Simultaneous, phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody enhances antiangiogenic effects in vivo.

abstract：:Newly diagnosed immune thrombocytopenia occurs in 3-5/100 000 children < 14 y per year. Bleeding symptoms do not correlate with platelet count. Diagnostic approach includes history, clinical examination and analysis of blood count with blood smear by experienced hematologist. Additional investigations are only necessa...

journal_title：Klinische Padiatrie

authors： Eberl W,Dickerhoff R,Pediatric Committee of Society of Thrombosis and Hemostasis Research.

更新日期：2012-04-01 00:00:00

abstract：:Glutaracidemia/glutaraciduria type I is an acute or subacute neuropathic disorder of infancy or early childhood. The following symptoms characterize the clinical course: macrocephalus present at birth, cerebral atrophy revealed by CT or MRI scans, most striking in the frontal and temporal lobes, choreoathetosis and dy...

journal_title：Klinische Padiatrie

authors： Voll R,Hoffmann GF,Lipinski CG,Trefz FK,Weisser J

更新日期：1993-03-01 00:00:00

abstract：:Since reliable diagnosis of cystic fibrosis (CF) is still difficult, the occurrence of serum markers CA 19-9, CA 50 and elastase 1 was analysed. Serum levels of CA 19-9, CA 50, CA 125 and elastase 1 were estimated in 54 CF patients as well as in a control group of 66 children of similar age suffering from various othe...

journal_title：Klinische Padiatrie

authors： Uhlenbruck G,Scheuring U,Dienst C,Kaiser D,Roth B,Skopnik H

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Transumbilical laparoscopic-assisted appendectomy (TULAA) is fast and cost-effective since no endoloops, staplers or wound protection devices are used. We analyzed the effects of TULAA as first approach for perforated (PA) and non-perforated (NPA) appendicitis in children. PATIENTS:We performed a retrospect...

journal_title：Klinische Padiatrie

authors： Dübbers M,Nikolaou E,Fuchs H,Fischer J,Alakus H,Leers J,Bruns C,Cernaianu G

更新日期：2018-07-01 00:00:00

abstract：:The investigation of Immunoglobulins-and Total protein concentrations in saliva of healthy children shows an agreement with literature, a maturation in individual development of the saliva-producing organs in the mouth. ...

journal_title：Klinische Padiatrie

authors： Tympner KD,Dörfler S

更新日期：1980-09-01 00:00:00

abstract：:Megestrol acetate (MA) is a synthetic, orally active derivative of the naturally occurring hormone progesterone. MA is increasingly used to correct loss of appetite and improve the nutritional status. We used MA in an adolescent with growth hormone (GH) deficiency due to former irradiation therapy in order to evaluate...

journal_title：Klinische Padiatrie

authors： Schmid I,Stachel DK,Freudenberg S,Schmitt M,Schuster F,Haas RJ

更新日期：2002-03-01 00:00:00

abstract：:The diagnosis of HFI is easily missed during childhood. It should be suspected in children presenting with hepatomegaly and an isolated increase in GGT. A carefully taken nutritional history forms the basis of the diagnosis of HFI which can be confirmed by molecular analysis with a sensitivity of > 95%. I.v. fructose ...

journal_title：Klinische Padiatrie

authors： Wössmann W,Wiemann J,Körber F,Gortner L

更新日期：2000-05-01 00:00:00

abstract：:Radio-labelled antimyosin-monoclonal antibodies (AMA) have been introduced to demonstrate myocardial necrosis after cardiac infarction or in cardiac allograft transplants. As rhabdomyosarcoma (RMS) and leiomyosarcoma (LMS) are tumors of myogenic origin, thus often containing myosin, we decided to use the 111In-labelle...

journal_title：Klinische Padiatrie

authors： Koscielniak E,Reuland P,Schilling F,Feine U,Treuner J

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Alcoholism during pregnancy is one of the most common factors in western societies causing persisting congenital and multiple physical as well as neurological impairments. Finding the diagnosis at first sight puts medical professionals into a demanding situation. Therefore the objective of this study was to ...

journal_title：Klinische Padiatrie

authors： Alex K,Feldmann R

更新日期：2012-03-01 00:00:00

abstract：:The are various opinions about the optimal therapy of endemic goiter in adolescents. From 106 patients (75 girls) suffering from endemic goiter 50 patients (group A) were treated with 300 micrograms iodine per day and 56 patients (group B) with 100 micrograms iodine plus 100 micrograms levothyroxine per day. Before th...

