Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation.

abstract：:The abelian sandpile is a cellular automaton which serves as the archetypical model to study self-organized criticality, a phenomenon occurring in various biological, physical, and social processes. Its recurrent configurations form an abelian group, whose identity is a fractal composed of self-similar patches. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lang M,Shkolnikov M

更新日期：2019-02-19 00:00:00

abstract：:Escherichia coli DnaJ functions as a typical molecular chaperone in coordination with other heat shock proteins such as DnaK and GrpE in a variety of cellular processes. In this study, it was found that E. coli possesses an analogue of DnaJ, as judged from not only its primary structure but also its possible function....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueguchi C,Kakeda M,Yamada H,Mizuno T

更新日期：1994-02-01 00:00:00

abstract：:We report a comprehensive cartography of selective responses to visual letters and words in the human ventral occipito-temporal cortex (VOTC) with direct neural recordings, clarifying key aspects of the neural basis of reading. Intracerebral recordings were performed in a large group of patients (n = 37) presented wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lochy A,Jacques C,Maillard L,Colnat-Coulbois S,Rossion B,Jonas J

更新日期：2018-08-07 00:00:00

abstract：:Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker encodes a homologue of the moth Gram-negative bacteria-binding protein (GNBP), and another corresponds to a serine protease-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dimopoulos G,Richman A,Müller HM,Kafatos FC

更新日期：1997-10-14 00:00:00

abstract：:An effective metabolism is essential to all living organisms, including the important human pathogen Staphylococcus aureus. To establish successful infection, S. aureus must scavenge nutrients and coordinate its metabolism for proliferation. Meanwhile, it also must produce an array of virulence factors to interfere wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding Y,Liu X,Chen F,Di H,Xu B,Zhou L,Deng X,Wu M,Yang CG,Lan L

更新日期：2014-11-18 00:00:00

abstract：:In higher eukaryotic cells, mitochondria are essential subcellular organelles for energy production, cell signaling, and the biosynthesis of biomolecules. The mitochondrial DNA (mtDNA) genome is indispensable for mitochondrial function because it encodes protein subunits of the electron transport chain and a full set ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu W,Boyd RM,Tree MO,Samkari F,Zhao L

更新日期：2019-09-03 00:00:00

abstract：:Molecular diversity of ion channel structure and function underlies variability in electrical signaling in nerve, muscle, and nonexcitable cells. Regulation by variable auxiliary subunits is a major mechanism to generate tissue- or cell-specific diversity of ion channel function. Mammalian large-conductance, voltage- ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan J,Aldrich RW

更新日期：2012-05-15 00:00:00

abstract：:Recent studies have indicated that mammalian cells contain a cytosolic protein disaggregation machinery comprised of Hsc70, DnaJ homologs, and Hsp110 proteins, the last of which acts to accelerate a rate-limiting step of nucleotide exchange of Hsc70. We tested the ability of transgenic overexpression of a Thy1 promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagy M,Fenton WA,Li D,Furtak K,Horwich AL

更新日期：2016-05-10 00:00:00

abstract：:Chemosensory proteins (CSPs) have been proposed to transport hydrophobic chemicals from air to olfactory or taste receptors. They have been isolated from several sensory organs of a wide range of insect species. The x-ray structure of CSPMbraA6, a 112-aa antennal protein from the moth Mamestra brassicae (Mbra), was sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campanacci V,Lartigue A,Hällberg BM,Jones TA,Giudici-Orticoni MT,Tegoni M,Cambillau C

更新日期：2003-04-29 00:00:00

abstract：:Metal-inducible transcription of metallothionein (MT) genes involves the interaction of metal-responsive trans-acting factors with specific promoter DNA sequence elements. In this report, we present a genetic selection using the baker's yeast, Saccharomyces cerevisiae, to clone a gene from Candida glabrata encoding a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou PB,Thiele DJ

