CD98 modulates integrin beta1 function in polarized epithelial cells.

abstract：:S100 proteins have attracted great interest in recent years because of their cell- and tissue-specific expression and association with various human pathologies. Most S100 proteins are small acidic proteins with calcium-binding domains - the EF hands. It is thought that this group of proteins carry out their cellular ...

journal_title：Journal of cell science

authors： Hsieh HL,Schäfer BW,Cox JA,Heizmann CW

更新日期：2002-08-01 00:00:00

abstract：:Wound healing crucially relies on the mechanical activity of fibroblasts responding to TGFβ1 and to forces transmitted across focal adhesions. Integrin-linked kinase (ILK) is a central adapter recruited to integrin β1 tails in focal adhesions mediating the communication between cells and extracellular matrix. Here, we...

journal_title：Journal of cell science

authors： Blumbach K,Zweers MC,Brunner G,Peters AS,Schmitz M,Schulz JN,Schild A,Denton CP,Sakai T,Fässler R,Krieg T,Eckes B

更新日期：2010-11-15 00:00:00

abstract：:A number of epithelia form tubulocysts in vitro when overlaid with type I collagen gel. Because collagen receptors are generally believed to be expressed on the basolateral domain, the mechanism by which collagen elicits this morphogenetic response from the apical surface is unclear. To investigate the role of beta 1 ...

journal_title：Journal of cell science

authors： Zuk A,Matlin KS

更新日期：1996-07-01 00:00:00

abstract：:Apoptosis, or programmed cell death, involves a cascade of regulatory events leading to the activation of specific proteases. However, the key substrates for these proteases remain to be identified. We previously demonstrated that levels of five unidentified polypeptides were specifically increased in neurons from emb...

journal_title：Journal of cell science

authors： Villa PG,Henzel WJ,Sensenbrenner M,Henderson CE,Pettmann B

更新日期：1998-03-01 00:00:00

abstract：:The neuroprotective role of carbon monoxide (CO) has been studied in a cell-autonomous mode. Herein, a new concept is disclosed - CO affects astrocyte-neuron communication in a paracrine manner to promote neuroprotection. Neuronal survival was assessed when co-cultured with astrocytes that had been pre-treated or not ...

journal_title：Journal of cell science

authors： Queiroga CS,Alves RM,Conde SV,Alves PM,Vieira HL

更新日期：2016-08-15 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival, neurite outgrowth and synaptic plasticity by activating the receptor tropomyosin receptor kinase B (TrkB, also known as NTRK2). TrkB has been shown to undergo recycling after BDNF stimulation. We have previously reported that full-l...

journal_title：Journal of cell science

authors： Sui WH,Huang SH,Wang J,Chen Q,Liu T,Chen ZY

更新日期：2015-03-15 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP1) is a nuclear enzyme that can trigger caspase-independent necrosis. Two main mechanisms for this have been proposed: one involving RIP1 and JNK kinases and mitochondrial permeability transition (MPT), the other involving calpain-mediated activation of Bax and mitochondrial release ...

journal_title：Journal of cell science

authors： Douglas DL,Baines CP

更新日期：2014-10-01 00:00:00

abstract：:Intracellular membrane fusion occurs with exquisite coordination and specificity. Each fusion event requires three basic components: Rab-GTPases organize the fusion site; SNARE proteins act during fusion; and N-ethylmaleimide-sensitive factor (NSF) plus its cofactor alpha-SNAP are required for recycling or activation ...

journal_title：Journal of cell science

authors： Ungermann C,Langosch D

更新日期：2005-09-01 00:00:00

abstract：:Antithrombin inhibits chemokine-induced migration of neutrophils by activating heparan sulfate proteoglycan-dependent signaling. Whether antithrombin affects migration of other types of leukocytes is not known. We investigated the effects of antithrombin on spontaneous and chemokine-triggered migration of lymphocytes ...

journal_title：Journal of cell science

authors： Kaneider NC,Reinisch CM,Dunzendorfer S,Römisch J,Wiedermann CJ

更新日期：2002-01-01 00:00:00

abstract：:The nuclear division of Oxyrrhis marina is a very distinct one among the mitoses of dinoflagellates that have been studies. Using synchronized populations, we have investigated the ultrastructural changes in this nuclear division. In interphase, nuclei can be classified into two groups on the basis of the shapes of th...

