Abstract:
:Bacterial MocR transcriptional regulators possess an N-terminal DNA-binding domain containing a conserved helix-turn-helix module and an effector-binding and/or oligomerization domain at the C-terminus, homologous to fold type-I pyridoxal 5'-phosphate (PLP) enzymes. Since a comprehensive structural analysis of the MocR regulators is still missing, a comparisons of Firmicutes MocR sequences was undertook to contribute to the understanding of the structural characteristics of the C-terminal domain of these proteins, and to shed light on the structural and functional relationship with fold type-I PLP enzymes. Results of this work suggest the presence of at least three subgroups within the MocR sequences and provide a guide for rational site-directed mutagenesis studies aimed at deciphering the structure-function relationships in this new protein family.
journal_name
Comput Biol Chemjournal_title
Computational biology and chemistryauthors
Milano T,Contestabile R,Lo Presti A,Ciccozzi M,Pascarella Sdoi
10.1016/j.compbiolchem.2015.05.003subject
Has Abstractpub_date
2015-10-01 00:00:00pages
55-61eissn
1476-9271issn
1476-928Xpii
S1476-9271(15)30008-6journal_volume
58pub_type
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