journal_title：Klinische Padiatrie

authors： Rönnefarth G,Kauf E,Deschner F,Forberger M

更新日期：1996-05-01 00:00:00

abstract：:A boy with dysplastic features had to be treated for recurrent diarrhoea and bronchitis since his tenth month of life. Defects in humoral and cellular immunity were found. The ecto-mesodermal abnormalities are so characteristic that in connection with the immunological changes it seems to be justified to assume a yet ...

journal_title：Klinische Padiatrie

authors： Tympner KD,Belohradsky B,Eife R,Klose PK

更新日期：1978-11-01 00:00:00

abstract：:630 neonates with risk factors of perinatal hearing impairment were screened of hearing loss by means of registration of transient otoacoustic emissions before discharge from the newborn nursery. Neonates were screened additionally by means of brainstem evoked response audiometry, if they had bilateral negative emissi...

journal_title：Klinische Padiatrie

authors： Sitka U,Rehm K,Rasinski C

更新日期：1998-03-01 00:00:00

abstract：:Screening for Hypothyroidism is part of the Austrian Newborn Screening for Inborn Errors and centralized (ca. 85.000 births/year). It began 1976 in 2 provinces and covers the whole country since 7.6.1978. Primary T4 and selective TSH on 3 mm discs is used. Control frequency is 0.14%, the frequency of permanent primary...

journal_title：Klinische Padiatrie

authors： Thalhammer O

更新日期：1981-09-01 00:00:00

abstract：:The observation of constitutional chromosome abnormalities in a one and half year old boy with Wiedemann-Beckwith syndrome (WBS) and hepatoblastoma prompted us to review the currently available literature dealing with this subject. In approximately 500 published cases with complete and incomplete forms of WBS, 42 mali...

journal_title：Klinische Padiatrie

authors： Haas OA,Zoubek A,Grümayer ER,Ferstl G,Gadner H

更新日期：1987-07-01 00:00:00

abstract：:Centralized treatment of critically ill pediatric patients and related problems are presented. Pediatric intensive care allows to overbridge deranged or interrupted organ functions while simultaneously treating the disease causing the disturbance. Its efficiency depends on continuity of medical care. Medical and nursi...

journal_title：Klinische Padiatrie

authors： Wille L

更新日期：1980-09-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is the most common neurocutaneous disease. The clinical manifestations are diverse. Some of the skeletal changes are most relevant to the patient. We report on 9 patients with NF1 who presented with typical pseudarthrosis. In 8 of these children the lower extremity was involved. In 2 cas...

journal_title：Klinische Padiatrie

authors： Ramelli GP,Slongo T,Weis J,Tschäppler H,Vassella F

更新日期：2000-01-01 00:00:00

abstract：:In the present study the possibility of immunophenotyping of routinely prepared (air dried) peripheral blood and bone marrow smears is described after storage. The immunoenzymatical alkaline-phosphatase-anti-alkaline-phosphatase (APAAP)-method was carried out in differently stored blood smears (+4 degrees C and -80 de...

journal_title：Klinische Padiatrie

authors： Ebener U,Hauser S,Wehner S,Kornhuber B

更新日期：1989-07-01 00:00:00

abstract：:The pros and cons of home monitoring especially for premature infants with continuing apneic episodes and/or chronic lung disease are an ongoing discussion. The controversy spans socio-economic requirements, medical indication as well as patient and family needs. Here, the costs of home monitoring and follow-up care o...

journal_title：Klinische Padiatrie

authors： Förster KM,Immler S,Ensslen M,Flemmer A,Schulze A,von Poblotzki M,Genzel-Boroviczény O,Heinen F,Hilgendorff A

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Disproportionate short stature may impair the quality of life (QoL) of patients and their families. This study aimed to evaluate a self-help supported counseling concept to increase the QoL of the participants. METHODS:QoL data from 58 children/adolescents (8-17 years) with a diagnosis of achondroplasia was...

journal_title：Klinische Padiatrie

authors： Rohenkohl AC,Sommer R,Kahrs S,Bullinger M,Klingebiel KH,Quitmann JH

更新日期：2016-01-01 00:00:00

abstract：:In case of painful scoliosis, a search for etiologic factors in the vertebral spinal canal and adjacent structures should be made. MRI with Gadolinium is useful to look for various pathology in and around the spine in particular of spinal cord. CT scanning is indispensible for bony details. Thus CT and MRI are complem...