journal_title：Journal of cell science

authors： Gao XP,Li JY

更新日期：1986-09-01 00:00:00

abstract：:The conventional kinesin motor transports many different cargos to specific locations in neurons. How cargos regulate motor function remains unclear. Here we focus on KIF5, the heavy chain of conventional kinesin, and report that the Kv3 (Shaw) voltage-gated K(+) channel, the only known tetrameric KIF5-binding protein...

journal_title：Journal of cell science

authors： Barry J,Xu M,Gu Y,Dangel AW,Jukkola P,Shrestha C,Gu C

更新日期：2013-05-01 00:00:00

abstract：:We have performed a screening analysis of differential gene expression using a defined in vitro model of human capillary tube formation. Gene array, differential display and cDNA library screening were used to identify both known and novel differentially expressed genes. Major findings include: the upregulation and fu...

journal_title：Journal of cell science

authors： Bell SE,Mavila A,Salazar R,Bayless KJ,Kanagala S,Maxwell SA,Davis GE

更新日期：2001-08-01 00:00:00

abstract：:Inhibitory and excitatory neurons exhibit distinct patterns of development in the mammalian cerebral cortex. The morphological development of inhibitory and excitatory neurons derived from fetal rat cerebral cortex has now been compared in vitro. Inhibitory neurons were identified by immunofluorescence staining with a...

journal_title：Journal of cell science

authors： Hayashi K,Kawai-Hirai R,Harada A,Takata K

更新日期：2003-11-01 00:00:00

abstract：:How vesicle trafficking components actively contribute to regulation of paracrine signaling is unclear. We genetically uncovered a requirement for α-soluble NSF attachment protein (α-Snap) in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway during Drosophila egg de...

journal_title：Journal of cell science

authors： Saadin A,Starz-Gaiano M

更新日期：2018-11-30 00:00:00

abstract：:It has been demonstrated that proteins covalently conjugated to folic acid may be taken up by cells via endocytosis after binding to a folate binding protein (FBP) in the cell membrane. The proteins taken up in this manner remain catalytically active and they may modify physiological processes occurring in the cytosol...

journal_title：Journal of cell science

authors： Turek JJ,Leamon CP,Low PS

更新日期：1993-09-01 00:00:00

abstract：:Increased deposition of collagen in extracellular matrix (ECM) leads to increased tissue stiffness and occurs in breast tumors. When present, this increases tumor invasion and metastasis. Precisely how this deposition is regulated and maintained in tumors is unclear. Much has been learnt about mechanical signal transd...

journal_title：Journal of cell science

authors： Zhang K,Grither WR,Van Hove S,Biswas H,Ponik SM,Eliceiri KW,Keely PJ,Longmore GD

更新日期：2016-05-15 00:00:00

abstract：:Retinoic acid (RA) plays key roles in cell differentiation and growth arrest by activating nuclear RA receptors (RARs) (α, β and γ), which are ligand-dependent transcription factors. RARs are also phosphorylated in response to RA. Here, we investigated the in vivo relevance of the phosphorylation of RARs during RA-ind...

journal_title：Journal of cell science

authors： Al Tanoury Z,Gaouar S,Piskunov A,Ye T,Urban S,Jost B,Keime C,Davidson I,Dierich A,Rochette-Egly C

更新日期：2014-05-01 00:00:00

abstract：:The cohesin complex prevents premature segregation of duplicated chromosomes by providing resistance to the pole-ward pull by spindle microtubules. The centromeric region (or sister kinetochores) bears the majority of this force and undergoes transient separation prior to anaphase, indicative of its elastic nature. A ...

journal_title：Journal of cell science

authors： Zhang T,Lim HH,Cheng CS,Surana U

更新日期：2006-02-01 00:00:00

abstract：:The activation of phospholipase C (PLC) is a conserved mechanism of receptor-activated cell signaling at the plasma membrane. PLC hydrolyzes the minor membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], and continued signaling requires the resynthesis and availability of PI(4,5)P2 at the plasma membrane....

journal_title：Journal of cell science

authors： Balakrishnan SS,Basu U,Shinde D,Thakur R,Jaiswal M,Raghu P

更新日期：2018-08-03 00:00:00

abstract：:The small GTPase Arf4 and the Arf GTPase-activating protein (GAP) ASAP1 cooperatively sequester sensory receptor cargo into transport carriers targeted to primary cilia, but the input that drives Arf4 activation in this process remains unknown. Here, we show, by using frog retinas and recombinant human proteins, that ...

journal_title：Journal of cell science

authors： Wang J,Fresquez T,Kandachar V,Deretic D

更新日期：2017-12-01 00:00:00

abstract：:Meiotic cell cycles differ from mitotic cell cycles in that the former lack S-phase in the interphase between meiosis I and meiosis II. To obtain clues for mechanisms involved in the cell cycle regulation unique to meiosis, we have examined changes in chromosomal morphology and H1 kinase activity during a meiotic peri...

