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An unusual 500,000 bases long oscillation of guanine and cytosine content in human chromosome 21.

Abstract：

:An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb. Five cycles of oscillation are observed in this region with six GC-rich peaks and five GC-poor valleys. The GC-poor valleys comprise regions with low density of CpG islands and, alternating between the two DNA strands, low gene density regions. Consequently, the long-range oscillation of GC% result in spacing patterns of both CpG island density, and to a lesser extent, gene densities.

journal_name

Comput Biol Chem

journal_title

Computational biology and chemistry

authors

Li W,Holste D

doi

10.1016/j.compbiolchem.2004.09.011

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

393-9

issue

5-6

eissn

1476-9271

issn

1476-928X

pii

S1476-9271(04)00084-2

journal_volume

28

pub_type

杂志文章

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