更新日期：1991-07-15 00:00:00

abstract：:Volumetric detection and accurate quantification of fluorescent proteins in entire animals would greatly enhance our ability to monitor biological processes in vivo. Here we present a quantitative tomographic technique for visualization of superficial and deep-seated (>2-3 mm) fluorescent protein activity in vivo. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zacharakis G,Kambara H,Shih H,Ripoll J,Grimm J,Saeki Y,Weissleder R,Ntziachristos V

更新日期：2005-12-20 00:00:00

abstract：:Cytochrome P450 enzymes are monooxygenases that contain a functional heme b group linked to a conserved cysteine with a thiolate bond. In the native state, the central iron atom is hexacoordinated with a covalently bound water molecule. The exclusion of solvent molecules from the active site is essential for efficient...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oprea TI,Hummer G,Garcia AE

更新日期：1997-03-18 00:00:00

abstract：:In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of HIV-1 infection on vaccination with an Ad5 vaccine. We propose that this was due to activation and expansion of Ad5-specific mucosal-homing memory CD4 T cells. To t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benlahrech A,Harris J,Meiser A,Papagatsias T,Hornig J,Hayes P,Lieber A,Athanasopoulos T,Bachy V,Csomor E,Daniels R,Fisher K,Gotch F,Seymour L,Logan K,Barbagallo R,Klavinskis L,Dickson G,Patterson S

更新日期：2009-11-24 00:00:00

abstract：:The annual migration of ∼1.2 million wildebeest (Connochaetes taurinus) through the Serengeti Mara Ecosystem is the largest remaining overland migration in the world. One of the most iconic portions of their migration is crossing of the Mara River, during which thousands drown annually. These mass drownings have been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subalusky AL,Dutton CL,Rosi EJ,Post DM

更新日期：2017-07-18 00:00:00

abstract：:Relatively little is understood about the dynamics of global host-pathogen transcriptome changes that occur during bacterial infection of mucosal surfaces. To test the hypothesis that group A Streptococcus (GAS) infection of the oropharynx provokes a distinct host transcriptome response, we performed genome-wide trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shea PR,Virtaneva K,Kupko JJ 3rd,Porcella SF,Barry WT,Wright FA,Kobayashi SD,Carmody A,Ireland RM,Sturdevant DE,Ricklefs SM,Babar I,Johnson CA,Graham MR,Gardner DJ,Bailey JR,Parnell MJ,Deleo FR,Musser JM

更新日期：2010-03-09 00:00:00

abstract：:Supercritical fluids are a unique class of nonaqueous media in which biocatalytic reactions can occur. The physical properties of supercritical fluids, which include gas-like diffusivities and liquid-like densities, can be predictably controlled with changing pressure. This paper describes how adjustment of pressure, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamat SV,Iwaskewycz B,Beckman EJ,Russell AJ

更新日期：1993-04-01 00:00:00

abstract：:Lipoproteins are emulsion particles that consist of lipids and apolipoproteins. Their natural function is to transport lipids and/or cholesterol to different tissues. We have taken advantage of the hydrophobic interior of these natural emulsions to solubilize DNA. Negatively charged DNA was first complexed with cation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hara T,Tan Y,Huang L

更新日期：1997-12-23 00:00:00

abstract：:Natural selection does not necessarily favor maximal reproduction because reproduction imposes fitness costs, reducing parental survival, and offspring quality. Here, we show that parents in a preindustrial population in North America incurred fitness costs from reproduction, and women incurred greater costs than men....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penn DJ,Smith KR

更新日期：2007-01-09 00:00:00

abstract：:Tropical birds are relatively long-lived and produce few offspring, which develop slowly and mature relatively late in life, the slow end of the life-history axis, whereas temperate birds lie at the opposite end of this continuum. We tested the hypothesis that tropical birds have evolved a reduced basal metabolic rate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiersma P,Muñoz-Garcia A,Walker A,Williams JB

更新日期：2007-05-29 00:00:00

abstract：:A two-dimensional model of the expansion of a crack in an elastic medium is considered in which friction depends on the slip rate and the modulus of cohesion depends on the speed of expansion of the crack. Elastic waves are neglected (quasi-static model). Under some conditions, the expansion of the crack is realized b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barenblatt GI,Keilis-Borok VI,Vishik MM

