Abstract：
OBJECTIVES:Biomedical applications, such as analysis and management of mass spectrometry proteomics experiments, involve heterogeneous platforms and knowledge, massive data sets, and complex algorithms. Main requirements of such applications are semantic modeling of the experiments and data analysis, as well as high performance computational platforms. In this paper we propose a software platform allowing to model and execute biomedical applications on the Grid. METHODS:Computational Grids offer the required computational power, whereas ontologies and workflow help to face the heterogeneity of biomedical applications. In this paper we propose the use of domain ontologies and workflow techniques for modeling biomedical applications, whereas Grid middleware is responsible for high performance execution. As a case study, the modeling of a proteomics experiment is discussed. RESULTS:The main result is the design and first use of PROTEUS, a Grid-based problem-solving environment for biomedical and bioinformatics applications. CONCLUSION:To manage the complexity of biomedical experiments, ontologies help to model applications and to identify appropriate data and algorithms, workflow techniques allow to combine the elements of such applications in a systematic way. Finally, translation of workflow into execution plans allows the exploitation of the computational power of Grids. Along this direction, in this paper we present PROTEUS discussing a real case study in the proteomics domain.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Cannataro M,Cuda G,Veltri Pkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
221-6issue
2eissn
0026-1270issn
2511-705Xpii
05020221journal_volume
44pub_type
杂志文章abstract：OBJECTIVES:The International Medical Informatics Association (IMIA) today is an inclusive organization that represents the medical and health informatics world through its multiple member countries as well as affiliate, corporate and academic institutions, plus working groups and regions. The IMIA leadership deemed thi...
journal_title：Methods of information in medicine
pub_type： 社论
doi：
更新日期：2006-01-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of METHODs of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". BACKGROUND:SALUS project aims at building an interoperability platform and a dedicated toolkit to enable secondary use of electronic health records (EHR) data for ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0025
更新日期：2015-01-01 00:00:00
abstract：:Reliable record linkage is a prerequisite for high-quality population-based disease registration. Rapid developments in computer processing have made record linkage both more efficient and more reliable in recent years. At the same time, concerns about confidentiality increasingly hinder record linkage in many disease...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Questions like 'How is your health? How are you feeling? How have you been?' now can be answered in a different way due to innovative health self-quantification apps and devices. These apps and devices generate data that enable individuals to be informed and more responsible about their own health. OBJECTIV...
journal_title：Methods of information in medicine
pub_type： 杂志文章,评审
doi：10.3414/ME15-02-0007
更新日期：2017-01-09 00:00:00
abstract：:Requirements and approaches of Software Engineering education in the field of Medical Informatics are described with respect to the impact of (1) experiences characterizing the "software misery", (2) status and tendencies in software methodology, and (3) educational status and needs in computer science education influ...
journal_title：Methods of information in medicine
pub_type： 杂志文章,评审
doi：
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Diagnosis and management of dementia is a complex process and primary care physicians are under-equipped to deal with uncertainties in the provision of optimal care for the patient. OBJECTIVE:To develop a computer decision support system (CDSS) which could assist physicians with diagnosis and management and...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:The aim of this paper is twofold. First, we describe two important dimensions of patient care information systems (PCIS) evaluation: the domain of evaluation and the different phases of the PCIS implementation. Second, we claim that, though Randomized Controlled Trials (RCTs) are often still seen as the stand...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:The healthcare sector is facing an enormous acceleration due to the emergence of new knowledge, drugs, devices and diseases. Professional competence, continuing education, service excellence and patient benefits can be facilitated by the developments in information and computer technology--computer literacy ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:We present an algorithm for reconstructing the bifurcation structure of a dynamical system from time series. The method consists in finding a parameterized predictor function whose bifurcation structure is similar to that of the given system. Nonlinear autoregressive (NAR) models with polynomial terms are employed as ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:The barbell squat is a popularly used lower limb rehabilitation exercise. It is also an integral exercise in injury risk screening protocols. To date athlete/patient technique has been assessed using expensive laboratory equipment or subjective clinical judgement; both of which are not without shortcomings. ...
