Abstract：
OBJECTIVES:We discuss supervised classification techniques applied to medical diagnosis based on gene expression profiles. Our focus lies on strategies of adaptive model selection to avoid overfitting in high-dimensional spaces. METHODS:We introduce likelihood-based methods, classification trees, support vector machines and regularized binary regression. For regularization by dimension reduction, we describe feature selection methods: feature filtering, feature shrinkage and wrapper approaches. In small sample-size situations efficient methods of data re-use are needed to assess the predictive power of a model. We discuss two issues in using cross-validation: the difference between in-loop and out-of-loop feature selection, and estimating model parameters in nested-loop cross-validation. RESULTS:Gene selection does not reduce the dimensionality of the model. Tuning parameters enable adaptive model selection. The feature selection bias is a common pitfall in performance evaluation. Model selection and performance evaluation can be combined by nested-loop cross-validation. CONCLUSIONS:Classification of microarrays is prone to overfitting. A rigorous and unbiased assessment of the predictive power of the model is a must.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Markowetz F,Spang Rkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
438-43issue
3eissn
0026-1270issn
2511-705Xpii
05030438journal_volume
44pub_type
杂志文章abstract：OBJECTIVES:The purpose of this work is to develop a health information platform connecting most health facilities in the Rhône-Alpes region. The health platform called SIS-RA is used through a Web interface. An iconic interface is dedicated to the platform and presents information in a unique way for all users. METHOD...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:The single leg squat (SLS) is a common lower limb rehabilitation exercise. It is also frequently used as an evaluative exercise to screen for an increased risk of lower limb injury. To date athlete / patient SLS technique has been assessed using expensive laboratory equipment or subjective clinical judgement...
journal_title：Methods of information in medicine
pub_type： 临床试验,杂志文章
doi：10.3414/ME16-02-0002
更新日期：2017-03-23 00:00:00
abstract：OBJECTIVES:In this work, a cellular automaton software package for simulating different infectious diseases, storing the simulation results in a data warehouse system and analyzing the obtained results to generate prediction models as well as contingency plans, is proposed. The Brisbane H3N2 flu virus, which has been s...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-02-0025
更新日期：2010-01-01 00:00:00
abstract：:A Bonhoeffer-van der Pol equation with a stable limit cycle is proposed as a model of the pacemaker in the sino-atrial node to explain heart rate regulation. Standard tools, such as the phase transition curve in nonlinear dynamic system theory, are used to analyze the model and results are compared with other studies ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVES:In 1998, we reported a steady increase in the number of publications indexed in MedLine with the MeSH term 'Medical Records Systems, Computerized'. No signs indicating an increasing interest of high-impact medical journals to publish on the computer-based patient record could be determined. In this review we...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:This paper tries to compare six Health Informatics/Medical Informatics (HI/MI) programs by a number of attributes in standardized form. The different programs and their curricula were summarized at the 5th IMIA Working Conference on HI/MI Education at Heidelberg/Heilbronn. The presentation is condensed to a synoptical...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：BACKGROUND:Unsupervised home exercise is a major component of physical therapy (PT). This study proposes an inexpensive, inertial measurement unit-based wearable device to capture kinematic data to facilitate exercise. However, conveying and interpreting kinematic data to non-experts poses a challenge due to the comple...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.1055/s-0040-1710380
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:To investigate the nonlinear characteristics of visual evoked potentials (VEPs), and their correlation with the visual responses on parvocellular and magnocellular pathways. First and second-order kernels of the VEPs elicited by several checkerboard patterns were estimated, and their relations to the visual ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:A non-parametric method is presented for modelling nonlinear dynamic mechanisms of respiratory sinus arrhythmia (RSA) in anesthesia caused by positive pressure ventilation. RR interval sequences are shown with Tsay's linearity test to contain both short-term and long-term nonlinear components, which cannot completely ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVES:To discuss application areas of information technology in medicine and health care on the occasion of the opening of the Private Universität für Medizinische Informatik und Technik Tirol/University for Health Informatics and Technology Tyrol (UMIT) at Innsbruck, Tyrol, Austria. RESULTS AND CONCLUSIONS:Impor...
journal_title：Methods of information in medicine
pub_type：
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:Benchmarking statements provide a mechanism for making academic standards explicit within a subject area. They allow comparisons between courses to be based on learning outcomes rather than by defining a curriculum. No such statement has been produced for informatics. In the absence of any established benchm...
journal_title：Methods of information in medicine
pub_type： 杂志文章,评审
doi：10.1160/me0442
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to explore suitable spatial filters for inverse estimation of cortical potentials from the scalp electroencephalogram. The effect of incorporating noise covariance into inverse procedures was examined by computer simulations and tested in human experiment. METHODS:The paramet...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Questions like 'How is your health? How are you feeling? How have you been?' now can be answered in a different way due to innovative health self-quantification apps and devices. These apps and devices generate data that enable individuals to be informed and more responsible about their own health. OBJECTIV...
