Cell therapy in shock: a reasonable prospect or a lost cause?

Abstract:

:Almost any insult to the body can set in motion the sequence of physiologic and biochemical changes leading to shock. In the absence of effective treatment widespread disruption of the body's biological mechanisms inevitably follows. This review will describe some of cellular and subcellular disturbances associated with the shock syndrome, the persistence of which lead to (multiple) organ failure. Current views as to the mechanisms of these disturbances will be outlined with particular reference to hypovolemic and septic shock. Finally, an indication will be given of the relevant therapeutic implications, now and in the future.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Ledingham IM

doi

10.1016/0300-9572(89)90055-5

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

S85-99

eissn

0300-9572

issn

1873-1570

pii

0300-9572(89)90055-5

journal_volume

18 Suppl

pub_type

杂志文章,评审
  • Performance of coronary angiography and intervention after out of hospital cardiac arrest.

    abstract:AIMS:Out of Hospital Cardiac Arrest (OHCA) is frequently attributed to coronary artery disease, thus guidelines recommend coronary angiography (CAG) for survivors of OHCA. However, the real-world application of these guidelines is unknown, and we sought to evaluate CAG practices in the contemporary OHCA population. ME...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2018.10.007

    authors: Kearney KE,Maynard C,Smith B,Rea TD,Beatty A,McCabe JM

    更新日期:2018-12-01 00:00:00

  • From agonal to output: An ECG history of a successful pre-hospital thoracotomy.

    abstract::This case report describes the first reported successful UK pre-hospital thoracotomy performed outside the London HEMS system. Continuous ECG monitoring during the procedure has allowed presentation of sequential ECGs recorded during the procedure. ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2007.05.026

    authors: Deakin CD

    更新日期:2007-12-01 00:00:00

  • Incidence and factors associated with cardiac arrest complicating emergency airway management.

    abstract:OBJECTIVE:Cardiac arrest (CA) is a rare but recognized complication of emergency airway management. Our aim was to measure the incidence of peri-intubation CA during emergency intubation and identify factors associated with this complication. METHODS:Retrospective cohort study of emergency endotracheal intubations per...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2013.07.022

    authors: Heffner AC,Swords DS,Neale MN,Jones AE

    更新日期:2013-11-01 00:00:00

  • Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat.

    abstract::Serum lactic acidosis is characterized by a pH less than 7.25 and lactate greater than 5 mEq. Although sodium bicarbonate (NaHCO3) is standard treatment for this condition, clinical and experimental studies suggest that high doses of NaHCO3 may be ineffectual or even detrimental to brain, cardiovascular, and respirato...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/0300-9572(88)90015-9

    authors: Dimlich RV,Biros MH,Widman DW,Kaplan J

    更新日期:1988-01-01 00:00:00

  • Drowning: a review of epidemiology, pathophysiology, treatment and prevention.

    abstract::Although often preventable, drowning remains a leading cause of accidental death, especially in children. New definitions classify drowning as the process of experiencing respiratory impairment from submersion or immersion in a liquid. The key pathophysiological feature in drowning is hypoxia. Accurate neurological pr...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/j.resuscitation.2004.06.007

    authors: Salomez F,Vincent JL

    更新日期:2004-12-01 00:00:00

  • A pragmatic checklist to identify pediatric ICU patients at risk for cardiac arrest or code bell activation.

    abstract:BACKGROUND:In-hospital cardiac arrest is a rare event associated with significant morbidity and mortality. The ability to identify the ICU patients at risk for cardiac arrest could allow the clinical team to prepare staff and equipment in anticipation. METHODS:This pilot study was completed at a large tertiary care pe...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2015.11.017

    authors: Niles DE,Dewan M,Zebuhr C,Wolfe H,Bonafide CP,Sutton RM,DiLiberto MA,Boyle L,Napolitano N,Morgan RW,Stinson H,Leffelman J,Nishisaki A,Berg RA,Nadkarni VM

    更新日期:2016-02-01 00:00:00

  • A comparison of European Trauma Registries. The first report from the EuroTARN Group.

    abstract:UNLABELLED:Trauma management systems have grown in response to regional variations in trauma population, geographical conditions and the provisions of care. National Trauma Registries are being established to improve patient outcomes. However international comparisons could provide the potential to record regional perf...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2007.06.023

    authors: Edwards A,Di Bartolomeo S,Chieregato A,Coats T,Della Corte F,Giannoudis P,Gomes E,Groenborg H,Lefering R,Leppaniemi A,Lossius HM,Ortenwal P,Roise O,Rusnak M,Sturms L,Smith M,Bondegaard Thomsen A,Willett K,Woodford M,

