Role of HCV coinfection towards disease progression and survival in HIV-1 infected children: a follow-up study of 10 years.

Abstract:

:The present study was taken up to evaluate the pattern of disease progression and survival in a group of HIV-1 positive children, coinfected with HCV infection (n=25) in comparison to those without such coinfection (n=23). There was a significant negative correlation between the rate of decline of the CD4 + T cell percentage and the duration of the AIDS-free interval in most (80.0 per cent) of the HCV seropositive children showing such decline (r=-0.588; p=0.005). The HCV seropositive children had twofold higher risk of progression to development of AIDS than HCV seronegatives (RR=2.51; 95 per cent CI:1.34-4.69; p=0.004). There was a significant negative correlation between the rate of decline of CD4 + T cell percentage and overall survival duration for HCV seropositive group (r=-0.609; p=0.003). Moreover, children coinfected with HCV had more than twofold higher risks of death than those without HCV (RR=2.39; 95 per cent CI:1.17-4.89; p<0.01). It appears that HCV infection may be an important contributor to the rapid disease progression and increase in mortality in HCV-HIV-1 coinfected children of thalassemia major.

journal_name

J Trop Pediatr

authors

Shivraj SO,Chattopadhya D,Grover G,Kumar A,Baveja UK

doi

10.1093/tropej/fmi103

keywords:

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

206-11

issue

3

eissn

0142-6338

issn

1465-3664

pii

fmi103

journal_volume

52

pub_type

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