当前位置： SCI文献检索 > JOURNAL OF NEUROCHEMISTRY期刊下所有文献 > High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation.

High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation.

Abstract：

:Neural stem cells (NSCs) play an essential role in both the developing embryonic nervous system through to adulthood where the capacity for self-renewal may be important for normal function of the CNS, such as in learning, memory and response to injury. There has been much excitement about the possibility of transplantation of NSCs to replace damaged or lost neurones, or by recruitment of endogenous precursors. However, before the full potential of NSCs can be realized, it is essential to understand the physiological pathways that control their proliferation and differentiation, as well as the influence of extrinsic factors on these processes. In the present study we used the NSC line C17.2 and primary embryonic cortical NSCs (cNSCs) to investigate the effects of the environmental contaminant methylmercury (MeHg) on survival and differentiation of NSCs. The results show that NSCs, in particular cNSCs, are highly sensitive to MeHg. MeHg induced apoptosis in both models via Bax activation, cytochrome c translocation, and caspase and calpain activation. Remarkably, exposure to MeHg at concentrations comparable to the current developmental exposure (via cord blood) of the general population in many countries inhibited spontaneous neuronal differentiation of NSCs. Our studies also identified the intracellular pathway leading to MeHg-induced apoptosis, and indicate that NSCs are more sensitive than differentiated neurones or glia to MeHg-induced cytotoxicity. The observed effects of MeHg on NSC differentiation offer new perspectives for evaluating the biological significance of MeHg exposure at low levels.

journal_name

J Neurochem

journal_title

Journal of neurochemistry

authors

Tamm C,Duckworth J,Hermanson O,Ceccatelli S

doi

10.1111/j.1471-4159.2006.03718.x

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

69-78

issue

1

eissn

0022-3042

issn

1471-4159

pii

JNC3718

journal_volume

97

pub_type

杂志文章

相关文献

JOURNAL OF NEUROCHEMISTRY文献大全
  • Involvement of OCTN2 and B0,+ in the transport of carnitine through an in vitro model of the blood-brain barrier.

    abstract：:Carnitine is known to accumulate in brain, therefore transport of carnitine through the blood-brain barrier was studied in an in vitro system using bovine brain capillary endothelial cells (BBCEC) grown on filter inserts in a co-culture system with glial cells. Long-term exposure of BBCEC to carnitine resulted in a hi...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2004.02752.x

    authors： Berezowski V,Miecz D,Marszałek M,Bröer A,Bröer S,Cecchelli R,Nałecz KA

    更新日期：2004-11-01 00:00:00

  • Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala.

    abstract：:Most recent studies aimed at defining the cellular and molecular mechanisms of Pavlovian fear conditioning have focused on protein kinase signaling pathways and the transcription factor cAMP-response element binding protein (CREB) that promote fear memory consolidation in the lateral nucleus of the amygdala (LA). Desp...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2009.06491.x

    authors： Ploski JE,Park KW,Ping J,Monsey MS,Schafe GE

    更新日期：2010-02-01 00:00:00

  • Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning.

    abstract：:Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) have an extraordinary capacity to withstand prolonged and profound reductions in blood flow and oxygen delivery to the brain without incurring any cellular damage. As such, the hibernation torpor of I. tridecemlineatus provides a valuable model of tolerance ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.13368

    authors： Miyake S,Wakita H,Bernstock JD,Castri P,Ruetzler C,Miyake J,Lee YJ,Hallenbeck JM

    更新日期：2015-12-01 00:00:00

  • Membrane viscosity correlates with alpha 1-adrenergic signal transduction of the aged rat cerebral cortex.

    abstract：:We investigated, using adult (2-month-old) and senescent (12- and 24-month-old) rats, the effects of aging on the relationship between the alpha 1-adrenergic coupling system and the membrane viscosity of the cerebral cortex. There was no age-related difference in the KD values of [3H]prazosin binding on the membranes....