    更新日期:2007-11-01 00:00:00

  • Effect of mattress deflection on CPR quality assessment for older children and adolescents.

    abstract:UNLABELLED:Appropriate chest compression (CC) depth is associated with improved CPR outcome. CCs provided in hospital are often conducted on a compliant mattress. The objective was to quantify the effect of mattress compression on the assessment of CPR quality in children. METHODS:A force and deflection sensor (FDS) w...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2009.02.006

    authors: Nishisaki A,Nysaether J,Sutton R,Maltese M,Niles D,Donoghue A,Bishnoi R,Helfaer M,Perkins GD,Berg R,Arbogast K,Nadkarni V

    更新日期:2009-05-01 00:00:00

  • Work factors associated with return to work in out-of-hospital cardiac arrest survivors.

    abstract:INTRODUCTION:Although the survival rate after out-of-hospital cardiac arrest (OHCA) has increased over time, little is known about the return to work of OHCA survivors. We aim to evaluate prevalence and factors associated with return to work (RTW) in OHCA survivors. PATIENTS AND METHODS:All consecutive OHCA survivors ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2018.05.021

    authors: Descatha A,Dumas F,Bougouin W,Cariou A,Geri G

    更新日期:2018-07-01 00:00:00

  • Use of advanced life support skills.

    abstract:BACKGROUND:The Advanced Life Support (ALS) Provider Course trains healthcare professionals in a standardised approach to the management of a cardiac arrest. In the setting of limited resources for healthcare training, it is important that courses are fit for purpose in addressing the needs of both the individual and he...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/s0300-9572(03)00101-1

    authors: Hulme J,Perkins GD,Baldock C,MacNamara A

    更新日期:2003-07-01 00:00:00

  • Mortality in patients resuscitated from out-of-hospital cardiac arrest based on automated blood cell count and neutrophil lymphocyte ratio at admission.

    abstract:INTRODUCTION:The neutrophil lymphocyte ratio(NLR) is a marker of systemic inflammation. We hypothesized that admission NLR is related to mortality and that epinephrine application during resuscitation influences NLR in patients after successful resuscitation from out of hospital cardiac arrest (OHCA). METHODS:This ret...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2017.05.006

    authors: Weiser C,Schwameis M,Sterz F,Herkner H,Lang IM,Schwarzinger I,Spiel AO

    更新日期:2017-07-01 00:00:00

  • Treatment of calcium channel blocker intoxication with insulin infusion: case report and literature review.

    abstract::We present a case report of successful treatment of shock induced by the calcium channel blocker (CCB) diltiazem. A 75-year-old woman took a combination of tablets, including diltiazem. Soon after arrival, she developed haemodynamic shock which persisted despite treatment with fluids, dopamine, dobutamine, norepinephr...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-9572(03)00026-1

    authors: Marques M,Gomes E,de Oliveira J

    更新日期:2003-05-01 00:00:00

  • A randomized controlled trial of chest compression only CPR for older adults-a pilot study.

    abstract:UNLABELLED:Older people are trained infrequently in cardiopulmonary resuscitation (CPR), yet are more likely to witness a cardiac arrest. Older people who are CPR trained perform CPR when witnessing a cardiac arrest. OBJECTIVE:To assess whether elderly adults (>55 years) who receive chest-compression only cardiopulmon...

    journal_title:Resuscitation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0300-9572(03)00123-0

    authors: Swor R,Compton S,Vining F,Ososky Farr L,Kokko S,Pascual R,Jackson RE

    更新日期:2003-08-01 00:00:00

  • A new positive end-expiratory pressure valve for manually operated artificial ventilation.

    abstract::The application of positive end-expiratory pressure (PEEP) as part of artificial ventilation is currently considered a basic provision to provide adequate treatment of critically ill patients in intensive care units. Hitherto only the application of intermittent positive pressure ventilation (IPPV) with an end-expirat...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/0300-9572(78)90030-8

    authors: Dick W,Milewski P,Lotz P,Ahnefeld FW

    更新日期:1978-01-01 00:00:00

  • Impact of transport to critical care medical centers on outcomes after out-of-hospital cardiac arrest.

    abstract:BACKGROUND:Post-resuscitation care has emerged as an important predictor of survival from out-of-hospital cardiac arrest (OHCA). In Japan, selected hospitals are certified as Critical Care Medical Centers (CCMCs) based on their ability and expertise. HYPOTHESIS:Outcome after OHCA is better in patients transported to a...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2010.02.008

    authors: Kajino K,Iwami T,Daya M,Nishiuchi T,Hayashi Y,Kitamura T,Irisawa T,Sakai T,Kuwagata Y,Hiraide A,Kishi M,Yamayoshi S

