Abstract：
:We present the mechanism of interaction of Wnt network module, which is responsible for periodic somitogenesis, with p53 regulatory network, which is one of the main regulators of various cellular functions, and switching of various oscillating states by investigating p53-Wnt model. The variation in Nutlin concentration in p53 regulating network drives the Wnt network module to different states, stabilized, damped and sustain oscillation states, and even to cycle arrest. Similarly, the change in Axin2 concentration in Wnt could able to modulate the p53 dynamics at these states. We then solve the set of coupled ordinary differential equations of the model using quasi steady state approximation. We, further, demonstrate the change of p53 and GSK3 interaction rate, due to hypothetical catalytic reaction or external stimuli, can able to regulate the dynamics of the two network modules, and even can control their dynamics to protect the system from cycle arrest (apoptosis).
journal_name
Comput Biol Chemjournal_title
Computational biology and chemistryauthors
Zubbair Malik M,Ali S,Alam MJ,Ishrat R,Brojen Singh RKdoi
10.1016/j.compbiolchem.2015.07.014subject
Has Abstractpub_date
2015-12-01 00:00:00pages
55-66eissn
1476-9271issn
1476-928Xpii
S1476-9271(15)30096-7journal_volume
59 Pt Bpub_type
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