Abstract：
:The long QT syndrome (LQTS) and the Brugada syndrome (BrS) are the most common genetic causes of malignant ventricular arrhythmias and sudden cardiac death in young patients with normal cardiac morphology. To date, more than 250 different mutations in seven genes have been identified as causing LQTS, whereas the only gene identified to be linked to BrS is SCN5A. In both syndromes, gene-specific mutations have been shown to be associated with specific phenotypic expressions. Risk stratification in LQTS and BrS is based mainly upon a constellation of electrocardiographic findings and a history of prior symptoms. In patients identified as high risk for arrhythmic mortality, the implantable cardioverter defibrillator is the most effective treatment and has been shown to provide near-complete protection during long-term follow-up.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Goldenberg I,Moss AJ,Zareba Wdoi
10.1007/s11886-005-0088-1keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
349-56issue
5eissn
1523-3782issn
1534-3170journal_volume
7pub_type
杂志文章,评审abstract：:Sudden cardiac death (SCD) is the leading cause of death in the United States. Although SCD occurs most commonly in patients with established heart disease, SCD can also be the initial manifestation of cardiovascular disease. Efforts to reduce the incidence of SCD include aggressive treatment of heart disease and its ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-004-0036-5
更新日期：2004-09-01 00:00:00
abstract：:Aldosterone is the principal circulating mineralocorticoid in humans, and aldosterone synthesis normally occurs in the face of volume depletion and renin stimulation. In primary and secondary aldosteronism, aldosterone synthesis continues despite volume expansion and causes hypertension. Other steroid hormones that ar...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-005-0059-6
更新日期：2005-11-01 00:00:00
abstract：PURPOSE OF REVIEW:The present review aims to discuss the recent advances in surgical management of spontaneous intracerebral hemorrhage (ICH), safety and efficacy of minimally invasive surgical techniques, and the existing evidence supporting their use. RECENT FINDINGS:Newer surgical techniques, collectively referred ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-1078-4
更新日期：2018-10-11 00:00:00
abstract：:Exercise intolerance in patients with chronic heart failure (CHF) shows no correlation to the degree of left ventricular dysfunction. This surprising finding has directed attention to peripheral changes in CHF: reduced endothelium-dependent vasodilation and altered skeletal muscle metabolism. Physical exercise trainin...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-999-0041-9
更新日期：1999-05-01 00:00:00
abstract：:The scientific selection of antithrombotic therapy has been dominated by group-based interpretation of data in the form of probability-based statistics in evidence-based medicine. Because the data in large randomized trials are grouped and averaged, the relationship to initial conditions of the patient is lost. There ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-003-0083-3
更新日期：2003-03-01 00:00:00
abstract：:A number of reports demonstrate the importance of serum triglyceride values in predicting the clinical onset of vascular disease. However, adjustment for measurements highly correlated with triglyceride (TG) levels, such as history of diabetes, body mass index, and high-density lipoprotein cholesterol (HDL-C), lessen ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-001-0060-7
更新日期：2001-09-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of low-density lipoprotein-cholesterol (LDL-C) lowering therapies is to safely achieve a consistent and long-term reduction in exposure of the vasculature to atherogenic lipoproteins in order to reduce the risk of atherosclerotic cardiovascular (CV) disease and the associated CV events, such a...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01427-6
更新日期：2020-10-21 00:00:00
abstract：:Sodium is an essential nutrient, mostly ingested as salt (sodium chloride). Average sodium intake ranges from 3 to 6 g per day (7.5-15 g/day of salt) in most countries, with regional variations. Increasing levels of sodium intake have a positive association with higher blood pressure. Randomized controlled trials repo...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-014-0529-9
更新日期：2014-01-01 00:00:00
abstract：:Diabetic patients who present with an acute coronary syndrome (ACS) have a particularly adverse prognosis, largely contributed by increased platelet reactivity and higher burden of disease severity. Diabetic patients with ACS derive a greater benefit from established therapies, particularly platelet-inhibiting therapi...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-010-0118-5
更新日期：2010-07-01 00:00:00
abstract：:Noninvasive cardiac imaging techniques have made a striking impact on the evaluation and management of pericardial disorders. Two-dimensional and Doppler echocardiography are the methods of choice in the evaluation of pericardial effusion and cardiac tamponade. Magnetic resonance imaging, computed tomography, and tran...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-002-0124-3
更新日期：2002-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of this report is to describe the main aspects of sex-related differences in non-ischemic dilated cardiomyopathies (DCM), focusing on chemotherapy-induced heart failure (HF) and investigating the possible therapeutic implications and clinical management applications in the era of personalized ...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01377-z
更新日期：2020-08-08 00:00:00
abstract：:Systemic embolic complications in patients with cardiomyopathy are associated with significant morbidity and mortality. Despite the lack of prospective, randomized control data, the literature supports the use of left ventricular ejection fraction as an important determinant of the need for systemic anticoagulation th...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-000-0006-5
更新日期：2000-03-01 00:00:00
abstract：:Hypertension is highly prevalent affecting nearly one third of the US adult population. Though generally approached as an outpatient disorder, elevated blood pressure is observed in a majority of hospitalized patients. The spectrum of hypertensive disease ranges from patients with hypertensive emergency including mark...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-015-0648-y
更新日期：2015-11-01 00:00:00
