Abstract:
:Lymphocyte subsets, activation markers and apoptosis were assessed in 20 HIV-exposed noninfected (ENI) children born to HIV-infected women who were or not exposed to antiretroviral (ARV) drugs during pregnancy and early infancy. ENI children and adolescents were aged 6-18 years and they were compared to 25 age-matched healthy non-HIV-exposed children and adolescents (Control). ENI individuals presented lower CD4(+) T cells/mm(3) than Control group (control: 1120.3 vs. ENI: 876.3; t-test, p = 0.030). ENI individuals had higher B-cell apoptosis than Control group (Control: 36.6%, ARV exposed: 82.3%, ARV nonexposed: 68.5%; Kruskal-Wallis, p < 0.05), but no statistical difference was noticed between those exposed and not exposed to ARV. Immune activation in CD4(+) T, CD8(+) T and in B cells was comparable in ENI and in Control children and adolescents. Subtle long-term immune alterations might persist among ENI individuals, but the clinical consequences if any are unknown, and these children require continued monitoring.
journal_name
J Trop Pediatrjournal_title
Journal of tropical pediatricsauthors
Miyamoto M,Pessoa SD,Ono E,Machado DM,Salomão R,Succi RC,Pahwa S,de Moraes-Pinto MIdoi
10.1093/tropej/fmq024subject
Has Abstractpub_date
2010-12-01 00:00:00pages
427-32issue
6eissn
0142-6338issn
1465-3664pii
fmq024journal_volume
56pub_type
杂志文章abstract:BACKGROUND:Results in neonatal screening programs aiming at detection of congenital adrenal hyperplasia (CAH) can only report elevated levels of 17-hydroxy-progesterone (17-OHP), without being able to differentiate presence or absence of salt loss. AIM:To predict presence or absence of salt loss in newborn infants wit...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmv078
更新日期:2016-04-01 00:00:00
abstract::A protocol of nutritional rehabilitation using fermented milk, vegetable oil, and castor sugar has been tested on 54 Senegalese children age 6-36 months admitted with acute diarrhoea and malnutrition. At time of admission, 39 per cent of children were dehydrated and 26 per cent had sugar intolerance. In the course of ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/35.6.281
更新日期:1989-12-01 00:00:00
abstract::The association between the clinical outcome of chloroquine treatment and mutations in the putative Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene at codon 76 and multidrug resistance gene 1 (Pf mdr1) at codon 86 were investigated among 406 children with uncomplicated malaria presenting at five ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fml076
更新日期:2007-02-01 00:00:00
abstract::A hospital-based descriptive recall study was conducted to assess the relationship, if any, between breastfeeding practices and morbidity from respiratory and diarrhoeal diseases in infants. A total of 343 infants (285 admitted patients and 58 controls) were recruited. Clinical and sociodemographic data and details re...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/45.2.115
更新日期:1999-04-01 00:00:00
abstract::HIV/AIDS is an infection characterized by immune cell dysfunction and subsequent immunodeficiency, as well as intestinal disorder. Probiotics are live microbial feed supplements that beneficially affect the host animal by improving intestinal microbial balance and promoting health benefits. The goals of this study wer...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1093/tropej/fmm066
更新日期:2008-02-01 00:00:00
abstract::The cornerstone of emergency management of sepsis is early, goal-directed therapy. The purpose of this study was to evaluate the effect of intraosseous (IO) vs. intravenous (IV) access for resuscitation of patients with septic shock admitted to pediatric intensive care unit. This prospective interventional randomized ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1093/tropej/fmx061
