Abstract：
:Heart muscle diseases are traditionally classified according to their peculiar pathophysiologic features such as "dilated," "hypertrophic," "restrictive," and "arrhythmogenic right ventricular" cardiomyopathy. The extraordinary advances accomplished in the last two decades in molecular genetics have allowed the identification of the genetic background of most of these conditions. According to the 1995 World Health Organization definition of cardiomyopathies as "diseases of the myocardium associated with cardiac dysfunction," they should include not only forms with hemodynamic dysfunction, but also conduction and rhythm disturbances. Arrhythmias are per se a sign of cardiac dysfunction and may reflect an underlying myocardial electrical disease with or without structural abnormalities as features. Nonstructural arrhythmogenic heart diseases include long and short QT syndromes, Brugada syndrome, Lènegre disease, and catecholaminergic polymorphic ventricular tachycardia. These conditions are defined as "channelopathies" because they are the consequence of cardiac ion channel gene mutations. Long and short QT syndromes are mostly caused by either sodium or potassium ion channel gene mutations; Brugada syndrome and Lènegre disease are both related to a defective sodium channel gene; and polymorphic ventricular tachycardia is the result of an abnormal ryanodine receptor regulating calcium release from the sarcoplasmic reticulum. These nonstructural inherited arrhythmic conditions should be regarded as cardiomyopathies because the myocyte is abnormal, although the heart is apparently intact. It is time for a new classification of cardiomyopathies taking into account the underlying gene mutations and the cellular level of expression of encoded proteins, thus distinguishing cytoskeleton (cytoskeletalopathies), desmosomal (desmosomalopathies), sarcomeric (sarcomyopathies), and ion channel (channelopathies) cardiomyopathies.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Corrado D,Basso C,Thiene Gdoi
10.1016/j.jelectrocard.2005.06.101keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
81-7issue
4 Suppleissn
0022-0736issn
1532-8430pii
S0022-0736(05)00119-6journal_volume
38pub_type
杂志文章,评审abstract：:Clinically based studies have indicated that patients who have suffered myocardial infarction (MI) exhibit lower heart rate variability (HRV). Such associations have not been reported at the population level. To investigate whether MI is related to lower HRV in the general population, the authors examined a stratified...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(96)80082-3
更新日期：1996-07-01 00:00:00
abstract：:In order to differentiate the vectorcardiogram (VCG) in high posterior infarction (HPI) from VCGs of normal subjects, right ventricular hypertrophy (RVH) and primary myocardial disease (PMD), the following criteria were presented; cases satisfying the criteria could be diagnosed as high posterior infarction. In cases ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(78)80107-1
更新日期：1978-04-01 00:00:00
abstract：:The authors focus on computational separation of the individual patterns of occlusion of the major segments of the right coronary artery. The raw patterns of occlusion throughout 15 standard subdivisions of the coronary arterial tree and body surface isoarea maps for 8 consecutive 10-msec intervals of QRS were examine...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(07)80106-3
更新日期：1989-01-01 00:00:00
abstract：:Ventricular tachycardia arising from a healed myocardial infarction scar continues to be a significant cause of morbidity and mortality. Drug therapy has been inadequate to meet this challenge, and implantable devices are limited by expense and technical problems. We have proposed the use of gene therapy for cardiac a...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2007.05.036
更新日期：2007-11-01 00:00:00
abstract：:A rigorous mathematical analysis of Electrocardiogram (ECG) data is presented in this paper, as a decision support system for ECG interpretation. The mathematical analysis: provides a new insight to the ECG data, provides flexibility for future understanding of the heart system or the ECG, and avoids the need of measu...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:Percutaneous radiofrequency catheter ablation (RFCA) has a very high success rate for certain arrhythmias, such as Wolff-Parkinson-White syndrome and idiopathic ventricular tachycardias in the right ventricular outflow tract. These arrhythmias are typically characterized by a single site of arrhythmogenic tissue that ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(94)80073-1
更新日期：1994-01-01 00:00:00
