Invasive pneumococcal disease in pediatric organ transplant recipients: a high-risk population.

Abstract:

:There are few studies on invasive pneumococcal disease in pediatric transplant recipients. Given this fact plus the advent of pneumococcal conjugate vaccines, we conducted a retrospective study at a major pediatric transplant center. The objectives were to determine the incidence and outcomes of invasive pneumococcal diseases in the patient population and to examine the timing of these infections after transplantation. We determined that invasive disease occurred at a rate that was significantly greater than the rate extrapolated from generally healthy children <5 yr of age (176 episodes per 100 000 children per year vs. 35-68.3 per 100 000 children per year). In addition, disease occurred at a median of approximately 20 months after transplantation, thereby theoretically allowing enough time for vaccination with the 7-valent conjugate vaccine. The study also documented significant missed vaccination opportunities.

journal_name

Pediatr Transplant

authors

Tran L,Hébert D,Dipchand A,Fecteau A,Richardson S,Allen U

doi

10.1111/j.1399-3046.2005.00275.x

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

183-6

issue

2

eissn

1397-3142

issn

1399-3046

pii

PTR275

journal_volume

9

pub_type

杂志文章
  • A systematic review of immunosuppressant adherence interventions in transplant recipients: Decoding the streetlight effect.

    abstract::Non-adherence to immunosuppressant medications is an important risk factor for graft dysfunction. To evaluate the effectiveness of adherence-enhancing interventions, we reviewed adherence intervention studies in solid organ transplant recipients (all ages). Using the following databases: PsycINFO, PubMed, Scopus, and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13086

    authors: Duncan S,Annunziato RA,Dunphy C,LaPointe Rudow D,Shneider BL,Shemesh E

    更新日期:2018-02-01 00:00:00

  • Post-transplant glucose status in 61 pediatric renal transplant recipients: preliminary results of five Turkish pediatric nephrology centers.

    abstract::To assess the incidence, risk factors and outcomes of PTDM, a total of 61 non-diabetic children (24 girls, 37 boys, age: 14.5 +/- 2.1 yr) were examined after their first kidney transplantation (37.3 +/- 21.6 months) with an OGTT. At baseline, 16 (26.2%) patients had IGT, 45 (73.8%) had NGT, and no patient had PTDM. No...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1399-3046.2009.01192.x

    authors: Buyan N,Bilge I,Turkmen MA,Bayrakci U,Emre S,Fidan K,Baskin E,Gok F,Bas F,Bideci A

    更新日期:2010-03-01 00:00:00

  • Haploidentical hematopoietic stem cell transplantation for paediatric high-risk T-cell acute lymphoblastic leukaemia.

    abstract::Paediatric HR T-cell ALL demonstrates dismal prognosis with chemotherapy, and poor outcomes could be improved with allo-SCT. HID-SCT is an almost immediately available choice; however, few studies have focused on the outcomes of HID-SCT for paediatric HR T-ALL. Forty-eight consecutive HR T-ALL children who underwent H...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12704

    authors: Xu ZL,Huang XJ,Liu KY,Chen H,Zhang XH,Han W,Chen YH,Wang FR,Wang JZ,Wang Y,Chen Y,Yan CH,Xu LP

    更新日期:2016-06-01 00:00:00

  • Living donor lobar lung transplantation: the pediatric experience.

    abstract::Living donor (LD) lobar lung transplantation is now an accepted alternative to cadaveric lung transplantation in selected patients with end-stage lung disease. This study reviews the Childrens Hospital Los Angeles LD experience of 17 patients (mean 13.2 +/- 2.7 yrs; range 9.3-18.5 yrs). 12 LD patients had end-stage cy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Woo MS,MacLaughlin EF,Horn MV,Wong PC,Rowland JM,Barr ML,Starnes VA

    更新日期:1998-08-01 00:00:00

  • Simultaneous surgical and interventional radiological approach to treat complicated biliary strictures after pediatric liver transplantation.

    abstract::Post-transplantation biliary strictures occur in 5-15% of the pediatric liver transplant patients and are conventionally managed by interventional radiological techniques. Failure of this treatment leads to reoperation and sometimes to retransplantation. Herein, we describe a surgical approach and interventional radio...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00212.x

    authors: Salvalaggio PR,Bambini DA,Donaldson J,Saker M,Whitington PF,Alonso EM,Superina RA

    更新日期:2004-10-01 00:00:00

  • Risk for post-transplant lymphoproliferative disorder after polyclonal antibody induction in kidney transplantation.

