The aspartate aminotransferase-like domain of Firmicutes MocR transcriptional regulators.

Abstract:

:Bacterial MocR transcriptional regulators possess an N-terminal DNA-binding domain containing a conserved helix-turn-helix module and an effector-binding and/or oligomerization domain at the C-terminus, homologous to fold type-I pyridoxal 5'-phosphate (PLP) enzymes. Since a comprehensive structural analysis of the MocR regulators is still missing, a comparisons of Firmicutes MocR sequences was undertook to contribute to the understanding of the structural characteristics of the C-terminal domain of these proteins, and to shed light on the structural and functional relationship with fold type-I PLP enzymes. Results of this work suggest the presence of at least three subgroups within the MocR sequences and provide a guide for rational site-directed mutagenesis studies aimed at deciphering the structure-function relationships in this new protein family.

journal_name

Comput Biol Chem

authors

Milano T,Contestabile R,Lo Presti A,Ciccozzi M,Pascarella S

doi

10.1016/j.compbiolchem.2015.05.003

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

55-61

eissn

1476-9271

issn

1476-928X

pii

S1476-9271(15)30008-6

journal_volume

58

pub_type

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