abstract：:An academic 12-lead electrocardiogram (ECG) core laboratory aims to provide the highest possible quality ECG recording, measurement, and storage to aid clinicians in research into important cardiovascular outcomes and to maximize the credibility of scientific results based solely, or in part, on ECG data. This positio...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2001.22028
更新日期：2001-01-01 00:00:00
abstract：:The myocardial electrical conduction is significantly influenced by the sympathetic and parasympathetic nervous systems. Hypervagotonia refers to increased vagal tone leading to sinus bradycardia, sinus pause, or any degree of atrioventricular (AV) block. There are many clinical, electrocardiographic, and electrophysi...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2009.07.018
更新日期：2009-11-01 00:00:00
abstract：:In a 66-year-old male with subacute extensive anterior wall myocardial infarction, we report a change in ST vector orientation from a basal anterior to a mid anterior after coronary artery recanalization of the proximal left anterior descending coronary artery with rotational atherectomy. The ST vector shift on the fr...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2009.05.001
更新日期：2009-09-01 00:00:00
abstract：:Reliable cardiovascular (CV) risk assessment by a noninvasive tool would be of great value for CV event prevention. The present study consists of 187 coronary artery disease patients with 8 years of follow-up. Eight vectorcardiographic parameters characterizing different aspects of ventricular repolarization were anal...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2010.05.004
更新日期：2010-07-01 00:00:00
abstract：:The vectorcardiographic basis of indeterminate QRS axis has not been elucidated. Accordingly, Frank lead VCGs were obtained on ten consecutive subjects with biphasic QRS complexes in the six extremity leads. The frontal plane vector in each case showed a very narrow loop inscribed in a symmetrical fashion around the E...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(82)80022-8
更新日期：1982-01-01 00:00:00
abstract：:A retrospective study was conducted to define the incidence of ventricular ectopic beats with exit block (concealed extrasystoles). Of 904 Holter recordings, 92 were admitted for study on the basis of sufficient ventricular ectopic beats on rhythm strips. Concealed bigeminy conforming to the equation of S = 2n - 1 (wh...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(83)80017-x
更新日期：1983-04-01 00:00:00
abstract：:Atrial arrhythmias are diagnosed on the basis of the analysis of P wave morphology, timing and rate, the surface electrocardiogram, and intracardiac recordings. Recent intracardiac studies have demonstrated dissimilar atrial rhythms with direct intra-atrial recordings, the former otherwise not evident on the surface E...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(91)90010-j
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:Simulation of the electrical activation of the heart and its comparison with real in vivo activation is a promising method in testing potential determinants of excitation. Simulation of the electrical activity of the human heart is now emerging as a step forward for understanding and predicting electrophysio...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2008.12.008
更新日期：2009-03-01 00:00:00
abstract：:Prognosis and risk factors for patients age 35years or younger with Brugada syndrome (BrS) were prospectively explored in a sub-analysis of the Japan Idiopathic Ventricular Fibrillation Study (J-IVFS) registry. During the period from February 2002 to January 2011, 69 cases (mean age 30±6years, male=66) of the young (a...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:The authors present a case of trifascicular block: complete right bundle branch block, tachycardia-dependent left anterior hemiblock, and bradycardia-dependent left posterior hemiblock. There is, in addition, a complicating independent AV junctional rhythm that is in most instances not affected by the conducted sinus ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(89)90037-x
更新日期：1989-07-01 00:00:00
abstract：UNLABELLED:The increased QRS voltage is considered to be a specific electrocardiogram (ECG) sign of left ventricular hypertrophy (LVH), and it is expected that the QRS voltage reflects the increase in left ventricular mass (LVM). However, the increased QRS voltage is only one of QRS patterns observed in patients with L...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2009.07.014
更新日期：2010-05-01 00:00:00
abstract：:Five male patients with chronic stable ventricular arrhythmias underwent a placebo controlled ascending dose study with oral cibenzoline, a new type 1 antiarrhythmic drug. Ambulatory ECG (Holter) recordings and electrophysiologic studies were done while on placebo and on the maximum dose of cibenzoline. Drug toxicity,...