    更新日期:2010-05-01 00:00:00

  • The effect of the number and level of emergency medical technicians on patient outcomes following out of hospital cardiac arrest in Taipei.

    abstract:AIM:The effect of the number and level of on-scene emergency medical technicians (EMTs) on the outcomes of patients with out-of-hospital cardiac arrest (OHCA) remains unclear. We aimed to test the association between the number and level of EMTs and the outcomes of patients with OHCA. METHODS:We analysed Utstein-based...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2017.11.048

    authors: Sun JT,Chiang WC,Hsieh MJ,Huang EP,Yang WS,Chien YC,Wang YC,Lee BC,Sim SS,Tsai KC,Ma MH,Chen LW

    更新日期:2018-01-01 00:00:00

  • Is external defibrillation an electric threat for bystanders?

    abstract:BACKGROUND:Safety precautions during defibrillation and cardioversion are generally taken very seriously. The actual hazard for bystanders and rescuers, however, has rarely been investigated. Recently, continuing chest compressions during defibrillation has been suggested to improve outcome from cardiac arrest. This ar...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/j.resuscitation.2009.01.002

    authors: Hoke RS,Heinroth K,Trappe HJ,Werdan K

    更新日期:2009-04-01 00:00:00

  • Causes and prognosis of cardiac arrest in a population admitted to a general hospital; a diagnostic and therapeutic problem.

    abstract:BACKGROUND:The purpose of this study was to determine the causes and the prognosis of consecutive patients resuscitated from cardiac arrest occurring in a general hospital. We assessed 28 females and 94 males (aged 13-82 years) who were resuscitated from cardiac arrest not attributable to acute myocardial infarction. V...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/s0300-9572(03)00154-0

    authors: Brembilla-Perrot B,Miljoen H,Houriez P,Beurrier D,Nippert M,Vançon AC,de la Chaise AT,Louis P,Mock L,Sadoul N,Andronache M

    更新日期:2003-09-01 00:00:00

  • Out-of-hospital thrombolysis during cardiopulmonary resuscitation in patients with high likelihood of ST-elevation myocardial infarction.

    abstract::Up to 90% of cardiac arrests are due to acute myocardial infarction or severe myocardial ischaemia. Thrombolysis is an effective treatment for ST-elevation myocardial infarction (STEMI), but there is no evidence or guideline to put forward a thrombolysis strategy during cardiopulmonary resuscitation (CPR). In two phys...

    journal_title:Resuscitation

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.resuscitation.2007.07.012

    authors: Arntz HR,Wenzel V,Dissmann R,Marschalk A,Breckwoldt J,Müller D

    更新日期:2008-02-01 00:00:00

  • An international collaborative clinical study mechanism for resuscitation research.

    abstract::Recent experimental and clinical studies of cardiac arrest, suggesting a brain damage ameliorating effect of thiopental loading, stimulated the development of an international randomized clinical trial of brain resuscitation. Twelve collaborating hospitals in 9 countries are testing the efficacy of post-cardiac arrest...

    journal_title:Resuscitation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0300-9572(82)90022-3

    authors: Abramson NS,Safar P,Detre K,Kelsey S,Reinmuth O,Snyder J

    更新日期:1982-06-01 00:00:00

  • The cardiac arrest survival score: A predictive algorithm for in-hospital mortality after out-of-hospital cardiac arrest.

    abstract:BACKGROUND:Out-of-hospital cardiac arrest (OHCA) is associated with high mortality. Current methods for predicting mortality post-arrest require data unavailable at the time of initial medical contact. We created and validated a risk prediction model for patients experiencing OHCA who achieved return of spontaneous cir...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2019.09.009

    authors: Balan P,Hsi B,Thangam M,Zhao Y,Monlezun D,Arain S,Charitakis K,Dhoble A,Johnson N,Anderson HV,Persse D,Warner M,Ostermayer D,Prater S,Wang H,Doshi P

    更新日期:2019-11-01 00:00:00

  • The performance of the National Early Warning Score and National Early Warning Score 2 in hospitalised patients infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

    abstract:INTRODUCTION:Since the introduction of the UK's National Early Warning Score (NEWS) and its modification, NEWS2, coronavirus disease 2019 (COVID-19), has caused a worldwide pandemic. NEWS and NEWS2 have good predictive abilities in patients with other infections and sepsis, however there is little evidence of their per...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2020.10.039

    authors: Kostakis I,Smith GB,Prytherch D,Meredith P,Price C,Chauhan A,Portsmouth Academic ConsortIum For Investigating COVID-19 (PACIFIC-19).