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To evaluate vitamin D status of preterm and term low birthweight (LBW) and term normal birth weight (NBW; weight ≥ 2500 g) infants at birth and in early infancy. METHODS:We enrolled 220 LBW and 119 NBW infants along with their mothers. Blood samples of both infants and mothers were taken within 48 h of birth...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fms013
更新日期:2012-12-01 00:00:00
abstract::Ascariasis is one of the most common helminthic infestations in humans. Massive infestation can give rise to serious complications such as intestinal obstruction. We present a 4-year-old boy, who presented with acute flaccid quadriparesis due to the hypokalemic alkalosis induced by severe vomiting. Severe vomiting was...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmp044
更新日期:2010-02-01 00:00:00
abstract::Burkitt's lymphoma is the most common childhood cancer in Africa. Most prevalent in areas endemic for malaria, the disease, a malignant growth of lymphoid tissue, usually presents itself as a large tumour of the jaw. When first characterized in the 1950s, the lymphoma was thought to spread by some infectious agent. Su...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章,评审
doi:10.1093/tropej/36.3.114
更新日期:1990-06-01 00:00:00
abstract::Sixteen cases of external hydrocephalus (EH) were seen from January 1993 to June 1995. There were 13 (81.3 per cent) male and three female children. Fourteen (87.5 per cent) were under 12 months of age. Three siblings with EH were seen in one family. All but three of the 16 recovered over time without medical or surgi...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/44.3.153
更新日期:1998-06-01 00:00:00
abstract::In this study, we have prospectively recorded healthcare-associated infections (HAIs) in NICU and found incidence density as 18 infections per 1000 patient days. Of the infections, 51.3% was bacteriemia (BSI), and 45.1% was ventilator-associated pneumonia (VAP). Gram-negative microorganisms were predominant in VAP and...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmq060
更新日期:2011-06-01 00:00:00
abstract::Idiopathic pulmonary haemosiderosis (IPH) is a rare disorder characterized by recurrent bouts of haemoptysis, iron deficiency anaemia, and pulmonary infiltrates on chest radiograph. We present such a case and believe that it is the first report from the Middle East. ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/46.4.243
更新日期:2000-08-01 00:00:00
abstract::Missed opportunities and inappropriately time immunization substantially reduced the coverage achieved in Mozambique and Guinea Conakry. During coverage surveys in Mozambique, we noted dates of attendance at a health facility for growth monitoring or vaccination, and in Conakry we also abstracted dates of curative car...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/37.4.153
更新日期:1991-08-01 00:00:00
abstract::Effective cancer registration is required for the development of cancer management policies, but is often deficient in the developing world. In 2008 cancer registration was set up Banso Baptist Hospital and Mbingo Baptist Hospital in the Northwest region of Cameroon, using the Pediatric Oncology Networked Database (PO...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmaa038
更新日期:2020-10-06 00:00:00
abstract::To reduce malnutrition and improve child survival, school feeding programmes have been established in many parts of Africa, although prevalence of child malnutrition and anaemia remains high, especially in urban slums. The objective of this study is to evaluate the effect of a school feeding programme in the slums of ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fms070
更新日期:2013-06-01 00:00:00
abstract::A randomized controlled trial was conducted over a 1-year period (November 2001-November 2002) in Addis Ababa to study the effectiveness of early Kangaroo mother care before stabilization of low birthweight infants as compared with the conventional method of care. There were 259 babies weighing less than 2000 g during...
