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Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study.

Abstract：

BACKGROUND:For out-of-hospital cardiac arrest (OHCA) to be predicted and prevented, it is imperative the healthcare system has access to those vulnerable before the event occurs. We aimed to determine the extent of contact to the healthcare system before OHCA. METHODS:All patients in Denmark with a registered OHCA June 1, 2001-December 31, 2005 were matched on age and sex with 10 random controls from the entire Danish population. We estimated the association with OHCA by conditional logistic regression analyses, and we determined the proportion of patients in contact with the healthcare system before OHCA from hospital admissions or claimed prescriptions. RESULTS:We identified 12,089 patients with an OHCA. Of these, 62% (7548) and 85% (10,312) were in contact with the healthcare system up to 30 days and 1 year before OHCA, respectively. Association with OHCA up to 30 days before the event pertained to myocardial infarction (odds ratio (OR)=6.4, 95% confidence interval (CI): 4.7-8.6)); heart failure (OR=5.1, CI: 4.1-6.3); ischemic heart disease (OR=1.9, CI: 1.6-2.4); and cardiac dysrhythmia (OR=1.8, CI: 1.4-2.2). Concomitant pharmacotherapy up to 30 days before OHCA with the strongest association was: corticosteroids (systemic) (OR=2.7, CI: 2.5-3.0), bronchial dilators (OR=2.5, CI: 2.3-2.7), anti-psychotic medication (OR=2.1, CI: 1.9-2.3), and digoxin (OR=2.1, CI: 2.0-2.3). Similar results were found for associations up to 1 year before OHCA. CONCLUSION:Contrary to general belief, the majority of OHCA patients are in contact with the healthcare system shortly before OHCA.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Weeke P,Folke F,Gislason GH,Lippert FK,Olesen JB,Andersson C,Fosbøl EL,Charlot MG,Kanters JK,Poulsen HE,Nielsen SL,Køber L,Torp-Pedersen C

doi

10.1016/j.resuscitation.2010.06.025

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1657-63

issue

12

eissn

0300-9572

issn

1873-1570

pii

S0300-9572(10)00374-6

journal_volume

81

pub_type

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