abstract：:The Fontan operation has been nothing short of revolutionary in its influence on the modern management of patients born with functionally univentricular hearts. The vast majority of these individuals are now surviving well into adulthood. In the 45 years since its introduction, however, there has been increasing recog...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0716-y
更新日期：2016-05-01 00:00:00
abstract：:Over the last several decades, significant advances and improvements in care of transplant patients have resulted in markedly improved outcomes. A number of options are available for patients with advanced cardiopulmonary dysfunction requiring transplantation. There is a debate about when isolated heart or isolated lu...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0713-1
更新日期：2016-04-01 00:00:00
abstract：PURPOSE OF REVIEW:This is an in-depth review on the mechanism of action, clinical utility, and drug-drug interactions of colchicine in the management of pericardial disease. RECENT FINDINGS:Recent evidence about therapeutic targets on pericarditis has demonstrated that NALP3 inflammasome blockade is the cornerstone in...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-018-1008-5
更新日期：2018-06-14 00:00:00
abstract：:Aortic valve replacement can produce dramatic benefit in the setting of aortic stenosis. The potential for morbidity and mortality associated with thoracotomy, cardiopulmonary bypass, and aortotomy has fostered a search for alternatives. Early experience with transcatheter endovascular aortic valve implantation demons...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-008-0019-z
更新日期：2008-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Several interrelated mechanisms promote the development of hypertension in obesity, often contributing to end organ damage including cardiovascular disease and chronic kidney disease. RECENT FINDINGS:The treatment of hypertension in obesity is complicated by a high prevalence of resistant hypertensio...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0912-4
更新日期：2017-08-24 00:00:00
abstract：PURPOSE OF REVIEW:Acute rejection is one of the most feared complications of cardiac transplantation. Developing non-invasive methods for detection and surveillance of acute rejection have long been a goal for post-transplant care. RECENT FINDINGS:Here, we will review molecular diagnostic tests that are currently in u...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0915-1
更新日期：2017-10-13 00:00:00
abstract：:Hypertension in children and adolescents is becoming a greater problem in the developed world. Although traditionally thought of as usually secondary to renal, vascular, or endocrine causes, primary hypertension is becoming the most common form seen in childhood. This changing epidemiology is related to the recent obe...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-015-0661-1
更新日期：2015-12-01 00:00:00
abstract：:Cardiac implantable electronic device (CIED) infections are complex medical problems that are increasingly encountered. They are associated with significant morbidity and mortality with tremendous economic cost. The current review will emphasize the prevention, diagnosis, and treatment of this clinical entity using th...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0733-x
更新日期：2016-06-01 00:00:00
abstract：:Revascularization in stable ischemic heart disease (SIHD) is indicated in patients on optimal medical therapy with angina and/or demonstrable ischemia and a significant stenosis in one or more epicardial coronary arteries. Angiography alone, however, cannot accurately determine the hemodynamic significance of coronary...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0711-3
更新日期：2016-04-01 00:00:00
abstract：:Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority bein...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0804-z
更新日期：2016-12-01 00:00:00
abstract：:Shared decision-making, central to evidence-based medicine and good patient care, begins and ends with the patient. It is the process by which a clinician and a patient jointly make a health decision after discussing options, potential benefits and harms, and considering the patient's values and preferences. Patient e...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0729-6
更新日期：2016-05-01 00:00:00
abstract：PURPOSE OF REVIEW:An examination of the current ACC/AHA and ESC/EAS Guidelines on the management of dyslipidemias for common ground and differences. RECENT FINDINGS:There is much common ground. Both note that ASCVD is, in most people, the product of a number of risk factors, notably tobacco exposure, hyperlipidemia, h...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-017-0857-7
更新日期：2017-06-01 00:00:00
abstract：:Antiarrhythmic drugs are widely used, but are of modest efficacy and have important side effects. However, even with the advance of catheter ablation for atrial fibrillation and ventricular tachycardia, antiarrhythmic drugs remain an important tool for treating arrhythmias. Antiarrhythmic drug development has remained...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-013-0410-2
更新日期：2013-10-01 00:00:00
abstract：:Since 1971, the Fontan operation has been performed for the repair of single-ventricle physiology. This ingenious operation commits a single ventricle to the systemic circulation and takes advantage of cardiovascular and respiratory physiology to propel deoxygenated blood to the lungs, thus minimizing right-to-left sh...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/BF02938382
更新日期：2007-07-01 00:00:00
abstract：PURPOSE OF REVIEW:To determine if subsidizing the cost of a food-based intervention for managing hyperlipidemia could be cost-effective under commercial insurance and/or Medicare coverage scenarios. RECENT FINDINGS:A large number of patients eligible for pharmaceutical treatment of hyperlipidemia either cannot or will...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01397-9
更新日期：2020-09-10 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this paper is to review present knowledge regarding biological pacemakers created by somatic reprogramming as a platform for mechanistic and metabolic understanding of the rare subpopulation of pacemaker cells, with the ultimate goal of creating biological alternatives to electronic pacing...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-020-01281-6
更新日期：2020-03-30 00:00:00
abstract：:In STEMI, primary PCI restores macrovascular coronary blood flow effectively but microvascular perfusion remains a challenge. Thrombus has the potential to embolize to the microvasculature limiting effective coronary blood flow. Thrombus burden is associated with a higher mortality and manual aspiration thrombectomy h...
journal_title：Current cardiology reports
pub_type： 杂志文章,评审
doi：10.1007/s11886-016-0707-z
更新日期：2016-03-01 00:00:00