更新日期：1981-09-01 00:00:00

abstract：:Peritoneal macrophages were obtained from DBA/2 mice that were untreated or after the injection of bacillus Calmette-Guerin (BCG), thioglycollate broth, proteose-peptone broth, or gamma-irradiated P-815 tumor cells. These macrophages were "activated" to become cytotoxic for a fibroblast cell line (L 929) by the additi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumenthal EJ,Roberts WK,Vasil A,Talmage DW

更新日期：1983-04-01 00:00:00

abstract：:Pentamidine, diminazene aceturate (Berenil), isometamidium chloride (Samorin), and ethidium bromide, which are important antitrypanosomal drugs, promote linearization of Trypanosoma equiperdum minicircle DNA (the principal component of kinetoplast DNA, the mitochondrial DNA in these parasites). This effect occurs at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shapiro TA,Englund PT

更新日期：1990-02-01 00:00:00

abstract：:By combining the pairwise interactions between proteins, as predicted by the conserved co-occurrence of their genes in operons, we obtain protein interaction networks. Here we study the properties of such networks to identify functional modules: sets of proteins that together are involved in a biological process. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snel B,Bork P,Huynen MA

更新日期：2002-04-30 00:00:00

abstract：:Peptide-protein interactions are important mediators of cellular-signaling events. Consensus binding motifs (also known as short linear motifs) within these contacts underpin molecular recognition, yet have poor pharmacological properties as discrete species. Here, we present methods to transform intact peptides into ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawson KV,Rose TE,Harran PG

更新日期：2013-10-01 00:00:00

abstract：:A major barrier to the design of immunotherapeutics and vaccines for cancer is the idiosyncratic nature of many tumor antigens and the possibility that T cells may be tolerant of broadly distributed antigens. We have devised an experimental strategy that exploits species differences in protein sequences to circumvent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Theobald M,Biggs J,Dittmer D,Levine AJ,Sherman LA

更新日期：1995-12-19 00:00:00

abstract：:Routine dietary consumption of foods that contain aflatoxins is the second leading cause of environmental carcinogenesis worldwide. Aflatoxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B1 (AFB1) to its epoxide form that reacts with N7 guanine in DNA. The resulting AFB1-N7-dG adduct under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin YC,Owen N,Minko IG,Lange SS,Tomida J,Li L,Stone MP,Wood RD,McCullough AK,Lloyd RS

更新日期：2016-11-29 00:00:00

abstract：:The uncatalyzed reactions of O(2) (S = 1) with organic substrates (S = 0) are thermodynamically favorable but kinetically slow because they are spin-forbidden and the one-electron reduction potential of O(2) is unfavorable. In nature, many of these important O(2) reactions are catalyzed by metalloenzymes. In the case ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pau MY,Lipscomb JD,Solomon EI

更新日期：2007-11-20 00:00:00

abstract：:HIV-1 envelope glycoprotein is the primary target for HIV-1-specific antibodies. The native HIV-1 envelope spike on the virion surface is a trimer, but trimeric gp140 and monomeric gp120 currently are believed to induce comparable immune responses. Indeed, most studies on the immunogenicity of HIV-1 envelope oligomers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovacs JM,Nkolola JP,Peng H,Cheung A,Perry J,Miller CA,Seaman MS,Barouch DH,Chen B

更新日期：2012-07-24 00:00:00

abstract：:Soon after the initiation of sporulation, Bacillus subtilis divides asymmetrically to produce sister cells that have very different developmental fates. Recently, it has been proposed that the differential gene expression which begins soon after this division is due to cell-specific activation of the transcription fac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis PJ,Partridge SR,Errington J

更新日期：1994-04-26 00:00:00

abstract：:The ever-increasing industrial demand for nylon-6 (polycaprolactam) necessitates the development of environmentally benign methods of producing its precursor, epsilon-caprolactam, from cyclohexanone. It is currently manufactured in two popular double-step processes, each of which uses highly aggressive reagents, and e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas JM,Raja R

更新日期：2005-09-27 00:00:00