journal_title：Journal of electrocardiology
pub_type： 临床试验,杂志文章
doi：10.1016/s0022-0736(84)80020-5
更新日期：1984-01-01 00:00:00
abstract：:The authors investigated 244 consecutive patients with suspected coronary artery disease by coronary angiography and quantitative left ventriculography to compare the Minnesota Q/QS code (MC) with clinical electrocardiographic (ECG) interpretation. Patients who were suspected to have wall motion abnormalities for reas...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/0022-0736(93)90006-y
更新日期：1993-04-01 00:00:00
abstract：:A 63 year old man with angina pectoris was found to have frequent extrasystoles separated by odd as well as even numbers of conducted sinus beats. Analysis of 935 conducted sinus beats showed that premature ventricular beats without interpolation were separated by odd numbers of conducted sinus beats in 117 sequences ...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(82)80033-2
更新日期：1982-01-01 00:00:00
abstract：:T-wave alternans (TWA) on the electrocardiogram have been frequently associated with long QT syndrome (LQTS) and abrupt rate change. The present study investigated the effect of the potassium channel opener nicorandil on the repolarization alternans at the endocardium and the epicardium in the left ventricle. Electroc...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1054/jelc.2000.8398
更新日期：2000-07-01 00:00:00
abstract：INTRODUCTION:"Cardiac memory" (CM) refers to a change in repolarization induced by an altered pathway of activation, manifested after resumption of spontaneous ventricular activation (SVA). AIMS:To investigate for the first time in humans the effects of left ventricular (LV) pacing on CM development through vectorcard...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2015.05.007
更新日期：2015-07-01 00:00:00
abstract：:New developments in instrumentation, in clinical application, as well as in data analysis and visualization have provided new momentum to magnetocardiography (MCG). On one hand robust, easy to use and budget-priced MCG-systems entered the market and are applied to a multi-centred clinical study. On the other hand high...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2004.08.035
更新日期：2004-01-01 00:00:00
abstract：:A case of concealed ventricular bigeminy is reported in which the number of sinus QRS complexes intervening between two successive noninterpolated extrasystoles was always uneven. Coupling intervals of manifest extrasystoles to the preceding sinus QRS complexes were almost fixed and much longer than sinus QT intervals...
journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/s0022-0736(96)80100-2
更新日期：1996-10-01 00:00:00
abstract：:We previously showed that increased intracardiac repolarization lability predicts life-threatening ventricular arrhythmias in patients with structural heart disease. Patients with structural heart disease frequently take antiarrhythmic drugs (AADs), which directly affect repolarization. The effect of AADs on the predi...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2009.07.011
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:Assess effect of right ventricular pacing (RVP) on left ventricular (LV) activation in heart failure patients with left bundle branch block (LBBB). BACKGROUND:LV activation during RVP is regarded as similar to LBBB; hence novel CRT algorithms may avoid RVP by adopting "fusion" pacing with intrinsic RBB-media...
journal_title：Journal of electrocardiology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jelectrocard.2014.09.002
更新日期：2015-01-01 00:00:00
abstract：:This study employs a bifurcation analysis approach to elucidate the effect of the key ion channels on cardiac arrhythmias and thereby explain the efficacy of antiarrhythmic drugs in controlling arrhythmias. The model used for the analysis contains the key ion channels involved in the ventricular action potential--fast...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/s0022-0736(95)80055-7
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Conflicting results have been reported on the predictive value of the electrocardiographic left ventricular hypertrophy (LVH) in the general population. This meta-analysis sought to compare the predictive value of different electrocardiographic criteria of LVH in the general population. METHODS:We comprehen...
journal_title：Journal of electrocardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jelectrocard.2020.07.001
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:We have previously used a 12-lead, signal-processed ECG to calculate blood potassium levels. We now assess the feasibility of doing so with a smartphone-enabled single lead, to permit remote monitoring. PATIENTS AND METHODS:Twenty-one hemodialysis patients held a smartphone equipped with inexpensive FDA-appr...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2017.06.008
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:There is a controversy regarding the association between QRS width and ventricular arrhythmias (VAs). We hypothesized that predictive value of the QRS width could be improved if QRS width were considered in the context of the sum magnitude of the absolute QRST integral in 3 orthogonal leads sum absolute QRST...
journal_title：Journal of electrocardiology
pub_type： 杂志文章
doi：10.1016/j.jelectrocard.2010.07.013
更新日期：2010-11-01 00:00:00
