Abstract：
:Recoding events occur in competition with standard readout of the transcript, and are site-specific. Recoding is the reprogramming of mRNA translation by localized alterations in the standard translational rules. Frame-shifting is one class of recoding and defined as protein translations that start not at the first, but either at the second (+1 frame-shift) or the third (-1 frame-shift) nucleotide of the codon. Coding sequences lack stop codons, but frame-shifted sequences contain many stop codons, termed off-frame stops or hidden stops. These hidden stops terminate frame-shifted translation, potentially decreasing energy, and resource waste on non-functional proteins. Our results support this putative ancient adaptive event for the selection of codons that can be part of hidden stop codons. All taxonomic groups represent positive correlation between codon usage frequencies and contribution of codons to hidden stops in off-frame context. Our analysis on nuclear and mitochondrial genomic data revealed phylogenomic selection of ambush mechanism. Strongest impact of this event was found in viruses and bacteria. It has been suggested that this mechanism has occurred and been utilized in the early stages of evolution.
journal_name
Comput Biol Chemjournal_title
Computational biology and chemistryauthors
Singh TR,Pardasani KRdoi
10.1016/j.compbiolchem.2009.04.002subject
Has Abstractpub_date
2009-06-01 00:00:00pages
239-44issue
3eissn
1476-9271issn
1476-928Xpii
S1476-9271(09)00031-0journal_volume
33pub_type
杂志文章abstract：:Membrane electroporation seems to be a useful method for delivery of biological active compounds into the cell. Although it is known that this phenomenon is sensitive to the electric field intensity, duration of the electric pulse and its shape, it is not fully understood. In some theoretical descriptions it is postul...
journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2008.02.001
更新日期：2008-06-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2017.10.007
更新日期：2017-12-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/s0097-8485(02)00074-8
更新日期：2003-07-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2005.04.002
更新日期：2005-06-01 00:00:00
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journal_title：Computational biology and chemistry
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更新日期：2017-08-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2017.08.005
更新日期：2017-10-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2017.04.007
更新日期：2017-08-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2008.03.015
更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2020.107363
更新日期：2020-10-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2019.107192
更新日期：2020-02-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2005.12.001
更新日期：2006-04-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2016.09.001
更新日期：2016-10-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2010.12.005
更新日期：2011-02-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2018.10.003
更新日期：2018-12-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2018.11.029
更新日期：2019-02-01 00:00:00
abstract：:In this work, a framework is provided for identifying intracranial electroencephalography (iEEG) seizures based on discrete wavelet transform (DWT) analysis of iEEG signals using forward propagation and feedback neural networks. The performance of 5 different data sets combination classifications is studied using the ...
journal_title：Computational biology and chemistry
pub_type： 杂志文章
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更新日期：2020-06-19 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2019.107166
更新日期：2020-02-01 00:00:00
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journal_title：Computational biology and chemistry
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更新日期：2019-02-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2017.09.003
更新日期：2017-12-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2011.11.004
更新日期：2012-02-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2012.11.002
更新日期：2013-02-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2007.03.005
更新日期：2007-06-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2018.09.009
更新日期：2018-12-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2009.07.012
更新日期：2009-10-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2008.07.011
更新日期：2008-12-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2007.03.007
更新日期：2007-06-01 00:00:00
abstract：:Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism and plays a central role in DNA methylation and biosynthesis. MTHFR mutations may alter the cellular folate supply which in turn affects nucleic acid synthesis, DNA methylation and chromosomal damage. The identification of number...
journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2018.02.022
更新日期：2018-06-01 00:00:00