    abstract::The adjusted relative risk (aRR) for development of post-transplant lymphoproliferative disorder (PTLD) is higher in kidney transplant recipients receiving monoclonal antibody induction therapy, but the aRR between the different available polyclonal agents has not been investigated in detail. We analyzed data from the...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00361.x

    authors: Dharnidharka VR,Stevens G

    更新日期:2005-10-01 00:00:00

  • Sirolimus for solid organ transplantation in children.

    abstract::Sirolimus represents a major advancement in the field of solid organ transplantation and is being used as a rescue agent for acute and chronic rejection as well as for primary immunosuppression with good graft outcome. Although initial studies with sirolimus were in adults, now significant data have accumulated on the...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00305.x

    authors: Gupta P,Kaufman S,Fishbein TM

    更新日期:2005-06-01 00:00:00

  • Recurrence of primary disease in children after renal transplantation: an evidence-based update.

    abstract::The availability of new and more effective anti-rejection therapy has succeeded in reducing the incidence of acute cellular rejection in first months post-renal transplant. This in turn has escalated the order of significance of recurrence of primary disease in the renal allograft as a cause for patient morbidity and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1046/j.1399-3046.2003.00151.x

    authors: Seikaly MG

    更新日期:2004-04-01 00:00:00

  • A national conference to determine research priorities in pediatric solid organ transplantation.

    abstract::The need for evidence-based practice guidelines requires high quality, carefully controlled clinical research trials. This multidisciplinary conference attempted to: identify urgent clinical and research issues, identify obstacles to performing clinical trials, develop concepts for organ-specific and all-organ researc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00811.x

    authors: Bartosh SM,Ryckman FC,Shaddy R,Michaels MG,Platt JL,Sweet SC

    更新日期:2008-03-01 00:00:00

  • Nocturnal hypertension and left ventricular hypertrophy in pediatric renal transplant recipients in South India.

    abstract::HTN after renal transplantation is associated with cardiovascular morbidity. ABPM allows diagnosis of masked HTN and isolated nocturnal HTN. Longitudinal ABPM data in children post-transplant are limited. ABPM was performed in children post-transplant and repeated in 6-12 months. BP indices were used to determine the ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13710

    authors: Pais P,Dello Strologo L,Iyengar A,Velusamy V,Greenbaum LA

    更新日期:2020-06-01 00:00:00

  • Intraoperative blood loss and transfusion during primary pediatric liver transplantation: A single-center experience.

    abstract::Children undergoing liver transplantation are at a significant risk for intraoperative hemorrhage and thrombotic complications, we aim to identify novel risk factors for massive intraoperative blood loss and transfusion in PLT recipients and describe its impact on graft survival and hospital LOS. We reviewed all prima...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13449

    authors: Villarreal JA,Yoeli D,Ackah RL,Sigireddi RR,Yoeli JK,Kueht ML,Galvan NTN,Cotton RT,Rana A,O'Mahony CA,Goss JA

    更新日期:2019-06-01 00:00:00

  • Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation.

    abstract::The clinical significance of parvovirus B19 infection in pediatric solid-organ and bone marrow transplanted patients is unclear. The overall prevalence of parvovirus B19 infection in these patients is about 1-2% during the first year after transplantation. The most common symptom is anemia, but leukopenia and thromboc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2001.00035.x

    authors: Broliden K

    更新日期:2001-10-01 00:00:00

  • Delayed short-term administration of granulocyte colony-stimulating factor is a good mobilization strategy for harvesting autologous peripheral blood stem cells in pediatric patients with solid tumors.

    abstract::PBSCs have become the preferred source of autologous stem cells for supporting high-dose chemotherapy in childhood solid tumors. The aims of this retrospective study were to examine the optimal timing for administration of G-CSF after chemotherapy and to identify the patients from whom an optimal dose of PBSCs can be ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12137

    authors: Takahashi H,Kato M,Kikuchi A,Hanada R,Koh K

    更新日期:2013-11-01 00:00:00

  • ABPM vs office blood pressure to define blood pressure control in treated hypertensive paediatric renal transplant recipients.

    abstract::While 24-h ambulatory blood pressure monitoring (ABPM) is an established tool for monitoring antihypertensive therapy in adults, data in children are scarce. We retrospectively analysed whether office blood pressure (BP) is reliable for the diagnosis of BP control in 26 treated hypertensive paediatric renal transplant...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00595.x

    authors: Ferraris JR,Ghezzi L,Waisman G,Krmar RT

    更新日期:2007-02-01 00:00:00

  • Liver and combined lung and liver transplantation for cystic fibrosis: analysis of the UNOS database.