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1990.tb08822.x

    authors： Miyamoto A,Araiso T,Koyama T,Ohshika H

    更新日期：1990-07-01 00:00:00

  • Nuclear factor-kappa β as a therapeutic target for Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with worldwide prevalence. Its clinical manifestation involves the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs). NFTs occur in brain tissues as a result of both Aβ agglomeration and Tau phosphory...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/jnc.14687

    authors： Jha NK,Jha SK,Kar R,Nand P,Swati K,Goswami VK

    更新日期：2019-07-01 00:00:00

  • The blood-brain barrier in neurodegenerative disease: a rhetorical perspective.

    abstract：:Recent studies suggest that the function of the blood-brain barrier (BBB) is not static under normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing thinking about CNS function, and neurodegenerative disease in particular, is neurocentric excluding the impact of factors outside th...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/j.1471-4159.2009.06319.x

    authors： Carvey PM,Hendey B,Monahan AJ

    更新日期：2009-10-01 00:00:00

  • Protein kinase D exerts neuroprotective functions during oxidative stress via nuclear factor kappa B-independent signaling pathways.

    abstract：:Members of the protein kinase D (PKD) family of serine/threonine kinases are known to exert diverse roles in neuronal stress responses. Here, we show the transient activation and nuclear translocation of endogenous PKD upon oxidative stress induced by H2 O2 treatment in primary neuronal cultures. Using pharmacological...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14131

    authors： Liliom H,Tárnok K,Ábrahám Z,Rácz B,Hausser A,Schlett K

    更新日期：2017-09-01 00:00:00

  • Co-activation of PKA and PKC in cerebrocortical nerve terminals synergistically facilitates glutamate release.

    abstract：:Protein kinase A and protein kinase C are involved in processes that enhance glutamate release at glutamatergic nerve terminals. However, it is not known whether these two kinases co-exist within the same nerve terminal, nor is it clear what impact their simultaneous activation may have on neurotransmitter release. In...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2003.02065.x

    authors： Millán C,Torres M,Sánchez-Prieto J

    更新日期：2003-12-01 00:00:00

  • Repeated amphetamine treatment induces neurite outgrowth and enhanced amphetamine-stimulated dopamine release in rat pheochromocytoma cells (PC12 cells) via a protein kinase C- and mitogen activated protein kinase-dependent mechanism.

    abstract：:Repeated intermittent treatment with amphetamine (AMPH) induces both neurite outgrowth and enhanced AMPH-stimulated dopamine (DA) release in PC12 cells. We investigated the role of protein kinases in the induction of these AMPH-mediated events by using inhibitors of protein kinase C (PKC), mitogen activated protein ki...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2003.02127.x

    authors： Park YH,Kantor L,Guptaroy B,Zhang M,Wang KK,Gnegy ME

    更新日期：2003-12-01 00:00:00

  • Solubilization of the membrane-bound sialidase from pig brain by treatment with bacterial phosphatidylinositol phospholipase C.

    abstract：:The total pellet from pig forebrain (from which the cytosolic sialidase was completely washed out) was treated with phosphatidylinositol phospholipase C (PIPLC) and centrifuged at high speed. The supernatant contained sialidase and 5'-nucleotidase activities. The greatest liberation of sialidase was obtained after inc...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1990.tb04941.x

    authors： Chiarini A,Fiorilli A,Siniscalco C,Tettamanti G,Venerando B

    更新日期：1990-11-01 00:00:00

  • Thalamic synaptic transmission of sensory information modulated by synergistic interaction of adenosine and serotonin.

    abstract：:The thalamic synapses relay peripheral sensory information to the cortex, and constitute an important part of the thalamocortical network that generates oscillatory activities responsible for different vigilance (sleep and wakefulness) states. However, the modulation of thalamic synaptic transmission by potential slee...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12499

    authors： Yang YC,Hu CC,Huang CS,Chou PY

    更新日期：2014-03-01 00:00:00

  • Clozapine increases apolipoprotein D expression in rodent brain: towards a mechanism for neuroleptic pharmacotherapy.

    abstract：:In contrast to typical neuroleptic drugs, which have high affinities for dopamine D2 receptors, clozapine binds to multiple neurotransmitter receptors. The mechanisms responsible for its superior clinical efficacy over typical neuroleptics remain unknown. Using an automated genomics approach, total gene expression ana...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2001.00027.x

    authors： Thomas EA,Danielson PE,Nelson PA,Pribyl TM,Hilbush BS,Hasel KW,Sutcliffe JG

    更新日期：2001-02-01 00:00:00

  • Three distinct types of monoclonal antibodies after long-term immunization of rats with mouse nerve growth factor.

    abstract：:This article reports the results of a systematic investigation of the different types of antibodies produced in the course of a long-term immunization of rats with mouse nerve growth factor (NGF). We have characterized three types of monoclonal antibodies, namely: (1) antibodies that bind to NGF and inhibit its bindin...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1988.tb10565.x

    authors： Cattaneo A,Rapposelli B,Calissano P

    更新日期：1988-04-01 00:00:00

  • Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l.

