Improving the power to detect differentially expressed genes in comparative microarray experiments by including information from self-self hybridizations.

Abstract:

:Our ability to detect differentially expressed genes in a microarray experiment can be hampered when the number of biological samples of interest is limited. In this situation, we propose the use of information from self-self hybridizations to acuminate our inference of differential expression. A unified modelling strategy is developed to allow better estimation of the error variance. This principle is similar to the use of a pooled variance estimate in the two-sample t-test. The results from real dataset examples suggest that we can detect more genes that are differentially expressed in the combined models. Our simulation study provides evidence that this method increases sensitivity compared to using the information from comparative hybridizations alone, given the same control for false discovery rate. The largest increase in sensitivity occurs when the amount of information in the comparative hybridization is limited.

journal_name

Comput Biol Chem

authors

Gusnanto A,Tom B,Burns P,Macaulay I,Thijssen-Timmer DC,Tijssen MR,Langford C,Watkins N,Ouwehand W,Berzuini C,Dudbridge F

doi

10.1016/j.compbiolchem.2007.03.005

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

178-85

issue

3

eissn

1476-9271

issn

1476-928X

pii

S1476-9271(07)00053-9

journal_volume

31

pub_type

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