    abstract::A proportion of patients with CF develop cirrhosis and portal hypertension. LT and combined LLT are rarely performed in patients with CF. To determine the outcome of LT and LLT in patients with CF. Patients with CF who had LT or LLT between 10/1987 and 5/2008 were identified from UNOS database. A total of 182 children...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01460.x

    authors: Arnon R,Annunziato RA,Miloh T,Padilla M,Sogawa H,Batemarco L,Willis A,Suchy F,Kerkar N

    更新日期:2011-05-01 00:00:00

  • Combined liver-kidney transplantation for primary hyperoxaluria type I in children: Single Center Experience.

    abstract::Primary hyperoxalurias are rare inborn errors of metabolism with deficiency of hepatic enzymes that lead to excessive urinary oxalate excretion and overproduction of oxalate which is deposited in various organs. Hyperoxaluria results in serious morbid-ity, end stage kidney disease (ESKD), and mortality if left untreat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13313

    authors: Kotb MA,Hamza AF,Abd El Kader H,El Monayeri M,Mosallam DS,Ali N,Basanti CWS,Bazaraa H,Abdelrahman H,Nabhan MM,Abd El Baky H,El Sorogy STM,Kamel IEM,Ismail H,Ramadan Y,Abd El Rahman SM,Soliman NA

    更新日期:2019-02-01 00:00:00

  • Liver transplantation as a treatment option for three siblings with homozygous familial hypercholesterolemia.

    abstract::FH is a hereditary inherited disorder of cholesterol metabolism. Homozygous form of the disease associates severe form of atherosclerotic disease. Clinicians have been tried to inhibit the progression of the homozygous FH with medical and surgical treatment. We here present three siblings with homozygous FH who were s...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01469.x

    authors: Küçükkartallar T,Yankol Y,Kanmaz T,Topaloğlu S,Acarli K,Kalayoglu M

    更新日期:2011-05-01 00:00:00

  • Transfusion requirements during cadaveric and living donor pediatric liver transplantation.

    abstract::Surgical techniques that have been used during liver transplantation (LT) together with patient's coagulation profile and institutional practices are reported to have an effect on transfusion requirements. The aim of this study is to evaluate the transfusion requirement in both cadaveric (CDLT, n = 22) and living dono...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00284.x

    authors: Ulukaya S,Acar L,Ayanoglu HO

    更新日期:2005-06-01 00:00:00

  • Cyclosporine-induced white and grey matter central nervous system lesions in a pediatric renal transplant patient.

    abstract::Major neurologic complications secondary to cyclosporine are well documented and are known to include confusion, cortical blindness, seizure, spasticity, paresis, ataxia and coma. Most previous reports attribute these to white matter central nervous system (CNS) lesions or white/grey matter border lesions. Many predis...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Jeruss J,Braun SV,Reese JC,Guillot A

    更新日期:1998-02-01 00:00:00

  • Graft fibrosis in patients with biliary atresia after pediatric living-related liver transplantation.

    abstract::Although an LDLT can successfully treat biliary atresia (BA), some patients develop liver fibrosis or inflammation. To study the incidence and risk factors associated with these complications, we performed serial protocol biopsies. Twenty-four patients with BA who received a pediatric LDLT underwent protocol biopsies....

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01483.x

    authors: Ueno T,Tanaka N,Ihara Y,Takama Y,Yamada H,Mushiake S,Fukuzawa M

    更新日期:2011-08-01 00:00:00

  • Low incidence of adverse events in outpatient pediatric renal allograft biopsies.

    abstract::In 1999, our center implemented a policy of outpatient protocol biopsies as standard practice for the clinical management of pediatric renal allograft recipients. In order to determine the safety of this procedure, we conducted a retrospective chart audit of all outpatient renal allograft biopsies performed at our cen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00659.x

    authors: Birk PE,Blydt-Hansen TD,Dart AB,Kaita LM,Proulx C,Taylor G

    更新日期:2007-03-01 00:00:00

  • Dyslipidemia after pediatric renal transplantation-The impact of immunosuppressive regimens.

    abstract::Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Dat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12914

    authors: Habbig S,Volland R,Krupka K,Querfeld U,Dello Strologo L,Noyan A,Yalcinkaya F,Topaloglu R,Webb NJ,Kemper MJ,Pape L,Bald M,Kranz B,Taylan C,Höcker B,Tönshoff B,Weber LT

    更新日期:2017-05-01 00:00:00

  • Planning for the future of a pediatric kidney transplant recipient with special needs: A parent's perspective.