journal_title：Methods of information in medicine
pub_type： 杂志文章,评审
doi：10.3414/ME15-02-0007
更新日期：2017-01-09 00:00:00
abstract：OBJECTIVES:This study aims to demonstrate the usability of discourse analyses as a means of evaluating medical informatics systems by examining one particular computer-based data-to-text system for delivering neonatal health care information. METHODS:Six textual summaries of clinical information, three produced by hum...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0613
更新日期：2010-01-01 00:00:00
abstract：:Construction of medical knowledge bases for use in expert systems is an arduous task. We propose a procedure for obtaining medical knowledge via automated analysis of citations found in the National Library of Medicine's MEDLINE database. In this method, simple pattern of keywords and subheading co-occurrences are det...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:In this study, we attempted to discriminate the acceleration signal for horizontal level and stairway walking using wavelet-based fractal analysis method. The acceleration signal was measured close to the center of gravity of the body, while the subjects walked continuously in the corridor and up and down the stairs. ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Main requirements for an Anesthesia Information Management System (AIMS) are the supply of additional information for the anesthesiologist at his workstation and complete documentation of the anesthetic procedure. With the implementation of an AIMS (NarkoData) and effective user support, the quality of documentation a...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Studying workflow is a critical step in designing, implementing and evaluating informatics interventions in complex sociotechnical settings, such as hospital emergency departments (EDs). Known approaches to studying workflow in clinical settings attend to the activities of individual clinicians, thus being i...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME12-01-0079
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:Pulmonary disorders are frequently characterized by the presence of adventitious sounds added to the breathing or base lung sound (BLS). The aim of this work was to assess the features of BLS in extrinsic allergic alveolitis (EAA) patients in comparison to healthy subjects, applying linear and nonlinear analy...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME12-01-0037
更新日期：2013-01-01 00:00:00
abstract：:The illustration of a patient's history by a graphical primitive is discussed. Illustration technology is presented which simultaneously represents quantitative examination findings (e.g., laboratory values) and qualitative findings (e.g., from function diagnostics) by a single geometrical figure. Depending on the med...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVES:To provide a comprehensive bottom-up categorization of model-based segmentation techniques that allows to select, implement, and apply well-suited active contour models for segmentation of medical images, where major challenges are the high variability in shape and appearance of objects, noise, artifacts, pa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". BACKGROUND:Data sharing and integration between the clinical research data management system and the electronic health record system remains a challenging issue. T...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0019
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:The analysis of energetic ventricular variable changes during artificial ventilation, obtained by numerical simulation was done. Twenty-one sets of hemodynamic parameters for eight cardiosurgical patients were used to estimate left and right stroke work. The data were collected for three methods of ventilati...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Acute appendicitis is the most common cause of acute abdomen requiring surgical intervention. The clinical diagnosis of acute appendicitis is not always easy due to variable symptomatology, particularly at the onset. The contributions of history-taking and physical examination in the diagnosis of acute appendicitis wa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:A polygon-based graphical representation of laboratory test results using nonlinear scaling is described. It is argued that the nonlinearity of the scale and the use of colors in the representation facilitates interpretation of the test result in its relationship to the standard reference range and critical clinical d...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVES:Several researchers have proposed the use of logical ontologies as 'reference terminologies'. However, there are a number of unresolved issues. This article describes the development of a logical ontology for nursing interventions and presents the results of evaluation. METHODS:Initially this study involved...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:The use of electronic medical record (EMR) is anticipated to bring benefits for patients, physicians, and organizations. But limited physicians' acceptance of EMR presents a serious threat to its effective implementation. OBJECTIVES:The current study incorporates technology acceptance model (TAM) with two a...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.1055/s-0039-1695718
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVES:Biomedical ontologies exist to serve integration of clinical and experimental data, and it is critical to their success that they be put to widespread use in the annotation of data. How, then, can ontologies achieve the sort of user-friendliness, reliability, cost-effectiveness, and breadth of coverage that ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME9302
更新日期：2010-01-01 00:00:00
abstract：:The use of computers in the health sector has increased significantly during the last few years in Nigeria. This paper addresses the integration of health and informatics education, or health education and informatics education, or informatics education in health care delivery. It gives an introduction to the status o...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：OBJECTIVES:The traditional techniques of data analysis are often not sufficient to characterize the complex dynamics of respiration. In this study the respiratory pattern variability was analyzed using symbolic dynamics. METHODS:A group of 20 patients on weaning trials from mechanical ventilation were studied at two d...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
