Abstract:
OBJECTIVES:The objective of this work is to present the software tool ANTONIA, which has been developed to facilitate a quantitative analysis of perfusion-weighted MRI (PWI) datasets in general as well as the subsequent multi-parametric analysis of additional datasets for the specific purpose of acute ischemic stroke patient dataset evaluation. METHODS:Three different methods for the analysis of DSC or DCE PWI datasets are currently implemented in ANTONIA, which can be case-specifically selected based on the study protocol. These methods comprise a curve fitting method as well as a deconvolution-based and deconvolution-free method integrating a previously defined arterial input function. The perfusion analysis is extended for the purpose of acute ischemic stroke analysis by additional methods that enable an automatic atlas-based selection of the arterial input function, an analysis of the perfusion-diffusion and DWI-FLAIR mismatch as well as segmentation-based volumetric analyses. RESULTS:For reliability evaluation, the described software tool was used by two observers for quantitative analysis of 15 datasets from acute ischemic stroke patients to extract the acute lesion core volume, FLAIR ratio, perfusion-diffusion mismatch volume with manually as well as automatically selected arterial input functions, and follow-up lesion volume. The results of this evaluation revealed that the described software tool leads to highly reproducible results for all parameters if the automatic arterial input function selection method is used. CONCLUSION:Due to the broad selection of processing methods that are available in the software tool, ANTONIA is especially helpful to support image-based perfusion and acute ischemic stroke research projects.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Forkert ND,Cheng B,Kemmling A,Thomalla G,Fiehler Jdoi
10.3414/ME14-01-0007subject
Has Abstractpub_date
2014-01-01 00:00:00pages
469-81issue
6eissn
0026-1270issn
2511-705Xpii
14-01-0007journal_volume
53pub_type
杂志文章abstract::Requirements and approaches of Software Engineering education in the field of Medical Informatics are described with respect to the impact of (1) experiences characterizing the "software misery", (2) status and tendencies in software methodology, and (3) educational status and needs in computer science education influ...
journal_title:Methods of information in medicine
pub_type: 杂志文章,评审
doi:
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abstract:OBJECTIVES:The main objective is to show current topics and future trends in the field of medical signal processing which are derived from current research concepts. Signal processing as an integrative concept within the scope of medical informatics is demonstrated. METHODS:For all examples time-variant multivariate a...
journal_title:Methods of information in medicine
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/me0546
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journal_title:Methods of information in medicine
pub_type: 杂志文章
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journal_title:Methods of information in medicine
pub_type: 评论,社论
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
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journal_title:Methods of information in medicine
pub_type: 杂志文章
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME0582
更新日期:2009-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
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journal_title:Methods of information in medicine
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journal_title:Methods of information in medicine
pub_type: 杂志文章
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
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journal_title:Methods of information in medicine
pub_type: 杂志文章
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
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journal_title:Methods of information in medicine
pub_type: 社论
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
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journal_title:Methods of information in medicine
pub_type: 杂志文章
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journal_title:Methods of information in medicine
pub_type: 社论
doi:
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journal_title:Methods of information in medicine
pub_type: 杂志文章
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journal_title:Methods of information in medicine
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journal_title:Methods of information in medicine
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
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journal_title:Methods of information in medicine
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doi:
更新日期:1996-09-01 00:00:00
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