journal_title:Journal of tropical pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/tropej/fmh085
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:Hepatic abscess is a rare but potentially fatal entity in neonates. The aim of this study was to provide valuable data for diagnosis, management and prevention of hepatic abscess in preterm infants. METHODS:A retrospective chart review was made for patients diagnosed with hepatic abscesses between 2012 and 201...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章,评审
doi:10.1093/tropej/fmv103
更新日期:2016-06-01 00:00:00
abstract::beta-thalassaemia major, an autosomal recessive hemoglobinopathy, is one of the most common single gene disorders in multi-racial Malaysia. The control of beta-thalassaemia major requires a multi-disciplinary approach that includes population screening, genetic counselling, prenatal diagnosis and the option of termina...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmi052
更新日期:2005-12-01 00:00:00
abstract::The relationship between ocular manifestation of vitamin A deficiency and children's anaemic/morbidity status as well as the efficacy of vitamin A prophylaxis in preventing these conditions was determined. The prevalence of xerophthalmia in morbid children with anaemia and history of worm infestation, measles, and dia...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/39.2.89
更新日期:1993-04-01 00:00:00
abstract::The present study is aimed to describe the changes in the prevalence of symptoms of asthma, rhinitis and eczema among Brazilian adolescents (AD, 13-14 years old) between Phases 1 and 3 of the International Study of Asthma and Allergies in Childhood (ISAAC). The prevalence of self-reported symptoms of asthma, rhinitis ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fml044
更新日期:2007-02-01 00:00:00
abstract::143 neonates were diagnosed to have acquired systemic candidiasis out of a total 4530 admissions (3.2 per cent) to the neonatal intensive care unit (NICU) during a period of 6 1/2 years from January 1990 to June 1996. Mean age at onset was 10.4 days, mean birth weight 1454 g, and mean gestation was 31.7 weeks. Ninety-...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/44.2.104
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Nigeria has the largest number of global under-five deaths and almost half of these occur in the newborn period in an almost 50:50 ratio across hospital facilities and communities. We examine and describe risk factors for newborn mortality at a busy neonatal unit of a referral tertiary hospital in North-cent...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmaa126
更新日期:2021-01-09 00:00:00
abstract::In this study, 80 male and female sickle cell patients, aged 4-50 years, with mild (severity index, SI < 6) and severe (SI > or = 6) forms of the disease were investigated). The levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, cortisol, growth hormone (GH), free thyroxine (T4), and...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/38.6.307
更新日期:1992-12-01 00:00:00
abstract::In a prospective study at Sultan Qaboos University Hospital, 95 premature infants with birthweights equal or less than 1500 g were screened for intraventricular haemorrhage (IVH) using cranial ultrasound. Nineteen (20 per cent) were found to have developed IVH. Eight out of fourteen variables studied showed a signific...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/43.3.174
更新日期:1997-06-01 00:00:00
abstract::Echocardiography (ECHO), electrocardiography (ECG), and chest radiography (CXR) were performed in 44 children with kwashiorkor, and 44 age- and sex-matched controls. In patients with kwashiorkor, mean values obtained for end diastolic dimension (29.2 +/- 3.8 mm), end systolic dimension (20.9 +/- 2.8 mm), posterior ven...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/41.2.74
更新日期:1995-04-01 00:00:00
abstract::India with its 4 million cases of leprosy, accounts for one-third of the world's population of leprosy patients. One-fourth of them are below 15 years of age. We report a 5-year follow-up study of healthy children who were close contacts of leprosy patients, in order to: 1. detect subclinical infection and observe the...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/41.3.132
更新日期:1995-06-01 00:00:00
abstract::We report a case of cardiac tamponade due to air leak and fatal pneumopericardium that occurred after commercial flight transportation of a premature infant with chronic lung disease without respiratory distress. We review and discuss aspects of flight pathophysiology, and conclude that careful preparation before, and...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fms047
更新日期:2013-02-01 00:00:00
abstract::Liver involvement is commonly observed in patients with typhoid fever. However, a hepatitis-like picture with fever and jaundice is unusual and infrequently reported in the paediatric literature. Our aim was to characterize the clinical picture, biochemical features, and prognosis of typhoid hepatitis. One hundred cas...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/45.5.287
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Environmental enteropathy is an example of a poorly-understood intestinal disorder affecting millions of children worldwide, characterized by malabsorption and stunting. Although there is increasing interest in non-invasive means of assessing intestinal structure and function, the potential value of intestin...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmaa074
更新日期:2020-11-14 00:00:00
abstract::Enteropathogens were investigated in 406 children aged 0-3 years with diarrhoea attending the Salles Neto Municipal Hospital. Enteric bacterial pathogens were isolated from 49 per cent of the children. Enterotoxigenic Escherichia coli (ETEC) (20.9 per cent), enteropathogenic E. coli (EPEC) (16.5 per cent), rotavirus (...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/39.6.365
更新日期:1993-12-01 00:00:00