journal_title：Journal of cell science

authors： Ohsumi K,Sawada W,Kishimoto T

更新日期：1994-11-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) triggers apoptosis selectively in tumor cells through interaction with TRAIL-R1/DR4 or TRAIL-R2/DR5 and this process is considered a promising avenue for cancer treatment. TRAIL resistance, however, is frequently encountered and hampers anti-cancer ...

journal_title：Journal of cell science

authors： Azijli K,Yuvaraj S,Peppelenbosch MP,Würdinger T,Dekker H,Joore J,van Dijk E,Quax WJ,Peters GJ,de Jong S,Kruyt FA

更新日期：2012-10-01 00:00:00

abstract：:The Arabidopsis AINTEGUMENTA (ANT) gene, which encodes an APETALA2 (AP2)-like transcription factor, controls plant organ cell number and organ size throughout shoot development. ANT is thus a key factor in the development of plant shoots. Here, we have found that ANT plays an essential role in conferring salt toleranc...

journal_title：Journal of cell science

authors： Meng LS,Wang YB,Yao SQ,Liu A

更新日期：2015-08-01 00:00:00

abstract：:Coiled bodies are a special type of small round nuclear body, composed of coiled fibers and granules, especially prominent in the nucleoplasm of highly active cells (Brasch and Ochs (1992) Exp. Cell Res. 202, 211-223). Although no specific function has been assigned to coiled bodies, they contain spliceosome snRNAs an...

journal_title：Journal of cell science

authors： Ochs RL,Stein TW Jr,Tan EM

更新日期：1994-02-01 00:00:00

abstract：:Neutrophils enter sites of inflammation by crossing the endothelial lining of the blood vessel wall. VE-cadherin is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface. We have generated a monoclonal antibody against mouse VE-cadherin which inhibits electrical resistance of endoth...

journal_title：Journal of cell science

authors： Gotsch U,Borges E,Bosse R,Böggemeyer E,Simon M,Mossmann H,Vestweber D

更新日期：1997-03-01 00:00:00

abstract：:Activation and invasion of the vascular endothelium by Staphylococcus aureus is a major cause of sepsis and endocarditis. For endothelial cell invasion, S. aureus triggers actin polymerization through Cdc42, N-WASp (also known as WASL) and the Arp2/3 complex to assemble a phagocytic cup-like structure. Here, we show t...

journal_title：Journal of cell science

authors： Rauch L,Hennings K,Trasak C,Röder A,Schröder B,Koch-Nolte F,Rivera-Molina F,Toomre D,Aepfelbacher M

更新日期：2016-08-01 00:00:00

abstract：:A fundamental aspect in the morphogenesis of a polarized epithelium is the formation of structurally and functionally distinct apical and basal-lateral domains of the plasma membrane. The formation of these membrane domains involves the accumulation of domain-specific proteins and removal of incorrectly localized prot...

journal_title：Journal of cell science

authors： Wang AZ,Ojakian GK,Nelson WJ

更新日期：1990-01-01 00:00:00

abstract：:Certain embryonic tissue masses and cell aggregates behave like deformable solids during brief experimental manipulations but like viscous liquids in long-term organ cultures. To investigate these seemingly paradoxical physical properties, we have mechanically deformed cell aggregates derived from several embryonic ch...

journal_title：Journal of cell science

authors： Phillips HM,Steinberg MS

更新日期：1978-04-01 00:00:00

abstract：:Rat small hepatocytes have been shown to proliferate in culture and to form organoids with differentiated hepatocytes in vitro. To evaluate the degree of polarized transporter differentiation of rat small hepatocytes during 9 weeks of culturing, we studied the time-dependent expression and subcellular localization of ...

journal_title：Journal of cell science

authors： Sidler Pfändler MA,Höchli M,Inderbitzin D,Meier PJ,Stieger B

更新日期：2004-08-15 00:00:00

abstract：:Ligand-dependent nuclear import is crucial for the function of the androgen receptor (AR) in both health and disease. The unliganded AR is retained in the cytoplasm but, on binding 5alpha-dihydrotestosterone, it translocates into the nucleus and alters transcription of its target genes. Nuclear import of AR is mediate...

journal_title：Journal of cell science

authors： Cutress ML,Whitaker HC,Mills IG,Stewart M,Neal DE

更新日期：2008-04-01 00:00:00