    abstract：:Here we report the cloning of two cDNAs, Snf2h and Snf2l, encoding the murine members of the Imitation Switch (ISWI) family of chromatin remodeling proteins. To gain insight into their function we examined the spatial and temporal expression patterns of Snf2h and Snf2l during development. In the brain, Snf2h is preval...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2001.00324.x

    authors： Lazzaro MA,Picketts DJ

    更新日期：2001-05-01 00:00:00

  • The calcium-activated protease calpain regulates netrin-1 receptor deleted in colorectal cancer-induced axon outgrowth in cortical neurons.

    abstract：:During development, neurons extend axons toward their appropriate synaptic targets to establish functional neuronal connections. The growth cone, a highly motile structure at the tip of the axon, is capable of recognizing extracellular guidance cues and translating them into directed axon outgrowth through modulation ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14837

    authors： Duquette PM,Lamarche-Vane N

    更新日期：2020-02-01 00:00:00

  • Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary.

    abstract：:It is now clearly established that the brain has the capability of synthesizing various biologically active steroids including 17-hydroxypregnenolone (17OH-Delta(5)P), 17-hydroxyprogesterone (17OH-P), dehydroepiandrosterone (DHEA) and androstenedione (Delta(4)). However, the presence, distribution and activity of cyto...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2006.04209.x

    authors： Do Rego JL,Tremblay Y,Luu-The V,Repetto E,Castel H,Vallarino M,Bélanger A,Pelletier G,Vaudry H

    更新日期：2007-01-01 00:00:00

  • Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice.

    abstract：:Adenosine A2A receptors (A2A R) play a key role in modulating dopamine-dependent locomotor activity, as heralded by the sensitization of locomotor activity upon chronic A2A R blockade, which is associated with elevated dopamine levels and altered corticostriatal synaptic plasticity. Since the orphan receptor GPR37 has...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14653

    authors： Morató X,Gonçalves FQ,Lopes JP,Jauregui O,Soler C,Fernández-Dueñas V,Cunha RA,Ciruela F

    更新日期：2019-03-01 00:00:00

  • Brief, repeated exposure to substrates down-regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo.

    abstract：:In heterologous expression systems, dopamine transporter (DAT) cell-surface localization is reduced after relatively prolonged exposure to d-amphetamine (AMPH) or dopamine (DA), suggesting a role for substrate-mediated regulation of transporter function. Here, we investigated whether brief, repeated periods of substra...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2002.01133.x

    authors： Gulley JM,Doolen S,Zahniser NR

    更新日期：2002-10-01 00:00:00

  • Effects of local administration of L-, N-, and P/Q-type calcium channel blockers on spontaneous dopamine release in the striatum and the substantia nigra: a microdialysis study in rat.

    abstract：:The pivotal role for voltage-sensitive calcium channels in initiating synaptic transmitter release is undisputed, but it is only partly known to what extent the different subtypes contribute in vivo. Their importance for the dendritic release of dopamine has not been investigated in vivo previously. To evaluate compre...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1998.70041532.x

    authors： Bergquist F,Jonason J,Pileblad E,Nissbrandt H

    更新日期：1998-04-01 00:00:00

  • SCA14 mutation V138E leads to partly unfolded PKCγ associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization.

    abstract：:The protein kinase C γ (PKCγ) undergoes multistep activation and participates in various cellular processes in Purkinje cells. Perturbations in its phosphorylation state, conformation or localization can disrupt kinase signalling, such as in spinocerebellar ataxia type 14 (SCA14) that is caused by missense mutations i...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12491

    authors： Jezierska J,Goedhart J,Kampinga HH,Reits EA,Verbeek DS

    更新日期：2014-03-01 00:00:00

  • Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra.

    abstract：:We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1993.tb03631.x

    authors： Bolden-Watson C,Watson MA,Murray KD,Isackson PJ,Richelson E

    更新日期：1993-09-01 00:00:00

  • Glucocorticoids exacerbate the deleterious effects of gp120 in hippocampal and cortical explants.

    abstract：:Glucocorticoids (GCs), the adrenal steroids secreted during stress, can compromise the ability of hippocampal neurons to survive numerous necrotic insults. We have previously observed that GCs worsen the deleterious effects of gp120, the glycoprotein of the acquired immune deficiency syndrome virus, which can indirect...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2000.0741000.x

    authors： Yusim A,Franklin L,Brooke S,Ajilore O,Sapolsky R

    更新日期：2000-03-01 00:00:00

  • Non-proteolytic neurotrophic effects of tissue plasminogen activator on cultured mouse cerebrocortical neurons.