    更新日期:2020-11-08 00:00:00

  • San Antonio Vasopressin in Shock Symposium report.

    abstract::The San Antonio Vasopressin Symposium reviewed substantial accumulated data concerning vasopressin in haemorrhagic, septic, and cardiac arrest shock conditions and found that there is considerable evidence to support the use of vasopressin in overcoming vasopressin deficiency or insufficiency. The value of vasopressin...

    journal_title:Resuscitation

    pub_type:

    doi:10.1016/j.resuscitation.2010.06.005

    authors: Cohn SM,Blackbourne LH,Landry DW,Proctor KG,Walley KR,Wenzel V

    更新日期:2010-11-01 00:00:00

  • Delays and errors in cardiopulmonary resuscitation and defibrillation by pediatric residents during simulated cardiopulmonary arrests.

    abstract:BACKGROUND:The quality of life support delivered during cardiopulmonary resuscitation affects outcomes. However, little data exist regarding the quality of resuscitation delivered to children and factors associated with adherence to American Heart Association (AHA) resuscitation guidelines. PARTICIPANTS:Pediatric resi...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2009.03.020

    authors: Hunt EA,Vera K,Diener-West M,Haggerty JA,Nelson KL,Shaffner DH,Pronovost PJ

    更新日期:2009-07-01 00:00:00

  • Elimination of glutamate using CRRT for 72 h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial.

    abstract:AIM:Glutamine and glutamate are major mediators of secondary brain cell death during post-cardiac arrest syndrome. As there is an equilibrium between brain tissue and plasma concentrations of glutamine and glutamate, their elimination from systemic circulation by extracorporeal blood purification may ultimately lead to...

    journal_title:Resuscitation

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.resuscitation.2019.09.020

    authors: Nee J,Jörres A,Krannich A,Leithner C,Schroeder T,Munk AL,Enghard P,Moore C,Steppan S,Storm C

    更新日期:2019-11-01 00:00:00

  • Effects of dispatcher-initiated telephone cardiopulmonary resuscitation after out-of-hospital cardiac arrest: A nationwide, population-based, cohort study.

    abstract:AIM:This study aimed to investigate the effects of dispatcher-initiated telephone cardiopulmonary resuscitation (TCPR) in Japan using a nationwide population-based registry. METHODS:Adult Japanese patients with out-of-hospital cardiac arrest (OHCA; n = 582,483, age ≥18 years) were selected from a nationwide Utstein-st...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2019.08.031

    authors: Shibahashi K,Ishida T,Kuwahara Y,Sugiyama K,Hamabe Y

    更新日期:2019-11-01 00:00:00

  • Determination of heart rate in the baby at birth.

    abstract::The International Liaison Committee on Resuscitation (ILCOR) publishes guidelines on neonatal resuscitation, which are evidence-based where possible. Initial assessment of heart rate, breathing and colour is an essential part of newborn resuscitation and the guidelines state that heart rate may be assessed using a ste...

    journal_title:Resuscitation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.resuscitation.2003.10.002

    authors: Owen CJ,Wyllie JP

    更新日期:2004-02-01 00:00:00

  • Optimal in-hospital defibrillator placement.

    abstract:AIMS:To determine if mathematical optimization of in-hospital defibrillator placements can reduce in-hospital cardiac arrest-to-defibrillator distance compared to existing defibrillators in a single hospital. METHODS:We identified treated IHCAs and defibrillator placements in St. Michael's Hospital in Toronto, Canada ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2020.03.018

    authors: Leung KHB,Sun CLF,Yang M,Allan KS,Wong N,Chan TCY

    更新日期:2020-06-01 00:00:00

  • Rapid cardiac ultrasound of inpatients suffering PEA arrest performed by nonexpert sonographers.

    abstract:UNLABELLED:Cardiac arrest presenting as pulseless electrical activity (PEA) currently has a very low survival rate. Many of the conditions underlying PEA (cardiac tamponade, hypovolemia, and pulmonary embolus) are associated with specific cardiac ultrasound findings. The aim of this study was to evaluate a rapid cardia...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2005.04.007

    authors: Niendorff DF,Rassias AJ,Palac R,Beach ML,Costa S,Greenberg M

    更新日期:2005-10-01 00:00:00

  • Results from Austria's nationwide public access defibrillation (ANPAD) programme collected over 2 years.

    abstract:AIM OF THE STUDY:To analyse 2 years of experience after introducing automated external defibrillators (AED) all over Austria. MATERIALS AND METHODS:This observational study evaluated the number of privately purchased devices and the rate of local bystander-triggered AED deployments from November 2002 to December 2004....

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2007.11.019

    authors: Fleischhackl R,Roessler B,Domanovits H,Singer F,Fleischhackl S,Foitik G,Czech G,Mittlboeck M,Malzer R,Eisenburger P,Hoerauf K

    更新日期:2008-05-01 00:00:00