    abstract::I was asked to write this article to share with medical professionals, my view as a parent with a child who has special needs and needs a transplant. It is a detailed story from a parent's point of view on what it is like to have a child with special needs with serious medical complications and how I went about findin...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13906

    authors: Carney MT

    更新日期:2021-02-01 00:00:00

  • Successful resolution of inflammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis.

    abstract::This retrospective case series reviews our center's experience with sirolimus and a CNI as alternative therapy for the treatment of PTAH. It also characterizes regulatory T cells (Tregs) in PTAH. LT recipients with PTAH who had received or were receiving treatment with sirolimus were retrospectively identified (n = 12...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01648.x

    authors: Ekong UD,Mathew J,Melin-Aldana H,Wang D,Alonso EM

    更新日期:2012-03-01 00:00:00

  • Reno- and splenoportal anastomosis for a retransplant patient with situs inversus.

    abstract::PV thrombosis following pediatric LT is a serious complication that may lead to graft loss. LDLT poses limitations with regard to the availability of vein grafts for complex PV reconstructions. We herein report a unique reconstruction of the PV inflow in a one-yr-old boy with situs inversus undergoing re-LDLT. The inf...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.12703

    authors: Uchida H,Fukuda A,Sasaki K,Shigeta T,Hirata Y,Kanazawa H,Mali VP,Miyazaki O,Nosaka S,Sakamoto S,Mureo K

    更新日期:2016-06-01 00:00:00

  • ABO-incompatible deceased donor pediatric liver transplantation: Novel titer-based management protocol and outcomes.

    abstract::ABO-ILT have re-emerged as an alternate option for select patients awaiting transplant. However, treatment protocols for children undergoing deceased donor ABO-ILT are not standardized. We implemented a novel IS protocol for children undergoing deceased donor ABO-ILT based on pretransplant IH titers. Children with hig...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13263

    authors: Mysore KR,Himes RW,Rana A,Teruya J,Desai MS,Srivaths PR,Zaruca K,Calvert A,Guffey D,Minard CG,Morita E,Hensch L,Losos M,Kostousov V,Hui SR,Orange JS,Goss JA,Nicholas SK

    更新日期:2018-11-01 00:00:00

  • Antibody response to vaccination after haematopoietic cell transplantation in children using a reduced dose schedule-A retrospective cohort study.

    abstract::Children receiving HCT loose protective immunity to vaccines received pre-HCT. Therefore, revaccination post-HCT is of major importance. In Denmark, a vaccination schedule with fewer doses post-HCT has been used, including two doses for diphtheria, tetanus, polio, measles, mumps, and rubella, and one dose only for Hae...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13599

    authors: Jensen L,Poulsen A,Nygaard U,Scheike T,Riis MS,Pedersen FK,Heilmann C

    更新日期:2020-02-01 00:00:00

  • Plasmapheresis-resistant acute humoral rejection successfully treated with anti-C5 antibody.

    abstract::Even if kidney graft survival has improved during the last decades, sensitized pediatric patients are an emerging problem. We describe a 17-yr-old male who lost his first graft due to chronic rejection becoming hyperimmunized (CDC PRA 99.61%). A desensitization protocol based on high-dose IVIG, PP, and two Mabthera(®)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12187

    authors: Ghirardo G,Benetti E,Poli F,Vidal E,Della Vella M,Cozzi E,Murer L

    更新日期:2014-02-01 00:00:00

  • Severe cryptosporidiosis in a seven-year-old renal transplant recipient: case report and review of the literature.

    abstract::Cryptosporidium is an intracellular protozoa that can cause gastroenteritis in humans. In immunocompromised hosts, infection can be severe, leading to life-threatening persistent diarrhea. There is limited experience in treating this infection in solid organ transplants. Although newer drugs active against Cryptospori...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2006.00593.x

    authors: Hong DK,Wong CJ,Gutierrez K

    更新日期:2007-02-01 00:00:00

  • Squamous cell carcinoma development in Fanconi anemia patients who underwent hematopoietic stem cell transplantation.

    abstract::We examined SCC development of 24 FA patients, who received HSCT from HLA-matched relatives. In our BMT center, we applied low-dose CY + LFI + ATG (n:13) as conditioning regimen for FA patients between 1992 and 1999, and CY + BU + ATG (n:11) between 1999 and 2002. The aim of this study was to investigate SCC developme...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13706

    authors: Anak S,Yalman N,Bilgen H,Sepet E,Deviren A,Gürtekin B,Tunca F,Başaran B

    更新日期:2020-06-01 00:00:00