprioceptive neuromuscular facilitation (PNF) and static stretching (SS) on maximal voluntary contraction (MVC) and muscle activation in indoor soccer players. Thirty-three young adult men were divided into two groups: (i) sedentary and (ii) trained. Each group c...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12047

    authors: Reis Eda F,Pereira GB,de Sousa NM,Tibana RA,Silva MF,Araujo M,Gomes I,Prestes J

    更新日期:2013-11-01 00:00:00

  • Seven-site versus three-site method of body composition using BodyMetrix ultrasound compared to dual-energy X-ray absorptiometry.

    abstract::Obesity is a steadily growing epidemic affecting all segments of the population including college-aged students. The weight gain that is evidenced amid the transitional stage of college years increases the risks associated with cardiovascular and metabolic diseases. The BodyMetrix® BX-2000 (ULTRA) using a seven-site m...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12307

    authors: Baranauskas MN,Johnson KE,Juvancic-Heltzel JA,Kappler RM,Richardson L,Jamieson S,Otterstetter R

    更新日期:2017-05-01 00:00:00

  • Computer-assisted calculation of myocardial infarct size shortens the evaluation time of contrast-enhanced cardiac MRI.

    abstract:BACKGROUND:Delayed enhancement magnetic resonance imaging depicts scar in the left ventricle which can be quantitatively measured. Manual segmentation and scar determination is time consuming. The purpose of this study was to evaluate a software for infarct quantification, to compare with manual scar determination, and...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2007.00765.x

    authors: Rosendahl L,Blomstrand P,Heiberg E,Ohlsson J,Björklund PG,Ahlander BM,Engvall J

    更新日期:2008-01-01 00:00:00

  • Comparison of hand-to-hand bioimpedance and anthropometry equations versus dual-energy X-ray absorptiometry for the assessment of body fat percentage in 17-18-year-old conscripts.

    abstract::In the present study, hand-to-hand bioelectrical impedance analysis (BIA), skinfold (SKF) thickness and height-weight (body mass index, BMI)-based equations and dual-energy X-ray absorptiometry (DEXA), as a criterion method, were compared with each other in the assessment of body fat percentage (BF%) in 17-18-year-old...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/j.1475-097X.2004.00534.x

    authors: Lintsi M,Kaarma H,Kull I

    更新日期:2004-03-01 00:00:00

  • Comparison of air-displacement plethysmography results using predicted and measured lung volumes over a protracted period of time.

    abstract:BACKGROUND:Air-displacement plethysmography (ADP) systems can either measure or predict lung volume (LV) in their test trials. The repeatability of the predicted and the measured value is an important factor in the accuracy of the final test result. OBJECTIVE:Compare the variability and accuracy of ADP tests using pre...

    journal_title:Clinical physiology and functional imaging

    pub_type: 历史文章,杂志文章

    doi:10.1111/cpf.12129

    authors: Otterstetter R,Johnson KE,Kiger DL,Agnor SE,Kappler RM,Reinking M,Tessmer K

    更新日期:2015-09-01 00:00:00

  • Assessment of body composition by dual-energy X-ray absorptiometry, bioimpedance analysis and anthropometrics in children: the Physical Activity and Nutrition in Children study.

    abstract:OBJECTIVE AND METHODS:We compared InBody720 segmental multifrequency bioimpedance analysis (SMF-BIA) with Lunar Prodigy Advance dual-energy X-ray absorptiometry (DXA) in assessment of body composition among 178 predominantly prepubertal children. Segmental agreement analysis of body compartments was carried out, and in...

    journal_title:Clinical physiology and functional imaging

    pub_type: 杂志文章

    doi:10.1111/cpf.12118

    authors: Tompuri TT,Lakka TA,Hakulinen M,Lindi V,Laaksonen DE,Kilpeläinen TO,Jääskeläinen J,Lakka HM,Laitinen T

    更新日期:2015-01-01 00:00:00