    abstract：:Most biological effects of tissue plasminogen activator (tPA), such as fibrinolysis, are mediated by its protease activity. Recent studies, however, have demonstrated that tPA also has several protease-independent effects such as: neuroprotection, microglial activation, and promoting LTP formation. In order to gain a ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2007.04417.x

    authors： Lee HY,Hwang IY,Im H,Koh JY,Kim YH

    更新日期：2007-06-01 00:00:00

  • Development of sodium channel protein during chemically induced differentiation of neuroblastoma cells.

    abstract：:We have previously shown that the [3H]saxitoxin binding site of the sodium channel is expressed independently of the [125I]scorpion toxin binding site in chick muscle cultures and in rat brain. In the present work, we studied the development of the sodium channel protein during chemically induced differentiation of N1...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1987.tb05656.x

    authors： Baumgold J,Spector I

    更新日期：1987-04-01 00:00:00

  • Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target.

    abstract：:While it has been reported that familial Alzheimer's disease (FAD)-linked mutants of amyloid precursor protein (APP) and presenilin (PS)2 induce neuronal cytotoxicity in a manner sensitive to antioxidant and pertussis toxin (PTX), little of the mechanism for PS1-mediated neuronal cell death has been characterized. We ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.0022-3042.2001.00722.x

    authors： Hashimoto Y,Ito Y,Arakawa E,Kita Y,Terashita K,Niikura T,Nishimoto I

    更新日期：2002-02-01 00:00:00

  • Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB₁R signaling and anxiety-like behavior.

    abstract：:Endocannabinoids (eCB) are key regulators of excitatory/inhibitory neurotransmission at cannabinoid-1-receptor (CB1 R)-expressing axon terminals. The most abundant eCB in the brain, that is 2-arachidonoylglycerol (2-AG), is hydrolyzed by the enzyme monoacylglycerol lipase (MAGL), whose chronic inhibition in the brain ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.13267

    authors： Imperatore R,Morello G,Luongo L,Taschler U,Romano R,De Gregorio D,Belardo C,Maione S,Di Marzo V,Cristino L

    更新日期：2015-11-01 00:00:00

  • Glutamate and nitric oxide modulate ERK and CREB phosphorylation in the avian retina: evidence for direct signaling from neurons to Müller glial cells.

    abstract：:Glutamate signaling in the mature retinal tissue is very important for accurate sensory decoding by retinal neurons and orchestrates the fine-tuned output from the retina to higher-order centers at the cerebral cortex. In this study, we show that glutamate induces a rapid extracellular-regulated kinase and cAMP-respon...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2008.05778.x

    authors： Socodato RE,Magalhães CR,Paes-de-Carvalho R

    更新日期：2009-01-01 00:00:00

  • Treatment with normal prion protein delays differentiation and helps to maintain high proliferation activity in human embryonic stem cells.

    abstract：:The normal cellular form of prion protein (PrP(C)) has been shown to exhibit a diverse range of biological activities. Several recent studies highlighted potential involvement of PrP(C) in embryogenesis or in regulating stem cell self-renewal and proliferation. In the current study, we employed human embryonic stem ce...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2010.06601.x

    authors： Lee YJ,Baskakov IV

    更新日期：2010-07-01 00:00:00

  • Biogenic aldehydes in brain: characteristics of a reaction between rat brain tissue and indole-3-acetaldehyde.

    abstract：:When indole-3-acetaldehyde was incubated with rat brain tissue, an aldehyde dehydrogenase-independent irreversible disappearance of the aldehyde was found. This was accompanied by an increase in absorbance at 240-400 nm, with a peak at 310 nm. The results suggested that this change in absorbance was caused by a membra...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1985.tb04055.x

    authors： Nilsson GE,Tottmar O

    更新日期：1985-09-01 00:00:00

  • Kainate receptor-mediated depression of glutamatergic transmission involving protein kinase A in the lateral amygdala.

    abstract：:Kainate receptors (KARs) have been described as modulators of synaptic transmission at different synapses. However, this role of KARs has not been well characterized in the amygdala. We have explored the effect of kainate receptor activation at the synapse established between fibers originating at medial geniculate nu...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2012.07665.x

    authors： Negrete-Díaz JV,Duque-Feria P,Andrade-Talavera Y,Carrión M,Flores G,Rodríguez-Moreno A

    更新日期：2012-04-01 00:00:00