Abstract：
:The occurrence of similar structural repeats in a protein structure has evolved through gene duplication. These repeats act as a structural building block and form more than one compact structural and functional unit called a repeat domain. The protein families comprising similar structural repeats are mainly involved in protein-protein interactions as well as binding to other ligand molecules. The identification of internal sequence repeats in the primary structure is not sufficient for the analysis of structural repeats. Thus, a new method called ProSTRIP has been developed using dynamic programming to find the similar structural repeats in a three-dimensional protein structure. The detection of these repeats is made by calculating the protein backbone Calpha angles. An internet computing server is also created by implementing this method and enables graphical visualization of the results. It can be freely accessed at http://cluster.physics.iisc.ernet.in/prostrip/.
journal_name
Comput Biol Chemjournal_title
Computational biology and chemistryauthors
Sabarinathan R,Basu R,Sekar Kdoi
10.1016/j.compbiolchem.2010.03.006subject
Has Abstractpub_date
2010-04-01 00:00:00pages
126-30issue
2eissn
1476-9271issn
1476-928Xpii
S1476-9271(10)00022-8journal_volume
34pub_type
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