journal_title：Methods of information in medicine
pub_type： 临床试验,杂志文章
doi：10.3414/ME16-01-0141
更新日期：2017-10-26 00:00:00
abstract：:The use of computers in the field of medical education is common. Our purpose is to present a Computer-Assisted Instruction system which has been developed over ten years at the University of Compiègne and the University of Rennes Medical School. This system can be used to help the student to solve clinical cases by a...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Informatisation of drug prescription is an important topic in medical informatics. For several years now, computerized drug databases have been implemented. Usually only a small part of the prescriptions can be stored in prescription systems because of the format of the included information; prescriptions contain esse...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:The medical information systems of the future will probably include the entire medical record as well as a knowledge base, providing decision support for the physician during patient care. Data dictionaries will play an important role in integrating the medical knowledge bases with the clinical databases. This article...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems". BACKGROUND:Adaptation of the QT-interval to changes in heart rate reflects on the body-surface electrocardiogram the adaptation...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0039
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To present a geometric ruler to determine predictive values of binary diagnostic test results from prevalence, sensitivity and specificity without calculation. METHODS:On logarithmic scale the relationships between pre-/post-test odds and the likelihood ratio as well as sensitivity, specificity and the likel...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-01-0091
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:The analysis of energetic ventricular variable changes during artificial ventilation, obtained by numerical simulation was done. Twenty-one sets of hemodynamic parameters for eight cardiosurgical patients were used to estimate left and right stroke work. The data were collected for three methods of ventilati...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Differential Interference Contrast (DIC) microscopy is a powerful visualization tool used to study live biological cells. Its use, however, has been limited to qualitative observations. The inherent non-linear relation between the object properties and the image intensity makes quantitative analysis difficult. As a fi...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:To intensify the collaboration between WHO, the World Health Organization, and IMIA, the International Medical Informatics Association. METHODS:Identifying key areas of collaboration and publishing a joint communiqué during Medinfo 2007 in Brisbane, Australia. RESULTS AND CONCLUSIONS:WHO and IMIA have ident...
journal_title：Methods of information in medicine
pub_type： 社论
doi：10.1160/me5006
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:In our department, we have been using an Anesthesia Information Management System (AIMS) for five years. In this study, we tested to what extent data extracted from the AIMS could be suitable for the supervision and time-management of operating rooms. METHODS:From 1995 to 1999, all relevant data from 103,26...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:During the last decade there has been a wealth of papers discussing the development of scoring systems in medicine, some of which have led to fully operational computer-aided diagnostic systems. In this paper we sketch the development of a simple scoring system for one of the more common rheumatic diseases, rheumatoid...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:The objective of this work is to present the software tool ANTONIA, which has been developed to facilitate a quantitative analysis of perfusion-weighted MRI (PWI) datasets in general as well as the subsequent multi-parametric analysis of additional datasets for the specific purpose of acute ischemic stroke p...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-01-0007
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:ICD is used for coding medical diagnoses across the world, but there is no globally accepted coding system for health care procedures. The need for the introduction of a common international medical procedure classification has been addressed by the Australian NCCH, which proposed the International Classific...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-01-0007
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:The exchange of medical data from research and clinical routine across institutional borders is essential to establish an integrated healthcare platform. In this project we want to realize the standardized exchange of medical data between different healthcare institutions to implement an integrated and inter...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The availability of large amounts of data in heterogeneous formats and the rapid progress in fields such as computer based drug design, medical imaging and medical simulations have lead to a growing demand for large computational power and easy accessibility to heterogeneous data sources. OBJECTIVES:The goa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:For the statistical analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data, compartment models are a commonly used tool. By these models, the observed uptake of contrast agent in some tissue over time is linked to physiologic properties like capillary permeability and blood flow. Up ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-01-0131
更新日期：2016-01-01 00:00:00
abstract：:Psych Topix is a knowledge-based program which guides the clinician from an on-line clinical report to a search of the psychiatric literature or of other relevant databases. It provides this guidance by using an outline of key topics in a clinical field to provide "concept-based" links. Each topic is augmented with an...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:A tree-based method for estimating time-varying effects of baseline patient characteristics on survival is introduced. A Cox-type model for censored survival data is used in which the time-varying relative risks are modelled as piecewise constants. The tree method consists of three steps: 1. Growing the tree, in which...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVES:Our objective was to design and develop a mobile clinical decision support system for emergency triage of different acute pain presentations. The system should interact with existing hospital information systems, run on mobile computing devices (handheld computers) and be suitable for operation in weak-conne...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Medical informaticians are multidisciplinary professionals responsible for developing complex technical systems. The aim of this study was to investigate how a code of ethics can help medical informaticians in avoiding design failures. An exploratory case study was performed to identify factors related to failure duri...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVES:Complex physiological systems, such as the cardiovascular system, controlled by the autonomic nervous system, and the gait and posture system, controlled by the sensomotor nervous system, incorporate several controllers acting at different time scales. We investigated the question, whether the information fl...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
