Abstract：
:An intrathoracic pressure regulator (ITPR) is a device that can be added to the external end of a tracheal tube to create controlled negative airway pressure between positive pressure ventilations. The resulting downward bias of the airway pressure baseline promotes increased venous return and enhanced circulation during CPR and also during hypovolemic shock. In the present study, we exercised a mathematical model of the human cardiopulmonary system, including airways, lungs, a four chambered heart, great vessels, peripheral vascular beds, and the biomechanics of chest compression and recoil, to determine the relationship between systemic perfusion pressure during CPR and the value of baseline negative airway pressure in an ITPR. Perfusion pressure increases approximately 50% as baseline airway pressure falls from zero to -10 cm H2O. Thereafter perfusion pressure plateaus. Negative bias pressures exceeding -10 cm H2O are not needed in ITPR-CPR.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Babbs CF,Yannopoulos Ddoi
10.1016/j.resuscitation.2006.01.022subject
Has Abstractpub_date
2006-12-01 00:00:00pages
365-8issue
3eissn
0300-9572issn
1873-1570pii
S0300-9572(06)00213-9journal_volume
71pub_type
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