Serum immunoglobulin E in idiopathic nephrotic syndrome.

Abstract:

:Serum immunoglobulin E (IgE) and absolute eosinophil count (AEC) were assayed in 48 children with idiopathic nephrotic syndrome and 20 controls. The mean serum IgE (p < 0.001) and AEC (p < 0.05) were significantly raised in active nephrotic syndrome compared with controls. The mean values of IgE and AEC in nephrotic patients were 228.6 and 164.5 per cent of the normal mean, respectively. The serum IgE and AEC were significantly abnormal in all the subgroups (first attack, infrequent, and frequent relapsers), except AEC in infrequent relapses, when compared with the controls. No significant differences in the parameters were observed among the different subgroups of cases. In remission, the mean IgE and AEC were unchanged in comparison with their corresponding values at diagnosis. Thus, the levels are raised not only in active but also in remission, reflecting abnormal immune status even in the disease-free state.

journal_name

J Trop Pediatr

authors

Mishra OP,Ibrahim N,Usha,Das BK

doi

10.1093/tropej/50.3.149

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

149-52

issue

3

eissn

0142-6338

issn

1465-3664

journal_volume

50

pub_type

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