Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay.

Abstract:

AIM:To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. METHODS:A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy: normal control group (25 patients) and gastric cancer group (29 patients). Both groups were further divided into H pylori (+) and H pylori (-) subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique (HelicoBlot 2.0, Genelabs Diagnostics, Singapore). RESULTS:The positive rate of the immunoblotting test was as high as 88.9% in the H pylori (-) gastric cancer group and only 14.3% in the H pylori (-) normal control group with a statistically significant difference. CONCLUSION:The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.

journal_name

World J Gastroenterol

authors

Yang KC,Chu A,Liao CS,Lin YM,Wang GM

doi

10.3748/wjg.v12.i43.7029

subject

Has Abstract

pub_date

2006-11-21 00:00:00

pages

7029-32

issue

43

eissn

1007-9327

issn

2219-2840

journal_volume

12

pub_type

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