journal_title：Klinische Padiatrie

authors： Hoeffel C,Gaucher H,Hoeffel JC,Galloy MA,Arnould V

更新日期：1997-03-01 00:00:00

abstract：:The integration of colleagues from psychosocial occupations into the traditional team of doctors and nurses demands a holistic treatment concept, the general desire for interdisciplinary action, and readiness for patience in the process of mutual learning. The acceptance of the psychosocial services by the patient and...

journal_title：Klinische Padiatrie

authors： Janssen F

更新日期：1989-07-01 00:00:00

abstract：:Ten to fifteen percent of infants of myasthenic mothers develop neonatal myasthenia independent of the severity of the maternal disease. The antiacetylcholin receptor-protein antibodytiter (AChR-AK) was followed through the first twelve months in a boy who's mother suffered from myasthenia gravis (M.G.) since twelve y...

journal_title：Klinische Padiatrie

authors： Lischka A,Grisold W,Pollak A,Zeitelhofer J,Riegler R,Weninger M

更新日期：1984-09-01 00:00:00

abstract：:Objective: Toilet refusal syndrome (TRS) is a common disorder in toddlers, defined by use of diapers and refusal of toilet for defecation, while toilet phobia (TP) is a rare disorder in which toilets are avoided completely. Both disorders have not been described systematically in children, yet. Therefore, the aim was ...

journal_title：Klinische Padiatrie

authors： Wagner C,Niemczyk J,von Gontard A

更新日期：2017-01-01 00:00:00

abstract：:pO2 was measured transcutaneously (commercially available Clark Electrode, Bioelectronics Roche) with two different electrode temperatures in new born infants. The correlation between paO2 (arteria radialis) and ptcO2 was bad (r= 0,74) with electrode temperature of 42 degrees C. When the electrode was heated to 44 deg...

journal_title：Klinische Padiatrie

authors： Haschke F,Häckel F,Hohenauer L

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Burning pain of red and warm hands and/or feet are the classical symptoms of erythromelalgia. CASE REPORT:We describe the symptoms of acute idiopathic erythromelalgia and arterial hypertension in a five-year-old boy. Five days after a gastroenteritis the patient developed burning hands and feet in combinati...

journal_title：Klinische Padiatrie

authors： Zenz W,Zöhrer B,Zobel G,Schulze-Bauer C

更新日期：1999-11-01 00:00:00

abstract：:Case report of arthrogryposis multiplex congenita with histologically proved neutrogene atrophy of muscles. The also existing reduction deformities of the limbs, showing aplasia and hypoplasia of phalanges may hypothetically be of neuropathic origin. ...

journal_title：Klinische Padiatrie

authors： Eckel U,Spranger J,Klein H

更新日期：1979-05-01 00:00:00

abstract：:Dimenhydrinate overdosage in a 3(1/2) year-old-girl with dilative cardiomyopathy. Dimenhydrinate (Vomex(R)) is frequently used in the treatment of sickness and vomiting. The symptoms of overdosage present like an anticholinergic syndrome. We report on the clinical findings of an intoxication with dimenhydrinate in a 3...

journal_title：Klinische Padiatrie

authors： Girisch M,Hofbeck M,Rauch R,Apitz C,Sieverding L

更新日期：2009-01-01 00:00:00

abstract：:Meconium ileus equivalent (MIE) complicating cystic fibrosis of the pancreas (CF) increases in frequently with increasing age of patients. In the present paper the course of 11 children and adolescents with MIE diagnosed and treated at the University Dept. of Paediatrics in Zürich during the last 15 years, i.e. 9% of ...

journal_title：Klinische Padiatrie

authors： Rosenberg E,Shmerling DH

更新日期：1983-09-01 00:00:00

abstract：:The GPOH-MAHO trials designed in 3/82 and 7/88 for treatment of childhood testicular germ cell tumors registered 3/92 105 pts. In MAHO 82 study 57 pts. and in MAHO 88 study 48 pts. were treated. Histologically 60% of the tumors revealed yolk sac tumors (YST), 22% teratomas (TD) and 18% malignant teratomas (MTI, MTU, M...

journal_title：Klinische Padiatrie

authors： Haas RJ,Schmidt P,Göbel U,Harms D

更新日期：1993-07-01 00:00:00

abstract：:Interdisciplinary cooperation and networking determine the success of activities for supporting families at risk for early childhood abuse. The integration of the healthcare sector might be important.The medical standard of perinatal care at the University hospital includes information exchange about family risk facto...

journal_title：Klinische Padiatrie

authors： Clauß D,Deutsch J,Krol I,Haase R,Willard P,Müller-Bahlke T,Mauz-Körholz C,Körholz D

更新日期：2014-07-01 00:00:00